Magdalena J Laska

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. pmc Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active multiple sclerosis
    Magdalena Janina Laska
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    J Virol 86:3713-22. 2012
  2. doi request reprint p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses
    Magdalena J Laska
    Institute of Human Genetics, Aarhus University, DK 8000 Aarhus C, Denmark
    Biochim Biophys Acta 1800:1231-40. 2010
  3. pmc Endogenous retroviruses and multiple sclerosis-new pieces to the puzzle
    Kari K Nissen
    Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 4, DK 8000, Aarhus, C, Denmark
    BMC Neurol 13:111. 2013
  4. pmc Restriction genes for retroviruses influence the risk of multiple sclerosis
    Bjørn A Nexø
    Department of Biomedicine, Aarhus University, Aarhus C, Denmark
    PLoS ONE 8:e74063. 2013
  5. pmc Linkage disequilibrium mapping of a breast cancer susceptibility locus near RAI/PPP1R13L/iASPP
    Bjørn A Nexø
    Institute of Human Genetics, University of Aarhus, DK 8000 Aarhus C, Denmark
    BMC Med Genet 9:56. 2008
  6. ncbi request reprint Expression of the RAI gene is conducive to apoptosis: studies of induction and interference
    Magdalena J Laska
    Institute of Human Genetics, Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    Exp Cell Res 313:2611-21. 2007
  7. pmc Genetic association of multiple sclerosis with the marker rs391745 near the endogenous retroviral locus HERV-Fc1: analysis of disease subtypes
    Bettina Hansen
    Department of Biomedicine, Aarhus University, Aarhus C, Denmark
    PLoS ONE 6:e26438. 2011
  8. pmc No additional copies of HERV-Fc1 in the germ line of multiple sclerosis patients
    Kari K Nissen
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Virol J 9:188. 2012
  9. pmc The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1
    Bjørn A Nexø
    Department of Human Genetics, University of Aarhus, Aarhus C, Denmark
    PLoS ONE 6:e16652. 2011
  10. ncbi request reprint Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer
    Magdalena J Laska
    Institute of Human Genetics, University of Aarhus, Bartholin Building, DK 8000 Aarhus C, Denmark
    Cancer Lett 225:245-51. 2005

Detail Information

Publications10

  1. pmc Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active multiple sclerosis
    Magdalena Janina Laska
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    J Virol 86:3713-22. 2012
    ..HERV-Fc1 biology could be a compelling area for understanding the pathology of MS and possibly other autoimmune disorders...
  2. doi request reprint p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses
    Magdalena J Laska
    Institute of Human Genetics, Aarhus University, DK 8000 Aarhus C, Denmark
    Biochim Biophys Acta 1800:1231-40. 2010
    ..However, in the non-transformed cells it acts as a tumor suppressor which suggests that the role of PPP1R13L is multifaceted...
  3. pmc Endogenous retroviruses and multiple sclerosis-new pieces to the puzzle
    Kari K Nissen
    Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 4, DK 8000, Aarhus, C, Denmark
    BMC Neurol 13:111. 2013
    ..Observations in HIV-positive patients suggest that antiretroviral drugs can curb MS. Thus, these new findings regarding the etiology and pathogenesis of MS, suggest alternative ways to challenge autoimmune diseases. ..
  4. pmc Restriction genes for retroviruses influence the risk of multiple sclerosis
    Bjørn A Nexø
    Department of Biomedicine, Aarhus University, Aarhus C, Denmark
    PLoS ONE 8:e74063. 2013
    ..This indicates that the two TRIMs and BST2 influence the risk of disease and thus supports the hypothesis of a viral involvement. ..
  5. pmc Linkage disequilibrium mapping of a breast cancer susceptibility locus near RAI/PPP1R13L/iASPP
    Bjørn A Nexø
    Institute of Human Genetics, University of Aarhus, DK 8000 Aarhus C, Denmark
    BMC Med Genet 9:56. 2008
    ..The study groups included 434 postmenopausal breast cancer cases and an identical number of individually matched controls...
  6. ncbi request reprint Expression of the RAI gene is conducive to apoptosis: studies of induction and interference
    Magdalena J Laska
    Institute of Human Genetics, Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    Exp Cell Res 313:2611-21. 2007
    ..Thus, we hypothesize that RAI induction is necessary but not sufficient for apoptosis induction in non-transformed cells. Our results could be explained by a NF-kappaB mediated mechanism...
  7. pmc Genetic association of multiple sclerosis with the marker rs391745 near the endogenous retroviral locus HERV-Fc1: analysis of disease subtypes
    Bettina Hansen
    Department of Biomedicine, Aarhus University, Aarhus C, Denmark
    PLoS ONE 6:e26438. 2011
    ..003), while primary progressive disease was not. The ability to see genetic differences between subtypes of MS near this gene speaks for the involvement of the virus HERV-Fc1 locus in modifying the disease course of MS...
  8. pmc No additional copies of HERV-Fc1 in the germ line of multiple sclerosis patients
    Kari K Nissen
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Virol J 9:188. 2012
    ..We have found increased expression of HERV-Fc1 in MS patients suffering from recent attack, but the underlying mechanism for association is still unknown...
  9. pmc The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1
    Bjørn A Nexø
    Department of Human Genetics, University of Aarhus, Aarhus C, Denmark
    PLoS ONE 6:e16652. 2011
    ..We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis...
  10. ncbi request reprint Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer
    Magdalena J Laska
    Institute of Human Genetics, University of Aarhus, Bartholin Building, DK 8000 Aarhus C, Denmark
    Cancer Lett 225:245-51. 2005
    ..To our knowledge this is the first study of DNA repair gene polymorphisms and risk of testicular cancer...