Janne K. Klitgaard

Summary

Publications

  1. pmc Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae
    Nils J Faergeman
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Biochem J 380:907-18. 2004
  2. pmc The RNA-binding protein Hfq of Listeria monocytogenes: role in stress tolerance and virulence
    Janne K Christiansen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense M, Denmark
    J Bacteriol 186:3355-62. 2004
  3. pmc Identification of small Hfq-binding RNAs in Listeria monocytogenes
    Janne K Christiansen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    RNA 12:1383-96. 2006
  4. ncbi request reprint The response regulator ResD modulates virulence gene expression in response to carbohydrates in Listeria monocytogenes
    Marianne H Larsen
    Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Stigbøjlen 4, DK 1870 Frederiksberg C, Denmark
    Mol Microbiol 61:1622-35. 2006
  5. ncbi request reprint LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes
    Janne K Christiansen
    Department of Biochemistry and Molecular Biology, The Nucleic Acid Center, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Bioorg Med Chem 15:6135-43. 2007
  6. pmc Defining a role for Hfq in Gram-positive bacteria: evidence for Hfq-dependent antisense regulation in Listeria monocytogenes
    Jesper Sejrup Nielsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Nucleic Acids Res 38:907-19. 2010
  7. doi request reprint Thioridazine affects transcription of genes involved in cell wall biosynthesis in methicillin-resistant Staphylococcus aureus
    Mette Bonde
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    FEMS Microbiol Lett 318:168-76. 2011
  8. doi request reprint Reversal of methicillin resistance in Staphylococcus aureus by thioridazine
    Janne K Klitgaard
    Department of Clinical Microbiology, Institute of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark
    J Antimicrob Chemother 62:1215-21. 2008

Collaborators

Detail Information

Publications8

  1. pmc Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae
    Nils J Faergeman
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Biochem J 380:907-18. 2004
    ..We suggest that the reduced ceramide synthesis in Acb1p-depleted cells leads to severely altered vacuole morphology, perturbed vacuole assembly and strong inhibition of homotypic vacuole fusion...
  2. pmc The RNA-binding protein Hfq of Listeria monocytogenes: role in stress tolerance and virulence
    Janne K Christiansen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense M, Denmark
    J Bacteriol 186:3355-62. 2004
    ..This study provides, for the first time, information on the role of Hfq in the stress tolerance and virulence of a gram-positive pathogen...
  3. pmc Identification of small Hfq-binding RNAs in Listeria monocytogenes
    Janne K Christiansen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    RNA 12:1383-96. 2006
    ..All three sRNAs are expressed when L. monocytogenes multiplies within mammalian cells. This study represents the first attempt to identify sRNAs in L. monocytogenes...
  4. ncbi request reprint The response regulator ResD modulates virulence gene expression in response to carbohydrates in Listeria monocytogenes
    Marianne H Larsen
    Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Stigbøjlen 4, DK 1870 Frederiksberg C, Denmark
    Mol Microbiol 61:1622-35. 2006
    ..Thus, ResD is a central regulator of L. monocytogenes when present in the external environment...
  5. ncbi request reprint LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes
    Janne K Christiansen
    Department of Biochemistry and Molecular Biology, The Nucleic Acid Center, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Bioorg Med Chem 15:6135-43. 2007
    ..Efficient, binary hammerhead ribozymes were pursued in a combinatorial approach using a 6-times 5 library, which was analysed concerning the best combinations, buffer conditions and fragment ratios...
  6. pmc Defining a role for Hfq in Gram-positive bacteria: evidence for Hfq-dependent antisense regulation in Listeria monocytogenes
    Jesper Sejrup Nielsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Nucleic Acids Res 38:907-19. 2010
    ..Our findings indicate that modulation of translation by trans-encoded sRNAs may occur by both Hfq-dependent and -independent mechanisms, thus adding another layer of complexity to sRNA-mediated riboregulation in Gram-positive species...
  7. doi request reprint Thioridazine affects transcription of genes involved in cell wall biosynthesis in methicillin-resistant Staphylococcus aureus
    Mette Bonde
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    FEMS Microbiol Lett 318:168-76. 2011
    ..In the present study, we find indications that the mechanism underlying reversal of resistance by thioridazine relies on decreased expression of specific genes involved in cell wall biosynthesis...
  8. doi request reprint Reversal of methicillin resistance in Staphylococcus aureus by thioridazine
    Janne K Klitgaard
    Department of Clinical Microbiology, Institute of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark
    J Antimicrob Chemother 62:1215-21. 2008
    ..The aim of this study was to investigate whether thioridazine alone or in combination with oxacillin affects the transcription of the methicillin resistance gene mecA and the protein level of the encoded protein PBP2a...