L H Lassen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint CGRP may play a causative role in migraine
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 22:54-61. 2002
  2. ncbi request reprint The effect of nitric oxide synthase inhibition on histamine induced headache and arterial dilatation in migraineurs
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
    Cephalalgia 23:877-86. 2003
  3. ncbi request reprint A dose-response study of nitric oxide synthase inhibition in different vascular beds in man
    Lisbeth Hjorth Lassen
    Danish Headache Center, Department of Neurology, Glostrup University Hospital, 2600 Glostrup, Denmark
    Eur J Clin Pharmacol 59:499-505. 2003
  4. ncbi request reprint The effect of i.v. L-NG methylarginine hydrochloride (L-NMMA: 546C88) on basal and acetazolamide (Diamox) induced changes of blood velocity in cerebral arteries and regional cerebral blood flow in man
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Cephalalgia 25:344-52. 2005
  5. pmc Involvement of calcitonin gene-related peptide in migraine: regional cerebral blood flow and blood flow velocity in migraine patients
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    J Headache Pain 9:151-7. 2008
  6. ncbi request reprint Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Lancet 353:287-9. 1999
  7. ncbi request reprint Nitric oxide synthase inhibition: a new principle in the treatment of migraine attacks
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 18:27-32. 1998
  8. doi request reprint Prednisolone reduces nitric oxide-induced migraine
    P Tfelt-Hansen
    Department of Neurology, Danish Headache Centre, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Eur J Neurol 16:1106-11. 2009
  9. ncbi request reprint The CGRP-antagonist, BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers
    K A Petersen
    Danish Headache Center, University of Copenhagen, Department of Neurology, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Cephalalgia 25:139-47. 2005
  10. ncbi request reprint Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark and Department of Medicine, Kitasato University, Sagamihara, Japan
    Brain 122:1629-35. 1999

Detail Information

Publications11

  1. ncbi request reprint CGRP may play a causative role in migraine
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 22:54-61. 2002
    ..As intravenous administration of halphaCGRP causes headache and migraine in migraineurs, our study suggests that the increase in CGRP observed during spontaneous migraine attacks may play a causative role...
  2. ncbi request reprint The effect of nitric oxide synthase inhibition on histamine induced headache and arterial dilatation in migraineurs
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
    Cephalalgia 23:877-86. 2003
    ..Our results showed for the first time a craniospecificity for the vasodilating effect of histamine and for the arterial effects of NOS inhibition...
  3. ncbi request reprint A dose-response study of nitric oxide synthase inhibition in different vascular beds in man
    Lisbeth Hjorth Lassen
    Danish Headache Center, Department of Neurology, Glostrup University Hospital, 2600 Glostrup, Denmark
    Eur J Clin Pharmacol 59:499-505. 2003
    ..The present study was performed to evaluate the dose-response relation of L-NMMA to improve the design and interpretation of studies in migraine sufferers and other diseases...
  4. ncbi request reprint The effect of i.v. L-NG methylarginine hydrochloride (L-NMMA: 546C88) on basal and acetazolamide (Diamox) induced changes of blood velocity in cerebral arteries and regional cerebral blood flow in man
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Cephalalgia 25:344-52. 2005
    ..The percentage increase of V(mean) was 1.5 times that of rCBF (n = 8). Our data suggest that the basal tone of human cerebral arterioles but not of conduit arteries is NO-dependent. The action of acetazolamide in man is not NO-dependent...
  5. pmc Involvement of calcitonin gene-related peptide in migraine: regional cerebral blood flow and blood flow velocity in migraine patients
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    J Headache Pain 9:151-7. 2008
    ..005) and an increase in heart rate (58%) (P < 0.0001). CGRP dilates cerebral arteries, but the effect is so small that it is unlikely to be the only mechanism of CGRP-induced migraine...
  6. ncbi request reprint Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Lancet 353:287-9. 1999
    ..We aimed to show whether N(G)-monomethyl-L-arginine hydrochloride (L-NMMA), an inhibitor of NOS, is effective in relieving pain in such patients...
  7. ncbi request reprint Nitric oxide synthase inhibition: a new principle in the treatment of migraine attacks
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 18:27-32. 1998
    ..Symptoms such as phono- and photophobia were also significantly improved. A similar trend for nausea was not significant. We conclude that NO may be involved in the pain mechanisms throughout the course of spontaneous migraine attacks...
  8. doi request reprint Prednisolone reduces nitric oxide-induced migraine
    P Tfelt-Hansen
    Department of Neurology, Danish Headache Centre, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Eur J Neurol 16:1106-11. 2009
    ..Glyceryl trinitrate (GTN) induces delayed migraine attacks in migraine patients. The purpose of this study was to investigate whether pre-treatment with prednisolon could decrease this effect of GTN...
  9. ncbi request reprint The CGRP-antagonist, BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers
    K A Petersen
    Danish Headache Center, University of Copenhagen, Department of Neurology, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Cephalalgia 25:139-47. 2005
    ..These data suggest that BIBN4096BS is the first specific antimigraine drug without vasoactive effect...
  10. ncbi request reprint Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark and Department of Medicine, Kitasato University, Sagamihara, Japan
    Brain 122:1629-35. 1999
    ....
  11. ncbi request reprint Dipyridamole may induce migraine in patients with migraine without aura
    C Kruuse
    Danish Headache Centre and Department of Neurology, University of Copenhagen, Glostrup Hospital, Denmark
    Cephalalgia 26:925-33. 2006
    ....