Mogens Kilian

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. pmc Evolution of Streptococcus pneumoniae and its close commensal relatives
    Mogens Kilian
    Institute of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    PLoS ONE 3:e2683. 2008
  2. pmc Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnes
    Mogens Kilian
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, DK 8000 Aarhus C, Denmark
    J Clin Microbiol 50:1158-65. 2012
  3. pmc Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species
    Claudio Donati
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Genome Biol 11:R107. 2010
  4. pmc Assigning strains to bacterial species via the internet
    Cynthia J Bishop
    Department of Infectious Disease Epidemiology, Imperial College London, St, Mary s Hospital Campus, London, UK
    BMC Biol 7:3. 2009
  5. ncbi request reprint Recommended conservation of the names Streptococcus sanguis, Streptococcus rattus, Streptococcus cricetus, and seven other names included in the Approved Lists of Bacterial Names. Request for an opinion
    M Kilian
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Int J Syst Evol Microbiol 51:723-4. 2001
  6. ncbi request reprint Evolution of the paralogous hap and iga genes in Haemophilus influenzae: evidence for a conserved hap pseudogene associated with microcolony formation in the recently diverged Haemophilus aegyptius and H. influenzae biogroup aegyptius
    Mogens Kilian
    Department of Medical Microbiology and Immunology, University of Aarhus, DK 8000 Aarhus C, Denmark
    Mol Microbiol 46:1367-80. 2002
  7. pmc CRISPR/cas loci of type II Propionibacterium acnes confer immunity against acquisition of mobile elements present in type I P. acnes
    Holger Bruggemann
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    PLoS ONE 7:e34171. 2012
  8. pmc Population diversity and dynamics of Streptococcus mitis, Streptococcus oralis, and Streptococcus infantis in the upper respiratory tracts of adults, determined by a nonculture strategy
    Malene Bek-Thomsen
    Institute of Medical Microbiology and Immunology, The Bartholin Building, Aarhus University, DK 8000 Aarhus C, Denmark
    Infect Immun 76:1889-96. 2008
  9. pmc Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne
    Hans B Lomholt
    Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    PLoS ONE 5:e12277. 2010
  10. doi request reprint Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study
    Dorte Haubek
    Department of Community Oral Health and Pediatric Dentistry, University of Aarhus, Denmark
    Lancet 371:237-42. 2008

Collaborators

Detail Information

Publications42

  1. pmc Evolution of Streptococcus pneumoniae and its close commensal relatives
    Mogens Kilian
    Institute of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    PLoS ONE 3:e2683. 2008
    ..During their adaptation to a commensal life style, most of the lineages gradually lost the majority of genes determining virulence and became genetically distinct due to sexual isolation in their respective hosts...
  2. pmc Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnes
    Mogens Kilian
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, DK 8000 Aarhus C, Denmark
    J Clin Microbiol 50:1158-65. 2012
    ....
  3. pmc Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species
    Claudio Donati
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Genome Biol 11:R107. 2010
    ..Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group...
  4. pmc Assigning strains to bacterial species via the internet
    Cynthia J Bishop
    Department of Infectious Disease Epidemiology, Imperial College London, St, Mary s Hospital Campus, London, UK
    BMC Biol 7:3. 2009
    ....
  5. ncbi request reprint Recommended conservation of the names Streptococcus sanguis, Streptococcus rattus, Streptococcus cricetus, and seven other names included in the Approved Lists of Bacterial Names. Request for an opinion
    M Kilian
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Int J Syst Evol Microbiol 51:723-4. 2001
    ..Request for an Opinion...
  6. ncbi request reprint Evolution of the paralogous hap and iga genes in Haemophilus influenzae: evidence for a conserved hap pseudogene associated with microcolony formation in the recently diverged Haemophilus aegyptius and H. influenzae biogroup aegyptius
    Mogens Kilian
    Department of Medical Microbiology and Immunology, University of Aarhus, DK 8000 Aarhus C, Denmark
    Mol Microbiol 46:1367-80. 2002
    ..aegyptius and H. influenzae biogroup aegyptius occurred subsequent to this genetic event. The loss of Hap protein expression may be one of the genetic events that facilitated exploitation of the conjunctivae as a new niche...
  7. pmc CRISPR/cas loci of type II Propionibacterium acnes confer immunity against acquisition of mobile elements present in type I P. acnes
    Holger Bruggemann
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    PLoS ONE 7:e34171. 2012
    ..The CRISPR/cas locus is deleted in type I strains, which conceivably accounts for their ability to horizontally acquire fitness or virulence traits and might indicate that type I strains constitute a younger subpopulation of P. acnes...
  8. pmc Population diversity and dynamics of Streptococcus mitis, Streptococcus oralis, and Streptococcus infantis in the upper respiratory tracts of adults, determined by a nonculture strategy
    Malene Bek-Thomsen
    Institute of Medical Microbiology and Immunology, The Bartholin Building, Aarhus University, DK 8000 Aarhus C, Denmark
    Infect Immun 76:1889-96. 2008
    ..These findings provide a platform for understanding the mechanisms that govern the balance within the complex microbiota at mucosal sites and between the microbiota and the mucosal immune system of the host...
  9. pmc Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne
    Hans B Lomholt
    Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    PLoS ONE 5:e12277. 2010
    ..The results of the study indicate that particular clones of P. acnes play an etiologic role in acne while others are associated with health...
  10. doi request reprint Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study
    Dorte Haubek
    Department of Community Oral Health and Pediatric Dentistry, University of Aarhus, Denmark
    Lancet 371:237-42. 2008
    ..We did a population-based longitudinal study of adolescents to assess the role of the JP2 clone in the initiation of aggressive periodontitis...
  11. pmc Capsular gene typing of Streptococcus agalactiae compared to serotyping by latex agglutination
    Kaihu Yao
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
    J Clin Microbiol 51:503-7. 2013
    ..A procedure for convenient and reliable capsular gene typing to be included in epidemiological and surveillance studies of S. agalactiae is proposed...
  12. pmc Use of phylogenetic and phenotypic analyses to identify nonhemolytic streptococci isolated from bacteremic patients
    Tomonori Hoshino
    Institute of Medical Microbiology and Immunology, Aarhus University, Bartholin Building, DK 8000 Aarhus C, Denmark
    J Clin Microbiol 43:6073-85. 2005
    ..An analysis of the species distribution of 107 nonhemolytic streptococci from bacteremic patients showed a predominance of S. oralis and S. anginosus with various underlying infections...
  13. doi request reprint Proteomic and immunoproteomic analysis of Aggregatibacter actinomycetemcomitans JP2 clone strain HK1651
    Mette Rylev
    Department of Medical Microbiology and Immunology, School of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
    J Proteomics 74:2972-85. 2011
    ..actinomycetemcomitans combined with analyses of the humoral immune response and targeted against outer membrane proteins may provide important insight into the host relationship of this important pathogen...
  14. pmc Microevolution and patterns of dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans
    Dorte Haubek
    Department of Community Oral Health and Pediatric Dentistry, School of Dentistry, Faculty of Health Science, University of Aarhus, Vennelyst Boulevard 9, DK 8000 Aarhus C, Denmark
    Infect Immun 75:3080-8. 2007
    ..The colonization of family members by JP2 clone strains with unique point mutations provides strong evidence that there is intrafamilial transmission and suggests that dissemination of the JP2 clone is restricted to close contacts...
  15. doi request reprint Diversity of Capnocytophaga species in children and description of Capnocytophaga leadbetteri sp. nov. and Capnocytophaga genospecies AHN8471
    Ellen V G Frandsen
    Department of Oral Biology, Royal Dental College, Faculty of Health Sciences, University of Aarhus, DK 8000 Aarhus C, Denmark
    Int J Syst Evol Microbiol 58:324-36. 2008
    ..Another cluster not phenotypically distinguishable from C. ochracea and C. sputigena is designated Capnocytophaga genospecies AHN8471 (represented by strain AHN8471=CCUG 51856=NCTC 13374)...
  16. pmc Novel molecular method for identification of Streptococcus pneumoniae applicable to clinical microbiology and 16S rRNA sequence-based microbiome studies
    Christian F P Scholz
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
    J Clin Microbiol 50:1968-73. 2012
    ..This may avoid frequent misidentifications such as those we demonstrate to have occurred in previous reports and in reference sequence databases...
  17. pmc Delineation of Streptococcus dysgalactiae, its subspecies, and its clinical and phylogenetic relationship to Streptococcus pyogenes
    Anders Jensen
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
    J Clin Microbiol 50:113-26. 2012
    ..The results provide an improved basis for identification of clinically important pyogenic group streptococci and explain the overlapping spectrum of infections caused by the species associated with humans...
  18. pmc Novel loop-mediated isothermal amplification method for detection of the JP2 clone of Aggregatibacter actinomycetemcomitans in subgingival plaque
    Mitsuko Seki
    Institute of Medical Microbiology and Immunology, Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Clin Microbiol 46:1113-5. 2008
    ..Being independent of special equipment, this specific and sensitive method offers significant advantages for screening of patients on a population basis and in clinical settings...
  19. ncbi request reprint Horizontal transfer of the immunoglobulin A1 protease gene (iga) from Streptococcus to Gemella haemolysans
    Nobuko Takenouchi-Ohkubo
    Institute of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, Denmark
    Microbiology 152:2171-80. 2006
    ..haemolysans, and therefore that the IgA1 protease gene was transferred from Streptococcus to G. haemolysans...
  20. ncbi request reprint The etiology of periodontal disease revisited by population genetic analysis
    Mogens Kilian
    Department of Bacteriology, Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    Periodontol 2000 42:158-79. 2006
  21. ncbi request reprint Differences in iron acquisition from human haemoglobin among strains of Actinobacillus actinomycetemcomitans
    Hideaki Hayashida
    Department of Medical Microbiology and Immunology, University of Aarhus, The Bartholin Building, DK 8000 Aarhus C, Denmark
    Microbiology 148:3993-4001. 2002
    ..Thus, the presence of an hgpA pseudogene and the inability to use human haemoglobin as an iron source discriminate the high-toxic JP2 clone from low-toxic serotype b strains and most other strains of A. actinomycetemcomitans...
  22. ncbi request reprint Delineation of the genus Actinobacillus by comparison of partial infB sequences
    Niels Nørskov-Lauritsen
    Department of Clinical Microbiology, Aalborg Hospital, Aalborg, Denmark
    Int J Syst Evol Microbiol 54:635-44. 2004
    ..Greater intraspecies variation was observed with infB sequences than with 16S rRNA gene sequences, with notable exceptions. The apparent subdivision of some species by 16S rRNA analysis was most likely caused by RNA operon heterogeneity...
  23. ncbi request reprint Multilocus sequence phylogenetic study of the genus Haemophilus with description of Haemophilus pittmaniae sp. nov
    Niels Nørskov-Lauritsen
    Department of Clinical Microbiology, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Int J Syst Evol Microbiol 55:449-56. 2005
    ..Genotypic and phenotypic data show that the strains merit recognition as a novel species of Haemophilus. The name Haemophilus pittmaniae sp. nov. is proposed, with HK 85T (=CCUG 48703T=NCTC 13334T) as the type strain...
  24. pmc Molecular mapping to species level of the tonsillar crypt microbiota associated with health and recurrent tonsillitis
    Anders Jensen
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
    PLoS ONE 8:e56418. 2013
    ....
  25. ncbi request reprint Septicaemia associated with an Aerococcus viridans infection in immunodeficient mice
    Frederik Dagnaes-Hansen
    Department of Medical Microbiology and Immunology, University of Aarhus, DK 8000 Aarhus C, Denmark
    Lab Anim 38:321-5. 2004
    ..viridans. This is the first report of a spontaneous outbreak of septicaemia caused by A. viridans infection in immunodeficient laboratory mice and we conclude that A. viridans should be considered as a pathogen in immunodeficient mice...
  26. doi request reprint Prevalence and distribution of principal periodontal pathogens worldwide
    Mette Rylev
    Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Clin Periodontol 35:346-61. 2008
    ..There is evidence that some evolutionary lineages of bacteria have adapted to particular ethnic groups...
  27. doi request reprint Taxonomy of the Anginosus group of the genus Streptococcus and description of Streptococcus anginosus subsp. whileyi subsp. nov. and Streptococcus constellatus subsp. viborgensis subsp. nov
    Anders Jensen
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
    Int J Syst Evol Microbiol 63:2506-19. 2013
    ..The names S. anginosus subsp. whileyi subsp. nov. (type strain CCUG 39159(T) = DSM 25818(T) = SK1267(T)) and S. constellatus subsp. viborgensis subsp. nov. (type strain SK1359(T) = CCUG 62387(T) = DSM 25819(T)) are proposed...
  28. ncbi request reprint In situ identification of streptococci and other bacteria in initial dental biofilm by confocal laser scanning microscopy and fluorescence in situ hybridization
    Irene Dige
    Department of Dental Pathology, Operative Dentistry and Endodontics, School of Dentistry, University of Aarhus, Arhus, Denmark
    Eur J Oral Sci 115:459-67. 2007
    ....
  29. ncbi request reprint The Clostridium ramosum IgA proteinase represents a novel type of metalloendopeptidase
    Klaudia Kosowska
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus C DK 8000, Denmark
    J Biol Chem 277:11987-94. 2002
    ..The GC percentage of the iga gene is significantly higher than that for the entire genome of C. ramosum, suggesting that the gene was acquired recently in evolution...
  30. ncbi request reprint Staphylococcus aureus clonal dynamics and virulence factors in children with atopic dermatitis
    Hans Lomholt
    Department of Dermatology and Venerology, Aarhus University Hospital, Aarhus, Denmark
    J Invest Dermatol 125:977-82. 2005
    ..Increased severity of eczema was related to a change in agr group and may have been because of inflammation triggered by the takeover of an antigenically different clone, as agr groups represent ancient phylogenetic lineages...
  31. pmc Dynamics of Streptococcus agalactiae colonization in women during and after pregnancy and in their infants
    Søren Mose Hansen
    Department of Medical Microbiology and Immunology, The University of Aarhus, DK 8000 Aarhus C, Denmark
    J Clin Microbiol 42:83-9. 2004
    ..These observations strongly suggest differences in the properties and epidemiology of virulent GBS clones compared to clones commonly carried by healthy individuals...
  32. doi request reprint Degradation of uniquely glycosylated secretory immunoglobulin a in tears from patients with Pseudomonas aeruginosa keratitis
    Jeanet A Lomholt
    Institute of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    Invest Ophthalmol Vis Sci 49:4939-44. 2008
    ..To investigate the integrity of secretory (S)-IgA in tear fluid during bacterial keratitis and to evaluate the significance of specific Pseudomonas aeruginosa extracellular proteases in the observed degradation of S-IgA...
  33. ncbi request reprint Clonal relationship of recent invasive Haemophilus influenzae serotype f isolates from Denmark and the United States
    Brita Bruun
    Department of Clinical Microbiology, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    J Med Microbiol 53:1161-5. 2004
    ..The need for accurate serotyping of H. influenzae to enable reliable monitoring for Hib replacement by other capsular types is emphasized...
  34. ncbi request reprint Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns
    Trine H Mogensen
    Department of Infectious Diseases, Skejby Hospital, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
    J Leukoc Biol 80:267-77. 2006
    ..pneumoniae, H. influenzae, and N. meningitidis each activate several TLRs in species-specific patterns and show that infection with live pathogens may lead to activation of PRR not targeted by inactivated bacteria...
  35. ncbi request reprint Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Infect Dis 195:81-9. 2007
    ..In a prospective study, selected isolates of apparent H. influenzae had an altered phenotype. We tested the hypothesis that these variant strains were genetically different from typical H. influenzae...
  36. ncbi request reprint Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter
    Niels Nørskov-Lauritsen
    Department of Clinical Microbiology, Aarhus University Hospital Skejby, DK 8200 Aarhus N, Denmark
    Int J Syst Evol Microbiol 56:2135-46. 2006
    ..nov. (type strain HK316(T)=ATCC 33393(T)=CCUG 10787(T)=CCUG 12838(T)=CIP 103292(T)=NCTC 10977(T)). The species of the genus Aggregatibacter are independent of X factor and variably dependent on V factor for growth in vitro...
  37. pmc Host-derived pentapeptide affecting adhesion, proliferation, and local pH in biofilm communities composed of Streptococcus and Actinomyces species
    Mirva Drobni
    Department of Odontology Cariology, Umea University, SE 901 87 Umea, and Division of Clinical Immunology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Infect Immun 74:6293-9. 2006
    ..The present findings indicate the presence of a host-bacterium interaction in which a host peptide released by bacterial proteolysis affects key properties in biofilm formation...
  38. pmc Working mechanism of immunoglobulin A1 (IgA1) protease: cleavage of IgA1 antibody to Neisseria meningitidis PorA requires de novo synthesis of IgA1 Protease
    Gestur Vidarsson
    Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht UMCU, The Netherlands
    Infect Immun 73:6721-6. 2005
    ..Finally, our data suggest that cleavage of IgA1 by IgA1 protease releases a significant proportion of Fab fragments from the bacterium, probably as a result of their reduced avidity compared to that of whole antibodies...
  39. ncbi request reprint Antibiotic treatment and the diagnosis of Streptococcus pneumoniae in lower respiratory tract infections in adults
    Jens Korsgaard
    Department of Chest Diseases, Aarhus University Hospital Aalborg, Denmark
    Int J Infect Dis 9:274-9. 2005
    ..To analyze the possible influence of antibiotic treatment on the results of different diagnostic tests for the diagnosis of lower respiratory tract infections with Streptococcus pneumoniae...
  40. pmc Amino acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by streptococcal IgA1 proteases
    Margaret R Batten
    Department of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    Infect Immun 71:1462-9. 2003
    ..Hence, this study has identified key residues required for the recognition of the IgA1 hinge as a substrate by streptococcal IgA1 proteases, and it marks a preliminary step towards development of specific enzyme inhibitors...
  41. ncbi request reprint A unique variant of streptococcal group O-antigen (C-polysaccharide) that lacks phosphocholine
    Niklas Bergström
    Clinical Research Centre, Analytical Unit, Karolinska Institute, Huddinge Hospital, Sweden
    Eur J Biochem 270:2157-62. 2003
    ..This structure is identical to the double choline-substituted form of C-polysaccharide, except that it is substituted with ethanolamine instead of choline. This extends the number of recognized C-polysaccharide variants to four...
  42. pmc Competence without a competence pheromone in a natural isolate of Streptococcus infantis
    Ola Ween
    Department of Chemistry and Biotechnology, Agricultural University of Norway, N 1432 As, Norway
    J Bacteriol 184:3426-32. 2002
    ..A highly similar strain lacking comC was isolated independently from another individual, suggesting that strains with this phenotype are able to survive in nature in competition with wild-type strains...