Anette Mullertz

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Oral delivery of peptides and proteins using lipid-based drug delivery systems
    Ping Li
    University of Copenhagen, Faculty of Health and Medical Sciences, Department of Pharmacy, 2100 Copenhagen Ø, Denmark
    Expert Opin Drug Deliv 9:1289-304. 2012
  2. doi request reprint New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs
    Anette Mullertz
    Department of Pharmaceutics and Analytical Chemistry Bioneer FARMA, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark
    J Pharm Pharmacol 62:1622-36. 2010
  3. doi request reprint Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo
    Anette Mullertz
    Bioneer FARMA, Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Science, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Mol Pharm 9:237-47. 2012
  4. doi request reprint Colloidal structures in media simulating intestinal fed state conditions with and without lipolysis products
    Dimitrios G Fatouros
    Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Science, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark
    Pharm Res 26:361-74. 2009
  5. doi request reprint Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity
    Karen Kleberg
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Pharm Sci 99:3522-32. 2010
  6. ncbi request reprint Bioavailability of cinnarizine in dogs: effect of SNEDDS loading level and correlation with cinnarizine solubilization during in vitro lipolysis
    Anne T Larsen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark
    Pharm Res 30:3101-13. 2013
  7. doi request reprint Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: effects on physicochemical properties
    Anne Zimmermann
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen Ø, Denmark
    Eur J Pharm Biopharm 71:109-16. 2009
  8. doi request reprint Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats
    Henrik Tønsberg
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    J Pharm Pharmacol 63:817-24. 2011
  9. ncbi request reprint Biorelevant characterisation of amorphous furosemide salt exhibits conversion to a furosemide hydrate during dissolution
    Line Hagner Nielsen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    Int J Pharm 457:14-24. 2013
  10. doi request reprint In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks
    Dimitrios G Fatouros
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen, Denmark
    Eur J Pharm Biopharm 69:887-98. 2008

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Oral delivery of peptides and proteins using lipid-based drug delivery systems
    Ping Li
    University of Copenhagen, Faculty of Health and Medical Sciences, Department of Pharmacy, 2100 Copenhagen Ø, Denmark
    Expert Opin Drug Deliv 9:1289-304. 2012
    ....
  2. doi request reprint New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs
    Anette Mullertz
    Department of Pharmaceutics and Analytical Chemistry Bioneer FARMA, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark
    J Pharm Pharmacol 62:1622-36. 2010
    ..We also aim to offer suggestions for an improved classification system that will accommodate lipid based formulations that are not currently accommodated in the lipid formulation classification system...
  3. doi request reprint Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo
    Anette Mullertz
    Bioneer FARMA, Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Science, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Mol Pharm 9:237-47. 2012
    ....
  4. doi request reprint Colloidal structures in media simulating intestinal fed state conditions with and without lipolysis products
    Dimitrios G Fatouros
    Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Science, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark
    Pharm Res 26:361-74. 2009
    ..To study the ultrastructure of biorelevant media and digestion products of self-nanoemulsifying drug delivery system (SNEDDS) at high level BS/PL conditions...
  5. doi request reprint Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity
    Karen Kleberg
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Pharm Sci 99:3522-32. 2010
    ..The findings in this study suggest that the affinity of the drug to the different colloidal structures is determining for the solubility of the compound in the media...
  6. ncbi request reprint Bioavailability of cinnarizine in dogs: effect of SNEDDS loading level and correlation with cinnarizine solubilization during in vitro lipolysis
    Anne T Larsen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark
    Pharm Res 30:3101-13. 2013
    ..To investigate the effect of increasing the loading level of the poorly soluble drug cinnarizine in a self-nanoemulsifying drug delivery system (SNEDDS) both in vitro and in vivo...
  7. doi request reprint Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: effects on physicochemical properties
    Anne Zimmermann
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen Ø, Denmark
    Eur J Pharm Biopharm 71:109-16. 2009
    ..X-ray Photoelectron Spectroscopy (XPS) analysis of the surface composition and scanning electron microscopy studies on particle morphology suggested that the excipients adsorbed to specific faces of the crystals...
  8. doi request reprint Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats
    Henrik Tønsberg
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    J Pharm Pharmacol 63:817-24. 2011
    ....
  9. ncbi request reprint Biorelevant characterisation of amorphous furosemide salt exhibits conversion to a furosemide hydrate during dissolution
    Line Hagner Nielsen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    Int J Pharm 457:14-24. 2013
    ..It can be concluded that during biorelevant dissolution, the amorphous and crystalline furosemide salt converted to a trihydrate, whereas the amorphous acid exhibited fast conversion to the crystalline acid. ..
  10. doi request reprint In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks
    Dimitrios G Fatouros
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen, Denmark
    Eur J Pharm Biopharm 69:887-98. 2008
    ..These preliminary results suggest that the dynamic lipolysis model combined with the AFM-IVIVC can be a useful tool in the prediction of the in vivo behavior of lipid-based formulations...
  11. ncbi request reprint Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30
    Pia Thybo
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Pharm Dev Technol 13:375-86. 2008
    ..The stabilizing effect of the polymer was verified in the solid state, as all the SDs retained probucol in the amorphous state throughout the entire length of the stability study...
  12. doi request reprint Lipid-based formulations for oral administration of poorly water-soluble drugs
    Huiling Mu
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Int J Pharm 453:215-24. 2013
    ....
  13. doi request reprint Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80
    Marianne L Lind
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    Eur J Pharm Sci 35:211-8. 2008
    ..Furthermore, there was a good correlation between the halofantrine transport to blood and lymphatics in the chylomicron flow blocking model and published results from the mesenteric lymph-cannulated model...
  14. ncbi request reprint Influence of the solid form of siramesine hydrochloride on its behavior in aqueous environments
    Anne Zimmermann
    Faculty of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark
    Pharm Res 26:846-54. 2009
    ..To study the influence of solid form on the behavior of the salt siramesine hydrochloride in aqueous environments...
  15. doi request reprint Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats
    Henrik Tønsberg
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Denmark
    J Pharm Pharmacol 62:63-70. 2010
    ..The aim of this study was to examine the effects of formulations of polysorbate 80 (PS 80) and polyethylene glycol 400 (PEG 400) on the precipitation and oral bioavailability of the hydrophobic drug halofantrine...
  16. doi request reprint Precipitation of a poorly soluble model drug during in vitro lipolysis: characterization and dissolution of the precipitate
    Philip J Sassene
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Pharm Sci 99:4982-91. 2010
    ..Overall, dissolution studies along with XRPD and PLM analysis indicate that cinnarizine precipitating during in vitro lipolysis of this SMEDDS is not crystalline, suggesting an either amorphous form or a molecular dispersion...
  17. ncbi request reprint Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium
    Nrupa Borkar
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Eur J Pharm Sci 51:204-10. 2014
    ..In summary, the present study demonstrated the particle size dependence of bioavailability of fenofibrate loaded LMP in rat model which correlates well with the in vitro drug release performed in the biorelevant medium...
  18. doi request reprint Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy
    Anette Mullertz
    Department of Pharmacy, The Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
    J Pharm Pharmacol 65:1482-7. 2013
    ..In an attempt to gain insights for their structure at the ultrastructural level, samples from the lumen of ascending colon were collected from patients with ulcerative colitis in remission...
  19. doi request reprint Optimization of self nanoemulsifying drug delivery system for poorly water-soluble drug using response surface methodology
    Shan Ren
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Science, University of Copenhagen, Denmark
    Drug Dev Ind Pharm 39:799-806. 2013
    ..It was evident that drug precipitation during lipolysis was not affected by the level of co-solvent ethanol in the formulation, while it had pronounced impact on drug solubilization during the initial dispersion stage...
  20. doi request reprint Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies
    Karen Kleberg
    Department of Pharmaceutics and Analytical Chemistry Bioneer FARMA, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark
    J Pharm Pharmacol 62:1656-68. 2010
    ..Based on the knowledge of human intestinal fluids, compositions of biorelevant media and their impact on solubility, dissolution and permeability studies of poorly soluble drug compounds are discussed...
  21. doi request reprint A new approach to dissolution testing by UV imaging and finite element simulations
    Johan P Boetker
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark
    Pharm Res 30:1328-37. 2013
    ..In this study, a flexible numerical model was combined with a novel UV imaging system, allowing monitoring of the dissolution process with sub second time resolution...
  22. doi request reprint Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation
    Anne T Larsen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Eur J Pharm Sci 48:339-50. 2013
    ..Selection of in vitro optimisation parameters for SNEDDSs should be done carefully. It may not always be best to aim for the highest solubility in the preconcentrate and to avoid precipitation during in vitro lipolysis...
  23. doi request reprint Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy
    Johan P Boetker
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Mol Pharm 8:1372-80. 2011
    ..The combination of UV imaging and Raman spectroscopy is an efficient tool to obtain a deeper insight into the early events of the dissolution process...
  24. ncbi request reprint Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: in vivo bioavailability and dynamic in vitro lipolysis
    Anne Larsen
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    Pharm Res 25:2769-77. 2008
    ..To evaluate the use of Labrafil M2125CS as a lipid vehicle for danazol. Further, the possibility of predicting the in vivo behavior with a dynamic in vitro lipolysis model was evaluated...
  25. doi request reprint Phase transformations of amlodipine besylate solid forms
    Vishal Koradia
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen 2100, Denmark
    J Pharm Sci 100:2896-910. 2011
    ..The relative importance of the dissolution, nucleation, and growth steps for the transformation was elucidated using optical microscopy experiments. The transformation kinetics were found to be limited by nucleation and growth...
  26. ncbi request reprint Cinnarizine food-effects in beagle dogs can be avoided by administration in a Self Nano Emulsifying Drug Delivery System (SNEDDS)
    Martin Lau Christiansen
    University of Copenhagen, Faculty of Health and Medical Sciences, Universitetsparken 2, 2100 Copenhagen, Denmark
    Eur J Pharm Sci 57:164-72. 2014
    ..To elucidate if a SNEDDS approach can eliminate the food-effect on cinnarizine absorption and to, investigate if a nutritional drink, Fresubin energy, could mimic food effect in dogs for the poorly soluble compound cinnarizine...
  27. doi request reprint Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats
    Line Hagner Nielsen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Pharm Biopharm 85:942-51. 2013
    ..It can be concluded that the higher IDR and higher apparent solubility of the amorphous salt resulted in a faster Tmax compared to the amorphous and crystalline free acid...
  28. doi request reprint Spatial confinement can lead to increased stability of amorphous indomethacin
    Line Hagner Nielsen
    Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
    Eur J Pharm Biopharm 81:418-25. 2012
    ..It was observed that the amorphous indomethacin within these containers converted to the α-form of indomethacin (a metastable polymorph) which was unexpected at the storage conditions at 30 °C and 23% RH...
  29. doi request reprint Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems
    Ping Li
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    J Pharm Sci 102:2689-98. 2013
    ..In the specific case of insulin, the changes were found to be reversible, explaining the success of this strategy in previous studies...
  30. ncbi request reprint Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms
    Marianne L Lind
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Eur J Pharm Sci 32:261-70. 2007
    ..Further, a concentration dependent increase in the apparent permeability of etoposide was observed from apical to basolateral compartment, which indicated that components in the SIFs affects efflux mechanisms...
  31. ncbi request reprint Ex vivo correlation of the permeability of metoprolol across human and porcine buccal mucosa
    Emil Meng-Lund
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Pharm Sci 103:2053-61. 2014
    ..0 donor medium for 5.5 h. These data suggest that buccal mucosa from pigs can be used to predict human buccal absorption. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:2053-2061, 2014. ..
  32. doi request reprint Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging
    Sarah Gordon
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Pharm Dev Technol 18:1407-16. 2013
    ..The presented results highlight the complementary features of the utilized techniques and, in particular, the detailed information related to dissolution behavior which can be achieved by UV imaging. ..
  33. ncbi request reprint Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS
    Philip Carsten Christophersen
    Department of Pharmacy, Faculty of Health and Medical Science, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Eur J Pharm Sci 57:232-9. 2014
    ..The fasted state model correlated well with the in vivo results and although the fed state model did not accurately predict the fed state in vivo results, it could predict which formulation that would exhibit a food effect. ..
  34. doi request reprint In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems
    Anne T Larsen
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Denmark
    Int J Pharm 417:245-55. 2011
    ..Further, drug precipitated during in vitro lipolysis has been characterized by X-ray powder diffraction and polarized light microscopy...
  35. ncbi request reprint Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detection
    Anne Zimmermann
    Faculty of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Denmark
    J Pharm Biomed Anal 44:874-80. 2007
    ..The method was applied for determination of nine polymeric excipients and surfactants adsorbed to particles of the model drug. The extent of excipient adsorption varied between 0.07 and 1.39% (w/w) of the total particle weight...
  36. ncbi request reprint Refining stability and dissolution rate of amorphous drug formulations
    Holger Grohganz
    University of Copenhagen, Department of Pharmacy, Universitetsparken 2, 2100 Copenhagen, Denmark 45 3533 6032
    Expert Opin Drug Deliv 11:977-89. 2014
    ..However, amorphous systems are physically unstable. Therefore, pharmaceutical formulations scientists need to find ways to stabilise amorphous forms...
  37. pmc In vitro lipolysis data does not adequately predict the in vivo performance of lipid-based drug delivery systems containing fenofibrate
    Nicky Thomas
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark
    AAPS J 16:539-49. 2014
    ..The study suggests careful interpretation of in vitro performance criteria and revision of LbDDS optimization towards increased solubilization...
  38. ncbi request reprint Impact of sodium dodecyl sulphate on the dissolution of poorly soluble drug into biorelevant medium from drug-surfactant discs
    Peter Madelung
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    Int J Pharm 467:1-8. 2014
    ..The total amount of SDS in the discs only gave a minor increase in total surfactant concentration in the dissolution medium and did therefore not to any large extent affect the drug solubility in the bulk...
  39. doi request reprint Azone® decreases the buccal mucosal permeation of diazepam in a concentration-dependent manner via a reservoir effect
    Emil Meng-Lund
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
    J Pharm Sci 103:1133-41. 2014
    ..AZ provided a concentration-dependent reservoir for DIAZ in buccal mucosa, resulting in retarded release into the receptor chamber, an approach that may be exploited for controlled release of DIAZ...
  40. doi request reprint Miniaturized approach for excipient selection during the development of oral solid dosage form
    Dhara Raijada
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
    J Pharm Sci 103:900-8. 2014
    ..The proposed approach can be used for excipient selection and for early-stage performance testing of active pharmaceutical ingredient intended for oral solid dosage form...
  41. pmc Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs III - the Effect of Fed State Conditions on the In Vitro Release and Degradation of Desmopressin
    Philip C Christophersen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    AAPS J 16:875-83. 2014
    ....
  42. doi request reprint Bile salts and their importance for drug absorption
    Rene Holm
    Biologics and Pharmaceutical Science, H Lundbeck A S, Ottiliavej 9, DK 2500 Valby, Denmark
    Int J Pharm 453:44-55. 2013
    ..g. suspensions, solutions, cyclodextrin complexes or lipid based formulations, but a few exceptions have also been reported. ..
  43. ncbi request reprint Morphological observations on a lipid-based drug delivery system during in vitro digestion
    Dimitrios G Fatouros
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Eur J Pharm Sci 31:85-94. 2007
    ..Such methodology can be a useful tool for the strategic development of lipid-based formulations...
  44. ncbi request reprint Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful
    Rene Holm
    Preformulation, H Lundbeck A S, Ottiliavej 9, DK 2500 Valby, Denmark
    Eur J Pharm Sci 47:347-51. 2012
    ..This study therefore demonstrates that the pre-dosing of rats with Cholestyramine can not replace surgical bile duct cannulation if a formulation needs to be evaluated for its bile dependency...