Merete Lund Hetland

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi The CIMESTRA study: intra-articular glucocorticosteroids and synthetic DMARDs in a treat-to-target strategy in early rheumatoid arhtritis
    Merete L Hetland
    Department of Rheumatology, Glostrup Hospital, Glostrup, Denmark
    Clin Exp Rheumatol 30:S44-9. 2012
  2. ncbi Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects
    Kaspar R Nielsen
    Department of Clinical Immunology, Aalborg Hospital, Aarhus University Hospital, Reberbansgade, Pobox 561, 9000, Aalborg, Denmark
    Arthritis Res Ther 13:R109. 2011
  3. ncbi Direct comparison of treatment responses, remission rates, and drug adherence in patients with rheumatoid arthritis treated with adalimumab, etanercept, or infliximab: results from eight years of surveillance of clinical practice in the nationwide Danish
    Merete Lund Hetland
    DANBIO Registry, Copenhagen University Hospital, Department of Rheumatology, Hvidovre, Denmark
    Arthritis Rheum 62:22-32. 2010
  4. ncbi DANBIO--powerful research database and electronic patient record
    Merete Lund Hetland
    DANBIO, Department of Rheumatology RM, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark
    Rheumatology (Oxford) 50:69-77. 2011
  5. ncbi Do changes in prescription practice in patients with rheumatoid arthritis treated with biological agents affect treatment response and adherence to therapy? Results from the nationwide Danish DANBIO Registry
    M L Hetland
    DANBIO Registry, Department of Rheumatology, Hvidovre Hospital, Kettegard Alle 30, DK 2650, Hvidovre, Denmark
    Ann Rheum Dis 67:1023-6. 2008
  6. ncbi Circulating VEGF as a biological marker in patients with rheumatoid arthritis? Preanalytical and biological variability in healthy persons and in patients
    Merete Lund Hetland
    Department of Rheumatology, Copenhagen University Hospital, Hvidovre, Denmark
    Dis Markers 24:1-10. 2008
  7. ncbi Modern treatment strategies in rheumatoid arthritis
    Merete Lund Hetland
    Department of Rheumatology RM, Glostrup Hospital, Denmark
    Dan Med Bull 58:B4320. 2011
  8. ncbi Routine database registration of biological therapy increases the reporting of adverse events twentyfold in clinical practice. First results from the Danish Database (DANBIO)
    M L Hetland
    Department of Rheumatology, Copenhagen University Hospitals at Hvidovre, Denmark
    Scand J Rheumatol 34:40-4. 2005
  9. ncbi DANBIO: a nationwide registry of biological therapies in Denmark
    M L Hetland
    DANBIO, Copenhagen University Hospital at Hvidovre, Department of Rheumatology, Hvidovre, Denmark
    Clin Exp Rheumatol 23:S205-7. 2005
  10. ncbi Short- and long-term efficacy of intra-articular injections with betamethasone as part of a treat-to-target strategy in early rheumatoid arthritis: impact of joint area, repeated injections, MRI findings, anti-CCP, IgM-RF and CRP
    Merete Lund Hetland
    Department of Rheumatology, Glostrup Hospital, Glostrup, Denmark
    Ann Rheum Dis 71:851-6. 2012

Collaborators

Detail Information

Publications46

  1. ncbi The CIMESTRA study: intra-articular glucocorticosteroids and synthetic DMARDs in a treat-to-target strategy in early rheumatoid arhtritis
    Merete L Hetland
    Department of Rheumatology, Glostrup Hospital, Glostrup, Denmark
    Clin Exp Rheumatol 30:S44-9. 2012
    ..The CIMESTRA study applied an aggressive treatment with DMARD and intra-articular injections of glucocorticoids (i.a. GC) to control disease activity. This paper reviews the results of the five years' study...
  2. ncbi Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects
    Kaspar R Nielsen
    Department of Clinical Immunology, Aalborg Hospital, Aarhus University Hospital, Reberbansgade, Pobox 561, 9000, Aalborg, Denmark
    Arthritis Res Ther 13:R109. 2011
    ..YKL-40 concentrations are elevated in the serum of patients with RA compared to healthy subjects, and YKL-40 has been suggested to be an auto-antigen and may play a role in development of RA and in inflammation...
  3. ncbi Direct comparison of treatment responses, remission rates, and drug adherence in patients with rheumatoid arthritis treated with adalimumab, etanercept, or infliximab: results from eight years of surveillance of clinical practice in the nationwide Danish
    Merete Lund Hetland
    DANBIO Registry, Copenhagen University Hospital, Department of Rheumatology, Hvidovre, Denmark
    Arthritis Rheum 62:22-32. 2010
    ....
  4. ncbi DANBIO--powerful research database and electronic patient record
    Merete Lund Hetland
    DANBIO, Department of Rheumatology RM, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark
    Rheumatology (Oxford) 50:69-77. 2011
    ..In conclusion, DANBIO serves as an electronic patient 'chronicle' in routine care, and at the same time provides a powerful research database...
  5. ncbi Do changes in prescription practice in patients with rheumatoid arthritis treated with biological agents affect treatment response and adherence to therapy? Results from the nationwide Danish DANBIO Registry
    M L Hetland
    DANBIO Registry, Department of Rheumatology, Hvidovre Hospital, Kettegard Alle 30, DK 2650, Hvidovre, Denmark
    Ann Rheum Dis 67:1023-6. 2008
    ..Prescription practice for tumour necrosis factor alpha (TNFalpha) inhibitors has changed towards treating patients with lower disease activity...
  6. ncbi Circulating VEGF as a biological marker in patients with rheumatoid arthritis? Preanalytical and biological variability in healthy persons and in patients
    Merete Lund Hetland
    Department of Rheumatology, Copenhagen University Hospital, Hvidovre, Denmark
    Dis Markers 24:1-10. 2008
    ..Soluble vascular endothelial growth factor (VEGF) is a promising biomarker in monitoring rheumatoid arthritis (RA), but studies of pre-analytical and biologic variability are few...
  7. ncbi Modern treatment strategies in rheumatoid arthritis
    Merete Lund Hetland
    Department of Rheumatology RM, Glostrup Hospital, Denmark
    Dan Med Bull 58:B4320. 2011
    ..Differences between the TNFα inhibitors regarding efficacy and drug adherence were found. Predictors of disease course and treatment response were identified...
  8. ncbi Routine database registration of biological therapy increases the reporting of adverse events twentyfold in clinical practice. First results from the Danish Database (DANBIO)
    M L Hetland
    Department of Rheumatology, Copenhagen University Hospitals at Hvidovre, Denmark
    Scand J Rheumatol 34:40-4. 2005
    ..To present from the Danish Database for Biological Therapies in Rheumatology (DANBIO) the frequencies and types of adverse events as well as risk factors during treatment with biological agents in clinical practice...
  9. ncbi DANBIO: a nationwide registry of biological therapies in Denmark
    M L Hetland
    DANBIO, Copenhagen University Hospital at Hvidovre, Department of Rheumatology, Hvidovre, Denmark
    Clin Exp Rheumatol 23:S205-7. 2005
    ..Rheumatoid arthritis was the most prevalent diagnosis (75%) followed by ankylosing spondylitis (11%) and psoriatic arthritis (7%). Infections occurred in 43% of the treatment series...
  10. ncbi Short- and long-term efficacy of intra-articular injections with betamethasone as part of a treat-to-target strategy in early rheumatoid arthritis: impact of joint area, repeated injections, MRI findings, anti-CCP, IgM-RF and CRP
    Merete Lund Hetland
    Department of Rheumatology, Glostrup Hospital, Glostrup, Denmark
    Ann Rheum Dis 71:851-6. 2012
    ....
  11. ncbi Does clinical remission lead to normalization of EQ-5D in patients with rheumatoid arthritis and is selection of remission criteria important?
    Louise Linde
    Department of Rheumatology, Copenhagen University Hospital, Hvidovre, Denmark
    J Rheumatol 37:285-90. 2010
    ..To compare health-related quality of life (HRQOL) of patients with rheumatoid arthritis (RA) to that of the general population and to investigate the association with disease activity, focusing on different clinical remission criteria...
  12. ncbi What factors influence the health status of patients with rheumatoid arthritis measured by the SF-12v2 Health Survey and the Health Assessment Questionnaire?
    Louise Linde
    Department of Rheumatology, Hvidovre Hospital, 232 Kettegaard Allé 30, DK 2650 Hvidovre, Denmark
    J Rheumatol 36:2183-9. 2009
    ..We investigated how the HAQ and SF-12 were associated with socio-demographic, lifestyle, and disease- and treatment-related factors in patients with RA...
  13. ncbi Plasma adiponectin in patients with active, early, and chronic rheumatoid arthritis who are steroid- and disease-modifying antirheumatic drug-naive compared with patients with osteoarthritis and controls
    Trine Bay Laurberg
    Department of Rheumatology, Aarhus University Hospital, Noerrebrogade 44, Aarhus C, Denmark
    J Rheumatol 36:1885-91. 2009
    ....
  14. ncbi Detection, scoring and volume assessment of bone erosions by ultrasonography in rheumatoid arthritis: comparison with CT
    Uffe Møller Døhn
    Correspondence to Dr Uffe Møller Døhn, Department of Rheumatology, Copenhagen University Hospital at Slagelse, Slagelse DK 2600, Denmark
    Ann Rheum Dis 72:530-4. 2013
    ..Second, to establish the necessary bone volume loss on CT for US to reliably detect it as an erosion, and finally to compare two semiquantitative US-erosion scoring methods...
  15. ncbi Impact of tumour necrosis factor inhibitor treatment on radiographic progression in rheumatoid arthritis patients in clinical practice: results from the nationwide Danish DANBIO registry
    Lykke Midtbøll Ornbjerg
    Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark
    Ann Rheum Dis 72:57-63. 2013
    ..To compare radiographic progression during treatment with disease-modifying antirheumatic drugs (DMARD) and subsequent treatment with tumour necrosis factor α inhibitors (TNF-I) in rheumatoid arthritis (RA) patients in clinical practice...
  16. ncbi No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography study
    Uffe Møller Døhn
    Department of Rheumatology, Copenhagen University Hospitals at Hvidovre and Glostrup, Hvidovre, Denmark
    Ann Rheum Dis 70:252-8. 2011
    ..To assess the predictive value of MRI and ultrasonography for erosive progression on CT and compare MRI/ultrasonography/radiography for erosion detection/monitoring...
  17. ncbi Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: an investigator-initiated, multicenter, randomized, double-blind, par
    Merete Lund Hetland
    Copenhagen University Hospital, Hvidovre, Denmark
    Arthritis Rheum 54:1401-9. 2006
    ..Addition of cyclosporine improved the ACR20 and ACR-N responses, whereas the ACR50 and ACR70 responses, remission rates, and radiographic changes did not differ between the 2 study groups...
  18. ncbi Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment
    Trine Bay Laurberg
    Department of Rheumatology, Aarhus University Hospital, Norrebrogade 44, Building A1, 8000 Aarhus, Denmark
    Rheumatol Int 32:501-4. 2012
    ..IGF-IR-positive CD4+T-lymphocytes fraction decreased during treatment, but neither at week 0 nor at week 52 did it differ from healthy controls. No correlations were found to disease activity parameters...
  19. ncbi Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis
    Anne Friesgaard Christensen
    Department of Rheumatology, Odense University Hospital, SDR, Boulevard 29, DK 5000 Odense C, Denmark
    Arthritis Res Ther 12:R39. 2010
    ....
  20. ncbi Incidences of overall and site specific cancers in TNFα inhibitor treated patients with rheumatoid arthritis and other arthritides - a follow-up study from the DANBIO Registry
    Lene Dreyer
    Department of Rheumatology, Gentofte University Hospital, Hellerup, Denmark
    Ann Rheum Dis 72:79-82. 2013
    ..To investigate the incidence of cancer in arthritis patients treated with or without TNFα inhibitors (TNF-I)...
  21. ncbi Bone edema on magnetic resonance imaging is an independent predictor of rheumatoid arthritis development in patients with early undifferentiated arthritis
    Anne Duer-Jensen
    Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark
    Arthritis Rheum 63:2192-202. 2011
    ..To study magnetic resonance imaging (MRI) as a tool for early diagnosis of rheumatoid arthritis (RA) in patients with early undifferentiated arthritis (UA)...
  22. ncbi Efficacy of abatacept and tocilizumab in patients with rheumatoid arthritis treated in clinical practice: results from the nationwide Danish DANBIO registry
    Henrik Christian Leffers
    Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark
    Ann Rheum Dis 70:1216-22. 2011
    ....
  23. ncbi Do rheumatoid arthritis patients in clinical practice benefit from switching from infliximab to a second tumor necrosis factor alpha inhibitor?
    Elisabeth Hjardem
    Department of Rheumatology, Copenhagen University Hospital, Hvidovre, Denmark
    Ann Rheum Dis 66:1184-9. 2007
    ..To investigate the efficacy of switching to a second biological drug in rheumatoid arthritis (RA) patients...
  24. ncbi Circulating levels of interleukin-6, vascular endothelial growth factor, YKL-40, matrix metalloproteinase-3, and total aggrecan in spondyloarthritis patients during 3 years of treatment with TNFα inhibitors
    Susanne Juhl Pedersen
    Department of Rheumatology, Copenhagen University Hospital, Herlev and Gentofte, Denmark
    Clin Rheumatol 29:1301-9. 2010
    ..Larger prospective studies are required to clarify clinical utility of these biomarkers...
  25. ncbi Predictors of treatment response and drug continuation in 842 patients with ankylosing spondylitis treated with anti-tumour necrosis factor: results from 8 years' surveillance in the Danish nationwide DANBIO registry
    Bente Glintborg
    Department of Rheumatology, Gentofte University Hospital, Hellerup, Denmark
    Ann Rheum Dis 69:2002-8. 2010
    ....
  26. ncbi Health-related quality of life: validity, reliability, and responsiveness of SF-36, 15D, EQ-5D [corrected] RAQoL, and HAQ in patients with rheumatoid arthritis
    Louise Linde
    Department of Rheumatology, Copenhagen University Hospital, Hvidovre, Denmark
    J Rheumatol 35:1528-37. 2008
    ..To compare validity, reliability, and responsiveness of generic and disease specific health-related quality of life (HRQOL) instruments in rheumatoid arthritis (RA)...
  27. ncbi Mannose-binding lectin gene polymorphisms are associated with disease activity and physical disability in untreated, anti-cyclic citrullinated peptide-positive patients with early rheumatoid arthritis
    Søren Jacobsen
    Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Rheumatol 36:731-5. 2009
    ..To study the association between polymorphisms in the mannose-binding lectin gene (MBL2) and disease activity, physical disability, and joint erosions in patients with newly diagnosed rheumatoid arthritis (RA)...
  28. ncbi Prescription practice of biological drugs in rheumatoid arthritis during the first 3 years of post-marketing use in Denmark and Norway: criteria are becoming less stringent
    E Hjardem
    Copenhagen University Hospital at Hvidovre, Department of Rheumatology 232, , DK 2650 Hvidovre, Denmark
    Ann Rheum Dis 64:1220-3. 2005
    ..Prescriptions agreed well with the Dutch guidelines, but almost half the patients did not meet the UK guidelines...
  29. ncbi No erosive progression revealed by MRI in rheumatoid arthritis patients treated with etanercept, even in patients with persistent MRI and clinical signs of joint inflammation
    Uffe Møller Døhn
    Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Kettegaard Alle 30, 2650, Hvidovre, Denmark
    Clin Rheumatol 26:1857-61. 2007
    ..This small study supports that erosive progression judged by MRI is minimal in RA patients treated with etanercept, even in joints with persistent inflammation...
  30. ncbi Changes in plasma IL-6, plasma VEGF and serum YKL-40 during Treatment with Etanercept and Methotrexate or Etanercept alone in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy
    Lene Surland Knudsen
    Department of Rheumatology, Copenhagen University Hospital at Herlev, Denmark
    Biomark Insights 4:91-5. 2009
    ..014), and ESR (p = 0.024).Plasma IL-6, plasma VEGF and serum YKL-40, which reflect different aspects of the inflammatory process, may provide useful information regarding early differentiation of responders from non-responders...
  31. ncbi Serum cysteine proteases and their inhibitors in rheumatoid arthritis: relation to disease activity and radiographic progression
    Iben Jørgensen
    Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Clin Rheumatol 30:633-8. 2011
    ..The findings in this study support further investigation in the regulation of the activity of cathepsins and their inhibitors in erosive rheumatoid arthritis...
  32. ncbi What do patients in rheumatologic care know about the risks of NSAIDs?
    Lykke Midtbøll Ornbjerg
    Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Denmark
    J Clin Rheumatol 14:69-73. 2008
    ....
  33. ncbi Patterns of magnetic resonance imaging bone erosion in rheumatoid arthritis--which bones are most frequently involved and show the most change?
    Mikkel Ostergaard
    Department of Rheumatology and Department of Radiology, Copenhagen University Hospital at Glostrup, Copenhagen
    J Rheumatol 38:2014-7. 2011
    ....
  34. ncbi [Progress in rheumatology. The Danish Society of Rheumatology]
    Mikkel Østergaard
    Reumatologisk Afdeling Q107, Amtssygehuset i Herlev, DK 2730 Herlev
    Ugeskr Laeger 168:1240. 2006
  35. ncbi [Cancer in arthritis patients after anti-tumour necrosis factor therapy]
    Lene Dreyer
    TA Reumatologisk Klinik 4242, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 171:506-11. 2009
    ..It is being debated whether treatment of patients with rheumatic diseases with anti-TNF therapy is associated with an increased cancer incidence...
  36. ncbi [Health-related quality of life of patients with rheumatoid arthritis. Which factors are of significance?]
    Louise Linde
    Hvidovre Hospital, Reumatologisk afdeling
    Ugeskr Laeger 170:855-8. 2008
    ....
  37. ncbi Treatment response, drug survival, and predictors thereof in 764 patients with psoriatic arthritis treated with anti-tumor necrosis factor α therapy: results from the nationwide Danish DANBIO registry
    Bente Glintborg
    Gentofte University Hospital, Hellerup, Denmark
    Arthritis Rheum 63:382-90. 2011
    ..To investigate disease activity, treatment response, and drug survival, and predictors thereof, among Danish patients with psoriatic arthritis (PsA) receiving their first treatment series with a tumor necrosis factor α (TNFα) inhibitor...
  38. ncbi Drug survival and reasons for discontinuation of intramuscular methotrexate: a study of 212 consecutive patients switching from oral methotrexate
    L Linde
    Department of Rheumatology, Copenhagen University Hospital, Hvidovre Hospital, Hvidovre, Denmark
    Scand J Rheumatol 35:102-6. 2006
    ..To assess the drug survival and reasons for discontinuation of intramuscular methotrexate (imMTX) in rheumatological patients who had switched to imMTX from oral methotrexate (oMTX)...
  39. ncbi Erosive progression is minimal, but erosion healing rare, in patients with rheumatoid arthritis treated with adalimumab. A 1 year investigator-initiated follow-up study using high-resolution computed tomography as the primary outcome measure
    U Møller Døhn
    Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Ann Rheum Dis 68:1585-90. 2009
    ..With computed tomography (CT) and radiography, to investigate if repair of bone erosions, defined as regression of erosion scores, occurs during adalimumab treatment of patients with rheumatoid arthritis (RA)...
  40. ncbi MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA)
    M L Hetland
    Department of Rheumatology, Copenhagen University Hospital, Hvidovre, Denmark
    Ann Rheum Dis 68:384-90. 2009
    ..To identify predictors of radiographic progression in a 2-year randomised, double-blind, clinical study (CIMESTRA) of patients with early rheumatoid arthritis (RA)...
  41. ncbi Detection of rheumatoid arthritis bone erosions by two different dedicated extremity MRI units and conventional radiography
    A Duer-Jensen
    Department of Rheumatology, Copenhagen University Hospital, Kettegaards Alle 30, 2635 Hvidovre, Denmark
    Ann Rheum Dis 67:998-1003. 2008
    ..To compare the ability of two different dedicated extremity MRI (E-MRI) units and conventional radiography (CR) for identifying bone erosions in rheumatoid arthritis (RA) metacarpophalangeal (MCP) and wrist joints...
  42. ncbi Keitel Functional Test for patients with rheumatoid arthritis: translation, reliability, validity, and responsiveness
    Bente Holm
    Department of Physiotherapy, Copenhagen University Hospital at Hvidovre, Copenhagen, Denmark
    Phys Ther 88:664-78. 2008
    ..The purpose of this study was to translate the German Keitel Functional Test (KFT) into Danish and test it for reliability, concurrent and predictive validity, and responsiveness in patients with rheumatoid arthritis (RA)...
  43. ncbi Aggressive combination therapy with intra-articular glucocorticoid injections and conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis: second-year clinical and radiographic results from the CIMESTRA study
    M L Hetland
    Department of Rheumatology, Copenhagen University Hospital, Hvidovre, Denmark
    Ann Rheum Dis 67:815-22. 2008
    ..This paper presents the results of the second year of the randomised, controlled double-blind CIMESTRA (Ciclosporine, Methotrexate, Steroid in RA) study...
  44. ncbi Prednisolone treatment affects the performance of the QuantiFERON gold in-tube test and the tuberculin skin test in patients with autoimmune disorders screened for latent tuberculosis infection
    Erika Bélard
    Department of Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark
    Inflamm Bowel Dis 17:2340-9. 2011
    ..The objective was to evaluate the performance of the QuantiFERON Gold In-Tube (QFT-IT) and the Tuberculin Skin Test (TST)...
  45. ncbi Depigmentation--a rare side effect to intra-articular glucocorticoid treatment
    Cornelia Rogojan
    Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Denmark
    Clin Rheumatol 23:373-5. 2004
    ..We present a case of local skin depigmentation that occurred at the site of injection in a dark-skinned patient. Depigmentation is a rare complication of such therapy but may have important implications for dark-skinned patients...
  46. ncbi Low remission rates but long drug survival in rheumatoid arthritis patients treated with infliximab or etanercept: results from the nationwide Danish DANBIO database
    M Ostergaard
    Scand J Rheumatol 36:151-4. 2007