- Inhibition of human aromatase complex (CYP19) by antiepileptic drugsN W Jacobsen
Section of Toxicology and Environmental Chemistry, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen Ø, Denmark
Toxicol In Vitro 22:146-53. 2008..When adding carbamazepine to a range of valproate concentrations no additional inhibition was seen. The data for some of the AEDs show that side effects on steroid synthesis in humans due to inhibition of aromatase should be considered...
- Suggesting a testing strategy for possible endocrine effects of drug metabolitesN W Jacobsen
Department of Pharmaceutics and Analytical Chemistry, Section of Toxicology, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
Regul Toxicol Pharmacol 62:441-8. 2012..Subsequently, a five step integrated strategy for screening of the potential endocrine effects of drugs and their metabolites are proposed...