Filip Krag Knop

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi [The benefits of diagnostic imaging in general practice]
    Filip Krag Knop
    Almen Praksis ved Universitetet, Bartholinsgade 6, København K
    Ugeskr Laeger 168:794-8. 2006
  2. pmc Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits
    Bjørn H Ebdrup
    Center for Neuropsychiatric Schizophrenia Research, CNSR and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Psychiatric Center Glostrup, University of Copenhagen, DK 2600 Glostrup, Denmark
    BMC Med 10:92. 2012
  3. doi Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity
    Filip K Knop
    Department of Internal Medicine, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
    Diabetes Obes Metab 14:500-10. 2012
  4. ncbi Small-bowel hemangiosarcoma and capsule endoscopy
    F K Knop
    Dept of Gastrointestinal Surgery K, H S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Endoscopy 35:637. 2003
  5. ncbi Incretin-based therapy of type 2 diabetes mellitus
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, Hellerup, Denmark
    Curr Protein Pept Sci 10:46-55. 2009
  6. doi Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, Hellerup, Denmark
    Am J Physiol Endocrinol Metab 299:E10-3. 2010
  7. ncbi Incretin hormones and beta cell function in chronic pancreatitis
    Filip Krag Knop
    Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Dan Med Bull 57:B4163. 2010
  8. ncbi Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
    IDrugs 11:497-501. 2008
  9. ncbi The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Denmark
    Regul Pept 144:123-30. 2007
  10. ncbi [GLP-1-based treatment of type 2 diabetes mellitus]
    Filip Krag Knop
    Vilsbøll Gentofte Hospital, Medicinsk afdeling F
    Ugeskr Laeger 169:2095-9. 2007

Collaborators

Detail Information

Publications30

  1. ncbi [The benefits of diagnostic imaging in general practice]
    Filip Krag Knop
    Almen Praksis ved Universitetet, Bartholinsgade 6, København K
    Ugeskr Laeger 168:794-8. 2006
    ..We estimate the value of the diagnostic imaging examinations most frequently used by general practitioners and seek to evaluate their role in the primary health care system...
  2. pmc Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits
    Bjørn H Ebdrup
    Center for Neuropsychiatric Schizophrenia Research, CNSR and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Psychiatric Center Glostrup, University of Copenhagen, DK 2600 Glostrup, Denmark
    BMC Med 10:92. 2012
    ..Moreover, we account for similarities in brain changes between schizophrenia and overweight patients...
  3. doi Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity
    Filip K Knop
    Department of Internal Medicine, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
    Diabetes Obes Metab 14:500-10. 2012
    ....
  4. ncbi Small-bowel hemangiosarcoma and capsule endoscopy
    F K Knop
    Dept of Gastrointestinal Surgery K, H S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Endoscopy 35:637. 2003
  5. ncbi Incretin-based therapy of type 2 diabetes mellitus
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, Hellerup, Denmark
    Curr Protein Pept Sci 10:46-55. 2009
    ....
  6. doi Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, Hellerup, Denmark
    Am J Physiol Endocrinol Metab 299:E10-3. 2010
    ....
  7. ncbi Incretin hormones and beta cell function in chronic pancreatitis
    Filip Krag Knop
    Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Dan Med Bull 57:B4163. 2010
    ....
  8. ncbi Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
    IDrugs 11:497-501. 2008
    ..This feature review focuses on the challenges and feasibilities of replacing SU with incretin-based therapy in patients with T2DM...
  9. ncbi The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Denmark
    Regul Pept 144:123-30. 2007
    ..The incretin effect is reduced and the insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is abolished in patients with type 2 diabetes mellitus (T2DM)...
  10. ncbi [GLP-1-based treatment of type 2 diabetes mellitus]
    Filip Krag Knop
    Vilsbøll Gentofte Hospital, Medicinsk afdeling F
    Ugeskr Laeger 169:2095-9. 2007
    ..GLP-1-based therapy results in HbA1c reductions of approximately 1 percent point, and the lack of serious side effects and the low risk of hypoglycaemic episodes are unique traits...
  11. ncbi Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
    Diabetes 56:1951-9. 2007
    ..These results suggest that the reduced incretin effect is not a primary event in the development of type 2 diabetes, but rather a consequence of the diabetic state...
  12. ncbi Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
    F K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, DK 2900, Hellerup, Denmark
    Diabetologia 50:797-805. 2007
    ..We investigated glucagon responses during OGTT and isoglycaemic i.v. glucose infusion, respectively, to further elucidate the mechanisms behind the glucose intolerance in patients with type 2 diabetes...
  13. ncbi No hypoglycemia after subcutaneous administration of glucagon-like peptide-1 in lean type 2 diabetic patients and in patients with diabetes secondary to chronic pancreatitis
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, Hellerup, Denmark
    Diabetes Care 26:2581-7. 2003
    ..4 +/- 1.1 according to homeostasis model assessment (HOMA). In this study, we investigated diabetic patients with normal or close to normal insulin sensitivity...
  14. doi Resolution of type 2 diabetes following gastric bypass surgery: involvement of gut-derived glucagon and glucagonotropic signalling?
    F K Knop
    Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Diabetologia 52:2270-6. 2009
    ....
  15. ncbi Delayed ischemic cecal perforation despite optimal decompression after placement of a self-expanding metal stent: report of a case
    Filip K Knop
    Department of Gastrointestinal Surgery K, H S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Dis Colon Rectum 47:1970-3. 2004
    ..Furthermore, we underline the need to focus on the possibility of obstructions other than those being treated...
  16. ncbi Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution
    Filip K Knop
    Dept of Internal medicine F, Gentofte Hospital, Univ of Copenhagen, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
    Am J Physiol Endocrinol Metab 292:E324-30. 2007
    ..These results suggest that the secretion of GLP-1 and GIP is under influence of the digestion and absorption of nutrients in the small intestine and that PES increases insulin secretion...
  17. doi KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
    Kasper Aaboe
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, Hellerup DK 2900, Denmark
    J Clin Endocrinol Metab 94:603-8. 2009
    ..With this study we therefore aimed at clarifying the role of K(ATP) channel malfunction in the impaired function of GIP...
  18. ncbi The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype
    T Vilsbøll
    Department of Internal Medicine F, Gentofte Hospital, DK 2900 Hellerup, Denmark
    J Clin Endocrinol Metab 88:4897-903. 2003
    ..In conclusion, lack of GIP amplification of the late-phase plasma insulin response to glucose seems to be a consequence of diabetes mellitus, characterizing most, if not all, forms of diabetes...
  19. ncbi [Effect of incretin hormones GIP and GLP-1 for the pathogenesis of type 2 diabetes mellitus]
    Tina Vilsbøll
    Gentofte Hospital, Medicinsk afdeling F, Hellerup
    Ugeskr Laeger 169:2101-5. 2007
    ..It is currently unknown whether these defects are consequences of the diabetic state or primary pathogenetic factors...
  20. ncbi Self-expanding metal stents for colonic obstruction: experiences from 104 procedures in a single center
    Søren Meisner
    Department of Surgical Gastroenterology K, H S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Dis Colon Rectum 47:444-50. 2004
    ..In the past, colonic obstruction caused by malignancy most often resulted in high-risk operations, usually involving two-step procedures or leaving the patient with a stoma in case of disseminated disease...
  21. doi Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects
    K B Hansen
    Department of Clinical Physiology, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, DK 2600 Glostrup, Denmark
    J Clin Endocrinol Metab 95:3309-17. 2010
    ..We investigated whether reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet in healthy young males would impair the incretin effect...
  22. doi Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists
    K B Hansen
    Department of Clinical Physiology, Glostrup Hospital, University of Copenhagen, Nordre Ringvej, Copenhagen, Denmark
    Int J Clin Pract 63:1154-60. 2009
    ..In this review, the available data on the two drugs are presented and discussed...
  23. doi Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with Type 2 diabetes
    P V Højberg
    Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark
    Diabet Med 25:1268-75. 2008
    ..The aim of the present study was to investigate whether 4 weeks of near-normalization of blood glucose (BG) improves incretin hormone secretion and pancreatic B-cell function during a mixed meal...
  24. doi Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
    P V Højberg
    Department of Endocrinology, Hvidovre Hospital, Kettegaards Alle 30, DK 2650 Hvidovre, Denmark
    Diabetologia 52:199-207. 2009
    ..The aim of the present study was to investigate whether 4 weeks of near-normalisation of the blood glucose level could improve insulin responses to GIP and GLP-1 in patients with type 2 diabetes...
  25. doi Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes
    P V Højberg
    Department of Endocrinology, Hvidovre Hospital, Kettegaards Alle 30, 2650 Hvidovre, Denmark
    Diabetologia 51:632-40. 2008
    ..We investigated whether 4 weeks of near normalisation of blood glucose (BG) improves the potentiation of glucose-stimulated insulin secretion by GLP-1...
  26. doi Increased levels of YKL-40 and interleukin 6 in patients with chronic pancreatitis and secondary diabetes
    Morten Hansen
    Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, Hellerup, Denmark
    Pancreas 41:1316-8. 2012
    ....
  27. ncbi [Psoriasis is associated with type 2 diabetes]
    Mette Gyldenløve
    Dermato allergologisk Afdeling K, Gentofte Hospital, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Ugeskr Laeger 175:652-4. 2013
    ..The current review summarises the evidence in the field and calls for attention on diabetes risk assessment, preventive measures and treatment in patients with psoriasis...
  28. doi The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes
    Asger Lund
    Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, Hellerup, Denmark
    Am J Physiol Endocrinol Metab 300:E1038-46. 2011
    ..Our results indicate that the intestinal hormones, GIP, GLP-1, and GLP-2, may play a role in the inappropriate glucagon response to orally ingested glucose in T2DM with, especially, GIP, acting to increase glucagon secretion...
  29. ncbi Dulaglutide, a long-acting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes
    Espen Jimenez-Solem
    University of Copenhagen, Gentofte Hospital, Department of Internal Medicine F, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Curr Opin Mol Ther 12:790-7. 2010
    ..If dulaglutide possesses similar efficacy to other GLP-1 analogs, the once-weekly treatment will most likely be welcomed by patients with T2DM...
  30. pmc The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
    Jonathan C Schisler
    Department of Pharmacology, Sarah W Stedman Nutrition and Metabolism Center, Durham, NC 27704, USA
    Proc Natl Acad Sci U S A 102:7297-302. 2005
    ..1 mRNA in primary rat islets was accompanied by a significant decrease in GSIS relative to control cells. In sum, our studies have revealed roles for Nkx6.1 in suppression of glucagon expression and control of GSIS in islet beta cells...