J A Lundbaek

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc Spring constants for channel-induced lipid bilayer deformations. Estimates using gramicidin channels
    J A Lundbaek
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10021 USA
    Biophys J 76:889-95. 1999
  2. pmc Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes
    Jens A Lundbaek
    Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065, USA
    J R Soc Interface 7:373-95. 2010
  3. pmc Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs
    Jens A Lundbaek
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Gen Physiol 131:421-9. 2008
  4. pmc Amphiphile regulation of ion channel function by changes in the bilayer spring constant
    Jens A Lundbaek
    Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:15427-30. 2010
  5. ncbi request reprint Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity
    J A Lundbaek
    Novo Nordisk A S Måløv, Denmark
    Mol Pharmacol 68:680-9. 2005
  6. pmc Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol
    Jens A Lundbaek
    Novo Nordisk A S, Måløv, Denmark
    J Gen Physiol 123:599-621. 2004
  7. pmc Cholesterol-induced protein sorting: an analysis of energetic feasibility
    J A Lundbaek
    Institute of Biological Psychiatry, Sct Hans Hospital, Roskilde, DK 4000, Denmark
    Biophys J 84:2080-9. 2003
  8. ncbi request reprint Regulation of endothelial cell migration by amphiphiles - are changes in cell membrane physical properties involved?
    Lasse D E Jensen
    Department of Cancer and Immunobiology, Novo Nordisk A S, Novo Nordisk Park, Måløv, Denmark
    Angiogenesis 10:13-22. 2007
  9. ncbi request reprint GABA(A) receptor function is regulated by lipid bilayer elasticity
    Rikke Søgaard
    Research Institute of Biological Psychiatry, Sct Hans Hospital, Boserupvej 2, DK 4000 Roskilde, Denmark
    Biochemistry 45:13118-29. 2006
  10. ncbi request reprint ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation
    Uffe B Olsen
    Department of General Pharmacology, Novo Nordisk A S, 2760 Maaloev, Denmark
    Eur J Pharmacol 435:43-57. 2002

Collaborators

Detail Information

Publications10

  1. pmc Spring constants for channel-induced lipid bilayer deformations. Estimates using gramicidin channels
    J A Lundbaek
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10021 USA
    Biophys J 76:889-95. 1999
    ..The spring constant in nominally hydrocarbon-free bilayers agrees well with estimates based on a continuum analysis of inclusion-induced bilayer deformations using independently measured material constants...
  2. pmc Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes
    Jens A Lundbaek
    Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065, USA
    J R Soc Interface 7:373-95. 2010
    ..We further describe the use of gramicidin channels as molecular force probes for studying this mechanism, with a unique ability to discriminate between consequences of changes in monolayer curvature and bilayer elastic moduli...
  3. pmc Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs
    Jens A Lundbaek
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Gen Physiol 131:421-9. 2008
  4. pmc Amphiphile regulation of ion channel function by changes in the bilayer spring constant
    Jens A Lundbaek
    Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:15427-30. 2010
    ..The use of gA channels as molecular force probes provides a tool for quantitative, predictive studies of bilayer-mediated regulation of membrane protein function by amphiphiles...
  5. ncbi request reprint Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity
    J A Lundbaek
    Novo Nordisk A S Måløv, Denmark
    Mol Pharmacol 68:680-9. 2005
    ..We conclude that capsaicin can regulate VDSC function by altering bilayer elasticity. This mechanism may underlie the promiscuous regulation of membrane protein function by capsaicin and capsazepine-and by amphiphilic drugs generally...
  6. pmc Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol
    Jens A Lundbaek
    Novo Nordisk A S, Måløv, Denmark
    J Gen Physiol 123:599-621. 2004
    ..These results provide strong support for the notion that bilayer-protein hydrophobic coupling allows the bilayer elastic properties to regulate membrane protein function...
  7. pmc Cholesterol-induced protein sorting: an analysis of energetic feasibility
    J A Lundbaek
    Institute of Biological Psychiatry, Sct Hans Hospital, Roskilde, DK 4000, Denmark
    Biophys J 84:2080-9. 2003
    ..We conclude that cholesterol-induced changes in the bilayer physical properties allow for effective and accurate sorting which will be important generally for protein partitioning between different membrane domains...
  8. ncbi request reprint Regulation of endothelial cell migration by amphiphiles - are changes in cell membrane physical properties involved?
    Lasse D E Jensen
    Department of Cancer and Immunobiology, Novo Nordisk A S, Novo Nordisk Park, Måløv, Denmark
    Angiogenesis 10:13-22. 2007
    ..These results suggest that changes in cell membrane physical properties may generally contribute to the effects of amphiphiles on EC migration...
  9. ncbi request reprint GABA(A) receptor function is regulated by lipid bilayer elasticity
    Rikke Søgaard
    Research Institute of Biological Psychiatry, Sct Hans Hospital, Boserupvej 2, DK 4000 Roskilde, Denmark
    Biochemistry 45:13118-29. 2006
    ..We conclude that GABA(A) receptor function is regulated by lipid bilayer elasticity. PUFAs may generally regulate membrane protein function by affecting the elasticity of the host lipid bilayer...
  10. ncbi request reprint ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation
    Uffe B Olsen
    Department of General Pharmacology, Novo Nordisk A S, 2760 Maaloev, Denmark
    Eur J Pharmacol 435:43-57. 2002
    ..ReN 1869 represents a new class of antihistamines with pain-relieving properties that probably is mediated centrally through histamine H(1) receptors but alternative mechanisms of action cannot be excluded...