A Juul

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint IGF-I measurements. Epidemiological and clinical aspects
    Anders Juul
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark
    Front Horm Res 33:45-67. 2005
  2. doi request reprint Polysomnographic sleep, growth hormone insulin-like growth factor-I axis, leptin, and weight loss
    Michael H Rasmussen
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Obesity (Silver Spring) 16:1516-21. 2008
  3. ncbi request reprint European audit of current practice in diagnosis and treatment of childhood growth hormone deficiency
    Anders Juul
    Department of Growth and Reproduction, National University Hospital, Copenhagen, Denmark
    Horm Res 58:233-41. 2002
  4. ncbi request reprint Determination of insulin-like growth factor I in children: normal values and clinical use
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Horm Res 55:94-9. 2001
  5. ncbi request reprint The effects of oestrogens on linear bone growth
    A Juul
    Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Denmark
    Hum Reprod Update 7:303-13. 2001
  6. ncbi request reprint Androgens and the ageing male
    Anders Juul
    Department of Growth and Reproduction GR, Rigshospitalet Section 5064, Copenhagen, Denmark
    Hum Reprod Update 8:423-33. 2002
  7. ncbi request reprint Growth hormone treatment and risk of solid tumours. A statement from the Drugs and Therapeutics Committee of the European Society for Paediatric Endocrinology (ESPE)
    Anders Juul
    University Department of Growth and Reproduction, Rigshsopitalet, Copenhagen, Denmark
    Horm Res 60:103-4. 2003
  8. ncbi request reprint Serum levels of insulin-like growth factor I and its binding proteins in health and disease
    Anders Juul
    Department of Growth and Reproduction, University of Copenhagen, Blegdamsvej 9 Rigshopitalet, Section 5064, Copenhagen 2100, Denmark
    Growth Horm IGF Res 13:113-70. 2003
  9. ncbi request reprint Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study
    Anders Juul
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Circulation 106:939-44. 2002
  10. ncbi request reprint A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding
    M Chellakooty
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:820-6. 2006

Detail Information

Publications92

  1. ncbi request reprint IGF-I measurements. Epidemiological and clinical aspects
    Anders Juul
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark
    Front Horm Res 33:45-67. 2005
  2. doi request reprint Polysomnographic sleep, growth hormone insulin-like growth factor-I axis, leptin, and weight loss
    Michael H Rasmussen
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Obesity (Silver Spring) 16:1516-21. 2008
    ..We conclude that hyposomatotropism and hyperleptinemia in obesity are transient phenomena reversible with weight loss, whereas short sleep seems to persist after weight has been reduced dramatically...
  3. ncbi request reprint European audit of current practice in diagnosis and treatment of childhood growth hormone deficiency
    Anders Juul
    Department of Growth and Reproduction, National University Hospital, Copenhagen, Denmark
    Horm Res 58:233-41. 2002
    ..We have found much conformity but also numerous discrepancies between the recommendations of the Growth Hormone Research Society and the current practice in Europe...
  4. ncbi request reprint Determination of insulin-like growth factor I in children: normal values and clinical use
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Horm Res 55:94-9. 2001
    ..Thus, an IGF-I value should always be evaluated together with auxological information and GH testing results before a decision is taken on whether or not to start GH therapy...
  5. ncbi request reprint The effects of oestrogens on linear bone growth
    A Juul
    Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Denmark
    Hum Reprod Update 7:303-13. 2001
    ..Conversely, higher levels of oestrogens stimulate secondary sexual characteristics and epiphyseal fusion...
  6. ncbi request reprint Androgens and the ageing male
    Anders Juul
    Department of Growth and Reproduction GR, Rigshospitalet Section 5064, Copenhagen, Denmark
    Hum Reprod Update 8:423-33. 2002
    ..However, at this point in time, widespread use of testosterone in an elderly male population outside controlled clinical trials seems inappropriate...
  7. ncbi request reprint Growth hormone treatment and risk of solid tumours. A statement from the Drugs and Therapeutics Committee of the European Society for Paediatric Endocrinology (ESPE)
    Anders Juul
    University Department of Growth and Reproduction, Rigshsopitalet, Copenhagen, Denmark
    Horm Res 60:103-4. 2003
  8. ncbi request reprint Serum levels of insulin-like growth factor I and its binding proteins in health and disease
    Anders Juul
    Department of Growth and Reproduction, University of Copenhagen, Blegdamsvej 9 Rigshopitalet, Section 5064, Copenhagen 2100, Denmark
    Growth Horm IGF Res 13:113-70. 2003
  9. ncbi request reprint Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study
    Anders Juul
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Circulation 106:939-44. 2002
    ..Insulin-like growth factor I (IGF-I) has been suggested to be involved in the pathogenesis of atherosclerosis. We hypothesize that low IGF-I and high IGFBP-3 levels might be associated with increased risk of ischemic heart disease (IHD)...
  10. ncbi request reprint A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding
    M Chellakooty
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:820-6. 2006
    ..Many aspects of hormonal regulation and mechanisms of normal infancy growth are poorly understood...
  11. doi request reprint Urinary phthalates from 168 girls and boys measured twice a year during a 5-year period: associations with adrenal androgen levels and puberty
    A Mouritsen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 98:3755-64. 2013
    ..Little is known about the possible deleterious effects of phthalate exposure on endogenous sex steroid levels in children...
  12. ncbi request reprint Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels
    A M Andersson
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 82:3976-81. 1997
    ....
  13. ncbi request reprint Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty
    A Mouritsen
    Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:346-59. 2010
    ..The effects may differ between boys and girls, as there are sex differences in age at onset of puberty, hormonal profiles and prevalence of precocius puberty...
  14. doi request reprint High urinary phthalate concentration associated with delayed pubarche in girls
    H Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Androl 35:216-26. 2012
    ..We demonstrated that delayed pubarche, but not thelarche, was associated with high phthalate excretion in urine samples from 725 healthy school girls, which may suggest anti-androgenic actions of phthalates in our study group of girls...
  15. doi request reprint Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number
    C Mau Kai
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 23:1669-78. 2008
    ..Deletions in the azoospermia factor (AZF) region of the Y chromosome are frequent in infertile men. The clinical consequences and the mode of inheritance of these deletions are not yet clear...
  16. ncbi request reprint Normal bone mineral content but unfavourable muscle/fat ratio in Klinefelter syndrome
    L Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Arch Dis Child 93:30-4. 2008
    ..To evaluate body composition and bone mineral content (BMC) in children and adolescents with Klinefelter syndrome (KS)...
  17. ncbi request reprint Inhibin A, inhibin B, follicle-stimulating hormone, luteinizing hormone, estradiol, and sex hormone-binding globulin levels in 473 healthy infant girls
    M Chellakooty
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:3515-20. 2003
    ..In conclusion, reproductive hormones showed a large variation, and concentrations corresponded to those observed in puberty. Our findings support the concept of a minipuberty in infant girls similar to that in boys...
  18. ncbi request reprint Changes in anti-Müllerian hormone (AMH) throughout the life span: a population-based study of 1027 healthy males from birth (cord blood) to the age of 69 years
    L Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, and Department of Biostatistics, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 95:5357-64. 2010
    ..AMH is a testis-specific marker used for diagnosis in infants with ambiguous genitalia or bilateral cryptorchidism...
  19. ncbi request reprint Serum sex hormone-binding globulin levels in healthy children and girls with precocious puberty before and during gonadotropin-releasing hormone agonist treatment
    K Sørensen
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:3189-96. 2007
    ..The regulation of SHBG is complex and influenced by sex steroids and insulin...
  20. ncbi request reprint A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:1005-11. 2009
    ..The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys...
  21. doi request reprint Low semen volume in 47 adolescents and adults with 47,XXY Klinefelter or 46,XX male syndrome
    L Aksglaede
    University Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 32:376-84. 2009
    ..The small semen volume supports the notion of 47,XXY patients being androgen insufficient despite serum testosterone levels within the normal range...
  22. ncbi request reprint Skin morphological changes in growth hormone deficiency and acromegaly
    M Lange
    Department of Endocrinology, National University Hospital (Rigshospitalet, Copenhagen, Denmark
    Eur J Endocrinol 145:147-53. 2001
    ..Importantly, these changes are not fully reversed despite long-term and adequate GH treatment in patients with childhood onset GHD...
  23. doi request reprint Association between GH receptor polymorphism (exon 3 deletion), serum IGF1, semen quality, and reproductive hormone levels in 838 healthy young men
    M Andreassen
    Department of Growth and Reproduction GR, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Rigshospitalet Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur J Endocrinol 170:555-63. 2014
    ..A common genetic polymorphism in the gene encoding the GH receptor (GHR) results in deletion of the entire exon 3 sequence (GHRd3 isoform). The short GHRd3/d3 isoform seems more sensitive compared with full-length receptors (GHRfl/fl)...
  24. ncbi request reprint Growth hormone (GH) activity is associated with increased serum oestradiol and reduced anti-Müllerian hormone in healthy male volunteers treated with GH and a GH antagonist
    M Andreassen
    Department of Internal Medicine, Endocrine Unit, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Andrology 1:595-601. 2013
    ..As a novel observation, we found that high GH activity was associated with reduced levels of the Sertoli cell marker AMH. Further studies are needed to evaluate possible effects of GH on Sertoli cell function and/or spermatogenesis...
  25. ncbi request reprint Hormonal changes during GnRH analogue therapy in children with central precocious puberty
    J Muller
    Clinic of Growth and Reproduction, The Juliane Marie Centre, The University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Pediatr Endocrinol Metab 13:739-46. 2000
    ..These findings are in accord with the observed decrease in height velocity in children with CPP under treatment with GnRHa, and may also play a role in the relatively small gain in final height in most patients...
  26. doi request reprint Adverse metabolic risk profiles in Greenlandic Inuit children compared to Danish children
    T Munch-Andersen
    Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 21:1226-31. 2013
    ..The objective was, therefore, in the comparison with Danish children, to evaluate metabolic profiles in Greenlandic Inuit children from the capital in the southern and from the northern most villages..
  27. doi request reprint Early breast development in girls after prenatal exposure to non-persistent pesticides
    C Wohlfahrt-Veje
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 35:273-82. 2012
    ..In addition, lower serum AMH levels indicated a reduced pool of antral ovarian follicles. The long-term consequences of our findings with regard to establishment of future reproductive function still remain unknown...
  28. ncbi request reprint A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth
    M Chellakooty
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 89:384-91. 2004
    ..In addition, we found a highly significant association between the increase in placental GH and the increase in IGF-I. The gestational age at peak placental GH levels was associated with pregnancy length...
  29. ncbi request reprint The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficienc
    A Juul
    Department of Growth and Reproduction, National University Hospital, Copenhagen, Denmark
    J Clin Endocrinol Metab 83:4408-15. 1998
    ..We suggest that ALS determination may be used in future classification of adults suspected of GHD...
  30. ncbi request reprint Pubertal development in Danish children: comparison of recent European and US data
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark
    Int J Androl 29:247-55; discussion 286-90. 2006
    ..Therefore, we believe it is crucial to monitor the pubertal development closely in Denmark in the coming decades...
  31. ncbi request reprint Adiponectin levels measured in dried blood spot samples from neonates born small and appropriate for gestational age
    A Klamer
    Department of Neonatology section 5021, National University Hospital, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Eur J Endocrinol 157:189-94. 2007
    ..The aim of the study was to measure adiponectin levels in routinely collected neonatal DBSS taken on day 5 (range 3-12) postnatal from infants...
  32. ncbi request reprint New Danish reference values for height, weight and body mass index of children aged 0-5 years
    A M Nielsen
    National Institute of Public Health, Southern University of Denmark, Copenhagen, Denmark
    Acta Paediatr 99:268-78. 2010
    ..To derive new reference values for height, weight and body mass index (BMI) of children aged 0-5 years in Denmark and to compare them with the national reference from the 1970s and the 2006 WHO standard...
  33. doi request reprint Testicular function and fertility in men with Klinefelter syndrome: a review
    L Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, Section 5064, University of Copenhagen, Copenhagen, Denmark
    Eur J Endocrinol 168:R67-76. 2013
    ....
  34. doi request reprint Serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione and testosterone in children determined by TurboFlow-LC-MS/MS
    T Søeborg
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Clin Chim Acta 419:95-101. 2013
    ..The presented method is suitable in a clinical setting for simultaneous quantification of five steroids important for management of children with disorders of sex development and steroid biosynthesis defects...
  35. ncbi request reprint Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations
    N E Skakkebaek
    University Department of Growth and Reproduction GR, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:198-204; discussion 204-5. 2007
    ....
  36. ncbi request reprint A simple screening method for detection of Klinefelter syndrome and other X-chromosome aneuploidies based on copy number of the androgen receptor gene
    A M Ottesen
    Department of Growth and Reproduction, Juliane Marie Centre, Section GR 5064, The National University Hospital of Copenhagen, DK 2100, Copenhagen, Denmark
    Mol Hum Reprod 13:745-50. 2007
    ..Our findings demonstrated that the AR-qPCR technique is a simple and reliable screening method for diagnosis of patients with Klinefelter syndrome or other chromosomal disorders involving an aberrant number of X-chromosomes...
  37. ncbi request reprint Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality
    M Blomberg Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 35:499-510. 2012
    ..In conclusion, we suggest that CYP24A1 expression at the annulus may serve as a novel marker of semen quality and an objective proxy for sperm function...
  38. doi request reprint Maternal serum placental growth hormone, but not human placental lactogen or insulin growth factor-1, is positively associated with fetal growth in the first half of pregnancy
    N G Pedersen
    Department of Fetal Medicine and Ultrasound, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Ultrasound Obstet Gynecol 36:534-41. 2010
    ..To investigate if maternal levels of human placental lactogen (hPL), placental growth hormone (PGH) and insulin-like growth factor-1 (IGF-1) are associated with growth rate of the biparietal diameter (BPD) in the first half of pregnancy...
  39. ncbi request reprint Children conceived after intracytoplasmic sperm injection (ICSI): is there a role for the paediatrician?
    C Mau
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 93:1238-44. 2004
    ..The aim of the study was to evaluate current medical knowledge about children born after intracytoplasmic sperm injection (ICSI) with respect to congenital malformations, chromosome abnormalities and postnatal growth...
  40. ncbi request reprint Determination of insulin-like growth factor-I in the monitoring of growth hormone treatment with respect to efficacy of treatment and side effects: should potential risks of cardiovascular disease and cancer be considered?
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Horm Res 51:141-8. 1999
    ..Consequently, life-time exposure to IGF-I should be considered in all patients treated with GH, and IGF-I should preferably be kept within normal age-related ranges in children as well as in adults...
  41. ncbi request reprint Cardiovascular risk factors in men: The role of gonadal steroids and sex hormone-binding globulin
    J Gyllenborg
    Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Denmark
    Metabolism 50:882-8. 2001
    ..Thus, further studies on the potential role of SHBG in the development of ischemic heart disease (IHD) should be performed...
  42. ncbi request reprint The acid-labile subunit of the ternary insulin-like growth factor complex in cirrhosis: relation to liver dysfunction
    S Møller
    Department of Clinical Physiology, Herlev Hospital, Denmark
    J Hepatol 32:441-6. 2000
    ..The aim of the present study was therefore to measure circulating and hepatic venous concentrations of ALS in relation to hepatic function and the IGF axis...
  43. ncbi request reprint Continuation of growth hormone (GH) replacement in GH-deficient patients during transition from childhood to adulthood: a two-year placebo-controlled study
    N Vahl
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Denmark
    J Clin Endocrinol Metab 85:1874-81. 2000
    ..By contrast, continuation of GH therapy results in unaltered IGF-I and body composition. We recommend continuation of GH therapy in these patients, to be undertaken in collaboration between pediatricians and adult endocrinologists...
  44. ncbi request reprint Growth hormone enhances effects of endurance training on oxidative muscle metabolism in elderly women
    K H Lange
    Sports Medicine Research Unit, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 279:E989-96. 2000
    ..In conclusion, rhGH adds to the effects of endurance training on muscle oxidative enzymes and causes a reduction in body fat in elderly women...
  45. ncbi request reprint GH administration and discontinuation in healthy elderly men: effects on body composition, GH-related serum markers, resting heart rate and resting oxygen uptake
    K H Lange
    Sports Medicine Research Unit, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen, Denmark
    Clin Endocrinol (Oxf) 55:77-86. 2001
    ....
  46. ncbi request reprint Endurance training and GH administration in elderly women: effects on abdominal adipose tissue lipolysis
    K H Lange
    Sports Medicine Research Unit, Bispebjerg Hospital, DK 2400 Copenhagen NV, Denmark
    Am J Physiol Endocrinol Metab 280:E886-97. 2001
    ....
  47. ncbi request reprint The insulin-like growth axis in patients with autoimmune thyrotoxicosis: effect of antithyroid drug treatment
    T Zimmermann-Belsing
    Department of Endocrinology, PE 2131, University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Growth Horm IGF Res 14:235-44. 2004
    ....
  48. ncbi request reprint Serum inhibin B, FSH, LH and testosterone levels before and after human chorionic gonadotropin stimulation in prepubertal boys with cryptorchidism
    P Christiansen
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Denmark
    Eur J Endocrinol 147:95-101. 2002
    ..It is not known if inhibin B can be used to demonstrate early damage of seminiferous tubules in prepubertal boys with cryptorchidism...
  49. ncbi request reprint Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly
    S B Sneppen
    Department of Endocrinology, Rigshospitalet, Denmark
    Growth Horm IGF Res 11:384-91. 2001
    ..None of the parameters can at present be claimed to be superior to the others and thus all the measured parameters are recommended to be part of the evaluation of acromegalic patients...
  50. doi request reprint Menopause is associated with decreased whole body fat oxidation during exercise
    J Abildgaard
    Centre of Inflammation and Metabolism, Faculty of Health Sciences, Department of Infectious Diseases and CMRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 304:E1227-36. 2013
    ..06). We conclude that reduced whole body fat oxidation after menopause is associated with reduced LBM...
  51. ncbi request reprint Preserved fertility in a non-mosaic Klinefelter patient with a mutation in the fibroblast growth factor receptor 3 gene: case report
    A Juul
    Department of Growth and Reproduction GR, Rigshospitalet Section 5064, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod 22:1907-11. 2007
    ....
  52. doi request reprint Lower levels of circulating IGF-I in Type 1 diabetic women with frequent severe hypoglycaemia during pregnancy
    L Ringholm Nielsen
    Copenhagen Center for Pregnant Women with Diabetes, Departments of Endocrinology, Rigshospitalet, Faculty of Health Sciences, Copenhagen, Denmark
    Diabet Med 25:826-33. 2008
    ..We explored whether frequent severe hypoglycaemia during pregnancy in women with Type 1 diabetes is related to placental growth hormone (GH) and insulin-like growth factor I (IGF-I) levels...
  53. ncbi request reprint Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys
    Anna Maria Andersson
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Sect GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:4696-705. 2007
    ..These secular trends may also be reflected by changes in Leydig cell function...
  54. ncbi request reprint Continuation of growth hormone therapy versus placebo in transition-phase patients with growth hormone deficiency: impact on body composition, insulin sensitivity, and thyroid function
    Jens O L Jørgensen
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, Aarhus, Denmark
    J Pediatr Endocrinol Metab 15:1355-60. 2002
    ....
  55. ncbi request reprint Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:169-76. 2008
    ..Growth is a highly complex process regulated by the interaction between sex steroids and the GH IGF-axis. However, other factors such as sex chromosome-related genes play independent roles...
  56. ncbi request reprint Fetal growth velocity, size in early life and adolescence, and prediction of bone mass: association to the GH-IGF axis
    Rikke Beck Jensen
    University Department of Growth and Reproduction Rigshospitalet, Copenhagen, Denmark
    J Bone Miner Res 23:439-46. 2008
    ..These associations were mediated by the current height and weight, but it was not confirmed that alterations of the GH-IGF axis cause this...
  57. doi request reprint Changes in circulating level of IGF-I and IGF-binding protein-1 from the first to second trimester as predictors of preeclampsia
    Lars J Vatten
    Department of Public Health, Norwegian University of Science and Technology, NO 7489 Trondheim, Norway
    Eur J Endocrinol 158:101-5. 2008
    ..To assess whether circulating IGF-I and IGF-binding protein-1 (IGFBP-1) in the first and second trimester are associated with subsequent risk of preterm and term preeclampsia...
  58. ncbi request reprint [Testosterone treatment of elderly men. The so called andropause doesn't exist]
    Anders Juul
    HS Rigshospitalet, afdeling for vaekst og reproduktion GR 5064
    Ugeskr Laeger 164:4941-2. 2002
  59. pmc Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Eur J Endocrinol 158:803-10. 2008
    ..The aim of this study was to investigate the neuroendocrine integrity of the pituitary-gonadal axis in patients with primary testicular failure due to supernumerary X chromosomes...
  60. ncbi request reprint Subcutaneous abdominal adipose tissue lipolysis during exercise determined by arteriovenous measurements in older women
    Kai Henrik Wiborg Lange
    Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    J Am Geriatr Soc 50:275-81. 2002
    ..To characterize the lipolytic response in the subcutaneous abdominal adipose tissue in older women to endurance exercise...
  61. ncbi request reprint An audit of the insulin-tolerance test in 255 patients with pituitary disease
    Martin Lange
    Department of Endocrinology, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur J Endocrinol 147:41-7. 2002
    ..The aim of this study was to determine factors that may influence nadir blood glucose (BG) when using a mean insulin dose of 0.1 IU/kg body weight. Furthermore, we wanted to evaluate the safety and GH-related aspects of the ITT...
  62. ncbi request reprint GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men
    Kai Henrik Wiborg Lange
    Sports Medicine Research Unit, Bispebjerg Hospital, DK 2400 Copenhagen NV, Denmark
    J Clin Endocrinol Metab 87:513-23. 2002
    ..Our results do not support a role for GH as a means of increasing muscle strength or mass, either alone or combined with RT, in healthy elderly men; although GH administration alone may induce changes in MHC composition...
  63. ncbi request reprint Maximum likelihood estimation for Cox's regression model under nested case-control sampling
    Thomas H Scheike
    Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 KBH N, Denmark
    Biostatistics 5:193-206. 2004
    ..We illustrate the use of the MLE for these data and show how the maximum likelihood framework can be used to obtain information additional to the relative risk estimates of covariates...
  64. ncbi request reprint High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    Eur J Endocrinol 157:345-50. 2007
    ..The aim of this study was to evaluate the HPG axis in KS infants...
  65. ncbi request reprint Increase in maternal placental growth hormone during pregnancy and disappearance during parturition in normal and growth hormone-deficient pregnancies
    Ulla Lønberg
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Am J Obstet Gynecol 188:247-51. 2003
    ....
  66. ncbi request reprint [Growth hormone treatment of short children born small for gestational age]
    Henrik B Thybo Christesen
    Odense Universitetshospital, Børneafdelingen, H S Rigshospitalet, Afdeling for Vaekst
    Ugeskr Laeger 168:889-95. 2006
    ..The Danish consensus guidelines for diagnosis, treatment and control of short SGA children are described in this review...
  67. ncbi request reprint Protein intake at 9 mo of age is associated with body size but not with body fat in 10-y-old Danish children
    Camilla Hoppe
    Department of Human Nutrition and Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 79:494-501. 2004
    ..A high PI probably has both endocrine and physiologic effects and may increase the risk of obesity...
  68. ncbi request reprint Serum insulin-like growth factor-I (IGF-I) and growth in children born after assisted reproduction
    Claudia Mau Kai
    University Department of Growth and Reproduction, Rigshospitalet Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:4352-60. 2006
    ..Concern has been raised about the safety of assisted reproduction techniques for the offspring...
  69. ncbi request reprint Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects
    Michael Højby Rasmussen
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, DK 2650 Copenhagen, Denmark
    Eur J Endocrinol 155:575-81. 2006
    ..The main purpose of this study was to determine free IGF-I, ALS, IGFBPs-1-4, and IGFBPs-1-3 protease activity in relation to 24-h GH release before and after a short-term very low-calorie diet (VLCD)...
  70. ncbi request reprint Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 66:276-81. 2007
    ..The combined evaluation of serum LH and testosterone levels in the evaluation of testicular failure has not been widely advocated...
  71. ncbi request reprint The impact of idiopathic childhood-onset growth hormone deficiency (GHD) on bone mass in subjects without adult GHD
    Martin Lange
    Department of Endocrinology, Rigshospitalet, Glostrup, Denmark
    Clin Endocrinol (Oxf) 62:18-23. 2005
    ..The aim was to evaluate BMD and bone mineral content (BMC) in adults treated for idiopathic childhood-onset (CO) GHD, 18 years after stopping GH treatment...
  72. ncbi request reprint Pituitary-gonadal function in adolescent males born appropriate or small for gestational age with or without intrauterine growth restriction
    Rikke Beck Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 92:1353-7. 2007
    ..Being born small for gestational age (SGA) is suggested to influence female pituitary-gonadal axis, but only a few studies have focused on male pituitary-gonadal function...
  73. ncbi request reprint Insulin-like growth factor I (IGF-I) and IGF-binding protein 3 as diagnostic markers of growth hormone deficiency in infancy
    Rikke Beck Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Horm Res 63:15-21. 2005
    ..The diagnosis of growth hormone deficiency (GHD) in infancy is difficult, and no specific cutoff value during GH provocative testing is recommended in early life...
  74. ncbi request reprint Effect of growth hormone replacement therapy on pituitary hormone secretion and hormone replacement therapies in GHD adults
    Erika Hubina
    Department of Medicine, National Medical Center, Budapest, Hungary
    Horm Res 61:211-7. 2004
    ....
  75. ncbi request reprint High risk of adrenal insufficiency in adults previously treated for idiopathic childhood onset growth hormone deficiency
    Martin Lange
    Department of Endocrinology, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:5784-9. 2003
    ..It is imperative that pituitary axes other than the GH axis are tested at regular intervals, even in the absence of GHD in adulthood...
  76. ncbi request reprint Intrauterine growth retardation and consequences for endocrine and cardiovascular diseases in adult life: does insulin-like growth factor-I play a role?
    Rikke Bodin Beck Jensen
    University Department of Growth and Reproduction GR, Rigshospitalet, Copenhagen, Denmark
    Horm Res 60:136-48. 2003
    ..Thus IGF-I may serve as a link between fetal growth and adult-onset disease...
  77. ncbi request reprint Age at voice break in Danish boys: effects of pre-pubertal body mass index and secular trend
    Anders Juul
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:537-42. 2007
    ..Our findings indicate that puberty, as assessed by age at voice break in boys, may be starting earlier in Denmark as it has been observed in the USA, and suggest a relationship between pre-pubertal BMI and the timing of puberty...
  78. ncbi request reprint Reduced serum testosterone levels in infant boys conceived by intracytoplasmic sperm injection
    Claudia Mau Kai
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:2598-603. 2007
    ..Concern has been raised for the health of the offspring conceived by assisted reproduction technologies. Basal reproductive hormones around 3 months of age reflect the pituitary-testicular axis, which is transiently active at this age...
  79. ncbi request reprint Effect of weight loss on free insulin-like growth factor-I in obese women with hyposomatotropism
    Michael H Rasmussen
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Denmark
    Obesity (Silver Spring) 15:879-86. 2007
    ....
  80. ncbi request reprint The presence of the d3-growth hormone receptor polymorphism is negatively associated with fetal growth but positively associated with postnatal growth in healthy subjects
    Rikke Beck Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 92:2758-63. 2007
    ..A common polymorphism in the GH receptor (GHR) gene has been linked to increased growth response in GH-treated patients. No former study has focused on the association to prenatal growth...
  81. ncbi request reprint Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children
    Camilla Hoppe
    Department of Human Nutrition and the Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg, Denmark
    Am J Clin Nutr 80:447-52. 2004
    ..Whether the same association exists in industrialized countries, where protein intake is high, is not clear...
  82. ncbi request reprint Is human fecundity declining?
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:2-11. 2006
    ..This research effort can hardly be carried out without major support from governments and granting agencies making it possible to fund collaborative projects within novel research networks of scientists...
  83. ncbi request reprint The CSF and arterial to internal jugular venous hormonal differences during exercise in humans
    Mads K Dalsgaard
    Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Exp Physiol 89:271-7. 2004
    ..The results support the notion that the exercise-induced changes in brain metabolism are controlled by factors intrinsic to the brain...
  84. ncbi request reprint Putative effects of endocrine disrupters on pubertal development in the human
    Grete Teilmann
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Best Pract Res Clin Endocrinol Metab 16:105-21. 2002
    ..While it is very plausible that endocrine disrupters may disturb pubertal development, there is very little research on this and, therefore, we do not yet have any clear cause-effect relationships in humans...
  85. ncbi request reprint The sensitivity of the child to sex steroids: possible impact of exogenous estrogens
    Lise Aksglaede
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod Update 12:341-9. 2006
    ..Because no lower threshold for estrogenic action has been established, caution should be taken to avoid unnecessary exposure of fetuses and children to exogenous sex steroids and endocrine disruptors, even at very low levels...
  86. ncbi request reprint Longitudinal study of serum placental GH in 455 normal pregnancies: correlation to gestational age, fetal gender, and weight
    Marla Chellakooty
    Department of Growth and Reproduction, Righospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 87:2734-9. 2002
    ....
  87. ncbi request reprint Natural history of seminiferous tubule degeneration in Klinefelter syndrome
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Hum Reprod Update 12:39-48. 2006
    ....
  88. pmc Forty years trends in timing of pubertal growth spurt in 157,000 Danish school children
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 3:e2728. 2008
    ..The aim of our study was to determine if the age at onset of pubertal growth spurt (OGS) and at peak height velocity (PHV) during puberty show secular trends during four decades in a large cohort of school children...
  89. ncbi request reprint [Pituitary insufficiency following head trauma]
    Marianne C Klose
    Rigshospitalet, Endokrinologisk Afdeling, Afdelingen for Vaekst, København Ø
    Ugeskr Laeger 169:211-3. 2007
    ..As untreated hypopituitarism is likely to delay recovery and rehabilitation, this calls for a change in the current management of patients suffering traumatic brain injury. In this article, we will review current knowledge in this field...
  90. doi request reprint Thyroid autoantibodies and thyroid function in subjects exposed to Chernobyl fallout during childhood: evidence for a transient radiation-induced elevation of serum thyroid antibodies without an increase in thyroid autoimmune disease
    Laura Agate
    Department of Endocrinology, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Clin Endocrinol Metab 93:2729-36. 2008
    ..An increase in the prevalence of thyroid autoantibodies (ATAs) was reported 6-8 yr after the Chernobyl accident in radiation-exposed children and adolescents...
  91. ncbi request reprint Does breast feeding influence liver biochemistry?
    Marianne Hørby Jørgensen
    Department of Paediatrics, Hillerød Hospital, Hillerød, Denmark
    J Pediatr Gastroenterol Nutr 37:559-65. 2003
    ..The authors sought to determine how feeding mode affected liver biochemistry in healthy term infants...
  92. doi request reprint Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings
    Susan Y Euling
    National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC 20460, USA
    Pediatrics 121:S172-91. 2008
    ....