Research Topics
| Mogens KilianSummaryAffiliation: University of Aarhus Country: Denmark Publications
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Detail Information
Publications
Evolution of Streptococcus pneumoniae and its close commensal relativesMogens Kilian
Institute of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
PLoS ONE 3:e2683. 2008..During their adaptation to a commensal life style, most of the lineages gradually lost the majority of genes determining virulence and became genetically distinct due to sexual isolation in their respective hosts...- Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnesMogens Kilian
Department of Biomedicine, Faculty of Health Sciences, Aarhus University, DK 8000 Aarhus C, Denmark
J Clin Microbiol 50:1158-65. 2012.... - Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related speciesClaudio Donati
Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
Genome Biol 11:R107. 2010..Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group... - Assigning strains to bacterial species via the internetCynthia J Bishop
Department of Infectious Disease Epidemiology, Imperial College London, St, Mary s Hospital Campus, London, UK
BMC Biol 7:3. 2009.... 
Recommended conservation of the names Streptococcus sanguis, Streptococcus rattus, Streptococcus cricetus, and seven other names included in the Approved Lists of Bacterial Names. Request for an opinionM Kilian
Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
Int J Syst Evol Microbiol 51:723-4. 2001..Request for an Opinion...- Evolution of the paralogous hap and iga genes in Haemophilus influenzae: evidence for a conserved hap pseudogene associated with microcolony formation in the recently diverged Haemophilus aegyptius and H. influenzae biogroup aegyptiusMogens Kilian
Department of Medical Microbiology and Immunology, University of Aarhus, DK 8000 Aarhus C, Denmark
Mol Microbiol 46:1367-80. 2002..aegyptius and H. influenzae biogroup aegyptius occurred subsequent to this genetic event. The loss of Hap protein expression may be one of the genetic events that facilitated exploitation of the conjunctivae as a new niche... - CRISPR/cas loci of type II Propionibacterium acnes confer immunity against acquisition of mobile elements present in type I P. acnesHolger Bruggemann
Department of Biomedicine, Aarhus University, Aarhus, Denmark
PLoS ONE 7:e34171. 2012..The CRISPR/cas locus is deleted in type I strains, which conceivably accounts for their ability to horizontally acquire fitness or virulence traits and might indicate that type I strains constitute a younger subpopulation of P. acnes... - Population diversity and dynamics of Streptococcus mitis, Streptococcus oralis, and Streptococcus infantis in the upper respiratory tracts of adults, determined by a nonculture strategyMalene Bek-Thomsen
Institute of Medical Microbiology and Immunology, The Bartholin Building, Aarhus University, DK 8000 Aarhus C, Denmark
Infect Immun 76:1889-96. 2008..These findings provide a platform for understanding the mechanisms that govern the balance within the complex microbiota at mucosal sites and between the microbiota and the mucosal immune system of the host... - Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acneHans B Lomholt
Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
PLoS ONE 5:e12277. 2010..The results of the study indicate that particular clones of P. acnes play an etiologic role in acne while others are associated with health... 
Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort studyDorte Haubek
Department of Community Oral Health and Pediatric Dentistry, University of Aarhus, Denmark
Lancet 371:237-42. 2008..We did a population-based longitudinal study of adolescents to assess the role of the JP2 clone in the initiation of aggressive periodontitis...- Use of phylogenetic and phenotypic analyses to identify nonhemolytic streptococci isolated from bacteremic patientsTomonori Hoshino
Institute of Medical Microbiology and Immunology, Aarhus University, Bartholin Building, DK-8000 Aarhus C, Denmark
J Clin Microbiol 43:6073-85. 2005..An analysis of the species distribution of 107 nonhemolytic streptococci from bacteremic patients showed a predominance of S. oralis and S. anginosus with various underlying infections... - Proteomic and immunoproteomic analysis of Aggregatibacter actinomycetemcomitans JP2 clone strain HK1651Mette Rylev
Department of Medical Microbiology and Immunology, School of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
J Proteomics 74:2972-85. 2011..actinomycetemcomitans combined with analyses of the humoral immune response and targeted against outer membrane proteins may provide important insight into the host relationship of this important pathogen... - Diversity of Capnocytophaga species in children and description of Capnocytophaga leadbetteri sp. nov. and Capnocytophaga genospecies AHN8471Ellen V G Frandsen
Department of Oral Biology, Royal Dental College, Faculty of Health Sciences, University of Aarhus, DK 8000 Aarhus C, Denmark
Int J Syst Evol Microbiol 58:324-36. 2008..Another cluster not phenotypically distinguishable from C. ochracea and C. sputigena is designated Capnocytophaga genospecies AHN8471 (represented by strain AHN8471=CCUG 51856=NCTC 13374)... - Microevolution and patterns of dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitansDorte Haubek
Department of Community Oral Health and Pediatric Dentistry, School of Dentistry, Faculty of Health Science, University of Aarhus, Vennelyst Boulevard 9, DK 8000 Aarhus C, Denmark
Infect Immun 75:3080-8. 2007..The colonization of family members by JP2 clone strains with unique point mutations provides strong evidence that there is intrafamilial transmission and suggests that dissemination of the JP2 clone is restricted to close contacts... - Novel molecular method for identification of Streptococcus pneumoniae applicable to clinical microbiology and 16S rRNA sequence-based microbiome studiesChristian F P Scholz
Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
J Clin Microbiol 50:1968-73. 2012..This may avoid frequent misidentifications such as those we demonstrate to have occurred in previous reports and in reference sequence databases... - Delineation of Streptococcus dysgalactiae, its subspecies, and its clinical and phylogenetic relationship to Streptococcus pyogenesAnders Jensen
Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
J Clin Microbiol 50:113-26. 2012..The results provide an improved basis for identification of clinically important pyogenic group streptococci and explain the overlapping spectrum of infections caused by the species associated with humans... - Horizontal transfer of the immunoglobulin A1 protease gene (iga) from Streptococcus to Gemella haemolysansNobuko Takenouchi-Ohkubo
Institute of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, Denmark
Microbiology 152:2171-80. 2006..haemolysans, and therefore that the IgA1 protease gene was transferred from Streptococcus to G. haemolysans... - Differences in iron acquisition from human haemoglobin among strains of Actinobacillus actinomycetemcomitansHideaki Hayashida
Department of Medical Microbiology and Immunology, University of Aarhus, The Bartholin Building, DK 8000 Aarhus C, Denmark
Microbiology 148:3993-4001. 2002..Thus, the presence of an hgpA pseudogene and the inability to use human haemoglobin as an iron source discriminate the high-toxic JP2 clone from low-toxic serotype b strains and most other strains of A. actinomycetemcomitans... - Novel loop-mediated isothermal amplification method for detection of the JP2 clone of Aggregatibacter actinomycetemcomitans in subgingival plaqueMitsuko Seki
Institute of Medical Microbiology and Immunology, Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
J Clin Microbiol 46:1113-5. 2008..Being independent of special equipment, this specific and sensitive method offers significant advantages for screening of patients on a population basis and in clinical settings... - The etiology of periodontal disease revisited by population genetic analysisMogens Kilian
Department of Bacteriology, Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
Periodontol 2000 42:158-79. 2006 - Delineation of the genus Actinobacillus by comparison of partial infB sequencesNiels Nørskov-Lauritsen
Department of Clinical Microbiology, Aalborg Hospital, Aalborg, Denmark
Int J Syst Evol Microbiol 54:635-44. 2004..Greater intraspecies variation was observed with infB sequences than with 16S rRNA gene sequences, with notable exceptions. The apparent subdivision of some species by 16S rRNA analysis was most likely caused by RNA operon heterogeneity... - Multilocus sequence phylogenetic study of the genus Haemophilus with description of Haemophilus pittmaniae sp. novNiels Nørskov-Lauritsen
Department of Clinical Microbiology, Aarhus University Hospital, DK 8000 Aarhus, Denmark
Int J Syst Evol Microbiol 55:449-56. 2005..Genotypic and phenotypic data show that the strains merit recognition as a novel species of Haemophilus. The name Haemophilus pittmaniae sp. nov. is proposed, with HK 85T (=CCUG 48703T=NCTC 13334T) as the type strain... - Septicaemia associated with an Aerococcus viridans infection in immunodeficient miceFrederik Dagnaes-Hansen
Department of Medical Microbiology and Immunology, University of Aarhus, DK 8000 Aarhus C, Denmark
Lab Anim 38:321-5. 2004..viridans. This is the first report of a spontaneous outbreak of septicaemia caused by A. viridans infection in immunodeficient laboratory mice and we conclude that A. viridans should be considered as a pathogen in immunodeficient mice... - Prevalence and distribution of principal periodontal pathogens worldwideMette Rylev
Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
J Clin Periodontol 35:346-61. 2008..There is evidence that some evolutionary lineages of bacteria have adapted to particular ethnic groups... - Capsular gene typing of Streptococcus agalactiae compared to serotyping by latex agglutinationKaihu Yao
Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
J Clin Microbiol 51:503-7. 2013..A procedure for convenient and reliable capsular gene typing to be included in epidemiological and surveillance studies of S. agalactiae is proposed... - In situ identification of streptococci and other bacteria in initial dental biofilm by confocal laser scanning microscopy and fluorescence in situ hybridizationIrene Dige
Department of Dental Pathology, Operative Dentistry and Endodontics, School of Dentistry, University of Aarhus, Arhus, Denmark
Eur J Oral Sci 115:459-67. 2007.... - The Clostridium ramosum IgA proteinase represents a novel type of metalloendopeptidaseKlaudia Kosowska
Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus C DK-8000, Denmark
J Biol Chem 277:11987-94. 2002..The GC percentage of the iga gene is significantly higher than that for the entire genome of C. ramosum, suggesting that the gene was acquired recently in evolution... - Staphylococcus aureus clonal dynamics and virulence factors in children with atopic dermatitisHans Lomholt
Department of Dermatology and Venerology, Aarhus University Hospital, Aarhus, Denmark
J Invest Dermatol 125:977-82. 2005..Increased severity of eczema was related to a change in agr group and may have been because of inflammation triggered by the takeover of an antigenically different clone, as agr groups represent ancient phylogenetic lineages... - Molecular mapping to species level of the tonsillar crypt microbiota associated with health and recurrent tonsillitisAnders Jensen
Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
PLoS ONE 8:e56418. 2013.... - Degradation of uniquely glycosylated secretory immunoglobulin a in tears from patients with Pseudomonas aeruginosa keratitisJeanet A Lomholt
Institute of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
Invest Ophthalmol Vis Sci 49:4939-44. 2008..To investigate the integrity of secretory (S)-IgA in tear fluid during bacterial keratitis and to evaluate the significance of specific Pseudomonas aeruginosa extracellular proteases in the observed degradation of S-IgA... - Dynamics of Streptococcus agalactiae colonization in women during and after pregnancy and in their infantsSøren Mose Hansen
Department of Medical Microbiology and Immunology, The University of Aarhus, DK 8000 Aarhus C, Denmark
J Clin Microbiol 42:83-9. 2004..These observations strongly suggest differences in the properties and epidemiology of virulent GBS clones compared to clones commonly carried by healthy individuals... - Clonal relationship of recent invasive Haemophilus influenzae serotype f isolates from Denmark and the United StatesBrita Bruun
Department of Clinical Microbiology, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
J Med Microbiol 53:1161-5. 2004..The need for accurate serotyping of H. influenzae to enable reliable monitoring for Hib replacement by other capsular types is emphasized... - Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and AggregatibacterNiels Nørskov-Lauritsen
Department of Clinical Microbiology, Aarhus University Hospital Skejby, DK 8200 Aarhus N, Denmark
Int J Syst Evol Microbiol 56:2135-46. 2006..nov. (type strain HK316(T)=ATCC 33393(T)=CCUG 10787(T)=CCUG 12838(T)=CIP 103292(T)=NCTC 10977(T)). The species of the genus Aggregatibacter are independent of X factor and variably dependent on V factor for growth in vitro... - Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patternsTrine H Mogensen
Department of Infectious Diseases, Skejby Hospital, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
J Leukoc Biol 80:267-77. 2006..pneumoniae, H. influenzae, and N. meningitidis each activate several TLRs in species-specific patterns and show that infection with live pathogens may lead to activation of PRR not targeted by inactivated bacteria... - Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzaeTimothy F Murphy
Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
J Infect Dis 195:81-9. 2007..In a prospective study, selected isolates of apparent H. influenzae had an altered phenotype. We tested the hypothesis that these variant strains were genetically different from typical H. influenzae... - Working mechanism of immunoglobulin A1 (IgA1) protease: cleavage of IgA1 antibody to Neisseria meningitidis PorA requires de novo synthesis of IgA1 ProteaseGestur Vidarsson
Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht UMCU, The Netherlands
Infect Immun 73:6721-6. 2005..Finally, our data suggest that cleavage of IgA1 by IgA1 protease releases a significant proportion of Fab fragments from the bacterium, probably as a result of their reduced avidity compared to that of whole antibodies... - Host-derived pentapeptide affecting adhesion, proliferation, and local pH in biofilm communities composed of Streptococcus and Actinomyces speciesMirva Drobni
Department of Odontology/Cariology, , SE-901 87 Ume, and Division of Clinical Immunology, Karolinska University Hospital Huddinge, Stockholm, Sweden
Infect Immun 74:6293-9. 2006..The present findings indicate the presence of a host-bacterium interaction in which a host peptide released by bacterial proteolysis affects key properties in biofilm formation... - Amino acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by streptococcal IgA1 proteasesMargaret R Batten
Department of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
Infect Immun 71:1462-9. 2003..Hence, this study has identified key residues required for the recognition of the IgA1 hinge as a substrate by streptococcal IgA1 proteases, and it marks a preliminary step towards development of specific enzyme inhibitors... - A unique variant of streptococcal group O-antigen (C-polysaccharide) that lacks phosphocholineNiklas Bergström
Clinical Research Centre, Analytical Unit, Karolinska Institute, Huddinge Hospital, Sweden
Eur J Biochem 270:2157-62. 2003..This structure is identical to the double choline-substituted form of C-polysaccharide, except that it is substituted with ethanolamine instead of choline. This extends the number of recognized C-polysaccharide variants to four... - Competence without a competence pheromone in a natural isolate of Streptococcus infantisOla Ween
Department of Chemistry and Biotechnology, Agricultural University of Norway, N 1432 As, Norway
J Bacteriol 184:3426-32. 2002..A highly similar strain lacking comC was isolated independently from another individual, suggesting that strains with this phenotype are able to survive in nature in competition with wild-type strains... - Antibiotic treatment and the diagnosis of Streptococcus pneumoniae in lower respiratory tract infections in adultsJens Korsgaard
Department of Chest Diseases, Aarhus University Hospital Aalborg, Denmark
Int J Infect Dis 9:274-9. 2005..To analyze the possible influence of antibiotic treatment on the results of different diagnostic tests for the diagnosis of lower respiratory tract infections with Streptococcus pneumoniae...