Else K Hoffmann

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. doi request reprint On the role of TRPC1 in control of Ca2+ influx, cell volume, and cell cycle
    C P Madsen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Cell Physiol 303:C625-34. 2012
  2. doi request reprint Ion channels involved in cell volume regulation: effects on migration, proliferation, and programmed cell death in non adherent EAT cells and adherent ELA cells
    Else Kay Hoffmann
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 28:1061-78. 2011
  3. doi request reprint Physiology of cell volume regulation in vertebrates
    Else K Hoffmann
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 89:193-277. 2009
  4. ncbi request reprint Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications
    Maria Rasmussen
    Department of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Cell Physiol 294:C197-212. 2008
  5. ncbi request reprint Shrinkage insensitivity of NKCC1 in myosin II-depleted cytoplasts from Ehrlich ascites tumor cells
    Else K Hoffmann
    Department of Molecular Biology, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    Am J Physiol Cell Physiol 292:C1854-66. 2007
  6. ncbi request reprint Cholesterol modulates the volume-regulated anion current in Ehrlich-Lettre ascites cells via effects on Rho and F-actin
    Thomas Kjaer Klausen
    Department of Biochemistry, Institute of Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Cell Physiol 291:C757-71. 2006
  7. ncbi request reprint Cell cycle-dependent activity of the volume- and Ca2+-activated anion currents in Ehrlich lettre ascites cells
    Thomas Kjaer Klausen
    Department of Biochemistry, Institute for Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark
    J Cell Physiol 210:831-42. 2007
  8. pmc Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts
    Linda Schneider
    Department of Biology, Section of Cell and Developmental Biology, The August Krogh Building, University of Copenhagen, DK 2100 Copenhagen OE, Denmark
    Cell Physiol Biochem 25:279-92. 2010
  9. ncbi request reprint Roles of Na+/H+ exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts
    Maria L Rentsch
    Department of Biochemistry, Institute for Molecular Biology and Physiology, University of Copenhagen, 13 Universitetsparken, 2100 Copenhagen Ø, Denmark
    Pflugers Arch 454:649-62. 2007
  10. doi request reprint Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization
    Sune T Jørgensen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 31:366-78. 2013

Collaborators

Detail Information

Publications25

  1. doi request reprint On the role of TRPC1 in control of Ca2+ influx, cell volume, and cell cycle
    C P Madsen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Cell Physiol 303:C625-34. 2012
    ....
  2. doi request reprint Ion channels involved in cell volume regulation: effects on migration, proliferation, and programmed cell death in non adherent EAT cells and adherent ELA cells
    Else Kay Hoffmann
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 28:1061-78. 2011
    ..Finally, I shall also briefly review current investigations in these two cell lines that focuses on how changes in cell volume can regulate cell functions such as cell migration, proliferation, and programmed cell death...
  3. doi request reprint Physiology of cell volume regulation in vertebrates
    Else K Hoffmann
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 89:193-277. 2009
    ..A discussion of this issue concludes the review...
  4. ncbi request reprint Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications
    Maria Rasmussen
    Department of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Cell Physiol 294:C197-212. 2008
    ..In contrast, no evidence was found for the involvement of an NHE1-ezrin-PI3K-PKB pathway in counteracting shrinkage-induced cell death...
  5. ncbi request reprint Shrinkage insensitivity of NKCC1 in myosin II-depleted cytoplasts from Ehrlich ascites tumor cells
    Else K Hoffmann
    Department of Molecular Biology, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    Am J Physiol Cell Physiol 292:C1854-66. 2007
    ..Together these findings indicate that shrinkage activation of NKCC1 in EATC is dependent on the cortical F-actin network, myosin II, and MLCK...
  6. ncbi request reprint Cholesterol modulates the volume-regulated anion current in Ehrlich-Lettre ascites cells via effects on Rho and F-actin
    Thomas Kjaer Klausen
    Department of Biochemistry, Institute of Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Cell Physiol 291:C757-71. 2006
    ....
  7. ncbi request reprint Cell cycle-dependent activity of the volume- and Ca2+-activated anion currents in Ehrlich lettre ascites cells
    Thomas Kjaer Klausen
    Department of Biochemistry, Institute for Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark
    J Cell Physiol 210:831-42. 2007
    ..It is suggested that in ELA cells, entrance into the S phase requires an increase in VRAC activity and/or an increased potential for regulatory volume decrease (RVD), and at the same time a decrease in CaCC magnitude...
  8. pmc Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts
    Linda Schneider
    Department of Biology, Section of Cell and Developmental Biology, The August Krogh Building, University of Copenhagen, DK 2100 Copenhagen OE, Denmark
    Cell Physiol Biochem 25:279-92. 2010
    ..These data suggest that in coordination with cytoskeletal reorganization, the fibroblast primary cilium functions via ciliary PDGFRalpha signaling to monitor directional movement during wound healing...
  9. ncbi request reprint Roles of Na+/H+ exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts
    Maria L Rentsch
    Department of Biochemistry, Institute for Molecular Biology and Physiology, University of Copenhagen, 13 Universitetsparken, 2100 Copenhagen Ø, Denmark
    Pflugers Arch 454:649-62. 2007
    ..In spite of this, NHE inhibition slightly attenuates anoxia-induced cell death, likely due to the involvement of NHE in other anoxia-induced death pathways...
  10. doi request reprint Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization
    Sune T Jørgensen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 31:366-78. 2013
    ..The aim is to illustrate the effect of mutation of putative PKC consensus phosphorylation sites in the CysLT1R on desensitization and RVD...
  11. ncbi request reprint H-ras transformation sensitizes volume-activated anion channels and increases migratory activity of NIH3T3 fibroblasts
    Linda Schneider
    Department of Molecular Biology, University of Copenhagen, 13 Universitetsparken, 2100 Copenhagen, Oe, Denmark
    Pflugers Arch 455:1055-62. 2008
    ..We suggest that H-ras modulates the volume set point of VRAC and thus facilitates transient changes of cell volume required for faster cell migration...
  12. doi request reprint Does the intracellular ionic concentration or the cell water content (cell volume) determine the activity of TonEBP in NIH3T3 cells?
    Tina Rødgaard
    Department of Biology, University of Copenhagen, 13, Universitetsparken, DK 2100 Copenhagen, Denmark
    Am J Physiol Cell Physiol 295:C1528-34. 2008
    ..This strongly suggested that an increase in intracellular ionic concentration and not cell shrinkage is involved in TonEBP activation...
  13. doi request reprint Comparison of two anoxia models in rainbow trout cells by a 2-DE and MS/MS-based proteome approach
    Tune Wulff
    Department of Biochemistry, Institute of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Proteomics 8:2035-44. 2008
    ..This study therefore provides a valuable comparison of two different anoxia models and shows that great care should be taken when comparing the effects of anoxia in studies that have used different types and durations of anoxia...
  14. doi request reprint Cell volume regulation and signaling in 3T3-L1 pre-adipocytes and adipocytes: on the possible roles of caveolae, insulin receptors, FAK and ERK1/2
    Kathrine Eduardsen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 28:1231-46. 2011
    ....
  15. ncbi request reprint Homologous desensitisation of the mouse leukotriene B4 receptor involves protein kinase C-mediated phosphorylation of serine 127
    Jens Mollerup
    Department of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 20:143-56. 2007
    ..These data indicate that PKC-mediated phosphorylation at Ser-127 leads to mBLT1 desensitisation...
  16. doi request reprint Differential role for ERK2 in anoxia-induced activation of transcription and translation of Hsp70 in NIH 3T3 cells
    Carlo G Ossum
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 27:109-20. 2011
    ..Inhibition of ERK2 by the MEK inhibitor PD98059 resulted in strong inhibition of Hsp70 protein expression and simultaneous stimulation of hsp70 transcription...
  17. doi request reprint Osmosensory mechanisms in cellular and systemic volume regulation
    Stine Falsig Pedersen
    Department of Biology, University of Copenhagen, Universitetsparken 13, DK 2100, Copenhagen, Denmark
    J Am Soc Nephrol 22:1587-97. 2011
    ....
  18. doi request reprint Long term anoxia in rainbow trout investigated by 2-DE and MS/MS
    Tune Wulff
    Department of Biochemistry, Institute of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Proteomics 8:1009-18. 2008
    ..In conclusion, this study provides a thorough investigation of the effect of anoxia in a cell line from rainbow trout...
  19. ncbi request reprint Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i
    Tune Wulff
    Biochemical Department, August Krogh Institute, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1660:75-9. 2004
    ..Neither hTBAK1 nor hTASK2 was activated following stimulations with LTD4 (0.1 and 100 nM)...
  20. ncbi request reprint PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts
    Linda Schneider
    Department of Biochemistry, Institute for Molecular Biology and Physiology, University of Copenhagen, The August Krogh Building, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Curr Biol 15:1861-6. 2005
    ..We propose that ciliary PDGFRalphaalpha signaling is linked to tissue homeostasis and to mitogenic signaling pathways...
  21. pmc Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts
    Martin B Friis
    Department of Biochemistry, Institute of Molecular Biology and Physiology, The August Krogh Building, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen, Denmark
    J Physiol 567:427-43. 2005
    ....
  22. ncbi request reprint Modulation of KCNQ4 channel activity by changes in cell volume
    Charlotte Hougaard
    Biochemical Department, The August Krogh Institute, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1660:1-6. 2004
    ....
  23. ncbi request reprint Regulation of the mitogen-activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts
    Carlo G Ossum
    Institute of Molecular Biology and Physiology, Department of Biochemistry, The August Krogh Building, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    J Exp Biol 209:1765-76. 2006
    ..In addition, we demonstrated that the reactivation of p44ERK during recovery also was dependent on reactive oxygen species and a PP1/PP2A-like phosphatase...
  24. pmc TMEM16F (Anoctamin 6), an anion channel of delayed Ca(2+) activation
    Søren Grubb
    Department of Biology, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Gen Physiol 141:585-600. 2013
    ..Our data provide evidence that TMEM16F constitutes a Ca(2+)-activated anion channel or a pore-forming subunit of an anion channel with properties distinct from TMEM16A...
  25. ncbi request reprint Roles of the cytoskeleton and of protein phosphorylation events in the osmotic stress response in eel intestinal epithelium
    Maria G Lionetto
    Department of Biological and Environmental Sciences and Technologies, University of Lecce, Copenhagen, Denmark
    Cell Physiol Biochem 12:163-78. 2002
    ..It is suggested that NKCC regulation by hypertonic stress involves an interaction between the cytoskeleton and protein phosphorylation events...