Research Topics
| Anette MullertzSummaryAffiliation: University of Copenhagen Country: Denmark Publications
| Collaborators
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Detail Information
Publications
Oral delivery of peptides and proteins using lipid-based drug delivery systemsPing Li
University of Copenhagen, Faculty of Health and Medical Sciences, Department of Pharmacy, 2100 Copenhagen Ø, Denmark
Expert Opin Drug Deliv 9:1289-304. 2012..However, a better understanding of the mechanism of action in vivo is needed in order to improve the design and development of lipid-based DDS with the desired bioavailability and therapeutic profile...
New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugsAnette Mullertz
Department of Pharmaceutics and Analytical Chemistry Bioneer FARMA, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark
J Pharm Pharmacol 62:1622-36. 2010..We also aim to offer suggestions for an improved classification system that will accommodate lipid based formulations that are not currently accommodated in the lipid formulation classification system...- Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivoAnette Mullertz
Bioneer FARMA, Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Science, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
Mol Pharm 9:237-47. 2012.... - Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacityKaren Kleberg
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
J Pharm Sci 99:3522-32. 2010..The findings in this study suggest that the affinity of the drug to the different colloidal structures is determining for the solubility of the compound in the media... - Colloidal structures in media simulating intestinal fed state conditions with and without lipolysis productsDimitrios G Fatouros
Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Science, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark
Pharm Res 26:361-74. 2009..To study the ultrastructure of biorelevant media and digestion products of self-nanoemulsifying drug delivery system (SNEDDS) at high level BS/PL conditions... - Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: effects on physicochemical propertiesAnne Zimmermann
Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen Ø, Denmark
Eur J Pharm Biopharm 71:109-16. 2009..X-ray Photoelectron Spectroscopy (XPS) analysis of the surface composition and scanning electron microscopy studies on particle morphology suggested that the excipients adsorbed to specific faces of the crystals... - Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated ratsHenrik Tønsberg
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
J Pharm Pharmacol 63:817-24. 2011.... - In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networksDimitrios G Fatouros
Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen, Denmark
Eur J Pharm Biopharm 69:887-98. 2008..These preliminary results suggest that the dynamic lipolysis model combined with the AFM-IVIVC can be a useful tool in the prediction of the in vivo behavior of lipid-based formulations... - Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30Pia Thybo
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
Pharm Dev Technol 13:375-86. 2008..The stabilizing effect of the polymer was verified in the solid state, as all the SDs retained probucol in the amorphous state throughout the entire length of the stability study... - Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80Marianne L Lind
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
Eur J Pharm Sci 35:211-8. 2008..Furthermore, there was a good correlation between the halofantrine transport to blood and lymphatics in the chylomicron flow blocking model and published results from the mesenteric lymph-cannulated model... - Precipitation of a poorly soluble model drug during in vitro lipolysis: characterization and dissolution of the precipitatePhilip J Sassene
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
J Pharm Sci 99:4982-91. 2010..Overall, dissolution studies along with XRPD and PLM analysis indicate that cinnarizine precipitating during in vitro lipolysis of this SMEDDS is not crystalline, suggesting an either amorphous form or a molecular dispersion... - Influence of the solid form of siramesine hydrochloride on its behavior in aqueous environmentsAnne Zimmermann
Faculty of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark
Pharm Res 26:846-54. 2009..To study the influence of solid form on the behavior of the salt siramesine hydrochloride in aqueous environments... - Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in ratsHenrik Tønsberg
Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Denmark
J Pharm Pharmacol 62:63-70. 2010..The aim of this study was to examine the effects of formulations of polysorbate 80 (PS 80) and polyethylene glycol 400 (PEG 400) on the precipitation and oral bioavailability of the hydrophobic drug halofantrine... - Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studiesKaren Kleberg
Department of Pharmaceutics and Analytical Chemistry Bioneer FARMA, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark
J Pharm Pharmacol 62:1656-68. 2010..Based on the knowledge of human intestinal fluids, compositions of biorelevant media and their impact on solubility, dissolution and permeability studies of poorly soluble drug compounds are discussed... - Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopyJohan P Boetker
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
Mol Pharm 8:1372-80. 2011..The combination of UV imaging and Raman spectroscopy is an efficient tool to obtain a deeper insight into the early events of the dissolution process... - Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: in vivo bioavailability and dynamic in vitro lipolysisAnne Larsen
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
Pharm Res 25:2769-77. 2008..To evaluate the use of Labrafil M2125CS as a lipid vehicle for danazol. Further, the possibility of predicting the in vivo behavior with a dynamic in vitro lipolysis model was evaluated... - Phase transformations of amlodipine besylate solid formsVishal Koradia
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen 2100, Denmark
J Pharm Sci 100:2896-910. 2011..The relative importance of the dissolution, nucleation, and growth steps for the transformation was elucidated using optical microscopy experiments. The transformation kinetics were found to be limited by nucleation and growth... - Spatial confinement can lead to increased stability of amorphous indomethacinLine Hagner Nielsen
Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Eur J Pharm Biopharm 81:418-25. 2012..It was observed that the amorphous indomethacin within these containers converted to the α-form of indomethacin (a metastable polymorph) which was unexpected at the storage conditions at 30 °C and 23% RH... - A New Approach to Dissolution Testing by UV Imaging and Finite Element SimulationsJohan P Boetker
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark
Pharm Res 30:1328-37. 2013..In this study, a flexible numerical model was combined with a novel UV imaging system, allowing monitoring of the dissolution process with sub second time resolution... - Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanismsMarianne L Lind
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
Eur J Pharm Sci 32:261-70. 2007..Further, a concentration dependent increase in the apparent permeability of etoposide was observed from apical to basolateral compartment, which indicated that components in the SIFs affects efflux mechanisms... - In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systemsAnne T Larsen
Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Denmark
Int J Pharm 417:245-55. 2011..Further, drug precipitated during in vitro lipolysis has been characterized by X-ray powder diffraction and polarized light microscopy... - Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detectionAnne Zimmermann
Faculty of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Denmark
J Pharm Biomed Anal 44:874-80. 2007..The method was applied for determination of nine polymeric excipients and surfactants adsorbed to particles of the model drug. The extent of excipient adsorption varied between 0.07 and 1.39% (w/w) of the total particle weight... - Morphological observations on a lipid-based drug delivery system during in vitro digestionDimitrios G Fatouros
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
Eur J Pharm Sci 31:85-94. 2007..Such methodology can be a useful tool for the strategic development of lipid-based formulations... - Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessfulRene Holm
Preformulation, H Lundbeck A S, Ottiliavej 9, DK 2500 Valby, Denmark
Eur J Pharm Sci 47:347-51. 2012..This study therefore demonstrates that the pre-dosing of rats with Cholestyramine can not replace surgical bile duct cannulation if a formulation needs to be evaluated for its bile dependency... - Oral bioavailability of cinnarizine in dogs: Relation to SNEDDS droplet size, drug solubility and in vitro precipitationAnne T Larsen
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
Eur J Pharm Sci 48:339-50. 2013..Selection of in vitro optimisation parameters for SNEDDSs should be done carefully. It may not always be best to aim for the highest solubility in the preconcentrate and to avoid precipitation during in vitro lipolysis...