Ebba Nexo

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Nonradioactive vitamin B12 absorption test evaluated in controls and in patients with inherited malabsorption of vitamin B12
    Mustafa Vakur Bor
    Department of Clinical Biochemistry, NBG, As, Aalborg Hospital, Aarhus University Hospital, Denmark
    Clin Chem 51:2151-5. 2005
  2. ncbi request reprint Tyrosinase messenger RNA in peripheral blood is related to poor survival in patients with metastatic melanoma following interleukin-2-based immunotherapy
    Henrik Schmidt
    Department of Oncology bClinical Biochemistry, NBG, Aarhus University Hospital, Aarhus, Denmark
    Melanoma Res 15:409-16. 2005
  3. ncbi request reprint Diagnosis and treatment of vitamin B12 deficiency--an update
    Anne Mette Hvas
    Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark
    Haematologica 91:1506-12. 2006
  4. ncbi request reprint Quantification of holo-transcobalamin, a marker of vitamin B12 deficiency
    Ebba Nexo
    Department of Clinical Biochemistry, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Clin Chem 48:561-2. 2002
  5. ncbi request reprint Holo-transcobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study
    Ebba Nexo
    Department of Clinical Biochemistry, AKH, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Clin Chem 48:1768-71. 2002
  6. pmc Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility
    Ebba Nexo
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Am J Clin Nutr 94:359S-365S. 2011
  7. ncbi request reprint Autoantibodies against intrinsic factor (IF) measured with an ELISA using recombinant human IF as both catching and detecting reagent
    Ebba Nexo
    Department of Clinical Biochemistry, NBG, As, Aarhus University Hospital, Denmark
    Clin Chem Lab Med 43:351-6. 2005
  8. doi request reprint The vitamin B12 absorption test, CobaSorb, identifies patients not requiring vitamin B12 injection therapy
    Anne Mette Hvas
    Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark
    Scand J Clin Lab Invest 71:432-8. 2011
  9. pmc A single rainbow trout cobalamin-binding protein stands in for three human binders
    Eva Greibe
    Department of Clinical Biochemistry, Aarhus University Hospital, 8000 Aarhus, Denmark
    J Biol Chem 287:33917-25. 2012
  10. ncbi request reprint Pathologic assessment of melanoma sentinel nodes: a role for molecular analysis using quantitative real-time reverse transcription-PCR for MART-1 and tyrosinase messenger RNA
    Helene Nortvig Abrahamsen
    Institute of Pathology, Aarhus University Hospital, Aarhus Sygehus, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    Clin Cancer Res 11:1425-33. 2005

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Nonradioactive vitamin B12 absorption test evaluated in controls and in patients with inherited malabsorption of vitamin B12
    Mustafa Vakur Bor
    Department of Clinical Biochemistry, NBG, As, Aalborg Hospital, Aarhus University Hospital, Denmark
    Clin Chem 51:2151-5. 2005
    ..Current tests for evaluation of vitamin B(12) absorption are problematic because they involve the use of radioactively labeled vitamin B(12). We describe a vitamin B(12) absorption test that circumvents this problem...
  2. ncbi request reprint Tyrosinase messenger RNA in peripheral blood is related to poor survival in patients with metastatic melanoma following interleukin-2-based immunotherapy
    Henrik Schmidt
    Department of Oncology bClinical Biochemistry, NBG, Aarhus University Hospital, Aarhus, Denmark
    Melanoma Res 15:409-16. 2005
    ..Additional studies are needed before the prognostic value of tyrosinase mRNA in metastatic melanoma can be firmly established. Further evaluation of the combined measurement of tyrosinase mRNA and LDH is warranted...
  3. ncbi request reprint Diagnosis and treatment of vitamin B12 deficiency--an update
    Anne Mette Hvas
    Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark
    Haematologica 91:1506-12. 2006
    ..Once the diagnosis of vitamin B12 deficiency has been confirmed efficient treatment can be ensured either by injections every 2-3 month or by a daily dose of 1 mg vitamin B12...
  4. ncbi request reprint Quantification of holo-transcobalamin, a marker of vitamin B12 deficiency
    Ebba Nexo
    Department of Clinical Biochemistry, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Clin Chem 48:561-2. 2002
  5. ncbi request reprint Holo-transcobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study
    Ebba Nexo
    Department of Clinical Biochemistry, AKH, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Clin Chem 48:1768-71. 2002
    ..We examined the effect of oral vitamin B(12) treatment on fluctuations in plasma total cobalamin and its binding proteins transcobalamin (TC) and haptocorrin (HC)...
  6. pmc Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility
    Ebba Nexo
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Am J Clin Nutr 94:359S-365S. 2011
    ..To date, holoTC has not been used for population-based assessments of vitamin B-12 status, but we suggest that holoTC is a better marker than total vitamin B-12 for such studies...
  7. ncbi request reprint Autoantibodies against intrinsic factor (IF) measured with an ELISA using recombinant human IF as both catching and detecting reagent
    Ebba Nexo
    Department of Clinical Biochemistry, NBG, As, Aarhus University Hospital, Denmark
    Clin Chem Lab Med 43:351-6. 2005
    ..In conclusion, an ELISA using recombinant IF as both catching and detection reagent seems suitable for the detection of IF autoantibodies in plasma...
  8. doi request reprint The vitamin B12 absorption test, CobaSorb, identifies patients not requiring vitamin B12 injection therapy
    Anne Mette Hvas
    Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark
    Scand J Clin Lab Invest 71:432-8. 2011
    ..Treatment with vitamin B12 has virtually no side effects; however, life-long treatment is inconvenient for the patient and constitutes a cost for society...
  9. pmc A single rainbow trout cobalamin-binding protein stands in for three human binders
    Eva Greibe
    Department of Clinical Biochemistry, Aarhus University Hospital, 8000 Aarhus, Denmark
    J Biol Chem 287:33917-25. 2012
    ..In conclusion, only one soluble cobalamin-binding protein was identified in the rainbow trout, a protein that structurally behaves like an intermediate between the three human cobalamin-binding proteins...
  10. ncbi request reprint Pathologic assessment of melanoma sentinel nodes: a role for molecular analysis using quantitative real-time reverse transcription-PCR for MART-1 and tyrosinase messenger RNA
    Helene Nortvig Abrahamsen
    Institute of Pathology, Aarhus University Hospital, Aarhus Sygehus, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    Clin Cancer Res 11:1425-33. 2005
    ..We investigated whether quantitative reverse transcription-PCR (RT-PCR) detection of MART-1 and tyrosinase mRNAs could improve this specificity and contribute to SN assessment...
  11. doi request reprint Daily intake of 4 to 7 microg dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population
    Mustafa Vakur Bor
    Department of Clinical Biochemistry, AS Aarhus University Hospital, Aarhus, Denmark
    Am J Clin Nutr 91:571-7. 2010
    ..Studies have questioned whether the current Recommended Dietary Allowance (RDA) of 2.4 microg vitamin B-12/d is adequate...
  12. doi request reprint Assessment of vitamin B(12) absorption based on the accumulation of orally administered cyanocobalamin on transcobalamin
    Tore Forsingdal Hardlei
    Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
    Clin Chem 56:432-6. 2010
    ..We hypothesize that cyanocobalamin (CNCbl) is absorbed unchanged, thereby allowing measurement of the complex of CNCbl bound to TC (TC-CNCbl) to be used for studying the absorption of the vitamin...
  13. doi request reprint Vitamin B₁₂ dependent changes in mouse spinal cord expression of vitamin B₁₂ related proteins and the epidermal growth factor system
    Elena Mutti
    Department of Clinical Biochemistry, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus, Denmark
    Brain Res 1503:1-6. 2013
    ....
  14. pmc Hypoxia changes the expression of the epidermal growth factor (EGF) system in human hearts and cultured cardiomyocytes
    Mathias Munk
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 7:e40243. 2012
    ..The purpose of our study was to investigate the role of the complete EGF system in relation to hypoxia of the heart...
  15. doi request reprint Uptake of cobalamin and markers of cobalamin status: a longitudinal study of healthy pregnant women
    Eva Greibe
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 49:1877-82. 2011
    ..Currently, it is unknown whether the decline in plasma cobalamin observed during pregnancy is caused by malabsorption of the vitamin. This study examined cobalamin absorption and markers of cobalamin status during normal pregnancy...
  16. doi request reprint Association of cognitive impairment with combinations of vitamin B₁₂-related parameters
    Dorte L Lildballe
    Department of Clinical Biochemistry, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Clin Chem 57:1436-43. 2011
    ....
  17. ncbi request reprint Circulating tyrosinase and MART-1 mRNA does not independently predict relapse or survival in patients with AJCC stage I-II melanoma
    Henrik Schmidt
    Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
    J Invest Dermatol 126:849-54. 2006
    ..The serial measurements of tyrosinase and MART-1 mRNA in peripheral blood of stage I-II melanoma patients cannot be demonstrated to have independent prognostic impact on relapse-free survival...
  18. ncbi request reprint Plasma holotranscobalamin compared with plasma cobalamins for assessment of vitamin B12 absorption; optimisation of a non-radioactive vitamin B12 absorption test (CobaSorb)
    Anne Mette Hvas
    Department of Clinical Biochemistry, Skejby Hospital, Aarhus University Hospital, 8000 Aarhus, Denmark
    Clin Chim Acta 376:150-4. 2007
    ..A recently developed non-radioactive vitamin B(12) absorption test (CobaSorb) was further explored to identify the best marker for reflection of vitamin B(12) absorption and to determine the duration of the test...
  19. doi request reprint Expression of the epidermal growth factor system in eutopic endometrium from women with endometriosis differs from that in endometrium from healthy women
    Kirsten Ejskjaer
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Gynecol Obstet Invest 67:118-26. 2009
    ..Our aim is to identify differences in expression of the EGF system between endometriotic and normal endometrium...
  20. pmc Mouse transcobalamin has features resembling both human transcobalamin and haptocorrin
    Katrine Hygum
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 6:e20638. 2011
    ..Mouse TC has features in common with both human TC and HC. Our results suggest that the Cbl-binding proteins present in the circulation and exocrine glands may vary amongst species...
  21. ncbi request reprint Insulin-induced proliferation of bladder cancer cells is mediated through activation of the epidermal growth factor system
    Dorthe Ornskov
    Department of Clinical Biochemistry, Aarhus Sygehus, University Hospital in Aarhus, Denmark
    FEBS J 273:5479-89. 2006
    ..Furthermore, activation of HER1 is required for the insulin-induced increase in expression of the HER1 ligands heparin-binding epidermal growth factor-like growth factor, amphiregulin and epiregulin...
  22. ncbi request reprint Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum
    Anne L Morkbak
    Dept of Clinical Biochemistry, Aarhus University Hospital, Aarhus Sygehus, Denmark
    Haematologica 92:1711-2. 2007
    ..The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy...
  23. ncbi request reprint Circadian variation of holo-transcobalamin (holo-TC) and related markers
    Anne Mette Hvas
    Department of Clinical Biochemistry, SKS, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 43:760-4. 2005
    ..This supports the view that holo-TC is a marker of long-term vitamin B(12) status, and that samples may also be obtained from non-fasting subjects...
  24. doi request reprint Unexpected high plasma cobalamin : proposal for a diagnostic strategy
    Johan F B Arendt
    Department of Clinical Biochemistry, Aarhus University Hospital, Norrebrogade 44, 8000Aarhus C, Denmark
    Clin Chem Lab Med 51:489-96. 2013
    ..It is important to realise that high cobalamin levels can be an unspecific marker for cancer. If this can be ruled out, diseases of the liver and kidney should be considered...
  25. pmc Maximal load of the vitamin B12 transport system: a study on mice treated for four weeks with high-dose vitamin B12 or cobinamide
    Dorte L Lildballe
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 7:e46657. 2012
    ..This risk may lead to B12 deficiency during prolonged treatment...
  26. doi request reprint Complete pathologic response in lung tumors in two patients with metastatic non-small cell lung cancer treated with erlotinib
    Britta Weber
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    J Thorac Oncol 6:1946-9. 2011
    ..In some patients, residual tumor tissue can be visualized for several years without any signs of progression...
  27. pmc The cobalamin-binding protein in zebrafish is an intermediate between the three cobalamin-binding proteins in human
    Eva Greibe
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 7:e35660. 2012
    ..These findings support the hypothesis about a common ancestral gene for all cobalamin-binding proteins in higher vertebrates...
  28. doi request reprint Erlotinib accumulation in brain metastases from non-small cell lung cancer: visualization by positron emission tomography in a patient harboring a mutation in the epidermal growth factor receptor
    Britta Weber
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    J Thorac Oncol 6:1287-9. 2011
    ..In this study, we investigated the accumulation of [¹¹C]-erlotinib by positron emission tomography (PET) combined with computed tomography (CT) and magnetic resonance imaging (MRI)...
  29. ncbi request reprint Insulin induces a transcriptional activation of epiregulin, HB-EGF and amphiregulin, by a PI3K-dependent mechanism: identification of a specific insulin-responsive promoter element
    Dorthe Ornskov
    Department of Clinical Biochemistry, Aarhus Sygehus University Hospital in Aarhus, Denmark
    Biochem Biophys Res Commun 354:885-91. 2007
    ..We demonstrate that the insulin-induced expression of HB-EGF, AR, and EPI mRNA is completely prevented by the specific PI3K inhibitor Wortmannin, suggesting an involvement of the PI3K...
  30. ncbi request reprint The effect of recombinant human intrinsic factor on the uptake of vitamin B12 in patients with evident vitamin B12 deficiency
    Anne Mette Hvas
    Department of Clinical Biochemistry, Skejby Hospital and Aarhus Hospital, Aarhus University Hospital, Aarhus, Denmark
    Haematologica 91:805-8. 2006
    ..Twenty-eight patients with suspected vitamin B12 deficiency showed no additional increase in holoTC after intake of rhIF-B12. We conclude that rhIF promotes B12 absorption among patients with evident vitamin B12 deficiency...
  31. doi request reprint Three family members with elevated plasma cobalamin, transcobalamin and soluble transcobalamin receptor (sCD320)
    Elke Hoffmann-Lücke
    Department of Clinical Biochemistry, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Denmark
    Clin Chem Lab Med 51:677-82. 2013
    ..Plasma cobalamin is requested in order to diagnose cobalamin deficiency and low levels confirm a deficient state. Here, we present three family members with unexpected high levels of cobalamin...
  32. ncbi request reprint Holotranscobalamin as a predictor of vitamin B12 status
    Anne Mette Hvas
    Department of Clinical Biochemistry, Aarhus University Hospital, AKH, Aarhus, Denmark
    Clin Chem Lab Med 41:1489-92. 2003
    ..Large-scale clinical studies are warranted in order to clarify the usefulness of holotranscobalamin in the clinical setting...
  33. doi request reprint A new principle for measurement of cobalamin and corrinoids, used for studies of cobalamin analogs on serum haptocorrin
    Tore Forsingdal Hardlei
    Department of Clinical Biochemistry, As, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem 55:1002-10. 2009
    ..Transcobalamin (TC) and haptocorrin (HC) are serum corrinoid-binding proteins. We developed new methods for measurement of the corrinoids bound to HC and TC...
  34. ncbi request reprint Sensitive automated ELISA for measurement of vitamin D-binding protein (Gc) in human urine
    Anna Lis Lauridsen
    Department of Clinical Biochemistry, Norrebrogade, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem 51:1016-8. 2005
  35. ncbi request reprint Evaluation of the technical performance of novel holotranscobalamin (holoTC) assays in a multicenter European demonstration project
    Anne L Morkbak
    Department of Clinical Biochemistry, As, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 43:1058-64. 2005
    ..The results obtained using the holoTC RIA were similar to those obtained using the holoTC ELISA assay...
  36. doi request reprint Cobalamin and haptocorrin in human milk and cobalamin-related variables in mother and child: a 9-mo longitudinal study
    Eva Greibe
    Department of Clinical Biochemistry, Aarhus University Hospital, Norrebrogade 44, Building 9, 8000 Aarhus C, Denmark
    Am J Clin Nutr 98:389-95. 2013
    ....
  37. doi request reprint Vitamin B12 absorption judged by measurement of holotranscobalamin, active vitamin B12: evaluation of a commercially available EIA kit
    Eva Greibe
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 49:1883-5. 2011
    ..This study evaluates the use of a newly launched EIA kit for measurement of holoTC (active B12) in relation to the CobaSorb test...
  38. doi request reprint High concentrations of haptocorrin interfere with routine measurement of cobalamins in human serum and milk. A problem and its solution
    Dorte L Lildballe
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 47:182-7. 2009
    ..Human milk and occasional serum samples contain high concentrations of unsaturated haptocorrin, which influence accurate measurement of cobalamins...
  39. doi request reprint Positron emission tomography (PET) imaging with [11C]-labeled erlotinib: a micro-PET study on mice with lung tumor xenografts
    Ashfaque A Memon
    Department of Clinical Biochemistry, Medical Department V, Aarhus University Hospital, Aarhus Sygehus, Norrebrogade, Denmark
    Cancer Res 69:873-8. 2009
    ..These results pave the road for studies examining the benefit of [(11)C]-erlotinib PET in patients with lung tumors or other tumors overexpressing EGFR...
  40. ncbi request reprint Haptocorrin in humans
    Anne L Morkbak
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 45:1751-9. 2007
    ..In this study, we present data on the tissue expression of haptocorrin and on the relation between analogues on haptocorrin and vitamin B(12) status in humans...
  41. pmc Towards quantitative mRNA analysis in paraffin-embedded tissues using real-time reverse transcriptase-polymerase chain reaction: a methodological study on lymph nodes from melanoma patients
    Helene Nortvig Abrahamsen
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    J Mol Diagn 5:34-41. 2003
    ..Our findings suggest that quantitative analysis of mRNA in archive and routine diagnostic tissues may be possible...
  42. doi request reprint Transcobalamin deficiency caused by compound heterozygosity for two novel mutations in the TCN2 gene: a study of two affected siblings, their brother, and their parents
    Peter H Nissen
    Department of Clinical Biochemistry, As, Aarhus University Hospital, Norrebrogade 44, DK 8000, Aarhus C, Denmark
    J Inherit Metab Dis 33:269-74. 2010
    ....
  43. pmc Cobalamin analogues in humans: a study on maternal and cord blood
    Tore Forsingdal Hardlei
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 8:e61194. 2013
    ..All cobalamins (Cbl) to the foetus are delivered by the Cbl-specific protein transcobalamin (TC), and therefore analysis of cord serum for CorA may help to clarify the origin of CorA...
  44. pmc Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels
    Johan F B Arendt
    Department of Clinical Biochemistry, Aarhus University Hospital, Denmark
    PLoS ONE 7:e45979. 2012
    ..Measurement of serum cobalamin levels is routinely used to diagnose cobalamin deficiency. Surprisingly, approximately 15% of patients have high cobalamin levels and no consensus exists regarding the clinical implications...
  45. doi request reprint Validation of commercial assays for measurements of trefoil factor family peptides in serum
    Mie H Samson
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 49:2057-60. 2011
    ..Increased serum concentrations have been reported in a number of pathological conditions, which warrants the need for validated commercially available assays...
  46. doi request reprint Trefoil factors in human milk
    Else Marie Vestergaard
    Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
    Early Hum Dev 84:631-5. 2008
    ..The clinical significance of TFF present in human milk remains to be explored, both regarding development of the fetal gut and protection against necrotizing enterocolitis...
  47. doi request reprint Trefoil factor family peptides in the human foetus and at birth
    Mie H Samson
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Eur J Clin Invest 41:785-92. 2011
    ..Changing levels of expression are reflected in serum concentrations. Serum levels of TFF2 and TFF3 are highly elevated during pregnancy. Here, we explore a possible foetal origin of these increased levels...
  48. doi request reprint Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells
    Ashfaque A Memon
    Department of Clinical Biochemistry, NBG, As, Aarhus University Hospital, Aarhus C, Denmark
    Scand J Clin Lab Invest 71:45-51. 2011
    ..In conclusion we show that calcium-induced apoptosis in bladder cancer cells is delayed by HER1 receptor activation involving the Akt and PLCγ signalling pathways...
  49. ncbi request reprint Inhibition of the epidermal growth factor receptor in bladder cancer cells treated with the DNA-damaging drug etoposide markedly increases apoptosis
    Mathias Munk
    Department of Clinical Biochemistry, Aarhus University Hospital NBG, Aarhus, Denmark
    BJU Int 99:196-201. 2007
    ....
  50. doi request reprint Soluble transcobalamin receptor, sCD320, is present in human serum and relates to serum cobalamin - establishment and validation of an ELISA
    Johan Frederik Berg Arendt
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 50:515-9. 2012
    ..The cell-surface receptor, TCblR/CD320, binds and internalizes transcobalamin-bound cobalamin. So far, no assay has been developed in order to quantify the soluble form of the receptor...
  51. ncbi request reprint Increased TGF-alpha and EGF Receptor mRNA expression in response to neonatal unilateral partial ureter obstruction in rats
    Mustafa Vakur Bor
    Department of Clinical Biochemistry, NBG, Aarhus Hospital, Aarhus, Denmark
    Nephron Exp Nephrol 104:e76-82. 2006
    ..To evaluate the potential role of members of the epidermal growth factor (EGF) family in altered renal growth caused by partial ureteral obstruction in the developing obstructed and non-obstructed kidneys...
  52. ncbi request reprint Glycosylation independent measurement of the cobalamin binding protein haptocorrin
    Anne L Morkbak
    Department of Clinical Biochemistry, NBG, AS Aarhus University Hospital, Nørrebrogade 44, Aarhus DK 8000, Denmark
    Clin Chim Acta 356:184-90. 2005
    ..Haptocorrin carries the major part of the circulating vitamin B12. The protein is heavily glycosylated and this may have implications for its measurement...
  53. ncbi request reprint The chemotherapeutic agent VP16 increases the stability of HB-EGF mRNA by a mechanism involving the 3'-UTR
    Boe S Sorensen
    Department of Clinical Biochemistry, NBG, As, Aarhus University Hospital, AS Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Exp Cell Res 312:3651-8. 2006
    ..We demonstrate that mRNA stability and in particular the HB-EGF 3'-UTR is involved in the HB-EGF mRNA induction...
  54. doi request reprint Infrequency of low red blood cell (RBC) folate levels despite no folate fortification program: a study based on results from routine requests for RBC folate
    Mustafa Vakur Bor
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 46:401-4. 2008
    ....
  55. doi request reprint Trefoil factor family peptides in human saliva and cyclical cervical mucus. Method evaluation and results on healthy individuals
    Mie Hessellund Samson
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 49:861-8. 2011
    ..Data on concentrations of trefoil peptides in secretions are limited...
  56. ncbi request reprint Circulating HER2 DNA after trastuzumab treatment predicts survival and response in breast cancer
    Boe S Sorensen
    Department of Clinical Biochemistry, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Anticancer Res 30:2463-8. 2010
    ..Only a subset of breast cancer patients responds to the HER2 inhibitor trastuzumab, and methods to identify responders are needed...
  57. ncbi request reprint Enzymatic extraction of cobalamin from monoclonal antibody captured haptocorrin and transcobalamin
    Tore Forsingdal Hardlei
    Department of Clinical Biochemistry, As, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus, Denmark
    Clin Biochem 40:1392-7. 2007
    ..Current extraction methods for cobalamins from serum influence the molecular characteristics of the vitamin. Therefore, an extraction procedure that leaves the cobalamins unchanged is needed...
  58. pmc Metformin lowers serum cobalamin without changing other markers of cobalamin status: a study on women with polycystic ovary syndrome
    Eva Greibe
    Department of Clinical Biochemistry, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark
    Nutrients 5:2475-82. 2013
    ....
  59. doi request reprint Analytical validation of the Roche 25-OH Vitamin D Total assay
    Cindy Soendersoe Knudsen
    Department of Clinical Biochemistry, Aarhus University Hospital, Denmark
    Clin Chem Lab Med 50:1965-8. 2012
    ..Here we present a validation of the recently released Roche 25-OH Vitamin D Total assay (Vitamin D Total)...
  60. ncbi request reprint Female premenopausal fracture risk is associated with gc phenotype
    Anna Lis Lauridsen
    Department of Clinical Biochemistry, AKH, Aarhus University Hospital, Aarhus C, Denmark
    J Bone Miner Res 19:875-81. 2004
    ..This was concluded from a study on 595 Danish perimenopausal women 45-58 years of age (30,040 person years)...
  61. pmc Quantification of melanoma mRNA markers in sentinel nodes: pre-clinical evaluation of a single-step real-time reverse transcriptase-polymerase chain reaction assay
    Helene N Abrahamsen
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Sygehus, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    J Mol Diagn 6:253-9. 2004
    ....
  62. pmc Real-time quantitative PCR of microdissected paraffin-embedded breast carcinoma: an alternative method for HER-2/neu analysis
    Lise Mette Gjerdrum
    Institutes of Pathology, Aarhus University Hospital, Aarhus, Denmark
    J Mol Diagn 6:42-51. 2004
    ....
  63. ncbi request reprint S100beta protein in peripheral blood may predict progressive disease during interleukin-2 based immunotherapy in patients with metastatic melanoma
    Henrik Schmidt
    Department of Oncology, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Melanoma Res 14:211-5. 2004
    ....
  64. ncbi request reprint Down-regulation of S100C is associated with bladder cancer progression and poor survival
    Ashfaque Ahmed Memon
    Department of Clinical Biochemistry, As, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Denmark
    Clin Cancer Res 11:606-11. 2005
    ..Based on this observation, we quantified the S100C mRNA expression level with real-time PCR in bladder cancer biopsy samples obtained from 88 patients followed for a median of 23 months (range, 1-97 months)...
  65. ncbi request reprint Screening for vitamin B-12 and folate deficiency in older persons
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 77:1241-7. 2003
    ..Folate deficiency also results in elevated tHcy. Measurement of these metabolites can be used to screen for functional vitamin B-12 or folate deficiency...
  66. ncbi request reprint Comparative analysis of cobalamin binding kinetics and ligand protection for intrinsic factor, transcobalamin, and haptocorrin
    Sergey N Fedosov
    Protein Chemistry Laboratory, Department of Molecular and Structural Biology, University of Aarhus, Science Park, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark
    J Biol Chem 277:9989-96. 2002
    ..The above data suggest presence of a histidine-containing cap shielding the Cbl-binding site in TC. The cap coordinates to certain corrinoids and, possibly, produces an incapsulated Ado-radical when Cbl small middle dotAdo is bound...
  67. doi request reprint Long term biweekly 1 mg oral vitamin B12 ensures normal hematological parameters, but does not correct all other markers of vitamin B12 deficiency. A study in patients with inherited vitamin B12 deficiency
    Mustafa Vakur Bor
    Haematologica 93:1755-8. 2008
  68. ncbi request reprint Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status
    Kristina M von Castel-Roberts
    Departments of Food Science and Human Nutrition, University of Florida, Gainesville, USA
    Am J Clin Nutr 85:1057-61. 2007
    ..To develop a reliable clinical absorption test that uses holo-TC, it is necessary to determine the optimal timeline for vitamin B-12 administration and postdose assessment...
  69. ncbi request reprint Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Clin Chem 53:963-70. 2007
    ..Concentrations of this active component, carried on holotranscobalamin (holoTC), may be of greater relevance than total vitamin B(12)...
  70. ncbi request reprint Low vitamin B-12 status and risk of cognitive decline in older adults
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 86:1384-91. 2007
    ..Elevated total homocysteine (tHcy) concentrations have been associated with cognitive impairment, but it is unclear whether low vitamin B-12 or folate status is responsible for cognitive decline...
  71. ncbi request reprint Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention
    Øyvind Bleie
    Institute of Medicine, University of Bergen, Haukeland University Hospital, N 5021 Bergen, Norway
    Am J Clin Nutr 80:641-8. 2004
    ....
  72. ncbi request reprint Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study
    Harold Hin
    Hightown Surgery, Hightown Gardens, Banbury, UK
    Age Ageing 35:416-22. 2006
    ..low vitamin B12 concentrations are common in older people, but the clinical relevance of biochemical evidence of vitamin B12 deficiency in the absence of anaemia is uncertain...
  73. ncbi request reprint Facts and recommendations about total homocysteine determinations: an expert opinion
    Helga Refsum
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Clin Chem 50:3-32. 2004
    ....
  74. ncbi request reprint The cobalamin-binding proteins transcobalamin and haptocorrin in maternal and cord blood sera at birth
    Rima Obeid
    Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 52:263-9. 2006
    ..Transcobalamin (TC) carries approximately 25% of total plasma vitamin B12 and is 6% to 20% saturated with cobalamin. Haptocorrin (HC) binds approximately 80% of total cobalamin and is largely saturated with cobalamin...
  75. doi request reprint Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Br J Nutr 100:1054-9. 2008
    ..88)). There was no evidence of modification by high folate status of the associations of low B12 with anaemia or cognitive impairment in the setting of voluntary fortification, but periodic surveys are needed to monitor fortification...
  76. ncbi request reprint Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults
    Helga Refsum
    Oxford Centre for Gene Function, Laboratory of Physiology, Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Clin Chem 52:129-37. 2006
    ..We developed microbiological assays (MBAs) to identify determinants and to establish reference values for cobalamin bound to transcobalamin [holotranscobalamin (holoTC)] and total TC in plasma...