Søren Saxmose Nielsen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. doi A review of prevalences of paratuberculosis in farmed animals in Europe
    Søren Saxmose Nielsen
    Department of Large Animal Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Prev Vet Med 88:1-14. 2009
  2. doi Effect of days in milk and milk yield on testing positive in milk antibody ELISA to Mycobacterium avium subsp. paratuberculosis in dairy cattle
    Søren Saxmose Nielsen
    Department of Large Animal Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Vet Immunol Immunopathol 149:6-10. 2012
  3. doi Time to the occurrence of a decline in milk production in cows with various paratuberculosis antibody profiles
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    J Dairy Sci 92:149-55. 2009
  4. doi Dairy farmers' reasons for participation in the Danish control programme on bovine paratuberculosis
    Søren Saxmose Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Prev Vet Med 98:279-83. 2011
  5. ncbi Assessment of management-related risk factors for paratuberculosis in Danish dairy herds using Bayesian mixture models
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Science, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Prev Vet Med 81:306-17. 2007
  6. ncbi Bayesian mixture models for within-herd prevalence estimates of bovine paratuberculosis based on a continuous ELISA response
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Prev Vet Med 81:290-305. 2007
  7. doi Ante mortem diagnosis of paratuberculosis: a review of accuracies of ELISA, interferon-gamma assay and faecal culture techniques
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Vet Microbiol 129:217-35. 2008
  8. doi Transitions in diagnostic tests used for detection of Mycobacterium avium subsp. paratuberculosis infections in cattle
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Vet Microbiol 132:274-82. 2008
  9. doi Colostrum and milk as risk factors for infection with Mycobacterium avium subspecies paratuberculosis in dairy cattle
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    J Dairy Sci 91:4610-5. 2008
  10. doi Structured approach to design of diagnostic test evaluation studies for chronic progressive infections in animals
    Søren Saxmose Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Vet Microbiol 150:115-25. 2011

Collaborators

Detail Information

Publications44

  1. doi A review of prevalences of paratuberculosis in farmed animals in Europe
    Søren Saxmose Nielsen
    Department of Large Animal Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Prev Vet Med 88:1-14. 2009
    ..Because most of the reported studies did not yield prevalence estimates which were comparable to other studies, there is a continuing need for well-designed studies of the prevalence of MAP infections...
  2. doi Effect of days in milk and milk yield on testing positive in milk antibody ELISA to Mycobacterium avium subsp. paratuberculosis in dairy cattle
    Søren Saxmose Nielsen
    Department of Large Animal Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Vet Immunol Immunopathol 149:6-10. 2012
    ..Inclusion of milk yield in the interpretation of test results could improve the diagnostic value, resulting in more predictable patterns corresponding to progression of infection...
  3. doi Time to the occurrence of a decline in milk production in cows with various paratuberculosis antibody profiles
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    J Dairy Sci 92:149-55. 2009
    ....
  4. doi Dairy farmers' reasons for participation in the Danish control programme on bovine paratuberculosis
    Søren Saxmose Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Prev Vet Med 98:279-83. 2011
    ..Animal health advisors should consider the diversity of participation reasons and address the specific reasons of individual farmers when establishing a strategy for control of MAP infections in a herd...
  5. ncbi Assessment of management-related risk factors for paratuberculosis in Danish dairy herds using Bayesian mixture models
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Science, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Prev Vet Med 81:306-17. 2007
    ..Surprisingly, the hygiene level in the calving area was not found to affect the odds of infection...
  6. ncbi Bayesian mixture models for within-herd prevalence estimates of bovine paratuberculosis based on a continuous ELISA response
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Prev Vet Med 81:290-305. 2007
    ..This allowed a more informative ranking of the herds where low ranking and high ranking herds were easier to identify...
  7. doi Ante mortem diagnosis of paratuberculosis: a review of accuracies of ELISA, interferon-gamma assay and faecal culture techniques
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Vet Microbiol 129:217-35. 2008
    ..e. the subjects chosen for test evaluation should reflect the distribution of animals in the population where the test is intended to be used...
  8. doi Transitions in diagnostic tests used for detection of Mycobacterium avium subsp. paratuberculosis infections in cattle
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Vet Microbiol 132:274-82. 2008
    ....
  9. doi Colostrum and milk as risk factors for infection with Mycobacterium avium subspecies paratuberculosis in dairy cattle
    S S Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    J Dairy Sci 91:4610-5. 2008
    ..Overall, the results of the study suggested that source of milk was not of great importance for the transmission of MAP, but colostrum should be fed only from the dam of that calf...
  10. doi Structured approach to design of diagnostic test evaluation studies for chronic progressive infections in animals
    Søren Saxmose Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Vet Microbiol 150:115-25. 2011
    ..The description provides input on the process and deductive reasoning which are integral parts to develop a high-quality design of a DTE for chronic infectious diseases...
  11. doi Effect of management practices on paratuberculosis prevalence in Danish dairy herds
    S S Nielsen
    Department of Large Animal Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    J Dairy Sci 94:1849-57. 2011
    ..Furthermore, decreases in the prevalence of MAP-specific antibodies may not reflect discontinued transmission of MAP in all age groups...
  12. pmc Association between antibodies to Coxiella burnetii in bulk tank milk and perinatal mortality of Danish dairy calves
    Katrine T Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Acta Vet Scand 53:64. 2011
    ..burnetii on two outcomes associated with parturition in cattle: a) stillbirth; and b) stillbirth and neonatal mortality combined (perinatal death)...
  13. ncbi Variation of the milk antibody response to paratuberculosis in naturally infected dairy cows
    S S Nielsen
    Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Grønnegårdevej 8, DK 1870 Frederiksberg C, Denmark
    J Dairy Sci 85:2795-802. 2002
    ....
  14. doi Prevalence of Mycobacterium avium subsp. paratuberculosis infection in adult Danish non-dairy cattle sampled at slaughter
    Hisako Okura
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Prev Vet Med 94:185-90. 2010
    ..7% vs. median TP (non-dairy)=0.8%. For the individual non-dairy breeds, the median estimates were generally higher, illustrating the problems of ranking groups based on relatively small sample sizes...
  15. ncbi Age at occurrence of Mycobacterium avium subspecies paratuberculosis in naturally infected dairy cows
    S S Nielsen
    Department of Large Animal Sciences, The Royal Veterinary and Agricultural University, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    J Dairy Sci 89:4557-66. 2006
    ..These antibodies can be detected by ELISA with a test strategy that is different for younger and older cows. We suggest testing younger cows more frequently than older cows and that testing should be done prior to 350 d in milk...
  16. doi Occurrence of Mycobacterium avium subsp. paratuberculosis in milk at dairy cattle farms: a systematic review and meta-analysis
    Hisako Okura
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    Vet Microbiol 157:253-63. 2012
    ..10 (0.04-0.22) in BTM and 0.20 (0.12-0.32) in IM. Quantifying the MAP load in test-positive milk samples was not possible because very few articles provided quantitative information on individual samples...
  17. doi Spatial differences in occurrence of paratuberculosis in Danish dairy herds and in control programme participation
    Kristine Bihrmann
    University of Copenhagen, Frederiksberg C, Denmark
    Prev Vet Med 103:112-9. 2012
    ..Further studies are needed to evaluate these and other risk factors...
  18. ncbi Paratuberculosis in dairy cattle: variation of the antibody response in offspring attributable to the dam
    S S Nielsen
    Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    J Dairy Sci 85:406-12. 2002
    ..It was concluded that the parental contribution was significant, and both heritability of susceptibility and vertical transmission should be considered in any control programs on paratuberculosis in dairy cattle...
  19. ncbi Continuous-data diagnostic tests for paratuberculosis as a multistage disease
    N Toft
    Department of Large Animal Sciences, The Royal Veterinary and Agricultural University, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    J Dairy Sci 88:3923-31. 2005
    ..e., sensitivity and specificity)...
  20. ncbi Age-specific characteristics of ELISA and fecal culture for purpose-specific testing for paratuberculosis
    S S Nielsen
    Department of Large Animal Sciences, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    J Dairy Sci 89:569-79. 2006
    ..Purpose-specific tests are required to appropriately interpret and use test results for management of paratuberculosis, and relevant covariates, such as age, should be included when possible...
  21. ncbi Association between the presence of antibodies to Mycobacterium avium subspecies paratuberculosis and somatic cell count
    F M Baptista
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
    J Dairy Sci 91:109-18. 2008
    ....
  22. pmc Bovine renal lipofuscinosis: prevalence, genetics and impact on milk production and weight at slaughter in Danish cattle
    Jørgen S Agerholm
    Department of Disease Biology, University of Copenhagen, Bulowsvej 17, DK 1870 Frederiksberg C, Denmark
    Acta Vet Scand 51:7. 2009
    ..Recent studies have indicated a negative influence on the health of affected animals. The present study investigated the prevalence, genetics and effect of BRL on milk yield and weight at slaughter...
  23. doi Data from the Danish veterinary cancer registry on the occurrence and distribution of neoplasms in dogs in Denmark
    L B Brønden
    DACVIM SA, DECVIM CA and Oncology, Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Dyrlaegevej 16, Frederiksberg 1875, Denmark
    Vet Rec 166:586-90. 2010
    ..A standard morbidity ratio below 1 was observed in German shepherd dogs and Danish/Swedish farm dogs, suggesting a lower risk of cancer in these breeds...
  24. doi Escherichia coli shedding patterns in humans and dogs: insights into within-household transmission of phylotypes associated with urinary tract infections
    P Damborg
    Department of Disease Biology, Faculty of Life Sciences, University of Copenhagen, Denmark
    Epidemiol Infect 137:1457-64. 2009
    ..The frequent sharing of clones belonging to phylotypes B2 (n=7) or D (n=4) supports the hypothesis that urovirulent E. coli are transmitted between household members, including dogs, or may be acquired by a common source such as food...
  25. ncbi Comparison of contamination and growth of Mycobacterium avium subsp. paratuberculosis on two different media
    S S Nielsen
    Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    J Appl Microbiol 96:149-53. 2004
    ..The purpose of the study was to compare the growth of Mycobacterium avium subsp. paratuberculosis (Map) and the degree of contamination on Herrold's egg yolk medium (HEYM) and modified Löwenstein-Jensen medium (LJ)...
  26. doi Validation of data collected in the Danish Veterinary Cancer Registry
    L B Brønden
    Department of Small Animal Clinical Sciences, Faculty of Life Sciences, Dyrlaegevej 16, 1870 Frederiksberg C, Denmark
    Vet Comp Oncol 7:207-11. 2009
    ..1%; (8) date of birth: 76.7%. All variables except date of death, birth, and diagnosis met the required 95% agreement limit. Data on dates of birth, death and diagnosis were considered less suitable for further studies...
  27. pmc Carriage and fecal counts of cefotaxime M-producing Escherichia coli in pigs: a longitudinal study
    Katrine Hartung Hansen
    University of Copenhagen, Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, Frederiksberg, Denmark
    Appl Environ Microbiol 79:794-8. 2013
    ..001). These findings provide novel information about the epidemiology of ESBLs at the farm level and have important implications for assessments of risks of meat contamination during slaughter...
  28. doi Characterization of the long-term immune response to vaccination against Mycobacterium avium subsp. paratuberculosis in Danish dairy cows
    Vibeke Thulstrup Thomsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, 1870 Frederiksberg C, Denmark
    Vet Immunol Immunopathol 145:316-22. 2012
    ..In conclusion, immunization with whole-cell MAP vaccines elicits both humoral and cell-mediated immune reactions, which may interfere with surveillance and diagnosis of both MAP and M. bovis infections using currently available tests...
  29. pmc In vitro adherence of Staphylococcus pseudintermedius to canine corneocytes is influenced by colonization status of corneocyte donors
    Narayan Chandra Paul
    Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Stigbøjlen 4, 1870 Frederiksberg C, Denmark
    Vet Res 44:52. 2013
    ..This finding has important implications for understanding and preventing S. pseudintermedius skin colonization and infection. ..
  30. pmc Dynamics of specific anti-Mycobacterium avium subsp. paratuberculosis antibody response through age
    Søren Saxmose Nielsen
    Department of Large Animal Sciences, University of Copenhagen, Frederiksberg C, Denmark
    PLoS ONE 8:e63009. 2013
    ..This study provided a model for estimating the proportion of latent chronic infections that would progress to disease, and the results can be used to model infection dynamics...
  31. ncbi Prevalence and transmission of haemolytic Gallibacterium species in chicken production systems with different biosecurity levels
    Anders Miki Bojesen
    Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, Stigbøjlen 4, DK 1870 Frederiksberg C, Denmark
    Avian Pathol 32:503-10. 2003
    ..In general, flock infections resembled an 'all or none' type of colonization as practically all of the chickens in infected flocks sampled positive. There was no evidence of vertical transmission of Gallibacterium...
  32. pmc Apparent Prevalence of Beef Carcasses Contaminated with Mycobacterium avium subsp. paratuberculosis Sampled from Danish Slaughter Cattle
    Hisako Okura
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, 1870 Frederiksberg C, Denmark
    Vet Med Int 2011:152687. 2011
    ..The observed viable MAP prevalence in beef carcasses was low. However, detection of MAP and MAP DNA in muscle tissues suggested that bacteremia occurred in slaughtered cattle...
  33. ncbi Host-specific bacterial lineages in the taxon 2 and 3 complex of Pasteurellaceae
    A M Bojesen
    Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, DK 1870 Frederiksberg C, Denmark
    Syst Appl Microbiol 30:119-27. 2007
    ..The observed host specificity of taxon 2 and 3 organisms may be used in future diagnostics and studies elucidating aspects of pathogenicity and epidemiology associated with the different lineages and their respective hosts...
  34. ncbi Histopathology of oligofructose-induced acute laminitis in heifers
    M B Thoefner
    Department of Large Animal Sciences, The Royal Veterinary and Agricultural University of Copenhagen, DK 1870 Frederiksberg, Denmark
    J Dairy Sci 88:2774-82. 2005
    ..A weakened dermo-epidermal junction is a possible intermediate stage in the pathophysiology of bovine sole ulceration at the typical site...
  35. ncbi Comparison of two enzyme-linked immunosorbent assays for serologic diagnosis of paratuberculosis (Johne's disease) in cattle using different subspecies strains of Mycobacterium avium
    S S Nielsen
    Department of Animal Science and Animal Health, Royal Veterinary and Agricultural University, Copenhagen, Denmark
    J Vet Diagn Invest 13:164-6. 2001
    ..The AUC for the P-ELISA ROC curve was 0.9197, and the AUC for the A-ELISA ROC curve was 0.9149, demonstrating a negligible difference in efficiency of the 2 tests (z = 0.182)...
  36. ncbi Variance components of an enzyme-linked immunosorbent assay for detection of IgG antibodies in milk samples to Mycobacterium avium subspecies paratuberculosis in dairy cattle
    S S Nielsen
    Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Med B Infect Dis Vet Public Health 49:384-7. 2002
    ..9). Therefore, it was concluded that the intraplate variability could be ignored whereas the variability from the combined run-day-plate variable should be considered in any analyses based on the ELISA...
  37. doi Evaluation of test-strategies for estimating probability of low prevalence of paratuberculosis in Danish dairy herds
    E S G Sergeant
    International EpiLab, The National Veterinary Institute, Danish Technical University, Bulowsvej 27, 1790 Copenhagen V, Denmark
    Prev Vet Med 85:92-106. 2008
    ..Despite this, it appears as if the method is a useful approach for herd-classification for most herds in the Danish dairy industry...
  38. ncbi Relationship between antibodies against Mycobacterium avium subsp. paratuberculosis in milk and shape of lactation curves
    A Kudahl
    Department of Animal Health and Welfare, Danish Institute of Agricultural Sciences, PO Box 50, Foulum, DK 8830 Tjele, Denmark
    Prev Vet Med 62:119-34. 2004
    ..In third and older parities, a significant effect of the quadratic term of stOD indicated exponentially increased losses with increased ODs...
  39. ncbi Genetic variation and heritability of the antibody response to Mycobacterium avium subspecies paratuberculosis in Danish Holstein cows
    H Mortensen
    Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Denmark
    J Dairy Sci 87:2108-13. 2004
    ..e., heavy bacterial shedders may have been represented among the cows sampled. It does not appear that intrauterine transmission is of major importance in the transmission of paratuberculosis...
  40. ncbi Estimating receiver operating characteristic curves with covariates when there is no perfect reference test for diagnosis of Johne's disease
    C Wang
    Department of Statistical Science, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 89:3038-46. 2006
    ..We found that both milk yield and its interaction with age had significant effects on the disease process whereas only milk yield was significant on the testing procedure...
  41. ncbi Effects of Pseudomonas fluorescens M3/6 bacterial protease on plasmin system and plasminogen activation
    K A Frohbieter
    Department of Food Science, Purdue University, West Lafayette, IN 47907, USA
    J Dairy Sci 88:3392-401. 2005
    ....
  42. ncbi Activity and nature of plasminogen activators associated with the casein micelle
    B Ismail
    Purdue University, Department of Food Science, 745 Agricultural Mall Drive, West Lafayette, IN 47907, USA
    J Dairy Sci 89:3285-95. 2006
    ....
  43. ncbi Typing of Legionella isolates during an epidemiological investigation can be helpful but also misleading: an example from Greece
    E N Velonakis
    Department of Microbiology, National School of Public Health, Athens, Greece
    Euro Surveill 11:E060824.4. 2006
  44. ncbi Postoperative mortality in patients with liver cirrhosis undergoing transurethral resection of the prostate: a Danish nationwide cohort study
    S S Nielsen
    Department of Medicine V (Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
    BJU Int 87:183-6. 2001
    ..Advanced age, comorbidity and acute admission seemed to be associated with an increased postoperative mortality. CONCLUSION: This study indicates that TURP in patients with liver cirrhosis was associated with increased mortality...