Thomas Lavstsen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans
    Thomas Lavstsen
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Malar J 4:21. 2005
  2. pmc Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions
    Thomas Lavstsen
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
    Malar J 2:27. 2003
  3. pmc Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites
    Madeleine Dahlbäck
    Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Malar J 6:78. 2007
  4. doi request reprint Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains
    Gerald K K Cham
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    J Immunol 183:3356-63. 2009
  5. pmc Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum
    Christian W Wang
    Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Malar J 9:147. 2010
  6. pmc Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children
    Gerald K K Cham
    Centre for Medical Parasitology, University of Copenhagen, Copenhagen K, Denmark
    Infect Immun 78:4653-9. 2010
  7. ncbi request reprint Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria
    Ali Salanti
    Centre for Medical Parasitology at the Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Denmark
    Mol Microbiol 49:179-91. 2003
  8. pmc Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes
    Steven B Mwakalinga
    Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark
    Malar J 11:429. 2012
  9. pmc Evidence for the involvement of VAR2CSA in pregnancy-associated malaria
    Ali Salanti
    Centre for Medical Parasitology, Dept of Medical Microbiology and Immunology, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
    J Exp Med 200:1197-203. 2004
  10. pmc Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes
    Anja T R Jensen
    Department of Medical Microbiology and Immunology, The Panum Institute, Building 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
    J Exp Med 199:1179-90. 2004

Collaborators

Detail Information

Publications18

  1. pmc Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans
    Thomas Lavstsen
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Malar J 4:21. 2005
    ..Thus, severe malaria may be caused by parasites expressing PfEMP1 variants that afford parasites optimal sequestration in immunologically naive individuals and high effective multiplication rates...
  2. pmc Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions
    Thomas Lavstsen
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
    Malar J 2:27. 2003
    ..The sequence diversity and organization of the 3D7 PfEMP1 repertoire was investigated on the basis of the complete genome sequence...
  3. pmc Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites
    Madeleine Dahlbäck
    Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Malar J 6:78. 2007
    ..Two parasite populations were studied; an unselected population of NF54 and a selected population, NF54VAR2CSA, to compare both the transcription of var2csa and the expression pattern of the corresponding protein...
  4. doi request reprint Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains
    Gerald K K Cham
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    J Immunol 183:3356-63. 2009
    ..The identification of PfEMP1 domains expressed by parasites causing disease in infants and young children is important for development of vaccines protecting against severe malaria...
  5. pmc Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum
    Christian W Wang
    Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Malar J 9:147. 2010
    ..Sexual stage parasite surface proteins are of interest as candidate target antigens for transmission blocking vaccines...
  6. pmc Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children
    Gerald K K Cham
    Centre for Medical Parasitology, University of Copenhagen, Copenhagen K, Denmark
    Infect Immun 78:4653-9. 2010
    ..The results imply that anti-PfEMP1 antibodies effectively structure PfEMP1 expression and play a major role in limiting parasite multiplication in the blood...
  7. ncbi request reprint Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria
    Ali Salanti
    Centre for Medical Parasitology at the Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Denmark
    Mol Microbiol 49:179-91. 2003
    ..falciparum malaria. This var gene thus has the properties expected of a gene encoding the parasite adhesion molecule that initiates the pathology associated with PAM...
  8. pmc Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes
    Steven B Mwakalinga
    Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark
    Malar J 11:429. 2012
    ..A particular type B RIFIN, PF13_0006, has previously been shown to be strongly transcribed in the asexual and sexual stages of P. falciparum in vitro...
  9. pmc Evidence for the involvement of VAR2CSA in pregnancy-associated malaria
    Ali Salanti
    Centre for Medical Parasitology, Dept of Medical Microbiology and Immunology, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
    J Exp Med 200:1197-203. 2004
    ....
  10. pmc Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes
    Anja T R Jensen
    Department of Medical Microbiology and Immunology, The Panum Institute, Building 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
    J Exp Med 199:1179-90. 2004
    ..The proteins encoded by Group A var genes, such as PFD1235w/MAL7P1.1, appear to be involved in the pathogenesis of severe disease and are thus attractive candidates for a vaccine against life-threatening P. falciparum malaria...
  11. pmc Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1
    Sanne S Berger
    Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, Copenhagen University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e69117. 2013
    ....
  12. pmc Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers
    Louise Turner
    Department of International Health, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e29025. 2011
    ....
  13. ncbi request reprint Preferential transcription of conserved rif genes in two phenotypically distinct Plasmodium falciparum parasite lines
    Christian W Wang
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark
    Int J Parasitol 39:655-64. 2009
    ..This conclusion is experimentally supported by group-specific rif transcription in parasites with different VSA and PfEMP1 expression phenotypes...
  14. ncbi request reprint The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer
    Christian W Wang
    Department of International Health, Immunology, and Microbiology, University of Copenhagen, Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Parasitol Int 58:478-80. 2009
    ....
  15. pmc Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria
    Pamela A Magistrado
    Centre for Medical Parasitology at Department of Medical Microbiology and Immunology, University of Copenhagen, Denmark
    Infect Immun 75:2415-20. 2007
    ..These results indicate that homologues of PF11_0008 are present in P. falciparum field isolates and suggest that PF11_0008 CIDR2beta-reactive antibodies might be involved in protection against malaria episodes...
  16. pmc DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families
    Adam F Sander
    Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, Building 22 and 23, PO Box 2099, 1014 Copenhagen K, Denmark, Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen K, Denmark, Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark, Department of Biology, University of Copenhagen, Ole Maaloees Vej 5, DK 2200 Copenhagen N, Denmark, Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, 1350 Copenhagen, Denmark, Institute of Infection and Immunology Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, UK and Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Nucleic Acids Res 42:2270-81. 2014
    ..falciparum adhesion antigens. DSS-induced recombination may represent a common mechanism for optimizing the evolvability of virulence gene families in pathogens. ..
  17. pmc Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women
    Adam F Sander
    Centre for Medical Parasitology, Department of International Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Infect Dis 203:1679-85. 2011
    ..falciparum parasites to persist for a longer period of time during placental infections, probably because of their greater capacity for antigenic variation and evasion of variant-specific immune responses...
  18. pmc Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children
    Thomas Lavstsen
    Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, Faculty of Health Sciences, University of Copenhagen, Rigshospitalet, 1014 Copenhagen K, Denmark
    Proc Natl Acad Sci U S A 109:E1791-800. 2012
    ..This study specifies the var/PfEMP1 types expressed in severe malaria in children, and thereby provides unique targets for future efforts to prevent and treat severe malaria infections...