Steen B Haugaard

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi The immune marker soluble urokinase plasminogen activator receptor is associated with new-onset diabetes in non-smoking women and men
    S B Haugaard
    Clinical Research Centre, Copenhagen University, Denmark
    Diabet Med 29:479-87. 2012
  2. ncbi Growth factors, glucose and insulin kinetics after low dose growth hormone therapy in HIV-lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    J Infect 52:389-98. 2006
  3. ncbi Desaturation of excess intramyocellular triacylglycerol in obesity: implications for glycemic control
    S B Haugaard
    Department of Endocrinology, Copenhagen University Hospital, Hvidovre, Denmark
    Int J Obes (Lond) 34:500-10. 2010
  4. ncbi Depleted skeletal muscle mitochondrial DNA, hyperlactatemia, and decreased oxidative capacity in HIV-infected patients on highly active antiretroviral therapy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    J Med Virol 77:29-38. 2005
  5. ncbi Desaturation of skeletal muscle structural and depot lipids in obese individuals during a very-low-calorie diet intervention
    Steen B Haugaard
    Department of Endocrinology and Internal Medicine, Hvidovre University Hospital, University of Copenhagen, Hvidovre, Copenhagen, Denmark
    Obesity (Silver Spring) 15:117-25. 2007
  6. ncbi Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Clinical Research Unit 136, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Diabetes 54:3474-83. 2005
  7. ncbi Tumor necrosis factor alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, DK 2650 Copenhagen, Denmark
    Metabolism 55:175-82. 2006
  8. ncbi Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    J Infect 54:89-97. 2007
  9. ncbi Glucose-stimulated prehepatic insulin secretion is associated with circulating alanine, triglyceride, glucagon, lactate and TNF-alpha in patients with HIV-lipodystrophy
    S B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, Copenhagen, Denmark
    HIV Med 7:163-72. 2006
  10. ncbi Hyperproinsulinaemia in normoglycaemic lipodystrophic HIV-infected patients
    S B Haugaard
    Department of Endocrinology and Internal Medicine, Hvidovre University Hospital, Copenhagen, Denmark
    Eur J Clin Invest 36:436-45. 2006

Detail Information

Publications48

  1. ncbi The immune marker soluble urokinase plasminogen activator receptor is associated with new-onset diabetes in non-smoking women and men
    S B Haugaard
    Clinical Research Centre, Copenhagen University, Denmark
    Diabet Med 29:479-87. 2012
    ..This association has been previously suggested by using the less sensitive International Classification of Disease system to detect incident diabetes in the Danish MONICA 10 cohort...
  2. ncbi Growth factors, glucose and insulin kinetics after low dose growth hormone therapy in HIV-lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    J Infect 52:389-98. 2006
    ..Low-dose growth hormone (GH) administration has been suggested as a treatment for HIV-lipodystrophy...
  3. ncbi Desaturation of excess intramyocellular triacylglycerol in obesity: implications for glycemic control
    S B Haugaard
    Department of Endocrinology, Copenhagen University Hospital, Hvidovre, Denmark
    Int J Obes (Lond) 34:500-10. 2010
    ..In addition, it was validated if IMTG palmitic acid is associated with insulin resistance as suggested earlier...
  4. ncbi Depleted skeletal muscle mitochondrial DNA, hyperlactatemia, and decreased oxidative capacity in HIV-infected patients on highly active antiretroviral therapy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    J Med Virol 77:29-38. 2005
    ..Further, HIV may deplete sm-mtDNA of NAIVE, which in part could be mediated through an enhanced pro-inflammatory response...
  5. ncbi Desaturation of skeletal muscle structural and depot lipids in obese individuals during a very-low-calorie diet intervention
    Steen B Haugaard
    Department of Endocrinology and Internal Medicine, Hvidovre University Hospital, University of Copenhagen, Hvidovre, Copenhagen, Denmark
    Obesity (Silver Spring) 15:117-25. 2007
    ....
  6. ncbi Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Clinical Research Unit 136, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Diabetes 54:3474-83. 2005
    ..These results suggest mechanisms for the insulin resistance greatly enhancing the risk of type 2 diabetes in HIV lipodystrophy...
  7. ncbi Tumor necrosis factor alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, DK 2650 Copenhagen, Denmark
    Metabolism 55:175-82. 2006
    ..Furthermore, FFA may be a major determinant of LIPOX in HIV-infected patients on highly active antiretroviral therapy...
  8. ncbi Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    J Infect 54:89-97. 2007
    ..However, the correlation between fasting lactate and mitochondrial DNA may be weak or absent, implicating that other factors e.g. glucose turnover may contribute to hyperlactatemia...
  9. ncbi Glucose-stimulated prehepatic insulin secretion is associated with circulating alanine, triglyceride, glucagon, lactate and TNF-alpha in patients with HIV-lipodystrophy
    S B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, Copenhagen, Denmark
    HIV Med 7:163-72. 2006
    ....
  10. ncbi Hyperproinsulinaemia in normoglycaemic lipodystrophic HIV-infected patients
    S B Haugaard
    Department of Endocrinology and Internal Medicine, Hvidovre University Hospital, Copenhagen, Denmark
    Eur J Clin Invest 36:436-45. 2006
    ....
  11. ncbi Skeletal muscle structural lipids improve during weight-maintenance after a very low calorie dietary intervention
    Steen B Haugaard
    Dept of Endocrinology, Copenhagen University Hospital, Hvidovre, Denmark
    Lipids Health Dis 8:34. 2009
    ..Special focus was addressed to SMPL omega-3 FA, which is a lipid entity that influences insulin action...
  12. ncbi Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    Eur J Endocrinol 152:103-12. 2005
    ..Aiming to provide a detailed description of the metabolic adverse effects of HIV-lipodystrophy, we investigated several aspects of glucose metabolism, lipid metabolism and beta-cell function in lipodystrophic HIV-infected patients...
  13. ncbi Beta-cell dysfunction and low insulin clearance in insulin-resistant human immunodeficiency virus (HIV)-infected patients with lipodystrophy
    Steen B Haugaard
    Clinical Research Unit, Hvidovre University Hospital, University of Copenhagen, Denmark
    Clin Endocrinol (Oxf) 62:354-61. 2005
    ....
  14. ncbi Sex and muscle structural lipids in obese subjects - an impact on insulin action?
    S B Haugaard
    Copenhagen University Hospital, Hvidovre, Denmark
    Eur J Clin Invest 38:494-501. 2008
    ..The increased extramyocellular fat mass of obese women may act in a paracrine manner such that its release of free FA and cytokines may hamper in situ desaturation and elongation of FA in skeletal muscle phospholipids...
  15. ncbi [HIV-associated lipodystrophy syndrome. Diagnosis, prevalence, pathogenesis and metabolic complications]
    Steen B Haugaard
    Infektionsmedicinsk Afdeling og Endokrinologisk Klinik, H:S Hvidovre Hospital, DK-2650 Hvidovre
    Ugeskr Laeger 165:4215-8. 2003
  16. ncbi Intramyocellular triglyceride content in man, influence of sex, obesity and glycaemic control
    Steen B Haugaard
    Department of Endocrinology Clinical Research Centre, Copenhagen University Hospital, Hvidovre, DK 2650 Hvidovre, Denmark
    Eur J Endocrinol 161:57-64. 2009
    ..It remains unknown whether sex impacts on intramyocellular triglyceride (IMTG) in obesity, as has been shown in non-obese subjects, and, if so, whether this may have implications on the association between IMTG and insulin sensitivity...
  17. ncbi Insulin secretion in lipodystrophic HIV-infected patients is associated with high levels of nonglucose secretagogues and insulin resistance of beta-cells
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 287:E677-85. 2004
    ....
  18. ncbi Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients who display fat redistribution
    Steen B Haugaard
    Clinical Research Unit, Hvidovre University Hospital, DK 2650 Hvidore, Copenhagen, Denmark
    Metabolism 56:939-46. 2007
    ....
  19. ncbi In nondiabetic, human immunodeficiency virus-infected patients with lipodystrophy, hepatic insulin extraction and posthepatic insulin clearance rate are decreased in proportion to insulin resistance
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Metabolism 54:171-9. 2005
    ..1). Our data suggest that HEXi and MCRi are decreased in proportion to the degree of insulin resistance in nondiabetic HIV-infected patients with lipodystrophy...
  20. ncbi Toxic metabolic syndrome associated with HAART
    Steen B Haugaard
    Clinical Research Unit, Department of Endocrinology and Internal Medicine, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Expert Opin Drug Metab Toxicol 2:429-45. 2006
    ..An opinion on the remedies available to treat the metabolic abnormalities and phenotype of HALS is provided...
  21. ncbi Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss
    Rasmus Rabøl
    Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Metabolism 58:1145-52. 2009
    ....
  22. ncbi Circulating sex hormones and gene expression of subcutaneous adipose tissue oestrogen and alpha-adrenergic receptors in HIV-lipodystrophy: implications for fat distribution
    Ove Andersen
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Clin Endocrinol (Oxf) 67:250-8. 2007
    ..Oestradiol increases subcutaneous adipose tissue in humans possibly through binding to oestrogen-receptor-alpha, which in turn activates anti-lipolytic alpha2A-adrenergic-receptor...
  23. ncbi Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Denmark
    Metabolism 53:1565-73. 2004
    ..Furthermore, our data suggest that IGFBP-3 protease is a significant regulator of bioactive IGF-I in HIV-lipodystrophy...
  24. ncbi Different growth hormone sensitivity of target tissues and growth hormone response to glucose in HIV-infected patients with and without lipodystrophy
    Ove Andersen
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    Scand J Infect Dis 36:832-9. 2004
    ..01). GHBP was inversely correlated with AUC-GH (p <0.01). Our data suggest that GH-target tissues in LIPO are at least as GH-sensitive as in HIV-infected patients without lipodystrophy...
  25. ncbi Dietary intervention increases n-3 long-chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity
    Steen B Haugaard
    Department of Endocrinology and Internal Medicine, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Clin Endocrinol (Oxf) 64:169-78. 2006
    ..01). CONCLUSIONS: A hypocaloric low-fat dietary intervention programme increased incorporation of long-chain PUFAn-3 and reduced SFA in skeletal muscle membrane phospholipids of obese subjects, a setting that may impact on insulin action...
  26. ncbi suPAR associates to glucose metabolic aberration during glucose stimulation in HIV-infected patients on HAART
    Ove Andersen
    Department of Infectious Diseases, Copenhagen University, Hvidovre Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    J Infect 57:55-63. 2008
    ..Here we extend these findings by investigating the association of suPAR to glucose metabolic insufficiency during an oral glucose challenge (OGTT)...
  27. ncbi Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function
    Ove Andersen
    Department of Infectious Diseases, Internal Medicine and Endocrinology and Clinical Psysiology, Hvidovre University Hospital, Copenhagen, Denmark
    Metabolism 52:1343-53. 2003
    ..Furthermore, in HALS patients, impaired glucose metabolism most likely relates to decreased NOGM and to defects in beta-cell function...
  28. ncbi [Control and treatment of HIV-associated lipodystrophy syndrome and related metabolic complications]
    Birgitte Rønde Hansen
    infektionsmedicinsk afdeling 144, H S Hvidovre Hospital, DK 2650 Hvidovre
    Ugeskr Laeger 165:4218-20. 2003
  29. ncbi Sustained low-dose growth hormone therapy optimizes bioactive insulin-like growth factor-I level and may enhance CD4 T-cell number in HIV infection
    Ove Andersen
    Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Hvidovre, Copenhagen, Denmark
    J Med Virol 82:197-205. 2010
    ..07 and +36%, P = 0.02) compared to baseline levels. These data support the notion that low-dose rhGH regimens may increase expediently total and bioactive IGF-I and improve T-cell restoration in patients infected with HIV on HAART...
  30. ncbi Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women
    Nathalie T Bendsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    J Lipid Res 52:1821-8. 2011
    ..In conclusion, this dietary trial indicates that the mechanisms linking dietary IP-TFA to cardiovascular disease may involve activation of the TNFα system...
  31. ncbi Effect of hyperglycemia on mitochondrial respiration in type 2 diabetes
    Rasmus Rabøl
    Department of Biomedical Sciences, Faculty of Health Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    J Clin Endocrinol Metab 94:1372-8. 2009
    ..Whether hyperglycemia inhibits mitochondrial biogenesis and/or function is unknown. This study examined the effect of different levels of glycemia on skeletal muscle mitochondrial function in patients with T2DM...
  32. ncbi Impact of switching antiretroviral therapy on lipodystrophy and other metabolic complications: a review
    Birgitte R Hansen
    Department of Infectious Diseases, Hvidovre University Hospital, Denmark
    Scand J Infect Dis 36:244-53. 2004
    ..However the results are often inconsistent and difficult to interpret, mostly because of limitations in study design, patient number and duration of follow-up. The need for larger, controlled, randomized, long-term studies is evident...
  33. ncbi Soluble urokinase plasminogen activator receptor is a marker of dysmetabolism in HIV-infected patients receiving highly active antiretroviral therapy
    Ove Andersen
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, Copenhagen, Denmark
    J Med Virol 80:209-16. 2008
    ..Circadian suPAR concentration appeared stable, suggesting that sampling schedule does not affect measurement. Further studies addressing whether suPAR predicts lipodystrophy and dysmetabolism in HIV-infected patients are warranted...
  34. ncbi Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women
    Nathalie T Bendsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, DK 1958 Frederiksberg, Denmark
    Metabolism 60:906-13. 2011
    ..A study population with a stronger predisposition to insulin resistance and/or a longer duration of exposure may be required for insulin sensitivity to be affected by intake of industrial TFA...
  35. ncbi Improved thymic index, density and output in HIV-infected patients following low-dose growth hormone therapy: a placebo controlled study
    Birgitte R Hansen
    Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark
    AIDS 23:2123-31. 2009
    ..To investigate the effect of low-dose, long-term recombinant human growth hormone (rhGH) therapy on immune reconstitution in human immunodeficiency virus (HIV)-infected patients with focus on thymic index, density and output...
  36. ncbi The effect of a very low calorie diet on insulin sensitivity, beta cell function, insulin clearance, incretin hormone secretion, androgen levels and body composition in obese young women
    Pernille F Svendsen
    Department of Obstetrics and Gynaecology, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark
    Scand J Clin Lab Invest 72:410-9. 2012
    ..Evaluation of the effect of an 8-week very low calorie diet (VLCD, 500-600 kcal daily) on weight, body fat distribution, glucose, insulin and lipid metabolism, androgen levels and incretin secretion in obese women...
  37. ncbi Correlation of increases in 1,25-dihydroxyvitamin D during vitamin D therapy with activation of CD4+ T lymphocytes in HIV-1-infected males
    Ulrich Bang
    Department of Endocrinology, Hvidovre Hospital, Copenhagen, Denmark
    HIV Clin Trials 13:162-70. 2012
    ..In vitro studies have demonstrated effects of vitamin D on the growth and differentiation of these cells. We speculated whether supplementation with vitamin D could have an effect on CD4+ T lymphocytes or Tregs in HIV-1-infected males...
  38. ncbi Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels
    Aina S Lihn
    Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Tage Hansensgade 2, 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 285:E1072-80. 2003
    ..Increased cytokine mRNA in AT is hypothesized to exert an inhibitory effect on adiponectin gene expression and, consequently, to play a role in the reduced plasma adiponectin levels found in HALS patients...
  39. ncbi Low-dose growth hormone and human immunodeficiency virus-associated lipodystrophy syndrome: a pilot study
    O Andersen
    Hvidovre University Hospital, Copenhagen, Denmark
    Eur J Clin Invest 34:561-8. 2004
    ....
  40. ncbi Preanalytical handling of samples for measurement of plasma lactate in HIV patients
    O Andersen
    Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Denmark
    Scand J Clin Lab Invest 63:449-54. 2003
    ..11 +/- 0.04 mmol/L, p=0.009. It is concluded that major errors in measurements of p-lactate, anion gap and pH can be prevented by placing test tubes on crushed ice for up to 4 h until measurement...
  41. ncbi The prevalence of metabolic syndrome in Danish patients with HIV infection: the effect of antiretroviral therapy
    B R Hansen
    Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, Hvidovre DK 2650, Denmark
    HIV Med 10:378-87. 2009
    ..We investigated the prevalence of MS in a cohort of Danish HIV-infected patients and estimated the effect of the various classes of antiretroviral therapies on the prevalence of MS and its components...
  42. ncbi Long-term high-physiological-dose growth hormone reduces intra-abdominal fat in HIV-infected patients with a neutral effect on glucose metabolism
    B R Hansen
    Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark
    HIV Med 11:266-75. 2010
    ..The aim of the study was to investigate the effect of long-term high-physiological-dose recombinant human growth hormone (rhGH) therapy on fat distribution and glucose metabolism in HIV-infected patients...
  43. ncbi Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus
    L Eriksen
    Department of Biomedical Sciences, The Copenhagen Muscle Research Centre, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark
    Diabetologia 50:2245-53. 2007
    ..We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus...
  44. ncbi Enhanced glucagon-like peptide-1 (GLP-1) response to oral glucose in glucose-intolerant HIV-infected patients on antiretroviral therapy
    O Andersen
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    HIV Med 6:91-8. 2005
    ....
  45. ncbi Improved glycaemic control decreases inner mitochondrial membrane leak in type 2 diabetes
    R Rabøl
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes Obes Metab 11:355-60. 2009
    ..The purpose of the study was to test the hypothesis that mitochondrial efficiency increases as a result of insulin treatment in patients with type 2 diabetes...
  46. ncbi Increased plasma soluble uPAR level is a risk marker of respiratory cancer in initially cancer-free individuals
    Anne Langkilde
    Clinical Research Centre 136, Copenhagen University Hospital, Hvidovre, Denmark
    Cancer Epidemiol Biomarkers Prev 20:609-18. 2011
    ..This study tested the association between suPAR levels and incident respiratory, gastrointestinal, or other types of cancer in initially cancer-free individuals from a general population-based prospective study...
  47. ncbi Mild hyponatremia carries a poor prognosis in community subjects
    Ahmad Sajadieh
    Clinic of Cardiology, Copenhagen University Hospital, Amager, Denmark
    Am J Med 122:679-86. 2009
    ..Hyponatremia has been shown to predict adverse outcome in congestive heart failure and pneumonia among other common clinical entities, but its significance in the general population is elusive...
  48. ncbi Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
    J Eugen-Olsen
    Clinical Research Centre, Copenhagen University, Hvidovre Hospital, Hvidovre, Denmark
    J Intern Med 268:296-308. 2010
    ..Biomarkers of inflammation may aid in risk prediction and enable early intervention and prevention of disease...