Affiliation: University of Copenhagen
Højlund K, Beck Nielsen H. Impaired glycogen synthase activity and mitochondrial dysfunction in skeletal muscle: markers or mediators of insulin resistance in type 2 diabetes?. Curr Diabetes Rev. 2006;2:375-95 pubmed
Hojlund K, Wildner Christensen M, Eshøj O, Skjaerbaek C, Holst J, Koldkjaer O, et al
. Reference intervals for glucose, beta-cell polypeptides, and counterregulatory factors during prolonged fasting. Am J Physiol Endocrinol Metab. 2001;280:E50-8 pubmed
..We observed a diminished beta-cell response concomitant with an increased secretion of counterregulatory hormones. These results should be of clinical and scientific value in the investigation of hypoglycemic disorders...
Højlund K, Yi Z, Lefort N, Langlais P, Bowen B, Levin K, et al
. Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle. Diabetologia. 2010;53:541-51 pubmed publisher
..Further characterisation of phosphorylation of ATPsyn-beta may offer novel targets of treatment in human diseases with mitochondrial dysfunction, such as diabetes. ..
Højlund K, Hansen T, Lajer M, Henriksen J, Levin K, Lindholm J, et al
. A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene. Diabetes. 2004;53:1592-8 pubmed
Højlund K, Frystyk J, Levin K, Flyvbjerg A, Wojtaszewski J, Beck Nielsen H. Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes. Diabetologia. 2006;49:1283-91 pubmed
Højlund K, Glintborg D, Andersen N, Birk J, Treebak J, Frøsig C, et al
. Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment. Diabetes. 2008;57:357-66 pubmed
..Moreover, our data provide correlative evidence that hyperandrogenism in PCOS may contribute to insulin resistance. ..