[Danish clinical guidelines for epilepsy]Anne Sabers
Amtssygehuset i Glostrup, Epilepsiklinikken, Arhus Universitetshospital, Arhus Sygehus, Neurologisk, Glostrup
Ugeskr Laeger 168:773-6. 2006
..The specialist service should include a multidisciplinary team. Epilepsy surgery should be considered early in patients with refractory focal epilepsy...
Oral contraceptives reduce lamotrigine plasma levelsAnne Sabers
Danish Epilepsy Hospital, University of Aarhus, Denmark
Neurology 61:570-1. 2003
..0001), indicating that LTG plasma levels are reduced by >50% during OC co-medication. It is advisable to monitor LTG plasma levels in conjunction with initiation or withdrawal of OC in women on LTG therapy...
Epilepsy and pregnancy: lamotrigine as main drug usedA Sabers
Danish Epilepsy Hospital, Dianalund, Denmark
Acta Neurol Scand 109:9-13. 2004
..To study the risk of teratogenicity in infants of women with epilepsy...
[Treatment of epilepsy--where are we now? Danish Society of Epilepsy]Anne Sabers
Epilepsiklinikken, Amtssygehuset i Glostrup, DK-2600 Glostrup
Ugeskr Laeger 167:1384. 2005
Managing antiepileptic drugs during pregnancy and lactationAnne Sabers
The Epilepsy Clinic, Glostrup University Hospital, Glostrup, Denmark
Curr Opin Neurol 22:157-61. 2009
..This review discusses data on the pharmacokinetics of antiepileptic drugs (AEDs) in pregnancy and lactation, and the clinical consequences thereof, thus providing a basis for a rational management of AEDs during pregnancy and lactation...
Seizure frequency in pregnant women treated with lamotrigine monotherapyAnne Sabers
The Epilepsy Clinic, Glostrup University Hospital, Glostrup, Denmark
Epilepsia 50:2163-6. 2009
..It was demonstrated that with this close monitoring set-up, the risk of increased seizure frequency (19%) was not higher than that reported for other AED treatment regimens...
Effect of antiepileptic drugs on cognitive function in individuals with epilepsy: a comparative review of newer versus older agentsLars Brunbech
Danish Epilepsy Hospital, Dianalund, Denmark
Drugs 62:593-604. 2002
..In general, the new AEDs seem to display no or minor negative cognitive effects. In studies in which new AEDs have been compared with old AEDs, there was a tendency in favour of the new AEDs in some of the studies...
Pregnancy registries in epilepsy: a consensus statement on health outcomesK J Meador
Department of Neurology, Emory University, Atlanta, GA 30322, USA
Neurology 71:1109-17. 2008
..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED...
Pharmacology of antiepileptic drugs during pregnancy and lactationPage B Pennell
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Epilepsy Behav 11:263-9. 2007
..The report provides an overview of these key topics, highlights gaps in the current knowledge, and provides future directions for needed research...
Oral contraceptives induce lamotrigine metabolism: evidence from a double-blind, placebo-controlled trialJakob Christensen
Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
Epilepsia 48:484-9. 2007
..This study evaluates the effect of oral contraceptives on lamotrigine (LTG) plasma concentrations and urine excretion of LTG metabolites in a double-blind, placebo-controlled, crossover study in patients with epilepsy...
Oxcarbazepine concentrations during pregnancy: a retrospective study in patients with epilepsyJakob Christensen
Department of Clinical Pharmacology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
Neurology 67:1497-9. 2006
..0016), being 72% (SD = 13%) in the first trimester, 74% (SD = 17%) in the second trimester, 64% (SD = 6%) in the third trimester, and 108% (SD = 18%) after pregnancy vs the dose-corrected concentration before pregnancy...
[Fertility, contraception and pregnancy in patients with epilepsy]Jesper Erdal
H:S Rigshospitalet, Neurologisk Klinik,
Ugeskr Laeger 166:3925-9. 2004
Individual changes in lamotrigine plasma concentrations during pregnancyVaiva Petrenaite
Department of Clinical Neurophysiology 3063, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Epilepsy Res 65:185-8. 2005
..The pharmacokinetic changes display marked inter-patient variation, which stresses the importance of evaluating each woman individually by closely monitoring LTG concentrations until term...
An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem casesKristian Linnet
The Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Frederik V Vej 11, DK 2100 Copenhagen Ø, Denmark
Forensic Sci Int 177:248-51. 2008
..Oxcarbazepine intoxication was regarded as a possible cause of death. For the other 26 cases, the 10-hydroxycarbazepine concentrations ranged from 2.2 to 48mg/kg with a median of 25mg/kg...
Pharmacokinetic interactions between contraceptives and antiepileptic drugsAnne Sabers
The Epilepsy Clinic, Department of Neurology, Glostrup University Hospital, Denmark
Seizure 17:141-4. 2008
..It is therefore recommended that change in OC use is assisted by AED monitoring whenever possible...