Søren K Moestrup

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, 8000 Arhus C, Denmark
    Annu Rev Nutr 21:407-28. 2001
  2. ncbi request reprint Cubilin, a high-density lipoprotein receptor
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Curr Opin Lipidol 11:133-40. 2000
  3. ncbi request reprint The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C, Denmark
    J Biol Chem 273:5235-42. 1998
  4. ncbi request reprint CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response
    Søren K Moestrup
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Ann Med 36:347-54. 2004
  5. ncbi request reprint Composite organization of the cobalamin binding and cubilin recognition sites of intrinsic factor
    Sergey N Fedosov
    Protein Chemistry Laboratory, Department of Molecular and Structural Biology, University of Aarhus, Science Park, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark
    Biochemistry 44:3604-14. 2005
  6. ncbi request reprint Identification of the receptor scavenging hemopexin-heme complexes
    Vibeke Hvidberg
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Blood 106:2572-9. 2005
  7. ncbi request reprint Generation of a haptoglobin-hemoglobin complex-specific Fab antibody blocking the binding of the complex to CD163
    Ivo R Horn
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Eur J Haematol 71:289-93. 2003
  8. doi request reprint Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes
    Christian Brix Folsted Andersen
    Department of Medical Biochemistry, Aarhus University, 8000 Aarhus C, Denmark
    Nature 464:445-8. 2010
  9. pmc Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, Denmark
    J Clin Invest 96:1404-13. 1995
  10. ncbi request reprint Human intrinsic factor expressed in the plant Arabidopsis thaliana
    Sergey N Fedosov
    Protein Chemistry Laboratory, Department of Molecular and Structural Biology, University of Aarhus, Denmark
    Eur J Biochem 270:3362-7. 2003

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, 8000 Arhus C, Denmark
    Annu Rev Nutr 21:407-28. 2001
    ..Here we summarize and discuss the structural, genetic, and functional aspects of megalin and cubilin, with emphasis on their function as receptors for uptake of protein-associated vitamins, lipids, and hormones...
  2. ncbi request reprint Cubilin, a high-density lipoprotein receptor
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Curr Opin Lipidol 11:133-40. 2000
    ..This receptor, designated cubilin, may play an important role in the renal clearance of filterable apolipoprotein AI/HDL and in the maternal-fetal transport of cholesterol...
  3. ncbi request reprint The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C, Denmark
    J Biol Chem 273:5235-42. 1998
    ..Due to the high number of CUB domains, accounting for 88% of the protein mass, we propose the name cubilin for the novel receptor...
  4. ncbi request reprint CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response
    Søren K Moestrup
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Ann Med 36:347-54. 2004
    ..Furthermore, recent data indicate that soluble CD163 may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions...
  5. ncbi request reprint Composite organization of the cobalamin binding and cubilin recognition sites of intrinsic factor
    Sergey N Fedosov
    Protein Chemistry Laboratory, Department of Molecular and Structural Biology, University of Aarhus, Science Park, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark
    Biochemistry 44:3604-14. 2005
    ..The obtained parameters for ligand and receptor binding indicate that both full-length IF(50) and the fragments may be involved in Cbl assimilation...
  6. ncbi request reprint Identification of the receptor scavenging hemopexin-heme complexes
    Vibeke Hvidberg
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Blood 106:2572-9. 2005
    ..Furthermore, the data indicate a hitherto unknown role of LRP/CD91 in inflammation...
  7. ncbi request reprint Generation of a haptoglobin-hemoglobin complex-specific Fab antibody blocking the binding of the complex to CD163
    Ivo R Horn
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Eur J Haematol 71:289-93. 2003
    ..In addition to provide new insight into the changes occurring when Hp and Hb bind, the present study provides a new potential tool for measuring and removal of Hp-Hb complexes from plasma/serum...
  8. doi request reprint Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes
    Christian Brix Folsted Andersen
    Department of Medical Biochemistry, Aarhus University, 8000 Aarhus C, Denmark
    Nature 464:445-8. 2010
    ....
  9. pmc Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, Denmark
    J Clin Invest 96:1404-13. 1995
    ..In conclusion, a novel role of gp330 as a drug receptor is demonstrated. The new insight into the mechanism of epithelial uptake of polybasic drugs might provide a basis for future design of drugs with reduced toxicity...
  10. ncbi request reprint Human intrinsic factor expressed in the plant Arabidopsis thaliana
    Sergey N Fedosov
    Protein Chemistry Laboratory, Department of Molecular and Structural Biology, University of Aarhus, Denmark
    Eur J Biochem 270:3362-7. 2003
    ..The data presented show that recombinant plants have a great potential as a large-scale source of human IF for analytical and therapeutic purposes...
  11. ncbi request reprint Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region
    Mette Madsen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    J Biol Chem 279:51561-7. 2004
    ..In conclusion, SRCR domain 3 of CD163 is an exposed domain and a critical determinant for the calcium-sensitive coupling of haptoglobin.hemoglobin complexes...
  12. ncbi request reprint The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants
    Marianne Jensby Nielsen
    Department of Medical Biochemistry, University of Aarhus, Ole Worms Alle, Building 170, 8000 Aarhus C, Denmark
    J Leukoc Biol 79:837-45. 2006
    ....
  13. ncbi request reprint Megalin binds and mediates cellular internalization of folate binding protein
    Henrik Birn
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
    FEBS J 272:4423-30. 2005
    ..Megalin is expressed in several absorptive epithelia, including intestine and kidney proximal tubule, and thus the present findings provide a mechanism for intestinal and renal endocytic uptake of soluble FBP...
  14. ncbi request reprint Application of a fluorescent cobalamin analogue for analysis of the binding kinetics. A study employing recombinant human transcobalamin and intrinsic factor
    Sergey N Fedosov
    Protein Chemistry Laboratory, Department of Molecular Biology, University of Aarhus, Denmark
    FEBS J 273:4742-53. 2006
    ..In conclusion, the fluorescent analogue CBC can be used as a reporting agent in the kinetic studies, moreover, it seems to be applicable for imaging purposes in vivo...
  15. pmc Analysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related protein
    O M Andersen
    Laboratory of Gene Expression, Department of Molecular and Structural Biology, University of Aarhus, Gustav Wieds Vej 10, DK-8000 Aarhus C, Denmark
    Biochem J 357:289-96. 2001
    ....
  16. ncbi request reprint The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein
    R Kozyraki
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Nat Med 5:656-61. 1999
    ..The physiological relevance of the cubilin-apoA-I interaction was further emphasized by urinary apoA-I loss in some known cases of functional cubilin deficiency. Therefore, cubilin is a receptor in epithelial apoA-I/HDL metabolism...
  17. ncbi request reprint Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney
    X Y Zhai
    Department of Cell Biology, Institute of Anatomy and Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Kidney Int 58:1523-33. 2000
    ..Two giant glycoproteins, cubilin and megalin, constitute important endocytic receptors localized to the kidney proximal tubule...
  18. ncbi request reprint Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP). A conserved acidic residue in the complement-type repeats is important for recognition of RAP
    O M Andersen
    Laboratory of Gene Expression and Protein Chemistry Laboratory, Department of Molecular and Structural Biology, University of Aarhus, Gustav Wieds Vej 10, DK 8000 Aarhus C, Denmark
    J Biol Chem 275:21017-24. 2000
    ..We provide experimental evidence showing that two adjacent complement-type repeats, both containing a conserved acidic residue, represent a minimal unit required for efficient binding to RAP...
  19. pmc Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis
    S K Moestrup
    Department of Medical Biochemistry, Kommunehospitalet University of Aarhus, Denmark
    Proc Natl Acad Sci U S A 93:8612-7. 1996
    ..The expression of megalin in absorptive epithelia in the kidney and other tissues including yolk sac and placenta suggests a role of the receptor in vitamin B12 homeostasis and fetal vitamin B12 supply...
  20. ncbi request reprint How calcium makes endocytic receptors attractive
    Christian B F Andersen
    Department of Biomedicine, Aarhus University, Ole Worms Allé 3, 8000 Aarhus C, Denmark
    Trends Biochem Sci 39:82-90. 2014
    ....
  21. ncbi request reprint Assembly of the intrinsic factor domains and oligomerization of the protein in the presence of cobalamin
    Sergey N Fedosov
    Protein Chemistry Laboratory, Department of Molecular and Structural Biology, University of Aarhus, Denmark
    Biochemistry 43:15095-102. 2004
    ..However, linkage between two domains is not compulsory for Cbl binding. Advantages of the two-domain structure of IF are discussed...
  22. pmc Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
    R Kozyraki
    Departments of Medical Biochemistry and Cell Biology, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus, Denmark
    Proc Natl Acad Sci U S A 98:12491-6. 2001
    ..The megalin-dependent, cubilin-mediated endocytosis of Tf and the potential of the receptors thereby to facilitate iron uptake were further confirmed by analyzing the uptake of (125)I- and (59)Fe-labeled Tf in cultured yolk sac cells...
  23. pmc Cubilin is an albumin binding protein important for renal tubular albumin reabsorption
    H Birn
    Department of Cell Biology, University of Aarhus, Aarhus, Denmark
    J Clin Invest 105:1353-61. 2000
    ..This process may prove important for understanding interstitial renal inflammation and fibrosis caused by proximal tubule uptake of an increased load of filtered albumin...
  24. ncbi request reprint Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein
    E I Christensen
    Department of Cell Biology, University of Aarhus, Denmark
    J Histochem Cytochem 40:1481-90. 1992
    ..Furthermore, our results demonstrate the usefulness of semi-thin and ultra-thin cryosections in studies of ligand binding and subcellular localization of receptors with autoradiographic techniques...
  25. ncbi request reprint Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes
    S K Moestrup
    Institute of Medical Biochemistry, University of Aarhus, Denmark
    J Biol Chem 268:16564-70. 1993
    ..The results establish an endocytotic function of gp330 and suggest that gp330 is an important component of the fibrinolytic system in gp330-containing epithelial as found in, for example, kidney and lung...
  26. ncbi request reprint The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake
    Vibeke Hvidberg
    Institute of Medical Biochemistry, University of Aarhus, Denmark
    FEBS Lett 579:773-7. 2005
    ..Furthermore, a rat yolk sac cell line known to express high levels of megalin, endocytosed NGAL by a mechanism completely blocked by an antibody against megalin...
  27. ncbi request reprint Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding
    M Kristiansen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    J Biol Chem 274:20540-4. 1999
    ..In conclusion, the N-terminal cubilin region seems crucial for membrane association, whereas the CUB domain cluster harbors distinct sites for ligand binding...
  28. ncbi request reprint Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein
    H Birn
    Department of Cell Biology, 8000 Aarhus C, Denmark
    J Biol Chem 272:26497-504. 1997
    ..In conclusion, we have identified the epithelial IF-B12-binding receptor as a approximately 460-kDa RAP-binding protein facilitating endocytosis...
  29. ncbi request reprint Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein
    L Jacobsen
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 271:31379-83. 1996
    ..The domain structure suggests that sorLA-1 is an endocytic receptor possibly implicated in the uptake of lipoproteins and of proteases...
  30. ncbi request reprint Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin
    M Kristiansen
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Blood 96:405-9. 2000
    ..This now explains the malabsorption of Cbl and Cbl-dependent anemia in MGA1 patients with the FM1 mutation. (Blood. 2000;96:405-409)..
  31. ncbi request reprint Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules
    E I Christensen
    Department of Cell Biology, University of Aarhus, Denmark
    Eur J Cell Biol 66:349-64. 1995
    ....
  32. ncbi request reprint New insights into carrier binding and epithelial uptake of the erythropoietic nutrients cobalamin and folate
    Søren K Moestrup
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Curr Opin Hematol 13:119-23. 2006
    ..The present review describes new insight into protein handling of cobalamin and folate...
  33. ncbi request reprint Evidence for an essential role of megalin in transepithelial transport of retinol
    E I Christensen
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
    J Am Soc Nephrol 10:685-95. 1999
    ..The present data show that the absence of RBP-binding megalin causes a significantly increased loss of RBP and retinol in the urine, demonstrating a crucial role of megalin in vitamin A homeostasis...
  34. ncbi request reprint Membrane receptors for endocytosis in the renal proximal tubule
    E I Christensen
    Department of Cell Biology, University of Aarhus, Denmark
    Int Rev Cytol 180:237-84. 1998
    ..A better understanding of these receptors will give us new insight into these very important processes for the organism...
  35. ncbi request reprint Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules
    H Birn
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
    J Am Soc Nephrol 11:191-202. 2000
    ..The present data show that RAP is of crucial importance for normal processing and function of megalin, suggesting a chaperone-like function of this protein in the kidney proximal tubule...
  36. ncbi request reprint The role of the kidney in lipid metabolism
    Søren K Moestrup
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Curr Opin Lipidol 16:301-6. 2005
    ..We describe the renal receptor system and its role in lipid metabolism in health and disease, and discuss the general effect of the diseased kidney on lipid metabolism...
  37. ncbi request reprint CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma
    Jonas Heilskov Graversen
    Department of Medical Biochemistry, University of Aarhus, Ole Worms Alle, Building 170, 8000 Aarhus C, Denmark
    Int J Biochem Cell Biol 34:309-14. 2002
    ..The novel functional linkage of CD163 and Hp, which both are induced during inflammation, also reveal some interesting perspectives relating to the suggested anti-inflammatory properties of the receptor and the Hp phenotypes...
  38. ncbi request reprint Megalin-mediated endocytosis in renal proximal tubule
    E I Christensen
    Department of Cell Biology, University of Aarhus, Denmark
    Ren Fail 20:191-9. 1998
    ....
  39. pmc Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)
    A Nykjaer
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 98:13895-900. 2001
    ..This observation identifies spontaneous mutations in an endocytic receptor pathway affecting cellular uptake and metabolism of a steroid hormone...
  40. pmc beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C
    J Clin Invest 102:902-9. 1998
    ....
  41. ncbi request reprint Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes
    P A Andreasen
    Department of Molecular Biology, University of Aarhus, Denmark
    FEBS Lett 338:239-45. 1994
    ..Binding to alpha 2MR and gp330 is a novel kind of molecular recognition of serine proteinases and serpins...
  42. ncbi request reprint Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor
    T Kristensen
    Department of Molecular Biology, University of Aarhus, Denmark
    FEBS Lett 276:151-5. 1990
    ..It is suggested that LRP is the functional receptor for alpha 2-macroglobulin-proteinase complexes (alpha 2MR) and in addition may have as yet unsettled functions in lipoprotein metabolism...
  43. ncbi request reprint Nested sets of protein fragments and their use in epitope mapping: characterization of the epitope for the S4D5 monoclonal antibody binding to receptor associated protein
    L Ellgaard
    Department of Chemistry, University of Aarhus, Denmark
    J Immunol Methods 180:53-61. 1995
    ..The model study demonstrates the utility of nested sets of protein fragments as fast and inexpensive tools for epitope mapping...
  44. ncbi request reprint Specific binding of alpha-macroglobulin to complement-type repeat CR4 of the low-density lipoprotein receptor-related protein
    O M Andersen
    Laboratory of Gene Expression, Department of Molecular and Structural Biology, and Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Biochemistry 39:10627-33. 2000
    ....
  45. ncbi request reprint Identification of residues in alpha-macroglobulins important for binding to the alpha2-macroglobulin receptor/Low density lipoprotein receptor-related protein
    K L Nielsen
    Department of Chemistry, University of Aarhus, 8000 Arhus C, Denmark
    J Biol Chem 271:12909-12. 1996
    ..From this result and mutational evidence from other ligands for the alpha2-macroglobulin receptor, a tentative sequence motif for receptor binding is proposed...
  46. pmc CD163 and inflammation: biological, diagnostic, and therapeutic aspects
    Anders Etzerodt
    Department of Biomedicine, University of Aarhus, Aarhus C, Denmark
    Antioxid Redox Signal 18:2352-63. 2013
    ....
  47. doi request reprint Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin
    Rasmus Beedholm-Ebsen
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Blood 115:1632-9. 2010
    ..The identification of this Cbl export mechanism now allows the delineation of a coherent pathway for Cbl trafficking from food to the body cells...
  48. ncbi request reprint Megalin/gp330 mediates uptake of albumin in renal proximal tubule
    S Cui
    Department of Cell Biology, University of Aarhus, Denmark
    Am J Physiol 271:F900-7. 1996
    ..In conclusion, the present study demonstrates that megalin is a mediator of albumin reabsorption in renal proximal tubules...
  49. ncbi request reprint Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography
    C M Petersen
    Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C, Denmark
    J Biol Chem 272:3599-605. 1997
    ..Expression of a chimeric receptor containing the cytoplasmic tail of gp95/sortilin demonstrates evidence that the tail conveys colocalization with the cation-independent mannose6-phosphate receptor in endosomes and the Golgi compartment...
  50. ncbi request reprint The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin
    J Tauris
    Department of Medical Biochemistry, University of Aarhus, Denmark
    FEBS Lett 429:27-30. 1998
    ..Whereas sortilin bound only RAP domain III, megalin and LRP bound all RAP domains with the functional affinity order: domain III >domain I > domain II...
  51. ncbi request reprint Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin
    R Nielsen
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
    J Am Soc Nephrol 9:1767-76. 1998
    ..This study reveals a proximal tubule cell line expressing megalin in a functional manner well suited for binding, uptake, and transcellular transport studies...
  52. pmc Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding
    C Munck Petersen
    Department of Medical Biochemistry, University of Aarhus, Ole Worms Alle, Building 170, DK 8000 Aarhus C, Denmark
    EMBO J 18:595-604. 1999
    ....
  53. pmc The haptoglobin-CD163-heme oxygenase-1 pathway for hemoglobin scavenging
    Jens Haugbølle Thomsen
    Department of Biomedicine, University of Aarhus, Aarhus C, Denmark
    Oxid Med Cell Longev 2013:523652. 2013
    ..Future studies of animal models of inflammation should further define the importance of the pathway in the anti-inflammatory response...
  54. ncbi request reprint Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes
    M Madsen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Redox Rep 6:386-8. 2001
    ..g. the atherogenesis-promoting oxidation of LDL leading to foam cell formation and apoptosis in the vessel wall...
  55. ncbi request reprint Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP
    O M Andersen
    Laboratory of Gene Expression, Department of Molecular and Structural Biology, University of Aarhus, Aarhus, Denmark
    Biochemistry 40:15408-17. 2001
    ....
  56. ncbi request reprint Identification of the haemoglobin scavenger receptor
    M Kristiansen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Nature 409:198-201. 2001
    ..Specific CD163-mediated endocytosis of haptoglobin-haemoglobin complexes is measurable in cells transfected with CD163 complementary DNA and in CD163-expressing myelo-monocytic lymphoma cells...
  57. ncbi request reprint Mutational analysis of affinity and selectivity of kringle-tetranectin interaction. Grafting novel kringle affinity ontp the trtranectin lectin scaffold
    J H Graversen
    Laboratory of Gene Expression, Department of Molecular and Structural Biology and the Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 275:37390-6. 2000
    ..This study provides further insight into molecular determinants of importance for binding selectivity and affinity of C-type lectin kringle interactions...