Hanne B Moeller

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. ncbi request reprint Phosphorylation and ubiquitylation are opposing processes that regulate endocytosis of the water channel aquaporin-2
    Hanne B Moeller
    Department of Biomedicine, Center for Interactions of Proteins in Epithelial Transport InterPrET, Aarhus University, Aarhus DK 8000, Denmark
    J Cell Sci 127:3174-83. 2014
  2. pmc Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment
    Hanne B Moeller
    Department of Biomedicine, Aarhus University, and Department of Pediatrics, Aarhus University Hospital, Wilhelm Meyers Allé 3, Building 1234, Aarhus 8000, Denmark
    Endocr Rev 34:278-301. 2013
  3. doi request reprint Cell biology of vasopressin-regulated aquaporin-2 trafficking
    Hanne B Moeller
    Department of Biomedicine and Center for Interactions of Proteins in Epithelial Transport InterPrET, Aarhus University, Bldg 1233 Wilhelm Meyers Alle, Aarhus, 8000, Denmark
    Pflugers Arch 464:133-44. 2012
  4. doi request reprint Regulation of the water channel aquaporin-2 by posttranslational modification
    Hanne B Moeller
    The Water and Salt Research Center, Dept of Anatomy, Aarhus Univ, Denmark
    Am J Physiol Renal Physiol 300:F1062-73. 2011
  5. pmc Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus
    Emma T B Olesen
    Department of Biomedicine, Water and Salt Research Center, Aarhus University, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 108:12949-54. 2011
  6. pmc Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating
    Hanne B Moeller
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Am J Physiol Renal Physiol 296:F649-57. 2009
  7. pmc Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells
    Hanne B Moeller
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Kidney Int 75:295-303. 2009
  8. pmc Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions
    Hanne B Moeller
    Water and Salt Research Center, Department of Anatomy, Aarhus University, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 107:424-9. 2010
  9. doi request reprint Differential water permeability and regulation of three aquaporin 4 isoforms
    Robert A Fenton
    The Water and Salt Research Center, Department of Anatomy, University of Aarhus, 8000, Aarhus, Denmark
    Cell Mol Life Sci 67:829-40. 2010
  10. doi request reprint Recent discoveries in vasopressin-regulated aquaporin-2 trafficking
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Prog Brain Res 170:571-9. 2008

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Phosphorylation and ubiquitylation are opposing processes that regulate endocytosis of the water channel aquaporin-2
    Hanne B Moeller
    Department of Biomedicine, Center for Interactions of Proteins in Epithelial Transport InterPrET, Aarhus University, Aarhus DK 8000, Denmark
    J Cell Sci 127:3174-83. 2014
    ..Similar mechanisms might exist for other plasma membrane proteins. ..
  2. pmc Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment
    Hanne B Moeller
    Department of Biomedicine, Aarhus University, and Department of Pediatrics, Aarhus University Hospital, Wilhelm Meyers Allé 3, Building 1234, Aarhus 8000, Denmark
    Endocr Rev 34:278-301. 2013
    ..Additionally, we provide an overview of the exciting new treatment strategies that have been recently proposed for alleviating the symptoms of some forms of the disease and for bypassing G protein-coupled receptor signaling...
  3. doi request reprint Cell biology of vasopressin-regulated aquaporin-2 trafficking
    Hanne B Moeller
    Department of Biomedicine and Center for Interactions of Proteins in Epithelial Transport InterPrET, Aarhus University, Bldg 1233 Wilhelm Meyers Alle, Aarhus, 8000, Denmark
    Pflugers Arch 464:133-44. 2012
    ..Insight into the molecular mechanisms responsible for regulated AQP2 trafficking is proving to be fundamental for development of novel therapies for water balance disorders...
  4. doi request reprint Regulation of the water channel aquaporin-2 by posttranslational modification
    Hanne B Moeller
    The Water and Salt Research Center, Dept of Anatomy, Aarhus Univ, Denmark
    Am J Physiol Renal Physiol 300:F1062-73. 2011
    ....
  5. pmc Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus
    Emma T B Olesen
    Department of Biomedicine, Water and Salt Research Center, Aarhus University, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 108:12949-54. 2011
    ..Furthermore, EP2 selective agonists can partially compensate for a nonfunctional V2R, providing a rationale for new treatment strategies for hereditary nephrogenic diabetes insipidus...
  6. pmc Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating
    Hanne B Moeller
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Am J Physiol Renal Physiol 296:F649-57. 2009
    ..In contrast, AQP2 S261 phosphorylation is independent of the phosphorylation status of S256...
  7. pmc Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells
    Hanne B Moeller
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Kidney Int 75:295-303. 2009
    ..Our results show that S269 phosphorylated aquaporin-2 is exclusively associated with the apical plasma membrane, where it escapes endocytosis to remain at the cell surface...
  8. pmc Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions
    Hanne B Moeller
    Water and Salt Research Center, Department of Anatomy, Aarhus University, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 107:424-9. 2010
    ....
  9. doi request reprint Differential water permeability and regulation of three aquaporin 4 isoforms
    Robert A Fenton
    The Water and Salt Research Center, Department of Anatomy, University of Aarhus, 8000, Aarhus, Denmark
    Cell Mol Life Sci 67:829-40. 2010
    ..The M23 isoform was more sensitive to PKC regulation than the longer isoforms and was internalized significantly faster. Our results suggest a specific role for square array formation...
  10. doi request reprint Recent discoveries in vasopressin-regulated aquaporin-2 trafficking
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Prog Brain Res 170:571-9. 2008
    ..Determining how AQP-2 trafficking occurs at the molecular level is fundamental to understanding the physiology of water balance regulation and the pathophysiology of water balance disorders...
  11. doi request reprint New insights into regulated aquaporin-2 function
    Robert A Fenton
    Department of Biomedicine, Aarhus University and Center for Interactions of Proteins in Epithelial Transport, Aarhus University, Aarhus, Denmark
    Curr Opin Nephrol Hypertens 22:551-8. 2013
    ..In this article, we highlight some of the new insights into AQP2 function that have developed recently, with particular focus on the cell biological aspects of AQP2 regulation...
  12. pmc Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
    Christian K Holm
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Nat Immunol 13:737-43. 2012
    ..We suggest that membrane fusion is sensed as a danger signal with potential implications for defense against enveloped viruses and various conditions of giant-cell formation...
  13. pmc Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 105:3134-9. 2008
    ..Overall, our results are consistent with a dynamic effect of AVP on the phosphorylation and subcellular distribution of AQP2...