M Nordentoft

..Excess mortality among patients with severe mental disorders has not previously been investigated in detail in large complete national populations...

..Very few studies have focused on the population in such facilities...

..It is hypothesized that addition of cognitive training to a comprehensive psychosocial programme (OPUS) enhances both cognitive and everyday functional capacity of patients more than the comprehensive psychosocial programme alone...

..40 percent remain chronically psychotic...

..Family intervention reduces risk of remission and improve compliance with antipsychotic medication...

..Suicidal intent was not related to dangerousness of suicide method...

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..Finally, the state of the art is discussed with regard to prevention at the universal, the selected and the indicated level and clinical and research implications are outlined...

..The aim of this study was to evaluate whether DUP was shortened during the first 3 years after establishing detection teams without a concomitant information campaign...

..Estimates of lifetime risk of suicide in mental disorders were based on selected samples with incomplete follow-up...

..A crisis plan developed together with the patient can be helpful. Regular screening for risk of suicide should be implemented in psychiatric services...

..To examine the rationale and evidence supporting an early intervention approach in schizophrenia...

..To investigate the effect of integrated treatment on negative, psychotic and disorganised symptoms in patients with first episode psychosis...

..Rates of recovery and institutionalization contradict the assumption that the illness deteriorates progressively, since no changes in the rates are seen from two to five years...

..To examine the frequency and predictors of good outcome for patients with first-episode schizophrenia spectrum disorder (SSD)...

..The aim of the present study was to examine the independent contributions of DUP and of pre-morbid adjustment to the clinical and social outcomes of schizophrenia...

..It is evident that by offering housing, homelessness may be reduced, but the comparison of independent housing and group living did not reveal big differences...

..Patients with first-episode psychosis comprise a high-risk group in terms of suicide...

..Intensive early treatment for first-episode psychosis has been shown to be effective. It is unknown if the positive effects are sustained for 5 years...

..Suicide is a major public health problem and should be given high priority with regard to prevention and research. (ABSTRACT TRUNCATED)..

..Those with first-episode psychosis are at high-risk of suicide...

..In concert with the literature, it is concluded that the interregional differences indicate that compliance with treatment can be improved by better organization of the psychiatric treatment...

..CONCLUSION: Integrated treatment improved clinical outcome and adherence to treatment. The improvement in clinical outcome was consistent at one year and two year follow-ups...

..The objective was to investigate if antipsychotic polypharmacy is associated with the excess mortality from natural causes among patients with schizophrenia...

..In 1992, a Suicide Prevention Centre was opened in Copenhagen with a 2-week programme of social and psychological treatment. The aim of the study was to evaluate the effect of the Suicide Prevention Centre...

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..This study adds to the evidence that intensified treatment models are superior to standard treatment. A higher number of bed-days in Hospital-based Rehabilitation did not influence the effect on the outcomes measured...

..This study sought to identify predictors for poor adherence to medication among patients with first-episode schizophrenia-spectrum disorder...

..To study the change in risk of suicide among patients with schizophrenia and related disorders...

..Restricted access occurred concomittantly with a 55 percent decrease in suicide rate...

..3 days. The mean duration of restraint with a leather belt was 2.66 days. This study provides information about the level of use of coercive measures in first-episode schizophrenia-spectrum disorders in Denmark...

..g. the 'OPUS' treatment. However, the patients' perspective is also important and was investigated in the 'OPUS' study by analysing data concerning quality of life...

..Early detection programmes can reduce the duration of untreated psychosis. There is good evidence that interventions during the early phase of psychotic symptoms are effective in improving several outcomes...

..The results suggest abnormally slow acquisition of new intellectual information and skills in EOS patients during the first 5 years after full clinical presentation...

..Patients in integrated treatment had significantly fewer psychotic and negative symptoms, less comorbid substance abuse, better adherence to treatment and more satisfaction with treatment at one-year and two-year follow-ups...

..Restricted access occurred concomittantly with a 55% decrease in suicide rate...

..Social network has considerable impact on physical and mental health. Patients experiencing first-episode psychosis early in adult life may experience severe problems concerning development and maintenance of their social network...

..There was a consistent finding that use of cannabis was associated with an increased risk of later psychosis with an odds ratio of approximately 2, when adjusted for predisposition to mental illness and socio-demographic risk factors...

..It is recommended that the quality of Reason for Contact Coding be improved, that patients who have attempted suicide be approached assertively, and that the supportive and guiding principle be used in securing them treatment...

..To investigate mortality among users of hostels for homeless people in Copenhagen, and to identify predictors of death such as conditions during upbringing, mental illness, and misuse of alcohol and drugs...

..Few studies have reported the age- and gender-specific incidence of schizophrenia in people aged up to 71 years, and no studies have reported the cumulative incidence of schizophrenia in people aged up to 71 years...

..Women make more suicide attempts and experience lower self-esteem in spite of better social functioning...

..Only a few randomized clinical trials have tested the effect on transition rates of intervention programs for patients with sub-threshold psychosis-like symptoms...

..The families of patients with first-episode psychosis often play a major role in care and often experience lack of support...

..ACT, with its engaged and committed staff with sufficient time, focusing on social and practical issues, is successful in facilitating such a contact, as experienced by patients...

..g. reduced compliance to medication and psychosocial interventions, and increased level of psychotic-dimension symptoms. The aim of this study was to review literature on treatments of CUD in SSD-patients...

..To evaluate the effect of a multifaceted educational intervention on the frequency of antipsychotic co-prescribing in adult schizophrenia out-patients...

..Deprived social circumstances during childhood, poor school performance in early adolescence, and attending a youth club seemed to be independent markers of substance abuse in adult life...

..The aim of the present study was to investigate regional differences in treatment setting characteristics and in physician and nurse attitudes toward antipsychotic polypharmacy and clinical guidelines...

..Because early illness course and outcome may affect the long-term outcome of schizophrenia-spectrum disorders, it is especially important to address poor outcome in this early critical period...

..To describe clinical utility and adoption of routinely offered CYP2D6 and CYP2C19 genotyping (CYP test) in daily clinical practice of a psychiatric centre...

..Standard Mortality Rates were high for all causes of death (5.00), and especially for suicide (31.98). In conclusion, psychiatric emergency outreach seems to fulfil some of its purpose...

..In this article, we introduce to the reader a number of receptors and neurotransmitter-systems involved in cannabis-abuse. Subsequently, we introduce the connection between abuse - particularly cannabis-abuse - and psychotic disorders...

..The trial is designed to include 45 patients in each group. Statistical analysis will be done as intention to treat (all randomized patients). Results from the DEMO trial will be reported according to the CONSORT guidelines in 2008-2009...

..This study investigated these hormones in response to acute exercise using an incremental bicycle test...

..Reports of high relative risk associated with parental low socioeconomic status may be confounded and overestimated if not adjusted for the association with mental disorder and suicide in the family...

..Persons with a history of admission to a psychiatric hospital are at high risk for suicide, but little is known about how this is influenced by factors related to psychiatric hospitalization...

..First-episode psychosis intervention may improve the course and outcome of schizophrenic disorders...

..To explore the risk of suicide associated with occupation while evaluating the impact of socio-economic, demographic and psychiatric differences...

..This study examines the influence of cognitive function and change in cognitive function during adolescence on schizophrenia and bipolar disorders in adulthood and explores possible mechanisms for any associations...

..Furthermore, we examined the incidence of the disorders in a population-based cohort and evaluated our results in the context of the Kraepelinian dichotomization...

..Even though the level of continuity seemed higher in integrated treatment, this did not reduce the use of coercive measures compared to the use in standard treatment...

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..However, the magnitude of the excess mortality differs from one mental disorder to another, and the impact on mortality if a first-degree family member suffers from a mental disorder has never been examined in a population-based study...

..This preface aims to set the scene for a selection of contributions, derived from the array of new evidence reported in Copenhagen, and recently fully updated...

..Two British cohort studies have reported birth weight to be associated with self-reported depression in adulthood, even after adjustment for socio-economic factors...

..To estimate the risk of suicide in young people related to family and individual psychiatric and socioeconomic factors...