Affiliation: University of Aarhus
- Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humansRonan Mg Berg
Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
Crit Care 14:R16. 2010..We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation...
- Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volumeCarsten Lundby
Copenhagen Muscle Research Center, Rigshospitalet section 7652, 2100 Copenhagen, Denmark
J Physiol 578:309-14. 2007..9 and 53.9% during the study period, this mechanism seems as important for increasing arterial oxygen content as the well-known erythropoietic effect of Epo...
- Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and high altitude nativesCarsten Lundby
Copenhagen Muscle Center, Rigshospitalet section 7652, Blegdamsvej 9, 2100 Copenhagen O, Denmark
J Physiol 573:535-47. 2006..This would suggest that the major determinant V(o2max)for not to increase with acclimatization is the observed reduction in maximal leg blood flow and O(2) conductance...
- During hypoxic exercise some vasoconstriction is needed to match O2 delivery with O2 demand at the microcirculatory levelCarsten Lundby
Copenhagen Muscle Research Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
J Physiol 586:123-30. 2008..Peak cardiac output at altitude is not limited by excessive mean arterial pressure. Exercising leg .VO(2peak) is not limited by restricted vasodilatation in the altitude-acclimatized human...
- Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscleCarsten Lundby
Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 3, 2100 Copenhagen Ø, Denmark
J Appl Physiol 104:1154-60. 2008..However, in contrast to our hypothesis, prolonged Epo administration had no apparent effect on capillarization or muscle fiber hypertrophy...
- Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport?C Lundby
Copenhagen Muscle Research Center, Department of Anaesthesia, Rigshospitalet, Section 7652, Blegdamsvej 9, 2100 Copenhagen, Denmark
J Appl Physiol 105:581-7. 2008..The augmented hematocrit did not compromise peak cardiac output. In summary, in healthy humans, rHuEpo increases maximal oxygen consumption due to augmented systemic and muscular peak oxygen delivery...
- Testing for recombinant human erythropoietin in urine: problems associated with current anti-doping testingCarsten Lundby
Copenhagen Muscle Research Centre, Rigshospitalet section 7652, Blegdamsvej 9, 2100 Copenhagen, Denmark
J Appl Physiol 105:417-9. 2008..Recently the test has met serious critiques, and the aims of the present study were to investigate the detection power of the test as well as the variability in the test power comparing the results of two WADA-accredited laboratories...
- The response of human skeletal muscle tissue to hypoxiaCarsten Lundby
The Copenhagen Muscle Research Centre, Rigshospitalet Sect 7652, 2100, Copenhagen, Denmark
Cell Mol Life Sci 66:3615-23. 2009..On the other hand, combining hypoxia with exercise appears to improve some aspects of muscle O(2) transport and/or metabolism...
- Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacityJ J Thomsen
Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, 2100, Copenhagen Ø, Denmark
Eur J Appl Physiol 101:481-6. 2007..8% as compared to pre rHuEpo administration. In conclusion, in healthy non-athlete subjects rHuEpo administration prolongs submaximal exercise performance by about 54% independently of the approximately 12% increase in VO2max...
- The lactate paradox revisited in lowlanders during acclimatization to 4100 m and in high-altitude nativesG van Hall
The Copenhagen Muscle Research Centre, Rigshospitalet section 7652, 9 Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
J Physiol 587:1117-29. 2009..High-altitude natives from the Andes actually exhibit a higher anaerobic energy production than lowlanders after 8 weeks of acclimatization reflected by an increased muscle lactate accumulation and enhanced adenine nucleotide breakdown...
- Effects of prolonged recombinant human erythropoietin administration on muscle membrane transport systems and metabolic marker enzymesC Juel
Copenhagen Muscle Research Centre, Department of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
Eur J Appl Physiol 102:41-4. 2007..In conclusion, changes in muscle membrane transport proteins and selected muscle enzymes do not contribute to the Epo-induced improvement in performance...
- Exercise economy does not change after acclimatization to moderate to very high altitudeC Lundby
Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen Ø, Denmark
Scand J Med Sci Sports 17:281-91. 2007..In conclusion, results from several, independent investigations indicate that exercise economy remains unchanged after acclimatization to high altitude...
- Peak heart rate decreases with increasing severity of acute hypoxiaC Lundby
Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark
High Alt Med Biol 2:369-76. 2001..This study clearly demonstrates a progressive decrease in peak HR with increasing altitude, despite evidence of similar exercise effort and unchanged sympathetic excitation...
- Exercise performance in hypoxia after novel erythropoiesis stimulating protein treatmentC Lundby
The Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 9, 2100 Copenhagen O, Denmark RC dk
Scand J Med Sci Sports 16:35-40. 2006..0, before and after NESP treatment, respectively. NESP-injections in human subjects causes Hb and accordingly CaO2 to increase both in normoxia and hypoxia. Despite increases in CaO2 at maximal exercise in hypoxia VO2max is not increased...
- Human skeletal muscle and erythrocyte proteins involved in acid-base homeostasis: adaptations to chronic hypoxiaC Juel
Copenhagen Muscle Research Centre, August Krogh Institute, Denmark
J Physiol 548:639-48. 2003..Together, these changes suggest a hypoxia-induced increase in the capacity for lactate, HCO3- and H+ fluxes from muscle to blood and from blood to erythrocytes...
- The influence of intermittent altitude exposure to 4100 m on exercise capacity and blood variablesC Lundby
The Copenhagen Muscle Research Centre, Rigshospitalet, Blegdamsvej, Copenhagen Ø, Denmark
Scand J Med Sci Sports 15:182-7. 2005..0+/-0.2 and 4.2+/-0.2 L min(-1). It is concluded that intermittent hypoxic exposure to 4100 m altitude for 2 h daily and a total of 14 days does not affect exercise capacity...
- Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8 wk of acclimatization to 4,100 m and in high-altitude Aymara nativesCarsten Lundby
The Copenhagen Muscle Research Centre, Rigshospitalet, Sect 7652, 9 Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
Am J Physiol Regul Integr Comp Physiol 287:R1202-8. 2004..4 mmHg). In conclusion, lowlanders substantially improve pulmonary gas exchange with acclimatization, but even acclimatization for 8 wk is insufficient to achieve levels reached by high-altitude natives...
- Peak heart rates at extreme altitudesC Lundby
The Copenhagen Muscle Research Centre, Rigshospitalet, Denmark
High Alt Med Biol 2:41-5. 2001..The peak heart rates at 8,750 m are in agreement with other field studies, but considerably higher than values reported from hypobaric chamber studies...
- Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscleCarsten Lundby
The Copenhagen Muscle Research Centre at Rigshospitalet section 7652, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
J Exp Biol 207:3865-71. 2004..05). In conclusion, human muscle VEGF mRNA expression and capillary density are not significantly increased by 8 weeks of exposure to high altitude and are not increased in Aymara high-altitude natives compared with sea level residents...
- Substrate utilization in sea level residents during exercise in acute hypoxia and after 4 weeks of acclimatization to 4100 mC Lundby
The Copenhagen Muscle Research Centre, Copenhagen Ø, Denmark
Acta Physiol Scand 176:195-201. 2002..2 +/- 0.02 g min(-1) in ACrel and 0.3 +/- 0.02 g min(-1) in CHrel. In conclusion, substrate utilization is unaffected by AH and CH, when the work rate is matched to the same relative intensity as at SL...
- Human muscle net K(+) release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 mNikolai B Nordsborg
Copenhagen Muscle Research Center, Rigshospitalet Section, Copenhagen Ø, Denmark
Am J Physiol Regul Integr Comp Physiol 299:R306-13. 2010..9 +/- 0.8% in normoxia and -10.0 +/- 0.4% in hypoxia). It is concluded that leg net K(+) release is unrelated to anaerobic energy production and that acclimatization reduces leg net K(+) release during exercise...
- Relative workload determines exercise-induced increases in PGC-1alpha mRNANikolai Baastrup Nordsborg
Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
Med Sci Sports Exerc 42:1477-84. 2010..The hypothesis that brief intermittent exercise-induced increases in human skeletal muscle metabolic mRNA is dependent on relative workload was investigated...
- Assessment of total haemoglobin mass: can it detect erythropoietin-induced blood manipulations?Carsten Lundby
Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen Ø, Denmark
Eur J Appl Physiol 108:197-200. 2010..In our opinion the variability observed over time when assessing tHb is not justifiable in an anti-doping setting...
- Interleukin-6 response to exercise during acute and chronic hypoxiaCarsten Lundby
The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
Eur J Appl Physiol 91:88-93. 2004..We conclude that the plasma IL-6 concentration during exercise in hypoxia is intensity dependent, and that factors other than catecholamine levels are more important for its regulation...
- Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsiesCarsten Lundby
Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 9, 2100, Copenhagen, Denmark
Eur J Appl Physiol 95:351-60. 2005..In addition, the present study shows that multiple muscle biopsies obtained from the same muscle do not influence the mRNA response induced by an acute exercise bout for any of the genes examined...
- Skeletal muscle adaptations to prolonged exposure to extreme altitude: a role of physical activity?Masao Mizuno
The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark
High Alt Med Biol 9:311-7. 2008..Muscle enzyme activity was unaffected with altitude exposure in both groups, whereas muscle buffer capacity was increased...
- Effects of darbepoetin injections on erythrocyte membrane transport protein expressions in humansRikke Louise Rentsch
Copenhagen Muscle Research Centre, Institute of Molecular Biology and Physiology, The August Krogh Bldg, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen, Denmark
J Appl Physiol 101:164-8. 2006..However, increased incorporation of membrane proteins during erythrocyte formation may also be involved. We suggest that NESP improves the quality of erythrocyte membrane transport through these mechanisms...
- Skiing across the Greenland icecap: divergent effects on limb muscle adaptations and substrate oxidationJørn W Helge
Copenhagen Muscle Research Centre, National University Hospital, Denmark
J Exp Biol 206:1075-83. 2003..Although the number of subjects is limited, these results imply that the adaptation pattern after long-term, prolonged, low-intensity, whole body exercise may vary dramatically among muscles...
- Contraction-induced changes in skeletal muscle Na(+), K(+) pump mRNA expression - importance of exercise intensity and Ca(2+)-mediated signallingN B Nordsborg
Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
Acta Physiol (Oxf) 198:487-98. 2010..To investigate if exercise intensity and Ca(2+) signalling regulate Na(+),K(+) pump mRNA expression in skeletal muscle...
- Screening for recombinant human erythropoietin using [Hb], reticulocytes, the OFF(hr score), OFF(z score) and Hb(z score): status of the Blood PassportAndreas Bornø
Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Copenhagen Ø, Denmark
Eur J Appl Physiol 109:537-43. 2010..However, 42% of our rHuEpo-injected subjects were not detected. It should be emphasised that the test frequency in real world anti-doping is far less than the present study, and hence the detection rate will be lower...
- Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscleKristian Kiilerich
Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
Diabetes 59:26-32. 2010..To test the hypothesis that free fatty acid (FFA) and muscle glycogen modify exercise-induced regulation of PDH (pyruvate dehydrogenase) in human skeletal muscle through regulation of PDK4 expression...
- Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental modelsPeter Møller
Institute of Public Health, University of Copenhagen, The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen K, Denmark
IUBMB Life 60:707-23. 2008..Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity...
- Oxidative DNA damage and repair in skeletal muscle of humans exposed to high-altitude hypoxiaCarsten Lundby
The Copenhagen Muscle Research Centre, Rigshospitalet, DK 2200 Copenhagen N, Denmark
Toxicology 192:229-36. 2003....
- Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditionsCarsten Lundby
Copenhagen Muscle Research Centre, Copenhagen, Denmark
Eur J Appl Physiol 96:363-9. 2006..We propose that HIFs expression is upregulated with exercise and that it may be an important transcription factor that regulates adaptive gene responses to exercise...
- Detection of darbepoetin alfa misuse in urine and blood: a preliminary investigationJakob Morkeberg
The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Med Sci Sports Exerc 39:1742-7. 2007..The main objectives were to establish the period of detection of darbepoetin alfa by isoelectric focusing (IEF) and examine the applicability of blood algorithms and individual variations in blood variables in an antidoping context...
- Erythropoietin augments the cytokine response to acute endotoxin-induced inflammation in humansPernille Hojman
Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Cytokine 45:154-7. 2009..In contrast to our hypothesis, we find that EPO augments the acute inflammatory effect...
- Calcitonin gene-related peptide and adrenomedullin release in humans: effects of exercise and hypoxiaPhilip Hasbak
Department of Clinical Physiology and Nuclear Medicine, University Hospital of Herlev, Herlev, Denmark
Regul Pept 108:89-95. 2002..In conclusion, CGRP release during hypoxic exercise does not respond to domperidone-induced changes in circulating levels of noradrenaline, rather the release may be directly related to the production of lactate...
- Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal musclePaul Robach
Département médical, Ecole Nationale de Ski et d Alpinisme, Chamonix, France
Blood 109:4724-31. 2007..Thus, in HA, the elevated iron requirement associated with enhanced erythropoiesis presumably elicits iron mobilization and myoglobin down-modulation, suggesting an altered muscle oxygen homeostasis...
- Lactate metabolism at high altitudeCarsten Lundby
High Alt Med Biol 5:195-6; author reply 197-8. 2004
- Comment on Point:Counterpoint "positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume"Jose A L Calbet
J Appl Physiol 100:749. 2006
- Importance of hemoglobin concentration to exercise: acute manipulationsJose A L Calbet
Department of Physical Education, University of Las Palmas de Gran Canaria, Spain
Respir Physiol Neurobiol 151:132-40. 2006..V(O(2)(max) during exercise in acute hypoxia. Likewise, reducing [Hb] in altitude-acclimatized humans to pre-acclimatization values has no effect on (.)V(O(2)(max) during exercise in hypoxia...
- Erythropoietin depletes iron stores: antioxidant neuroprotection for ischemic stroke?Damian Miles Bailey
Stroke 37:2453. 2006
- The lactate paradox: does acclimatization to high altitude affect blood lactate during exercise?Peter D Wagner
Department of Medicine, University of California, San Diego, La Jolla, CA, USA
Med Sci Sports Exerc 39:749-55. 2007
- Contraction-induced increases in Na+-K+-ATPase mRNA levels in human skeletal muscle are not amplified by activation of additional muscle massNikolai Nordsborg
Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
Am J Physiol Regul Integr Comp Physiol 289:R84-91. 2005..In conclusion, activation of additional muscle mass does not result in a higher exercise-induced increase in Na(+)-K(+)-ATPase subunit-specific mRNA...
- Acute hypoxia and reoxygenation-induced DNA oxidation in human mononuclear blood cellsLotte Risom
Institute of Public Health, University of Copenhagen, Øster Farimagsgade 5A, Postbox 2099, DK 1014 Copenhagen K, Denmark
Mutat Res 625:125-33. 2007....