T Litman

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint ATPase activity of P-glycoprotein related to emergence of drug resistance in Ehrlich ascites tumor cell lines
    T Litman
    Department of Oncology, Herlev Hospital, University of Copenhagen, Denmark
    Biochim Biophys Acta 1361:147-58. 1997
  2. ncbi request reprint Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity
    T Litman
    Department of Oncology, Herlev Hospital, University of Copenhagen, Denmark
    Biochim Biophys Acta 1361:159-68. 1997
  3. ncbi request reprint Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity
    T Litman
    Department of Oncology, Herlev Hospital, University of Copenhagen, Denmark
    Biochim Biophys Acta 1361:169-76. 1997
  4. ncbi request reprint From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance
    T Litman
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark
    Cell Mol Life Sci 58:931-59. 2001
  5. ncbi request reprint Characterisation of non-P-glycoprotein multidrug-resistant Ehrlich ascites tumour cells selected for resistance to mitoxantrone
    D Nielsen
    Department of Oncology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Biochem Pharmacol 60:363-70. 2000
  6. ncbi request reprint Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ascites tumor cells after fractionated irradiation
    D Nielsen
    Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Int J Radiat Oncol Biol Phys 51:1050-7. 2001

Collaborators

Detail Information

Publications6

  1. ncbi request reprint ATPase activity of P-glycoprotein related to emergence of drug resistance in Ehrlich ascites tumor cell lines
    T Litman
    Department of Oncology, Herlev Hospital, University of Copenhagen, Denmark
    Biochim Biophys Acta 1361:147-58. 1997
    ..Between the 12th and the 36th passage an additional source of resistance emerged, which was not correlated with P-glycoprotein. Pumping of daunorubicin was negatively correlated with the cell volume for the different lines...
  2. ncbi request reprint Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity
    T Litman
    Department of Oncology, Herlev Hospital, University of Copenhagen, Denmark
    Biochim Biophys Acta 1361:159-68. 1997
    ....
  3. ncbi request reprint Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity
    T Litman
    Department of Oncology, Herlev Hospital, University of Copenhagen, Denmark
    Biochim Biophys Acta 1361:169-76. 1997
    ..Our data show that the substrate binding behavior of P-glycoprotein is complex with more than one binding site being present. This information could form the basis for the development of improved modulators of P-glycoprotein...
  4. ncbi request reprint From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance
    T Litman
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark
    Cell Mol Life Sci 58:931-59. 2001
    ..Finally, the clinical correlations, both for reversal of MDR in cancer and for drug delivery, are discussed...
  5. ncbi request reprint Characterisation of non-P-glycoprotein multidrug-resistant Ehrlich ascites tumour cells selected for resistance to mitoxantrone
    D Nielsen
    Department of Oncology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Biochem Pharmacol 60:363-70. 2000
    ....
  6. ncbi request reprint Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ascites tumor cells after fractionated irradiation
    D Nielsen
    Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Int J Radiat Oncol Biol Phys 51:1050-7. 2001
    ....