Genomes and Genes
Affiliation: University of Copenhagen
- Dynamic T-lymphocyte chemokine receptor expression induced by interferon-beta therapy in multiple sclerosisM Krakauer
Danish Multiple Sclerosis Research Center, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark
Scand J Immunol 64:155-63. 2006..Thus, it is imperative to distinguish acute effects of IFN-beta from steady-state effects...
- CD4(+) memory T cells with high CD26 surface expression are enriched for Th1 markers and correlate with clinical severity of multiple sclerosisM Krakauer
Danish Multiple Sclerosis Research Center, Department of Neurology, Section 2082, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
J Neuroimmunol 181:157-64. 2006..These changes were only partially normalised by treatment with interferon-beta. We point to this subset as a putative target for immunological monitoring of MS disease activity and of treatment efficacy...
- Increased IL-10 mRNA and IL-23 mRNA expression in multiple sclerosis: interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expressionM Krakauer
Danish Multiple Sclerosis Research Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet Copenhagen, Denmark
Mult Scler 14:622-30. 2008..We studied patterns of in vivo blood mononuclear cell (MNC) and whole blood cytokine and transcription factor mRNA expression before and during IFN-beta therapy in MS...
- Breakthrough disease during interferon-[beta] therapy in MS: No signs of impaired biologic responseD Hesse
Danish Multiple Sclerosis Research Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet
Neurology 74:1455-62. 2010..We studied the biologic response to treatment in a cohort of NAb-negative patients to test whether difference in responsiveness could segregate patients with and without breakthrough disease during therapy...
- Glatiramer acetate antibodies, gene expression and disease activity in multiple sclerosisF Sellebjerg
Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Denmark
Mult Scler 18:305-13. 2012..The immunological response to treatment may differ in patients who are stable on GA therapy and patients with breakthrough disease activity, but the results of previous studies are inconsistent...
- Disease protection and interleukin-10 induction by endogenous interferon-β in multiple sclerosis?D Hesse
Department of Neurology, Danish Multiple Sclerosis Research Center, Copenhagen University Hospital, Rigshospitalet, Denmark
Eur J Neurol 18:266-72. 2011..We studied the relationship between a type I interferon-like response in untreated patients with MS and disease activity...
- FOXP3, CBLB and ITCH gene expression and cytotoxic T lymphocyte antigen 4 expression on CD4(+) CD25(high) T cells in multiple sclerosisF Sellebjerg
Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Clin Exp Immunol 170:149-55. 2012..We hypothesize that this may reflect alterations in the inhibitory effect of CTLA-4 or in regulatory T cell function...
- Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MSF Sellebjerg
University of Copenhagen and Danish MS Research Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Neurology 73:2003-10. 2009..Our objective was to study B-cell chemokine concentrations in MS, their relationship with disease activity, and how treatment with methylprednisolone and natalizumab affected the concentration in CSF...
- Identification of new sensitive biomarkers for the in vivo response to interferon-beta treatment in multiple sclerosis using DNA-array evaluationF Sellebjerg
Department of Neurology, Danish Multiple Sclerosis Research Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Eur J Neurol 16:1291-8. 2009..We used DNA array analysis to identify genes that are strongly induced in blood cells by IFN-beta, and measured their expression in MS patients with different NAb levels...
- Increased T cell expression of CD154 (CD40-ligand) in multiple sclerosisJ Jensen
Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup Copenhagen, Denmark
Eur J Neurol 8:321-8. 2001..These results suggest involvement of CD154 in the pathogenesis of MS, and the shift from a relapsing-remitting to a secondary progressive disease course may be associated with constitutive, systemic CD154 expression...