Torben Bjerregaard Larsen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc Enoxaparin, effective dosage for intensive care patients: double-blinded, randomised clinical trial
    Sian Robinson
    Department of Anaesthesia and Intensive Care, Odense University Hospital OUH, SDR, Odense C, Denmark
    Crit Care 14:R41. 2010
  2. ncbi request reprint The Arg506Gln mutation (FV Leiden) among a cohort of 4188 unselected Danish newborns
    T B Larsen
    Department of Clinical Biochemistry, Vejle County Central Hospital, Denmark
    Thromb Res 89:211-5. 1998
  3. ncbi request reprint Maternal smoking, obesity, and risk of venous thromboembolism during pregnancy and the puerperium: a population-based nested case-control study
    Torben Bjerregaard Larsen
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Denmark
    Thromb Res 120:505-9. 2007
  4. ncbi request reprint ABO blood groups and risk of venous thromboembolism during pregnancy and the puerperium. A population-based, nested case-control study
    T B Larsen
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense, Denmark
    J Thromb Haemost 3:300-4. 2005
  5. ncbi request reprint Major genetic susceptibility for venous thromboembolism in men: a study of Danish twins
    Torben Bjerregaard Larsen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
    Epidemiology 14:328-32. 2003
  6. ncbi request reprint Platelets and anticoagulant capacity in patients with inflammatory bowel disease
    Torben Bjerregaard Larsen
    Department of Clinical Biochemistry, Section for Thrombosis and Hemostasis, Aalborg Hospital, Aalborg, Denmark
    Pathophysiol Haemost Thromb 32:92-6. 2002
  7. ncbi request reprint Validity of D-dimer tests in the diagnosis of deep vein thrombosis: a prospective comparative study of three quantitative assays
    T B Larsen
    Department of Clinical Biochemistry, Section for Thrombosis and Hemostasis, Aalborg Hospital, Aalborg, Denmark
    J Intern Med 252:36-40. 2002
  8. ncbi request reprint Hyperhomocysteinaemia, coagulation pathway activation and thrombophilia in patients with inflammatory bowel disease
    Larsen T Bjerregaard
    Dept of Clinical Biochemistry, Aalborg Hospital, Denmark
    Scand J Gastroenterol 37:62-7. 2002
  9. ncbi request reprint Sudden infant death syndrome, childhood thrombosis, and presence of genetic risk factors for thrombosis
    T B Larsen
    Department of Clinical Biochemistry, Vejle County Central Hospital, Vejle, Denmark
    Thromb Res 98:233-9. 2000
  10. ncbi request reprint Effect of anticoagulant therapy on the hypercoagulable state in patients carrying the factor V Arg506Gln mutation
    T B Larsen
    Department of Clinical Biochemistry, Vejle County Central Hospital, Denmark
    Thromb Res 92:157-62. 1998

Collaborators

Detail Information

Publications41

  1. pmc Enoxaparin, effective dosage for intensive care patients: double-blinded, randomised clinical trial
    Sian Robinson
    Department of Anaesthesia and Intensive Care, Odense University Hospital OUH, SDR, Odense C, Denmark
    Crit Care 14:R41. 2010
    ..This study aims to determine the subcutaneous (SC) dose of enoxaparin that would give the best anti-factor Xa levels in ICU patients...
  2. ncbi request reprint The Arg506Gln mutation (FV Leiden) among a cohort of 4188 unselected Danish newborns
    T B Larsen
    Department of Clinical Biochemistry, Vejle County Central Hospital, Denmark
    Thromb Res 89:211-5. 1998
    ..Equal gender distribution was found, and the Arg506Gln mutation is probably not a considerable risk factor in fetal life in the general population...
  3. ncbi request reprint Maternal smoking, obesity, and risk of venous thromboembolism during pregnancy and the puerperium: a population-based nested case-control study
    Torben Bjerregaard Larsen
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Denmark
    Thromb Res 120:505-9. 2007
    ..The aim of the present study was to examine the association between smoking, obesity (BMI>30), and risk for venous thromboembolism (VTE) during pregnancy and the puerperium...
  4. ncbi request reprint ABO blood groups and risk of venous thromboembolism during pregnancy and the puerperium. A population-based, nested case-control study
    T B Larsen
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense, Denmark
    J Thromb Haemost 3:300-4. 2005
    ..To examine possible associations of ABO blood types with the risk of venous thromboembolism (VTE) in pregnancy and the puerperium...
  5. ncbi request reprint Major genetic susceptibility for venous thromboembolism in men: a study of Danish twins
    Torben Bjerregaard Larsen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
    Epidemiology 14:328-32. 2003
    ..Although several genetic determinants (mutations or polymorphisms) have been associated with increased risk of venous thromboembolism, the overall influence of genetic factors on this disease is unknown...
  6. ncbi request reprint Platelets and anticoagulant capacity in patients with inflammatory bowel disease
    Torben Bjerregaard Larsen
    Department of Clinical Biochemistry, Section for Thrombosis and Hemostasis, Aalborg Hospital, Aalborg, Denmark
    Pathophysiol Haemost Thromb 32:92-6. 2002
    ....
  7. ncbi request reprint Validity of D-dimer tests in the diagnosis of deep vein thrombosis: a prospective comparative study of three quantitative assays
    T B Larsen
    Department of Clinical Biochemistry, Section for Thrombosis and Hemostasis, Aalborg Hospital, Aalborg, Denmark
    J Intern Med 252:36-40. 2002
    ..A third assay (Auto Dimer) became available during sample collection and has been included in the final assessment. The diagnostic performance of the Auto Dimer assay was evaluated on three different coagulation analysers...
  8. ncbi request reprint Hyperhomocysteinaemia, coagulation pathway activation and thrombophilia in patients with inflammatory bowel disease
    Larsen T Bjerregaard
    Dept of Clinical Biochemistry, Aalborg Hospital, Denmark
    Scand J Gastroenterol 37:62-7. 2002
    ....
  9. ncbi request reprint Sudden infant death syndrome, childhood thrombosis, and presence of genetic risk factors for thrombosis
    T B Larsen
    Department of Clinical Biochemistry, Vejle County Central Hospital, Vejle, Denmark
    Thromb Res 98:233-9. 2000
    ....
  10. ncbi request reprint Effect of anticoagulant therapy on the hypercoagulable state in patients carrying the factor V Arg506Gln mutation
    T B Larsen
    Department of Clinical Biochemistry, Vejle County Central Hospital, Denmark
    Thromb Res 92:157-62. 1998
    ..Thus, it seems that OAT with standard treatment doses is just as effective in patients with the Arg506Gln mutation as in comparable controls without the mutation...
  11. doi request reprint Alcohol intake and prognosis of atrial fibrillation
    Thure Filskov Overvad
    Department of Cardiology, Cardiovascular Research Centre, Aalborg University Hospital, Aalborg, Denmark
    Heart 99:1093-9. 2013
    ..To assess alcohol intake as a risk factor for adverse events among patients with incident atrial fibrillation (AF)...
  12. doi request reprint Efficacy and safety of dabigatran etexilate and warfarin in "real-world" patients with atrial fibrillation: a prospective nationwide cohort study
    Torben Bjerregaard Larsen
    Department of Cardiology, Cardiovascular Research Centre, Aalborg University Hospital, Aalborg, Denmark
    J Am Coll Cardiol 61:2264-73. 2013
    ....
  13. doi request reprint Bleeding events among new starters and switchers to dabigatran compared with warfarin in atrial fibrillation
    Torben Bjerregaard Larsen
    Department of Cardiology, Atrial Fibrillation Study Group, Aalborg University Hospital, Aalborg, Denmark Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark
    Am J Med 127:650-656.e5. 2014
    ..Evidence is limited on how prior VKA experience affects bleeding risk when initiating novel oral anticoagulant therapy. We investigated this among patients with atrial fibrillation initiating dabigatran therapy...
  14. doi request reprint Myocardial ischemic events in 'real world' patients with atrial fibrillation treated with dabigatran or warfarin
    Torben Bjerregaard Larsen
    Department of Cardiology, Aalborg AF Study Group, Aalborg University Hospital, Aalborg, Denmark Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark
    Am J Med 127:329-336.e4. 2014
    ..This may be particularly evident among "switchers" to dabigatran from VKA, as a result of discontinuation effects...
  15. doi request reprint Body mass index and adverse events in patients with incident atrial fibrillation
    Thure Filskov Overvad
    Department of Cardiology, Cardiovascular Research Centre, Aalborg University Hospital, Aalborg, Denmark
    Am J Med 126:640.e9-17. 2013
    ..To date, no anthropometric measure is included in any risk stratification scheme for stroke and death in atrial fibrillation patients...
  16. doi request reprint Mortality rate in type 2 myocardial infarction: observations from an unselected hospital cohort
    Lotte Saaby
    Department of Cardiology, Odense University Hospital, Odense, Denmark
    Am J Med 127:295-302. 2014
    ..The prognostic impact of this universal definition, with particular focus on type 2 myocardial infarction, has not been studied prospectively in unselected hospital patients...
  17. doi request reprint Age dependence of risk factors for stroke and death in young patients with atrial fibrillation: a nationwide study
    Line Melgaard
    From the Department of Cardiology, Atrial Fibrillation Study Group, Aalborg University Hospital, Aalborg, Denmark L M, F S T B L Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark L H R, F S, G Y H L, T B L and University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK G Y H L
    Stroke 45:1331-7. 2014
    ..The aim of this study was to examine the age dependence of risk factors for stroke and mortality in young patients with atrial fibrillation...
  18. doi request reprint Risk of stroke or systemic embolism in atrial fibrillation patients treated with warfarin: a systematic review and meta-analysis
    Ida Ehlers Albertsen
    Department of Cardiology, Aalborg AF Study Group, Aalborg University Hospital, Aalborg, Denmark
    Stroke 44:1329-36. 2013
    ..Our aim was to identify the risk factors that contribute to stroke risk in atrial fibrillation, although patients were taking OACs in a clinical trial setting...
  19. ncbi request reprint A review of medical records and discharge summary data found moderate to high predictive values of discharge diagnoses of venous thromboembolism during pregnancy and postpartum
    Torben Bjerregaard Larsen
    Department of Clinical Biochemistry and Genetics, Section for Thrombosis and Haemostasis, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense, Denmark Department of Clinical Epidemiology, Aarhus University Hospitals, DK 8000, Aarhus C, Denmark
    J Clin Epidemiol 58:316-9. 2005
    ....
  20. doi request reprint Duration of Diabetes Mellitus and Risk of Thromboembolism and Bleeding in Atrial Fibrillation: Nationwide Cohort Study
    Thure Filskov Overvad
    From the Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark T F O, F S, G Y H L, L H R, T B L Department of Cardiology, Atrial Fibrillation Study Group, Aalborg University Hospital, Aalborg, Denmark F S, I E A, T B L and University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom G Y H L, D A L
    Stroke 46:2168-74. 2015
    ..The purpose was to investigate duration of diabetes mellitus as a predictor of thromboembolism and anticoagulant-related bleeding in patients with atrial fibrillation...
  21. doi request reprint Monitoring of anticoagulant therapy applying a dynamic statistical model
    Peter Brønnum Nielsen
    Department of Cardiology, Aalborg AF Study Group, Cardiovascular Research Centre, Aalborg Hospital, Srd Skovvej 15, Denmark
    Comput Methods Programs Biomed 110:380-8. 2013
    ..Retrospective test of the model proved robustness to choices of initial parameters, and feasible prediction results of both INR values and suggested warfarin dosage, which may prove beneficial for both patients and healthcare takers...
  22. doi request reprint Dabigatran and warfarin for secondary prevention of stroke in atrial fibrillation patients: a nationwide cohort study
    Torben Bjerregaard Larsen
    Department of Cardiology, Aalborg Atrial Fibrillation Study Group, Aalborg University Hospital, Aalborg, Denmark Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark Electronic address
    Am J Med 127:1172-8.e5. 2014
    ..This register-based observational study compares dabigatran to warfarin for secondary stroke prevention in atrial fibrillation patients among both "new starters" on dabigatran and "switchers" to dabigatran from warfarin...
  23. pmc Primary and secondary prevention with new oral anticoagulant drugs for stroke prevention in atrial fibrillation: indirect comparison analysis
    Lars Hvilsted Rasmussen
    Thrombosis Research Unit, Aalborg University, Aalborg, Denmark
    BMJ 345:e7097. 2012
    ..A secondary objective was to do the same analysis in the primary prevention cohort...
  24. doi request reprint Added predictive ability of the CHA2DS2VASc risk score for stroke and death in patients with atrial fibrillation: the prospective Danish Diet, Cancer, and Health cohort study
    Torben Bjerregaard Larsen
    Department of Cardiology, Aalborg AF Study Group, Cardiovascular Research Centre, Aarhus University Hospital, Aalborg, Denmark
    Circ Cardiovasc Qual Outcomes 5:335-42. 2012
    ..The objective of this study was to evaluate the added predictive ability of the CHA(2)DS(2)VASc prediction rule for stroke and death in a nonanticoagulated population of patients with atrial fibrillation...
  25. doi request reprint Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients
    Mogens Tornby Stender
    Department of Surgical Gastroenterology A, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18 22, Aalborg, Denmark
    Thromb Haemost 99:396-400. 2008
    ..In conclusion, the combined use of pre-test probability and D-dimer test may be useful in ruling out preoperative DVT in colorectal cancer patients admitted for surgery...
  26. doi request reprint Female sex is associated with a lower risk of stroke in patients with heart failure
    Line Melgaard
    Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
    Am Heart J 169:396-403.e2. 2015
    ..Risk stratification schemes may improve clinical decision making in this patient population. This study investigated whether female sex is a risk factor for stroke in patients with heart failure in sinus rhythm...
  27. doi request reprint Use of psychotropic drugs following venous thromboembolism in youth. A nationwide cohort study
    Anette Arbjerg Højen
    Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark Clinical Nursing Research Unit, Aalborg University Hospital Science and Innovation Center, Aalborg University Hospital, Aalborg, Denmark Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark Electronic address
    Thromb Res 135:643-7. 2015
    ..Using psychotropic drug purchase as a proxy for mental health status, we investigated this issue in a large cohort of young incident venous thromboembolism patients...
  28. pmc Non-vitamin K antagonist oral anticoagulants and the treatment of venous thromboembolism in cancer patients: a semi systematic review and meta-analysis of safety and efficacy outcomes
    Torben Bjerregaard Larsen
    Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark
    PLoS ONE 9:e114445. 2014
    ..This study sought to investigate the relative efficacy and safety of non-vitamin K oral anticoagulants (NOACs) for the treatment of venous thromboembolism (VTE) in cancer patients...
  29. doi request reprint Renal function and non-vitamin K oral anticoagulants in comparison with warfarin on safety and efficacy outcomes in atrial fibrillation patients: a systemic review and meta-regression analysis
    Peter Brønnum Nielsen
    Department of Cardiology, Aalborg AF Study Group, Aalborg University Hospital, Aalborg, Denmark
    Clin Res Cardiol 104:418-29. 2015
    ..To investigate the relative effect of warfarin versus non-vitamin K oral anticoagulants (NOACs) in thrombotic and bleeding outcomes in subgroups of atrial fibrillation (AF) patients with varying degrees of renal dysfunction...
  30. doi request reprint Assessment of the CHA2DS2-VASc Score in Predicting Ischemic Stroke, Thromboembolism, and Death in Patients With Heart Failure With and Without Atrial Fibrillation
    Line Melgaard
    Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark
    JAMA 314:1030-8. 2015
    ..Its usefulness in a population of patients with heart failure (HF) is unclear...
  31. ncbi request reprint [Diagnostics: new methodological initiatives]
    Erik Magid
    Amager Hospital, Klinisk Biokemisk Afdeling
    Ugeskr Laeger 166:1664-6. 2004
  32. doi request reprint Atrial flutter and thromboembolic risk: a systematic review
    Henrik Vadmann
    Department of Cardiology, Atrial Fibrillation Study Group, Aalborg University Hospital, Aalborg, Denmark Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
    Heart 101:1446-55. 2015
    ....
  33. pmc Sex differences in treatment quality of self-managed oral anticoagulant therapy: 6,900 patient-years of follow-up
    Hanna Nilsson
    Department of Cardiothoracic and Vascular Surgery and Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 9:e113627. 2014
    ..The objective is to evaluate the sex-dependent effectiveness of PSM of oral anticoagulant therapy in everyday clinical practice...
  34. doi request reprint Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
    J Am Coll Cardiol 60:738-46. 2012
    ..This study sought to perform an indirect comparison analysis of dabigatran etexilate (2 doses), rivaroxaban, and apixaban for their relative efficacy and safety against each other...
  35. doi request reprint Self-testing and self-management of oral anticoagulation therapy in children
    Thomas Decker Christensen
    Thomas Decker Christensen, Department of Cardiothoracic and Vascular Surgery and Institute of Clinical Medicine, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Thromb Haemost 106:391-7. 2011
    ....
  36. ncbi request reprint Evaluation of a simple dosage scheme for transition from phenprocoumon to warfarin in oral anticoagulation
    C Kristiansen
    Department of Clinical Biochemistry, Vejle County Central Hospital, DK 7100, Vejle, Denmark
    Thromb Res 98:157-63. 2000
    ..No patients experienced haemorrhages or thromboembolic complications during the period of changeover. In conclusion, the proposed scheme for changing medication from phenprocoumon to warfarin is safe and convenient...
  37. ncbi request reprint High preoperative prevalence of deep venous thrombosis in patients with colorectal cancer
    M T Stender
    Department of Surgical Gastroenterology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18 22, DK 9100 Aalborg, Denmark
    Br J Surg 94:1100-3. 2007
    ..The aim of this observational study was to estimate the preoperative prevalence of DVT in patients with colorectal cancer...
  38. doi request reprint Classification of myocardial infarction: frequency and features of type 2 myocardial infarction
    Lotte Saaby
    Department of Cardiology, Odense University Hospital, Odense, Denmark
    Am J Med 126:789-97. 2013
    ..However, no specific criteria for type 2 myocardial infarction have been established...
  39. doi request reprint Denaturing high-performance liquid chromatography mutation analysis in patients with reduced Protein S levels
    Lise Bathum
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Denmark
    Clin Chim Acta 390:76-81. 2008
    ..The aim was to design a high-throughput genetic analysis based on denaturing high-performance liquid chromatography to identify sequence variations in the gene coding for Protein S...
  40. ncbi request reprint [The Danish clinical guidelines (Klaringsrapporter, 1996-2001: Insufficient evidence presented for the diagnostic accuracy of recommended clinical-biochemical tests]
    Per E Jørgensen
    Odense Universitetshospital, Afdeling KKA
    Ugeskr Laeger 166:1667-70. 2004
  41. doi request reprint More studies on outcomes using biochemical diagnostic tests are needed: findings from the Danish Society of Clinical Biochemistry
    Jonna Skov Madsen
    Clin Chem 54:1254-6. 2008