Peter L Jorgensen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Structure-function relationships based on ATP binding and cation occlusion at equilibrium in Na,K-ATPase
    P L Jorgensen
    Biomembrane Research Center, August Krogh Institute, University of Copenhagen, Denmark
    Acta Physiol Scand Suppl 643:79-87. 1998
  2. ncbi request reprint Regulation and function of lysine-substituted Na,K pumps in salt adaptation of Artemia franciscana
    Peter Leth Jorgensen
    Department of Molecular Biology, University of Copenhagen, Universitetsparken 13, Copenhagen OE, Denmark
    J Membr Biol 221:39-49. 2008
  3. ncbi request reprint [Status report on the research of Na,K-ATPase, Ca-ATPase and other P-type cation pumps]
    Peter Leth Jørgensen
    Københavns Universitet
    Ugeskr Laeger 166:1886-8. 2004
  4. ncbi request reprint Transmission of E1-E2 structural changes in response to Na+ or K+ binding in Na,K-ATPase
    Peter L Jorgensen
    Biomembrane Center, University of Copenhagen, Denmark
    Ann N Y Acad Sci 986:22-30. 2003
  5. ncbi request reprint Structure and mechanism of Na,K-ATPase: functional sites and their interactions
    Peter L Jorgensen
    Biomembrane Center, August Krogh Institute, Copenhagen University, Universitetsparken 13, 2100 Copenhagen OE, Denmark
    Annu Rev Physiol 65:817-49. 2003
  6. ncbi request reprint Role of conserved TGDGVND-loop in Mg2+ binding, phosphorylation, and energy transfer in Na,K-ATPase
    P L Jorgensen
    Biomembrane Research Center, August Krogh Institute, Copenhagen University, Denmark
    J Bioenerg Biomembr 33:367-77. 2001
  7. ncbi request reprint Aspects of gene structure and functional regulation of the isozymes of Na,K-ATPase
    P L Jorgensen
    Biomembrane Center, August Krogh Institute, Copenhagen University, Denmark
    Cell Mol Biol (Noisy-le-grand) 47:231-8. 2001
  8. ncbi request reprint Structure-function relationships of Na(+), K(+), ATP, or Mg(2+) binding and energy transduction in Na,K-ATPase
    P L Jorgensen
    Biomembrane Center, August Krogh Institute, Copenhagen University, Universitetsparken 13, 2100 OE, Copenhagen, Denmark
    Biochim Biophys Acta 1505:57-74. 2001
  9. doi request reprint Importance for absorption of Na+ from freshwater of lysine, valine and serine substitutions in the alpha1a-isoform of Na,K-ATPase in the gills of rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar)
    Peter Leth Jorgensen
    Department of Molecular Biology, University of Copenhagen, Universitetsparken 13, Copenhagen OE, Denmark
    J Membr Biol 223:37-47. 2008
  10. ncbi request reprint Cloning, expression, purification and crystallization of the N-domain from the alpha(2) subunit of the membrane-spanning Na,K-ATPase protein
    Lisbeth Haue
    Biomembrane Center, August Krogh Institute, Copenhagen University, Universitetsparken 13, 2100 Copenhagen OE, Denmark
    Acta Crystallogr D Biol Crystallogr 59:1259-61. 2003

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Structure-function relationships based on ATP binding and cation occlusion at equilibrium in Na,K-ATPase
    P L Jorgensen
    Biomembrane Research Center, August Krogh Institute, University of Copenhagen, Denmark
    Acta Physiol Scand Suppl 643:79-87. 1998
    ..These carboxylate groups in transmembrane segments 4, 5, and 6 therefore appear to be essential for high affinity occlusion of K(+)-ions...
  2. ncbi request reprint Regulation and function of lysine-substituted Na,K pumps in salt adaptation of Artemia franciscana
    Peter Leth Jorgensen
    Department of Molecular Biology, University of Copenhagen, Universitetsparken 13, Copenhagen OE, Denmark
    J Membr Biol 221:39-49. 2008
    ..Salt-induced expression of the alpha(2)(KK)-subunit Na,K-ATPase in A. franciscana may reduce the Na(+)/ATP ratio and enable the Na,K pump to extrude Na(+) against steeper gradients and, thus, contribute to salt adaptation...
  3. ncbi request reprint [Status report on the research of Na,K-ATPase, Ca-ATPase and other P-type cation pumps]
    Peter Leth Jørgensen
    Københavns Universitet
    Ugeskr Laeger 166:1886-8. 2004
  4. ncbi request reprint Transmission of E1-E2 structural changes in response to Na+ or K+ binding in Na,K-ATPase
    Peter L Jorgensen
    Biomembrane Center, University of Copenhagen, Denmark
    Ann N Y Acad Sci 986:22-30. 2003
    ..Protection of the chymotrypsin-sensitive bond at Leu266 in L2/3 and rotation of the A domain is more complete in the E(2)Mg-vanadate-ouabain complex than in the E(2)[2K] form...
  5. ncbi request reprint Structure and mechanism of Na,K-ATPase: functional sites and their interactions
    Peter L Jorgensen
    Biomembrane Center, August Krogh Institute, Copenhagen University, Universitetsparken 13, 2100 Copenhagen OE, Denmark
    Annu Rev Physiol 65:817-49. 2003
    ....
  6. ncbi request reprint Role of conserved TGDGVND-loop in Mg2+ binding, phosphorylation, and energy transfer in Na,K-ATPase
    P L Jorgensen
    Biomembrane Research Center, August Krogh Institute, Copenhagen University, Denmark
    J Bioenerg Biomembr 33:367-77. 2001
    ..Transmission of structural changes between the P-domain and cation sites in the membrane domain is evaluated in light of the protein structure, and the information from proteolytic or metal-catalyzed cleavage and mutagenesis studies...
  7. ncbi request reprint Aspects of gene structure and functional regulation of the isozymes of Na,K-ATPase
    P L Jorgensen
    Biomembrane Center, August Krogh Institute, Copenhagen University, Denmark
    Cell Mol Biol (Noisy-le-grand) 47:231-8. 2001
    ....
  8. ncbi request reprint Structure-function relationships of Na(+), K(+), ATP, or Mg(2+) binding and energy transduction in Na,K-ATPase
    P L Jorgensen
    Biomembrane Center, August Krogh Institute, Copenhagen University, Universitetsparken 13, 2100 OE, Copenhagen, Denmark
    Biochim Biophys Acta 1505:57-74. 2001
    ..Transition to the E(2)P form involves a shift of Mg(2+) coordination away from Asp(710) and Asn(713) and the two residues become more important for hydrolysis of the acyl phosphate bond at Asp(369)...
  9. doi request reprint Importance for absorption of Na+ from freshwater of lysine, valine and serine substitutions in the alpha1a-isoform of Na,K-ATPase in the gills of rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar)
    Peter Leth Jorgensen
    Department of Molecular Biology, University of Copenhagen, Universitetsparken 13, Copenhagen OE, Denmark
    J Membr Biol 223:37-47. 2008
    ....
  10. ncbi request reprint Cloning, expression, purification and crystallization of the N-domain from the alpha(2) subunit of the membrane-spanning Na,K-ATPase protein
    Lisbeth Haue
    Biomembrane Center, August Krogh Institute, Copenhagen University, Universitetsparken 13, 2100 Copenhagen OE, Denmark
    Acta Crystallogr D Biol Crystallogr 59:1259-61. 2003
    ..5 A, and diffract to 3.1 A. Complete data sets could be collected from native and thimerosal-treated crystals frozen in 50% sucrose. Five mercury positions were found and initial SIR phases calculated...
  11. ncbi request reprint Importance of Na,K-ATPase residue alpha 1-Arg544 in the segment Arg544-Asp567 for high-affinity binding of ATP, ADP, or MgATP
    Mette Dorph Jacobsen
    Biomembrane Research Center, Copenhagen University, 2100 Copenhagen OE, Denmark
    Biochemistry 41:1451-6. 2002
    ..In conclusion, Arg(544) is important for binding of ATP or ADP, probably by stabilizing the beta- or gamma-phosphate moieties and aligning the gamma-phosphate for interaction with the carboxylate group of Asp(369)...
  12. ncbi request reprint Expression of a Na,K-ATPase-EGFP chimera in COS cells: can internalization explain PKA- or PKC-mediated inhibition of 86Rb uptake?
    Bo Kristensen
    Biomembrane Center, The August Krogh Institute, University of Copenhagen, Universitetsparken 13, Denmark
    Ann N Y Acad Sci 986:546-7. 2003