Søren Nielsen

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. pmc Increased renal sodium absorption by inhibition of prostaglandin synthesis during fasting in healthy man. A possible role of the epithelial sodium channels
    Thomas G Lauridsen
    Department of Medical Research, Holstebro Hospital, Denmark
    BMC Nephrol 11:28. 2010
  2. pmc Aquaporin-11: a channel protein lacking apparent transport function expressed in brain
    Daniel A Gorelick
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Biochem 7:14. 2006
  3. ncbi request reprint Renal aquaporins: an overview
    S Nielsen
    Water and Salt Research Centre, University of Aarhus, Denmark
    BJU Int 90:1-6. 2002
  4. ncbi request reprint Aquaporins in the kidney: from molecules to medicine
    Søren Nielsen
    The Water and Salt Research Center, Institute of Anatomy, and Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark
    Physiol Rev 82:205-44. 2002
  5. ncbi request reprint Regulation and dysregulation of aquaporins in water balance disorders
    S Nielsen
    The Water and Salt Research Center, University of Aarhus, Aarhus C, Denmark
    J Intern Med 261:53-64. 2007
  6. ncbi request reprint COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction
    Rikke Nørregaard
    The Water and Salt Research Center, University of Aarhus, Denmark
    Am J Physiol Renal Physiol 289:F322-33. 2005
  7. ncbi request reprint Early release of neonatal ureteral obstruction preserves renal function
    Yimin Shi
    The Water and Salt Research Center, Institute of Experimental Clinical Research, Aarhus Univ Hospital Skejby, DK 8200 Aarhus, Denmark
    Am J Physiol Renal Physiol 286:F1087-99. 2004
  8. ncbi request reprint Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats
    Marie Louise Elkjaer
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 283:F1376-88. 2002
  9. doi request reprint Ureter obstruction alters expression of renal acid-base transport proteins in rat kidney
    Guixian Wang
    The Water and Salt Research Center, Aarhus University, Aarhus, Denmark
    Am J Physiol Renal Physiol 295:F497-506. 2008
  10. ncbi request reprint Reduced expression of Na-K-2Cl cotransporter in medullary TAL in vitamin D-induced hypercalcemia in rats
    Weidong Wang
    Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 282:F34-44. 2002

Detail Information

Publications90

  1. pmc Increased renal sodium absorption by inhibition of prostaglandin synthesis during fasting in healthy man. A possible role of the epithelial sodium channels
    Thomas G Lauridsen
    Department of Medical Research, Holstebro Hospital, Denmark
    BMC Nephrol 11:28. 2010
    ....
  2. pmc Aquaporin-11: a channel protein lacking apparent transport function expressed in brain
    Daniel A Gorelick
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Biochem 7:14. 2006
    ..Two recently described aquaporins, numbers 11 and 12, appear to be more distantly related to the other mammalian aquaporins and aquaglyceroporins...
  3. ncbi request reprint Renal aquaporins: an overview
    S Nielsen
    Water and Salt Research Centre, University of Aarhus, Denmark
    BJU Int 90:1-6. 2002
  4. ncbi request reprint Aquaporins in the kidney: from molecules to medicine
    Søren Nielsen
    The Water and Salt Research Center, Institute of Anatomy, and Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark
    Physiol Rev 82:205-44. 2002
    ..Continued analysis of the aquaporins is providing detailed molecular insight into the fundamental physiology and pathophysiology of water balance and water balance disorders...
  5. ncbi request reprint Regulation and dysregulation of aquaporins in water balance disorders
    S Nielsen
    The Water and Salt Research Center, University of Aarhus, Aarhus C, Denmark
    J Intern Med 261:53-64. 2007
    ....
  6. ncbi request reprint COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction
    Rikke Nørregaard
    The Water and Salt Research Center, University of Aarhus, Denmark
    Am J Physiol Renal Physiol 289:F322-33. 2005
    ..These data indicate that COX-2 may be an important factor contributing to the impaired renal water and sodium handling in response to BUO...
  7. ncbi request reprint Early release of neonatal ureteral obstruction preserves renal function
    Yimin Shi
    The Water and Salt Research Center, Institute of Experimental Clinical Research, Aarhus Univ Hospital Skejby, DK 8200 Aarhus, Denmark
    Am J Physiol Renal Physiol 286:F1087-99. 2004
    ..These results suggest that early release of neonatal obstruction provides dramatically better protection of renal function than release of obstruction after the maturation process is completed...
  8. ncbi request reprint Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats
    Marie Louise Elkjaer
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 283:F1376-88. 2002
    ..Downregulation of BSC-1, TSC, and ENaC may contribute to the urinary concentrating defect, whereas upregulation of NHE3 may be compensatory to prevent urinary Na+ loss and/or to maintain intracellular pH levels...
  9. doi request reprint Ureter obstruction alters expression of renal acid-base transport proteins in rat kidney
    Guixian Wang
    The Water and Salt Research Center, Aarhus University, Aarhus, Denmark
    Am J Physiol Renal Physiol 295:F497-506. 2008
    ....
  10. ncbi request reprint Reduced expression of Na-K-2Cl cotransporter in medullary TAL in vitamin D-induced hypercalcemia in rats
    Weidong Wang
    Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 282:F34-44. 2002
    ....
  11. ncbi request reprint Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats
    Soo Wan Kim
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 286:F922-35. 2004
    ..The decreased abundance of NHE3, BSC-1, TSC, and Na-K-ATPase may play a compensatory role to promote sodium excretion...
  12. ncbi request reprint EPO and alpha-MSH prevent ischemia/reperfusion-induced down-regulation of AQPs and sodium transporters in rat kidney
    Hong Gong
    The Water and Salt Research Center, University of Aarhus, Aarhus, Denmark
    Kidney Int 66:683-95. 2004
    ....
  13. ncbi request reprint Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney
    Sophie de Seigneux
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 293:F87-99. 2007
    ..The increased basolateral expression of AQP2 induced by aldosterone may play a significant role in water metabolism in conditions with increased sodium reabsorption in the CCD...
  14. ncbi request reprint Angiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction
    Anja M Jensen
    The Water and Salt Research Center, Univ of Aarhus, Institute of Clinical Medicine Dept of Clinical Physiology, Aarhus Univ Hospital, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
    Am J Physiol Renal Physiol 291:F1021-32. 2006
    ..In conclusion, candesartan prevents dysregulation of AQP2, sodium transporters, and development of polyuria seen in BUO. This strongly supports the view that candesartan protects kidney function in response to urinary tract obstruction...
  15. ncbi request reprint alpha-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstruction
    Chunling Li
    The Water and Salt Research Center, Institute of Clinical Medicine, University of Aarhus, Brendstrupgaardsvej, DK 8230 Aarhus N, Denmark
    Am J Physiol Renal Physiol 290:F384-96. 2006
    ....
  16. ncbi request reprint Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2 11beta-hydroxysteroid dehydrogenase in rats with CCl4-induced decompensated liver cirrhosis
    Soo Wan Kim
    The Water and Salt Research Center, University of Aarhus, Aarhus, Denmark DK 8000
    J Am Soc Nephrol 16:3196-210. 2005
    ..In conclusion, increased apical targeting of ENaC subunits combined with diminished abundance of 11betaHSD2 in the DCT2, CNT, and cortical collecting duct is likely to play a role in the sodium retaining stage of liver cirrhosis...
  17. ncbi request reprint NBCn1 is a basolateral Na+-HCO3- cotransporter in rat kidney inner medullary collecting ducts
    Jeppe Praetorius
    The Water and Salt Research Ctr, University of Aarhus, Wilhelm Meyers Allé Bldg 233, 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 286:F903-12. 2004
    ..In conclusion, NBCn1 is a basolateral Na(+)-HCO(3)(-) cotransporter of IMCD cells and is differentially regulated in IMCD and medullary thick ascending limb...
  18. ncbi request reprint Changes in cellular composition of kidney collecting duct cells in rats with lithium-induced NDI
    Birgitte Mønster Christensen
    Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Cell Physiol 286:C952-64. 2004
    ..These effects are likely to be important in lithium-induced nephrogenic diabetes insipidus...
  19. doi request reprint Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction
    Anja M Jensen
    The Water and Salt Research Center, Institute of Clinical Medicine, Univ of Aarhus, Dept of Clinical Physiology and Nuclear Medicine, Aarhus Univ Hospital Skejby, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
    Am J Physiol Renal Physiol 296:F127-34. 2009
    ..In addition, we have shown that angiotensin II regulates the V2 receptor complex and pS256-AQP2 in postobstructive kidney IM, probably by stimulating cAMP generation...
  20. ncbi request reprint Altered expression of renal acid-base transporters in rats with lithium-induced NDI
    Young Hee Kim
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 285:F1244-57. 2003
    ..This is likely to represent direct or compensatory effects to increase the capacity for HCO3- reabsorption, NH4+ reabsorption, and proton secretion to prevent the development of systemic metabolic acidosis...
  21. doi request reprint Cyclooxygenase 2 inhibition exacerbates AQP2 and pAQP2 downregulation independently of V2 receptor abundance in the postobstructed kidney
    Anja M Jensen
    The Water and Salt Research Center, Institute of Clinical Medicine, University of Aarhus, Aarhus, Denmark
    Am J Physiol Renal Physiol 298:F941-50. 2010
    ..The results indicate that COX-2 inhibition does not mimic AT1R blockade-mediated effects and that AT1R-mediated AQP2 regulation in the postobstructed kidney collecting duct is independent of COX-2 induction...
  22. ncbi request reprint Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction
    Chunling Li
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 285:F889-901. 2003
    ..In conclusion, downregulation of renal Na transporters in rats with BUO and release of BUO are likely to contribute to the associated urinary concentrating defect, increased urinary sodium excretion, and postobstructive polyuria...
  23. ncbi request reprint Reduced expression of renal Na+ transporters in rats with PTH-induced hypercalcemia
    Weidong Wang
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 286:F534-45. 2004
    ..Moreover, the increase in the CaR in the thick ascending limb (TAL) may indicate a potential role of the CaR in inhibiting Na transport in the TAL...
  24. ncbi request reprint Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
    Weidong Wang
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 290:F530-41. 2006
    ..The increased targeting of ENaC and AQP2 likely represents direct or compensatory effects to increase sodium and water reabsorption and to prevent volume depletion in response to prolonged ANP infusion...
  25. ncbi request reprint Glomerular and tubular function during AT1 receptor blockade in pigs with neonatal induced partial ureteropelvic obstruction
    Anni Eskild-Jensen
    Department of Clinical Physiology and Nuclear Medicine, University of Aarhus, Denmark
    Am J Physiol Renal Physiol 292:F921-9. 2007
    ..This may have diagnostic potential in children with suspected congenital obstruction. Our results also demonstrate compromised tubular functions in response to chronic PUUO despite preservation of glomerular function...
  26. ncbi request reprint Regulation of collecting duct AQP3 expression: response to mineralocorticoid
    Tae Hwan Kwon
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 283:F1403-21. 2002
    ..Therefore, in the collecting duct aldosterone may regulate, at least in part, AQP3 expression in addition to regulating Na and K transport...
  27. doi request reprint Rapid and segmental specific dysregulation of AQP2, S256-pAQP2 and renal sodium transporters in rats with LPS-induced endotoxaemia
    Emma T B Olesen
    The Water and Salt Research Centre, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Nephrol Dial Transplant 24:2338-49. 2009
    ..Next, we aimed to examine the changes of iNOS expression and activated macrophage infiltration in the kidney and the effects of iNOS inhibition on AQP2 and NKCC2 expression in LPS rats...
  28. doi request reprint Unilateral ureteral obstruction alters expression of acid-base transporters in rat kidney
    Guixian Wang
    Water and Salt Research Center, University of Aarhus, Aarhus, Denmark
    J Urol 182:2964-73. 2009
    ..To clarify the molecular mechanisms of these defects we examined expression levels of key acid-base transporters along the renal nephron segments and collecting duct...
  29. ncbi request reprint Lithium treatment induces a marked proliferation of primarily principal cells in rat kidney inner medullary collecting duct
    Birgitte Mønster Christensen
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Renal Physiol 291:F39-48. 2006
    ..This is likely to contribute to the remodeling of the collecting duct after Li treatment...
  30. ncbi request reprint AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors
    Weidong Wang
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 283:F1313-25. 2002
    ..Moreover, PDE inhibitor treatment significantly prevented the reduced expression of collecting duct AQPs and prevented the development of polyuria...
  31. ncbi request reprint Lithium-induced NDI in rats is associated with loss of alpha-ENaC regulation by aldosterone in CCD
    Jakob Nielsen
    The Water and Salt Research Center, Institute of Anatomy Bldg 233 Univ of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Renal Physiol 290:F1222-33. 2006
    ....
  32. ncbi request reprint Immunolocalization of AQP-5 in rat parotid and submandibular salivary glands after stimulation or inhibition of secretion in vivo
    Veronika Gresz
    Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Gastrointest Liver Physiol 287:G151-61. 2004
    ....
  33. doi request reprint Age-dependent renal expression of acid-base transporters in neonatal ureter obstruction
    Guixian Wang
    The Water and Salt Research Center, University of Aarhus, Aarhus C, Denmark
    Pediatr Nephrol 24:1487-500. 2009
    ....
  34. ncbi request reprint Increased expression but not targeting of ENaC in adrenalectomized rats with PAN-induced nephrotic syndrome
    Sophie de Seigneux
    The Water and Salt Research Center, Bldg 233 234, University of Aarhus, and Institute of Clinical Medicine, Aarhus University Hospital, Denmark
    Am J Physiol Renal Physiol 291:F208-17. 2006
    ..Am J Physiol Renal Physiol 286: F922-F935, 2004) is caused by aldosterone and that development of sodium retention can occur in the absence of aldosterone in NS...
  35. ncbi request reprint Altered expression of selected genes in kidney of rats with lithium-induced NDI
    Aleksandra Rojek
    The Water and Salt Research Ctr, Bldg 233 234, Institute of Anatomy, Univ of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 288:F1276-89. 2005
    ....
  36. ncbi request reprint Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus
    Jakob Nielsen
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Renal Physiol 290:F438-49. 2006
    ..This study shows that aldosterone treatment perturbs diabetes insipidus and is associated with AQP2 redistribution in CNT and iCCD likely mediated by the spironolactone-sensitive mineralocorticoid receptor...
  37. ncbi request reprint Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus
    Primoz Kotnik
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 288:F1053-68. 2005
    ..These results identify markedly reduced expression of COX-1, COX-2, and mPGES in IM in lithium-induced NDI. Furthermore, there were major changes in the expression of COX-1, COX-2, and mPGES in rats with CDI...
  38. ncbi request reprint COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction
    Rikke Nørregaard
    The Water and Salt Research Center, University of Aarhus, DK 8200 Aarhus N, Denmark
    Am J Physiol Renal Physiol 292:F1322-33. 2007
    ....
  39. ncbi request reprint Altered expression of epithelial sodium channel in rats with bilateral or unilateral ureteral obstruction
    Chunling Li
    The Water and Salt Research Center, University of Aarhus, DK 8230 Aarhus N, Denmark
    Am J Physiol Renal Physiol 293:F333-41. 2007
    ..These results suggest that altered expression of alpha-, beta-, and gamma-ENaC may contribute to impaired renal sodium and water handling in response to ureteral obstruction...
  40. ncbi request reprint Axial heterogeneity in basolateral AQP2 localization in rat kidney: effect of vasopressin
    Birgitte Mønster Christensen
    The Water and Salt Research Center, Institute of AnatomyUniversity of DK 8000 Aarhus, Denmark
    Am J Physiol Renal Physiol 284:F701-17. 2003
    ..Moreover, acute V(2)-receptor antagonist treatment did not cause retrieval of AQP2 from the BLM. In contrast, long-term dDAVP treatment caused a major increase in AQP2 expression in the BLM in CCD...
  41. pmc Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice
    Aleksandra M Rojek
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 104:3609-14. 2007
    ..Thus, AQP9 is important for hepatic glycerol metabolism and may play a role in glycerol and glucose metabolism in diabetes mellitus...
  42. ncbi request reprint AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism
    Mariusz T Skowronski
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 292:F956-65. 2007
    ..In conclusion, AQP7 is expressed in capillary endothelia of adipose tissue (and cardiac and striated muscle) and is upregulated in WAT in response to S-DM supporting its role in glycerol metabolism...
  43. ncbi request reprint Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI
    Jakob Nielsen
    The Water and Salt Research Center, Institute of Anatomy Bldg 233, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Renal Physiol 285:F1198-209. 2003
    ....
  44. ncbi request reprint Renal compensation to chronic hypoxic hypercapnia: downregulation of pendrin and adaptation of the proximal tubule
    Sophie de Seigneux
    The Water and Salt Research Center, Institute of Anatomy, Bldg 1234, Univ of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 292:F1256-66. 2007
    ....
  45. ncbi request reprint Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats
    Soo Wan Kim
    The Water and Salt Research Center, Bldg 233 234, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 290:F674-87. 2006
    ..The decreased abundance of NHE3, NKCC2, NCC, and Na-K-ATPase may play a compensatory role in promoting sodium excretion...
  46. ncbi request reprint Furosemide increases water content in renal tissue
    Michael Pedersen
    MR Research Centre, Aarhus University Hospital, University of Aarhus, Aarhus, Denmark
    Am J Physiol Renal Physiol 292:F1645-51. 2007
    ....
  47. ncbi request reprint Functional up-regulation of basolateral Na+-dependent HCO3- transporter NBCn1 in medullary thick ascending limb of K+-depleted rats
    Jakob K Jakobsen
    Institute of Physiology, University of Aarhus, Ole Worms Alle 160, 8000 Aarhus C, Denmark
    Pflugers Arch 448:571-8. 2004
    ..They also indicate that it is the delivery of luminal NH(4)(+) rather than systemic changes of pH that determine the expression of NBCn1...
  48. pmc Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 105:3134-9. 2008
    ..Overall, our results are consistent with a dynamic effect of AVP on the phosphorylation and subcellular distribution of AQP2...
  49. ncbi request reprint Neonatal ureteral obstruction alters expression of renal sodium transporters and aquaporin water channels
    Yimin Shi
    Institute of Experimental Clinical Research, Aarhus University, Aarhus, Denmark
    Kidney Int 66:203-15. 2004
    ..Recently, we demonstrated that ureteral obstruction in adult rats is associated with reduction in the abundance of renal aquaporins (AQPs) and renal sodium transporters, which paralleled an impaired urinary concentrating capacity...
  50. pmc Similar VLDL-TG storage in visceral and subcutaneous fat in obese and lean women
    Esben Søndergaard
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
    Diabetes 60:2787-91. 2011
    ..Differential lipid redistribution through lipoproteins may affect body fat distribution. This is the first study to investigate VLDL-triglyceride (VLDL-TG) storage in visceral fat...
  51. ncbi request reprint Downregulation of renal aquaporins in response to unilateral ureteral obstruction
    Chunling Li
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 284:F1066-79. 2003
    ....
  52. ncbi request reprint Increased expression of ENaC subunits and increased apical targeting of AQP2 in the kidneys of spontaneously hypertensive rats
    Soo Wan Kim
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 289:F957-68. 2005
    ..These results suggest that the increased protein abundance of ENaC subunits as well as the increased apical targeting of AQP2 may contribute to renal sodium and water retention observed during the development of hypertension in SHR...
  53. ncbi request reprint Reduced renal expression of AQP2, p-AQP2 and AQP3 in haemorrhagic shock-induced acute renal failure
    Hong Gong
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Building 233, Wilhelm Meyers Alle, DK 8000 Aarhus C, Denmark
    Nephrol Dial Transplant 18:2551-9. 2003
    ....
  54. ncbi request reprint Decreased expression of AQP2 and AQP4 water channels and Na,K-ATPase in kidney collecting duct in AQP3 null mice
    Soo Wan Kim
    Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Biol Cell 97:765-78. 2005
    ....
  55. ncbi request reprint AE2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading
    Sebastian Frische
    The Water and Salt Research Center, Bldg 233 234, Univ of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 286:F1163-70. 2004
    ..The regulation following NH(4)Cl loading of AE2b in the cTAL suggests a role for AE2 in transepithelial bicarbonate reabsorption in this segment...
  56. pmc Independent effects of testosterone on lipid oxidation and VLDL-TG production: a randomized, double-blind, placebo-controlled, crossover study
    Christian Høst
    Department of Endocrinology and Internal Medicine and the Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Aarhus, Denmark
    Diabetes 62:1409-16. 2013
    ..T is not a major determinant of resting VLDL-TG kinetics in men...
  57. doi request reprint Liver-specific Aquaporin 11 knockout mice show rapid vacuolization of the rough endoplasmic reticulum in periportal hepatocytes after amino acid feeding
    Aleksandra Rojek
    Water and Salt Research Center, Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Am J Physiol Gastrointest Liver Physiol 304:G501-15. 2013
    ..In conclusion, in the liver, deletion of AQP11 results in disrupted RER homeostasis and increased sensitivity to RER injury upon metabolic challenge with amino acids...
  58. doi request reprint Impaired insulin-mediated antilipolysis and lactate release in adipose tissue of upper-body obese women
    Birgitte Nellemann
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
    Obesity (Silver Spring) 20:57-64. 2012
    ..So, UBO women were metabolically inflexible with respect to insulins antilipolytic and lactate increasing effects in abdominal adipose tissue. These phenomena are probably both consequences of insulin resistance of adipose tissue...
  59. ncbi request reprint Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading
    Sebastian Frische
    The Water and Salt Research Center, Institute of Anatomy, and Institute of Experimental Clinical Research, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 284:F584-93. 2003
    ....
  60. ncbi request reprint Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II
    Tae Hwan Kwon
    The Water and Salt Research Center, University of Aarhus, Denmark
    Am J Physiol Renal Physiol 285:F152-65. 2003
    ..In conclusion, increased abundance of NHE3 and BSC-1 in mTAL cells as well as increased NHE3 in the proximal tubule brush border may contribute to enhanced renal Na+ and HCO3 reabsorption in response to ANG II...
  61. doi request reprint Increased renal adrenomedullin expression in rats with ureteral obstruction
    Rikke Nørregaard
    The Water and Salt Research Center, Clinical Institute, Univ of Aarhus, Dept of Clinical Physiology and Nuclear Medicine, Aarhus Univ Hospital Skejby, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
    Am J Physiol Regul Integr Comp Physiol 296:R185-92. 2009
    ..Hypoxia acting through HIF-1alpha accumulation may be an important pathway for the renal response to ureteral obstruction...
  62. ncbi request reprint Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues
    Helle Hasager Damkier
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Wilhelm Meyers Alle, Bldg 1 234, 8000 Aarhus C, Denmark
    Am J Physiol Regul Integr Comp Physiol 293:R2136-46. 2007
    ..In conclusion, the selected human tissues display distinct expression patterns of HCO(3)(-) transporters, which closely resemble that of rodent tissues...
  63. pmc Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation
    Jakob Nielsen
    Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 105:3634-9. 2008
    ..This study provides a comprehensive analysis of the proteins affected by lithium treatment in the IMCD and, as such, provides clues to potential lithium targets in the brain...
  64. ncbi request reprint Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade
    Jakob Nielsen
    The Water and Salt Research Center, Institute of Anatomy, Aarhus, Denmark
    Am J Physiol Renal Physiol 292:F382-94. 2007
    ..We provide new evidence for ENaC trafficking occurring independent of MR and GR activation in aldosterone-infused rats...
  65. ncbi request reprint Aldosterone-mediated apical targeting of ENaC subunits is blunted in rats with streptozotocin-induced diabetes mellitus
    Heidi O'Neill
    The Water and Salt Research Center, Building 233 234, University of Aarhus, DK 8000 Aarhus C, Denmark
    Nephrol Dial Transplant 23:1546-55. 2008
    ....
  66. ncbi request reprint Candesartan prevents long-term impairment of renal function in response to neonatal partial unilateral ureteral obstruction
    Sukru Oguzkan Topcu
    The Water and Salt Research Ctr, Institute of Clinical Medicine, University of Aarhus, DK 8200 Aarhus, Denmark
    Am J Physiol Renal Physiol 292:F736-48. 2007
    ....
  67. ncbi request reprint Acute peripheral metabolic effects of intraarterial leg infusion of somatostatin in healthy young men
    Thomas Krusenstjerna-Hafstrøm
    Department of Internal Medicine and Endocrinology MEA, Aarhus University Hospital, Aarhus C, Denmark
    J Clin Endocrinol Metab 96:2581-9. 2011
    ..Evidence suggests that somatostatin not only inhibits the secretion of GH but also suppresses GH action in peripheral tissues...
  68. doi request reprint Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes
    Sabina Jelen
    The Water and Salt Research Center, Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Am J Physiol Gastrointest Liver Physiol 303:G1279-87. 2012
    ..We conclude that AQP9 and unidentified UT-A urea channels constitute primary but redundant urea facilitators in murine hepatocytes...
  69. pmc Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice
    Aleksandra Rojek
    Water and Salt Research Center, Institute of Anatomy, and Department of Molecular Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 103:6037-42. 2006
    ..These results demonstrate that AQP2 in CNT is sufficient for postnatal survival and that AQP2 in CD is essential for regulation of body water balance and cannot be compensated for by other mechanisms...
  70. pmc Targeted disruption of the Cl-/HCO3- exchanger Ae2 results in osteopetrosis in mice
    Kaj Josephsen
    The Water and Salt Research Center, Faculty of Health Sciences, Department of Dental Pathology, Operative Dentistry and Endodontics, School of Dentistry, and Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 106:1638-41. 2009
    ..Furthermore, osteoclasts in Ae2-/- mice were dramatically enlarged and fail to form the normal ruffled border facing the lacunae. Thus, Ae2 is likely to be an essential component of the bone resorption mechanism in osteoclasts...
  71. ncbi request reprint NKCC1 and NHE1 are abundantly expressed in the basolateral plasma membrane of secretory coil cells in rat, mouse, and human sweat glands
    Lene N Nejsum
    The Water and Salt Research Center, Institute of Anatomy, Univ of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Cell Physiol 289:C333-40. 2005
    ....
  72. doi request reprint Dysregulation of renal aquaporins and epithelial sodium channel in lithium-induced nephrogenic diabetes insipidus
    Jakob Nielsen
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
    Semin Nephrol 28:227-44. 2008
    ..This includes dysregulation of renal aquaporins, epithelial sodium channel, and acid/base transporters. This review focuses on these issues with the aim to present this in context with clinically relevant features...
  73. pmc Postabsorptive VLDL-TG fatty acid storage in adipose tissue in lean and obese women
    Birgitte Nellemann
    Medical Department M, Aarhus University Hospital, Aarhus, Denmark
    Obesity (Silver Spring) 18:1304-11. 2010
    ..We suggest that the differences in VLDL-TG storage in abdominal and femoral fat that occur with progressive obesity are regulated through mechanisms other than LPL activity...
  74. doi request reprint Gender-specific effect of physical training on AQP7 protein expression in human adipose tissue
    Janne Lebeck
    Department of Biomedicine, The Water and Salt Research Center, Health, Aarhus University, Wilhelm Meyers Allé 3, 8000 Aarhus, Denmark
    Acta Diabetol 49:S215-26. 2012
    ..00009), resulting in a more than twofold higher abundance of AQP7 in women as compared with men. In conclusion, the adipose tissue glycerol channel, AQP7, is regulated in response to physical training in a gender-dependent manner in SAT...
  75. pmc Increased VLDL-triglyceride secretion precedes impaired control of endogenous glucose production in obese, normoglycemic men
    Lars P Sørensen
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
    Diabetes 60:2257-64. 2011
    ..To assess basal and insulin-mediated VLDL-triglyceride (TG) kinetics and the relationship between VLDL-TG secretion and hepatic insulin resistance assessed by endogenous glucose production (EGP) in obese and lean men...
  76. pmc Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men
    Lars P Sørensen
    Department of Endocrinology and Internal Medicine, University Hospital, Aarhus, Denmark
    Diabetes 60:88-96. 2011
    ..The objective was to compare basal and insulin mediated VLDL-TG kinetics, oxidation, and adipose tissue storage in type 2 diabetic and healthy (nondiabetic) men...
  77. ncbi request reprint Acute growth hormone administration induces antidiuretic and antinatriuretic effects and increases phosphorylation of NKCC2
    Henrik Dimke
    The Water and Salt Research Centre, Institute of Anatomy, University of Aarhus, 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 292:F723-35. 2007
    ..In conclusion, GH appears to exert its acute antinatriuretic and antidiuretic effects through indirect activation of NKCC2 in the mTAL...
  78. ncbi request reprint Chronic metabolic acidosis upregulates rat kidney Na-HCO cotransporters NBCn1 and NBC3 but not NBC1
    Tae Hwan Kwon
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 282:F341-51. 2002
    ..The increased abundance of NBCn1 may play a role in the reabsorption of NH in the mTAL and increased NBC3 in reabsorbing HCO...
  79. doi request reprint Ion transporters in secretory and cyclically modulating ameloblasts: a new hypothesis for cellular control of preeruptive enamel maturation
    Kaj Josephsen
    Department of Dental Pathology, Operative Dentistry, and Endodontics, Aarhus University, Aarhus, Denmark
    Am J Physiol Cell Physiol 299:C1299-307. 2010
    ....
  80. doi request reprint Pre-existing renal failure worsens the outcome after intestinal ischaemia and reperfusion in rats
    Martin Skott
    The Water and Salt Research Centre, University of Aarhus, Aarhus, Denmark
    Nephrol Dial Transplant 25:3509-17. 2010
    ..We aim to examine whether CKD increases the morbidity and mortality of AKI induced by intestinal ischaemia and reperfusion (I-I/R)...
  81. ncbi request reprint Bidirectional regulation of AQP2 trafficking and recycling: involvement of AQP2-S256 phosphorylation
    Lene N Nejsum
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Renal Physiol 288:F930-8. 2005
    ....
  82. ncbi request reprint Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Am J Physiol Renal Physiol 293:F748-60. 2007
    ..Confocal microscopy of isolated inner medullary collecting duct tubules showed that the V2R is expressed both intracellularly and in basolateral membrane domains...
  83. ncbi request reprint A current view of the mammalian aquaglyceroporins
    Aleksandra Rojek
    Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
    Annu Rev Physiol 70:301-27. 2008
    ..This review comprehensively discusses the recent discoveries in the field of aquaglyceroporins, alongside a brief overview of the so-called unorthodox aquaporins...
  84. doi request reprint The α-MSH analogue AP214 attenuates rise in pulmonary pressure and fall in ejection fraction in lipopolysaccharide-induced systemic inflammatory response syndrome in pigs
    Jens Kristensen
    Department of Clinical Physiology The Institute of Clinical Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark
    Clin Physiol Funct Imaging 31:54-60. 2011
    ..SIRS is associated with considerable morbidity and mortality. Consequently, new treatment modalities are still warranted to address the different aspects of the pathophysiological process...
  85. doi request reprint Reduction of ischemic stroke in rat brain by alpha melanocyte stimulating hormone
    Gang Chen
    MR Research Centre, University of Aarhus, Aarhus University Hospital, Skejby, Aarhus N, Denmark
    Neuropeptides 42:331-8. 2008
    ..Secondly, we showed that the infarct volume was reduced by alpha-MSH. The volumetric dimensions of the infarct areas measured by MRI were comparable to those measured by histology...
  86. doi request reprint Peroxisome proliferator-activated receptor gamma agonism modifies the effects of growth hormone on lipolysis and insulin sensitivity
    Morten B Krag
    Medical Department M, Aarhus University Hospital, Aarhus Sygehus, Aarhus C, Denmark
    Clin Endocrinol (Oxf) 69:452-61. 2008
    ....
  87. pmc Functional requirement of aquaporin-5 in plasma membranes of sweat glands
    Lene N Nejsum
    The Water and Salt Research Center and the Department of Human Genetics, University of Aarhus, DK 8000 Aarhus, Denmark
    Proc Natl Acad Sci U S A 99:511-6. 2002
    ....
  88. ncbi request reprint Distribution of sodium transporters and aquaporin-1 in the human choroid plexus
    Jeppe Praetorius
    The Water and Salt Research Center, Institute of Anatomy, Univ of Aarhus, Wilhelm Meyers Alle, Bldg 234, 8000 Aarhus C, Denmark
    Am J Physiol Cell Physiol 291:C59-67. 2006
    ..This general cross species pattern suggests central roles for these transporters in choroid plexus functions such as cerebrospinal fluid production...
  89. pmc Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice
    Zsolt Vajda
    Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus, Denmark
    Proc Natl Acad Sci U S A 99:13131-6. 2002
    ..Moreover, these results predict that interference with the subcellular localization of AQP4 may have therapeutic potential for delaying the onset of impending brain edema...
  90. doi request reprint Direct effect of methylprednisolone on renal sodium and water transport via the principal cells in the kidney
    Thomas G Lauridsen
    Department of Medical Research, Holstebro Hospital, University of Aarhus, Holstebro, Denmark
    Eur J Endocrinol 162:961-9. 2010
    ..We tested the hypothesis that methylprednisolone treatment increased renal water and sodium absorption by increased absorption via the aquaporin-2 (AQP2) water channels and the epithelial sodium channels (ENaCs) respectively...