P H Jensen

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. pmc FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy
    Christine L Kragh
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    PLoS ONE 8:e55243. 2013
  2. ncbi request reprint Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments
    P H Jensen
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark, Arpida AG, Munchenstein 4142, Switzerland
    J Biol Chem 275:21500-7. 2000
  3. ncbi request reprint Axonal transport of synucleins is mediated by all rate components
    P H Jensen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Eur J Neurosci 11:3369-76. 1999
  4. ncbi request reprint alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356
    P H Jensen
    Department of Medical Biochemistry, University of Aarhus, Ole Worms Alle, Building 170, DK 8000 Aarhus C, Denmark
    J Biol Chem 274:25481-9. 1999
  5. ncbi request reprint Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
    P H Jensen
    Department of Medical Biochemistry, Building 170, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 273:26292-4. 1998
  6. pmc Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC
    P H Jensen
    Department of Medical Biochemistry, University of Aarhus, Ole Worms Alle, Building 170, DK 8000 Aarhus C, Denmark
    Biochem J 323:539-46. 1997
  7. ncbi request reprint Ca2+ binding to alpha-synuclein regulates ligand binding and oligomerization
    M S Nielsen
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 276:22680-4. 2001
  8. pmc Caspase I-related protease inhibition retards the execution of okadaic acid- and camptothecin-induced apoptosis and PAI-2 cleavage, but not commitment to cell death in HL-60 cells
    P H Jensen
    Department of Medical Biochemistry, Aarhus University, Aarhus C, Denmark
    Br J Cancer 79:1685-91. 1999
  9. pmc Cleaved intracellular plasminogen activator inhibitor 2 in human myeloleukaemia cells is a marker of apoptosis
    P H Jensen
    Department of Medical Biochemistry, Aarhus University, Denmark
    Br J Cancer 70:834-40. 1994
  10. ncbi request reprint Localization of a single transglutaminase-reactive glutamine in the third domain of RAP, the alpha2-macroglobulin receptor-associated protein
    L K Rasmussen
    Protein Chemistry Laboratory, University of Aarhus, Denmark
    J Protein Chem 18:69-73. 1999

Collaborators

Detail Information

Publications13

  1. pmc FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy
    Christine L Kragh
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    PLoS ONE 8:e55243. 2013
    ....
  2. ncbi request reprint Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments
    P H Jensen
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark, Arpida AG, Munchenstein 4142, Switzerland
    J Biol Chem 275:21500-7. 2000
    ..MAP-1B also bound in vitro assembled alpha-synuclein fibrils. Thus, MAP-1B may be involved in the pathogenesis of Lewy bodies via its interaction with monomeric and fibrillar alpha-synuclein...
  3. ncbi request reprint Axonal transport of synucleins is mediated by all rate components
    P H Jensen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Eur J Neurosci 11:3369-76. 1999
    ..Two-dimensional gel electrophoresis revealed that both alpha- and beta-synuclein migrate through the nerve by slow component b in a ratio of 2:1...
  4. ncbi request reprint alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356
    P H Jensen
    Department of Medical Biochemistry, University of Aarhus, Ole Worms Alle, Building 170, DK 8000 Aarhus C, Denmark
    J Biol Chem 274:25481-9. 1999
    ..We propose that alpha-synuclein modulates the phosphorylation of soluble axonal tau and thereby indirectly affects the stability of axonal microtubules...
  5. ncbi request reprint Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
    P H Jensen
    Department of Medical Biochemistry, Building 170, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 273:26292-4. 1998
    ..We find alpha-synuclein with the A30P mutation of familial Parkinson's disease devoid of vesicle-binding activity and propose that mutant alpha-synuclein may accumulate, leading to assembly into Lewy body filaments...
  6. pmc Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC
    P H Jensen
    Department of Medical Biochemistry, University of Aarhus, Ole Worms Alle, Building 170, DK 8000 Aarhus C, Denmark
    Biochem J 323:539-46. 1997
    ..It is proposed that the multiple Abeta-binding sites in alpha-synuclein are involved in the development of amyloid plaques...
  7. ncbi request reprint Ca2+ binding to alpha-synuclein regulates ligand binding and oligomerization
    M S Nielsen
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 276:22680-4. 2001
    ..This suggests that Ca(2+) ions may both participate in normal alpha-synuclein functions in the nerve terminal and exercise pathological effects involved in the formation of Lewy bodies...
  8. pmc Caspase I-related protease inhibition retards the execution of okadaic acid- and camptothecin-induced apoptosis and PAI-2 cleavage, but not commitment to cell death in HL-60 cells
    P H Jensen
    Department of Medical Biochemistry, Aarhus University, Aarhus C, Denmark
    Br J Cancer 79:1685-91. 1999
    ..The results suggest that caspase I selective protease inhibition could antagonize parameters coupled to the execution phase of okadaic acid- and camptothecin-induced apoptosis, but not the commitment to cell death...
  9. pmc Cleaved intracellular plasminogen activator inhibitor 2 in human myeloleukaemia cells is a marker of apoptosis
    P H Jensen
    Department of Medical Biochemistry, Aarhus University, Denmark
    Br J Cancer 70:834-40. 1994
    ..The modified PAI-2 isoform was also detected in homogenates made from purified human mononuclear leukaemic cells aspirated from the bone marrow of patients suffering from acute and chronic myeloid leukaemia...
  10. ncbi request reprint Localization of a single transglutaminase-reactive glutamine in the third domain of RAP, the alpha2-macroglobulin receptor-associated protein
    L K Rasmussen
    Protein Chemistry Laboratory, University of Aarhus, Denmark
    J Protein Chem 18:69-73. 1999
    ..This residue is located in the third domain of RAP and is conserved among the RAP interspecies homologues. Insertion of a reporter group into the protein could prove useful to assess ligand/receptor interactions...
  11. ncbi request reprint The glycan structure of albumin Redhill, a glycosylated variant of human serum albumin
    U Kragh-Hansen
    Department of Medical Biochemistry, The University of Aarhus, Denmark
    Biochim Biophys Acta 1550:20-6. 2001
    ....
  12. ncbi request reprint Recombinant mannan-binding lectin (MBL) for therapy
    J C Jensenius
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Biochem Soc Trans 31:763-7. 2003
    ..A transfected human cell line produces MBL showing the same biological activity as plasma-derived MBL, and an essentially identical profile on MS. The production has been scaled up and clinical trials will start this year...
  13. ncbi request reprint alpha-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy
    W P Gai
    Department of Physiology and Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia
    Exp Neurol 181:68-78. 2003
    ..Our study indicates that GCI filaments are multilayered in structure, with alpha-synuclein oligomers forming the central core fibrils of the filaments...