S Loft

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Estimation of oxidative DNA damage in man from urinary excretion of repair products
    S Loft
    Department of Pharmacology, University of Copenhagen, Denmark
    Acta Biochim Pol 45:133-44. 1998
  2. ncbi request reprint Experimental study of oxidative DNA damage
    S Loft
    Institute of Public Health, Department of Clinical Pharmacology, Rigshospitalet University of Copenhagen, Denmark
    Free Radic Res 29:525-39. 1998
  3. ncbi request reprint High fat diet induced oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2-deoxyguanosine excretion in rats
    S Loft
    Institute of Public Health, University of Copenhagen, Denmark
    Free Radic Res 29:595-600. 1998
  4. ncbi request reprint Increased urinary excretion of 8-oxo-2'-deoxyguanosine, a biomarker of oxidative DNA damage, in urban bus drivers
    S Loft
    Institute of Public Health and Department of Pharmacology, University of Copenhagen, Panum Institute 18 5, DK 2200, Copenhagen, Denmark
    Mutat Res 441:11-9. 1999
  5. ncbi request reprint Effects of a Brussels sprouts extract on oxidative DNA damage and metabolising enzymes in rat liver
    M Sørensen
    Institute of Public Health, University of Copenhagen, 2200, Copenhagen, Denmark
    Food Chem Toxicol 39:533-40. 2001
  6. ncbi request reprint Effects of Brussels sprouts extracts on hydrogen peroxide-induced DNA strand breaks in human lymphocytes
    C Y Zhu
    Institute of Public Health, Faculty of Health Science, University of Copenhagen, Denmark
    Food Chem Toxicol 39:1191-7. 2001
  7. ncbi request reprint Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans
    P Møller
    Department of Pharmacology and Institute of Public Health, The Panum Institute, University of Copenhagen, Denmark
    FASEB J 15:1181-6. 2001
  8. doi request reprint Ambient air pollution triggers wheezing symptoms in infants
    Z J Andersen
    Department of Biostatistics, Institute of Public Health, Copenhagen University, Øster Farimagsgade 5 Entr B, P O Box 2099, 1014 Copenhagen K, Denmark
    Thorax 63:710-6. 2008
  9. ncbi request reprint Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion
    H E Poulsen
    Department of Clinical Pharmacology, Rigshospitalet, University Hospital Copenhagen, Denmark
    Free Radic Res 29:565-71. 1998
  10. ncbi request reprint Antioxidants, DNA damage and gene expression
    H E Poulsen
    Department of Clinical Pharmacology, Copenhagen University Hospital Rigshospitalet, Denmark
    Free Radic Res 33:S33-9. 2000

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Estimation of oxidative DNA damage in man from urinary excretion of repair products
    S Loft
    Department of Pharmacology, University of Copenhagen, Denmark
    Acta Biochim Pol 45:133-44. 1998
    ....
  2. ncbi request reprint Experimental study of oxidative DNA damage
    S Loft
    Institute of Public Health, Department of Clinical Pharmacology, Rigshospitalet University of Copenhagen, Denmark
    Free Radic Res 29:525-39. 1998
    ..So far, most animal experiments have concerned 8-oxodG and determination of additional damaged bases should be employed. An ideal animal model for prevention of oxidative DNA damage has yet to he developed...
  3. ncbi request reprint High fat diet induced oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2-deoxyguanosine excretion in rats
    S Loft
    Institute of Public Health, University of Copenhagen, Denmark
    Free Radic Res 29:595-600. 1998
    ..The present study suggests that a high fat diet increases oxidative DNA modification substantially irrespective of the saturation level of the fat. Energy intake appears to be the major determinant of the rate of modification...
  4. ncbi request reprint Increased urinary excretion of 8-oxo-2'-deoxyguanosine, a biomarker of oxidative DNA damage, in urban bus drivers
    S Loft
    Institute of Public Health and Department of Pharmacology, University of Copenhagen, Panum Institute 18 5, DK 2200, Copenhagen, Denmark
    Mutat Res 441:11-9. 1999
    ..This effect may be modified by the activity of CYP1A2 or a coregulated enzyme...
  5. ncbi request reprint Effects of a Brussels sprouts extract on oxidative DNA damage and metabolising enzymes in rat liver
    M Sørensen
    Institute of Public Health, University of Copenhagen, 2200, Copenhagen, Denmark
    Food Chem Toxicol 39:533-40. 2001
    ..However, the observed increase in oxidative DNA damage raises the question of whether greatly increased ingestion of cruciferous vegetables is beneficial...
  6. ncbi request reprint Effects of Brussels sprouts extracts on hydrogen peroxide-induced DNA strand breaks in human lymphocytes
    C Y Zhu
    Institute of Public Health, Faculty of Health Science, University of Copenhagen, Denmark
    Food Chem Toxicol 39:1191-7. 2001
    ..The results indicate that compounds, including sinigrin, in cooked and autolysed Brussels sprouts can enhance lymphocyte resistance towards H2O2-induced DNA strand breaks in vitro...
  7. ncbi request reprint Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans
    P Møller
    Department of Pharmacology and Institute of Public Health, The Panum Institute, University of Copenhagen, Denmark
    FASEB J 15:1181-6. 2001
    ..Hypoxia seems to deplete the antioxidant system of its capacity to withstand oxidative stress produced by exhaustive exercise...
  8. doi request reprint Ambient air pollution triggers wheezing symptoms in infants
    Z J Andersen
    Department of Biostatistics, Institute of Public Health, Copenhagen University, Øster Farimagsgade 5 Entr B, P O Box 2099, 1014 Copenhagen K, Denmark
    Thorax 63:710-6. 2008
    ..A study was undertaken to examine the effect of exposure to air pollution on wheezing symptoms in children under the age of 3 years with genetic susceptibility to asthma...
  9. ncbi request reprint Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion
    H E Poulsen
    Department of Clinical Pharmacology, Rigshospitalet, University Hospital Copenhagen, Denmark
    Free Radic Res 29:565-71. 1998
    ..50, p < 0.05). We conclude that 8-oxodG excretion is determined by factors like oxygen consumption and CYP1A2 activity rather than by factors like plasma antioxidant concentrations...
  10. ncbi request reprint Antioxidants, DNA damage and gene expression
    H E Poulsen
    Department of Clinical Pharmacology, Copenhagen University Hospital Rigshospitalet, Denmark
    Free Radic Res 33:S33-9. 2000
    ..The effect from supplementation with an antioxidant is difficult to predict, and ultimately must be assessed in clinical trials...
  11. ncbi request reprint Methods to detect DNA damage by free radicals: relation to exercise
    H E Poulsen
    Department of Clinical Pharmacology, Rigshospitalet, University Hospital Copenhagen, Denmark
    Proc Nutr Soc 58:1007-14. 1999
    ....
  12. ncbi request reprint Antioxidant intervention studies related to DNA damage, DNA repair and gene expression
    S Loft
    Institute of Public Health, The Panum Institute, Copenhagen, Denmark
    Free Radic Res 33:S67-83. 2000
    ..The effect of antioxidants on gene expression has been little studied in humans and only at the activity and protein level...
  13. ncbi request reprint Minor role of oxidative stress during intermediate phase of acute pancreatitis in rats
    P Kruse
    Department of Pharmacology, University of Copenhagen, Stavangergade 3, 3 th DK 2100 Copenhagen, Denmark
    Free Radic Biol Med 30:309-17. 2001
    ..Reactive oxygen species have a minor role in the intermediate stages of pancreatitis models...
  14. ncbi request reprint Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution
    M Pedersen
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Oester Farimagsgade 5A, 1353 K, Copenhagen, Denmark
    Environ Res 109:1012-20. 2009
    ..Given that increased DNA damage early in life indicate an increased risk for adverse health effects later in life, these findings justify intervention of pregnant women...
  15. doi request reprint Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze
    E V Bräuner
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Genes Immun 13:94-7. 2012
    ..There was no interaction between rs7216389 and tobacco smoke exposure...
  16. doi request reprint Long-term exposure to traffic-related air pollution and diabetes-associated mortality: a cohort study
    O Raaschou-Nielsen
    Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark
    Diabetologia 56:36-46. 2013
    ..The aim of this study was to investigate whether air pollution from traffic at a residence is associated with mortality related to type 1 or type 2 diabetes...
  17. ncbi request reprint Influence of intact and myrosinase-treated indolyl glucosinolates on the metabolism in vivo of metronidazole and antipyrine in the rat
    S Loft
    Department of Pharmacology, University of Copenhagen, Denmark
    Food Chem Toxicol 30:927-35. 1992
    ..The significance of this induction pattern in relation to cancer risk depends primarily on the activation/inactivation mechanism of the relevant carcinogen...
  18. ncbi request reprint Oxidative stress generated damage to DNA by gastrointestinal exposure to insoluble particles
    P Møller
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Øster Farimagsgade 5, Build 5, 2nd Floor, Postbox 2099, DK 1014 Copenhagen K, Denmark
    Curr Mol Med 12:732-45. 2012
    ..However, there is evidence indicating that gastrointestinal exposure to particulate matter is associated with oxidative damage to DNA and this might be associated with increased risk of cancer...
  19. ncbi request reprint Biomarkers of exposure to environmental tobacco smoke in infants
    M Sørensen
    Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Biomarkers 12:38-46. 2007
    ..In conclusion, nicotine in hair appears to be the biomarker most strongly associated with parental reports on exposure to ETS in infants...
  20. ncbi request reprint Size distribution and total number concentration of ultrafine and accumulation mode particles and hospital admissions in children and the elderly in Copenhagen, Denmark
    Z J Andersen
    Department of Biostatistics, Institute of Public Health, Copenhagen University, Øster Farimagsgade, 5 Entr B, PO Box 2099, 1014 Copenhagen K, Denmark
    Occup Environ Med 65:458-66. 2008
    ..To study the association between short-term exposure to ultrafine particles and morbidity in Copenhagen, Denmark...
  21. ncbi request reprint Oxidative DNA damage in male Wistar rats exposed to di-n-butyl phthalate
    A Wellejus
    Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    J Toxicol Environ Health A 65:813-24. 2002
    ..With respect to phthalate-induced oxidative DNA damage in the liver, it appears that the developmental stage during exposure is important...
  22. ncbi request reprint Effect of chemopreventive compounds from Brassica vegetables on NAD(P)H:quinone reductase and induction of DNA strand breaks in murine hepa1c1c7 cells
    C Y Zhu
    Institute of Public Health, Faculty of Health Science, University of Copenhagen, Denmark
    Food Chem Toxicol 41:455-62. 2003
    ..Both of these effects could be part of the suggested cancer preventive effect of cruciferous vegetables...
  23. doi request reprint Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population
    M S Nørskov
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitals and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Pharmacogenomics J 11:292-9. 2011
    ..9 (1.0-3.7) for GSTM1*0/0 versus GSTM1*1/0. In conclusion, exact CNV in GSTT1 and GSTM1 predict incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer...