Torben Hansen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Pancreatic beta-cell stimulation tests in transient and persistent congenital hyperinsulinism
    H B Christesen
    Department of Paediatrics, Odense University Hospital, Denmark
    Acta Paediatr 90:1116-20. 2001
  2. ncbi request reprint The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy
    Henrik B T Christesen
    Department of Pediatrics, Odense University Hospital, Odense, Denmark
    Diabetes 51:1240-6. 2002
  3. ncbi request reprint A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene
    Kurt Højlund
    Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Kloevervaenget 6, DK 5000, Odense C, Denmark
    Diabetes 53:1592-8. 2004
  4. pmc Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e6106. 2009
  5. ncbi request reprint High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia
    Tine D Clausen
    Department of Obstetrics, Copenhagen Center for Pregnant Women with Diabetes, Copenhagen University Hospital, Rigshospitalet, Denmark
    Diabetes Care 31:340-6. 2008
  6. pmc Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function
    Sara K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 110:827-33. 2002
  7. pmc Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e5469. 2009
  8. doi request reprint Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes
    Tine D Clausen
    Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, The Capital Region of Denmark, Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:2464-70. 2009
  9. ncbi request reprint Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?
    Pernille Poulsen
    Department of Endocrinology, Odense University Hospital, Odense C, Denmark
    Diabetes 52:194-8. 2003
  10. pmc Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:2534-40. 2008

Detail Information

Publications66

  1. ncbi request reprint Pancreatic beta-cell stimulation tests in transient and persistent congenital hyperinsulinism
    H B Christesen
    Department of Paediatrics, Odense University Hospital, Denmark
    Acta Paediatr 90:1116-20. 2001
    ..The beta-cell response to glucose and glucagon stimulation was blunted before, as well as after, pancreas resections. Compound heterozygosity for the SUR1 mutations 3992-3c to g and N188S was found...
  2. ncbi request reprint The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy
    Henrik B T Christesen
    Department of Pediatrics, Odense University Hospital, Odense, Denmark
    Diabetes 51:1240-6. 2002
    ..Mathematical modeling predicted a markedly lowered GSIR threshold of 1.5 mmol/l. The theoretical and practical implications are manifold and significant...
  3. ncbi request reprint A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene
    Kurt Højlund
    Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Kloevervaenget 6, DK 5000, Odense C, Denmark
    Diabetes 53:1592-8. 2004
    ....
  4. pmc Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e6106. 2009
    ..The objective of the present study was to investigate the association of common variation in the CHI3L1 locus with asthma, atopy and lung function in a large population-based sample of adults...
  5. ncbi request reprint High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia
    Tine D Clausen
    Department of Obstetrics, Copenhagen Center for Pregnant Women with Diabetes, Copenhagen University Hospital, Rigshospitalet, Denmark
    Diabetes Care 31:340-6. 2008
    ..We studied glucose tolerance in adult offspring of women with either gestational diabetes mellitus (GDM) or type 1 diabetes, taking the impact of both intrauterine hyperglycemia and genetic predisposition to type 2 diabetes into account...
  6. pmc Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function
    Sara K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 110:827-33. 2002
    ..Furthermore, they indicate that this regulation is essential to maintain normal pancreatic function...
  7. pmc Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e5469. 2009
    ..The aim of the present study was to investigate the putative association between SNPs and haplotype blocks of CHI3LI and T2D and T2D related quantitative traits...
  8. doi request reprint Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes
    Tine D Clausen
    Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, The Capital Region of Denmark, Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:2464-70. 2009
    ..In animal studies, exposure to intrauterine hyperglycemia increases the risk of cardiovascular disease through only partly understood epigenetic mechanisms. Human long-term follow-up studies on the same topic are few...
  9. ncbi request reprint Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?
    Pernille Poulsen
    Department of Endocrinology, Odense University Hospital, Odense C, Denmark
    Diabetes 52:194-8. 2003
    ..Accordingly, our study simultaneously supports a role for both the intrauterine environment (thrifty phenotype) and for genetics (thrifty genotype) in the etiology of insulin resistance and perhaps glucose intolerance in twins...
  10. pmc Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:2534-40. 2008
    ....
  11. ncbi request reprint Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    Agnar Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 39:218-25. 2007
    ....
  12. ncbi request reprint The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study
    Els C van Hove
    Leiden University Medical Center, Department of Molecular Cell Biology, Building 2, Room R2 005, Postal Zone S1 P, P O Box 9600, 2300 RC Leiden, Netherlands
    Diabetes 55:3193-6. 2006
    ..We conclude that it is unlikely that variation in HADHSC plays a major role in the pathogenesis of type 2 diabetes in the examined cohorts...
  13. ncbi request reprint Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study
    Pernille Koefoed Theil
    Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark
    Curr Eye Res 31:733-8. 2006
    ..They should therefore also have the higher lens fluorescence values...
  14. doi request reprint The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    J Clin Endocrinol Metab 93:2294-9. 2008
    ..Hepatic lipase plays a pivotal role in the metabolism of high-density lipoprotein (HDL) and low-density lipoprotein by involvement in reverse cholesterol transport and the formation of atherogenic small dense low-density lipoprotein...
  15. ncbi request reprint A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes
    Jakob Ek
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 55:1869-73. 2006
    ..In conclusion, a rare, novel mutation that disrupts a protein binding site in the pancreatic HNF4A promoter associates with late-onset diabetes...
  16. ncbi request reprint A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites
    Christian S Rose
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Diabetes 54:3026-31. 2005
    ..17-2.24]). In conclusion, the GCK -30G>A polymorphism associates with elevated fasting and post-OGTT glycemia in the middle-aged general population of whites, as well as with IGR and other features of the WHO-defined metabolic syndrome...
  17. ncbi request reprint Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites
    Lise Wegner
    Steno Diabetes Center, Niels Steensens Vej 2, NSP1 03, DK 2820 Gentofte, Denmark
    Diabetes 56:694-8. 2007
    ....
  18. ncbi request reprint Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Denmark
    Diabetes 56:3105-11. 2007
    ..Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants...
  19. ncbi request reprint Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:977-83. 2007
    ..Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes...
  20. ncbi request reprint Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy
    Masumi Kamiyama
    Laboratory for Diabetic Nephropathy, SNP Research Centre, Institute of Physical and Chemical Research, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Hum Genet 122:397-407. 2007
    ..G, P = 0.03, odds ratio = 1.91, 95% CI 1.07-3.42). These results suggest that the NCALD gene is a likely candidate for conferring susceptibility to diabetic nephropathy...
  21. ncbi request reprint Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites
    Thomas Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820, Gentofte, Denmark
    Mol Genet Metab 92:278-82. 2007
    ....
  22. ncbi request reprint A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
    Harald Staiger
    Internal Medicine IV, Medical Clinic Tübingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 57:514-7. 2008
    ..Based on HHEX's function during embryonic development of the ventral pancreas in mice, we investigated whether these SNPs affect beta-cell function in humans...
  23. doi request reprint Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:1136-42. 2008
    ..Due to the previous inconclusive quantitative trait associations, we also did studies of intermediate quantitative phenotypes...
  24. doi request reprint Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
    Alena Stancakova
    Department of Medicine, University of Kuopio and University Hospital, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 93:1924-30. 2008
    ..CDKAL1 is a recently discovered susceptibility gene for type 2 diabetes...
  25. pmc Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus
    Carlo Colombo
    Laboratory of Molecular Endocrinology and Metabolism, Bambino Gesu Children s Hospital, Scientific Institute and Department of Internal Medicine, University of Tor Vergata, Rome, Italy
    J Clin Invest 118:2148-56. 2008
    ..Similarly transfected INS-1E insulinoma cells had diminished viability compared with those expressing WT proinsulin. In conclusion, we find that mutations in the insulin gene that promote proinsulin misfolding may cause PNDM...
  26. ncbi request reprint A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians
    Shekher Anuradha
    Dr Mohans MV Diabetes Specialties Centre and Madras Diabetes Research Foundation, Gopalapuram, Chennai, India
    Diabetes Care 28:2430-5. 2005
    ..The aim of this study was to estimate the prevalence of Ala98Val polymorphism of the HNF1alpha gene in different types of diabetes in Asian Indians...
  27. ncbi request reprint Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    J Mol Med (Berl) 83:353-61. 2005
    ..02) and altered fasting plasma glucose (P=0.03). However, these later findings could not be replicated in additional studies. In conclusion, variants in CDKN1C may contribute to the inter-individual variation in birth weight...
  28. ncbi request reprint Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and kidney transplantation?
    Frantisek Saudek
    Diabetes Center, Institute for Clinical and Experimental Medicine, Praha, Czech Republic
    Transplantation 77:1298-301. 2004
    ..A hyperglycemic clamp test showed a normal beta-cell function. CONCLUSION: Identification of MODY3 among all C-peptide-positive patients with advanced diabetic nephropathy might help to select a specific group profiting from SPK...
  29. ncbi request reprint Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population
    Jeannet Lauenborg
    Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Diabetes Care 27:1194-9. 2004
    ....
  30. ncbi request reprint Type 2 diabetes mellitus--a multifactorial disease
    Torben Hansen
    Steno Diabetes Center, Hagedorn Research Institute, Copenhagen, Denmark
    Ann Univ Mariae Curie Sklodowska Med 57:544-9. 2002
    ..Understanding of diabetes pathogenesis is essential to the development of new methods of treatment and strategies of effective prevention of this disease...
  31. ncbi request reprint Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Pharmacogenetics 13:417-23. 2003
    ..In conclusion, the Leu162Val polymorphism of PPARalpha is associated with a decreased level of fasting serum triglyceride in glucose tolerant white subjects...
  32. ncbi request reprint A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity
    Timothy M Frayling
    Department of Diabetes and Vascular Medicine, Postgraduate School of Medicine and Health Science, University of Exeter, Exeter, U K
    Diabetes 52:872-81. 2003
    ..88 at 169-175 cM), and to chromosomes 3 (heterogeneity LOD [HLOD] score 1.27 at 124 cM) and 5 (HLOD score 1.22 at 175 cM) in 14 more strictly defined families. Our results provide evidence for further heterogeneity in MODY...
  33. ncbi request reprint The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes 52:573-7. 2003
    ..49, P = 0.00022). In conclusion, the widespread E23K polymorphism may have a diabetogenic effect by impairing glucose-induced insulin release and increasing BMI...
  34. ncbi request reprint Mutational analysis of the UCP2 core promoter and relationships of variants with obesity
    Louise T Dalgaard
    Steno Diabetes Center and Statens Serum Institute, 5 Artillerivej, Gentofte, DK 2300 Copenhagen, Denmark
    Obes Res 11:1420-7. 2003
    ..To identify polymorphisms in the human uncoupling protein 2 gene (UCP2) promoter and to investigate whether these were associated with obesity or weight gain...
  35. ncbi request reprint Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians
    Søren K Rasmussen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 51:3561-7. 2002
    ....
  36. ncbi request reprint The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes
    Jakob Ek
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 6, NSK1 14, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:3054-9. 2005
    ....
  37. ncbi request reprint [Chasing the genetic determinants of the presumed polygenic forms of type 2 diabetes. Status and perspectives]
    Oluf Borbye Pedersen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte
    Ugeskr Laeger 164:2163-6. 2002
  38. pmc Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha
    Katrine Almind
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:2124-8. 2002
    ..Thus, the Met-326Ile variant of p85alpha is functional for intracellular signaling and adipocyte differentiation but has small alterations in protein expression and activity that could play a role in modifying insulin action...
  39. ncbi request reprint PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Hypertension 45:565-70. 2005
    ..001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women...
  40. ncbi request reprint [Maturity-onset diabetes of the young--MODY. Molecular-genetic, pathophysiological and clinical characteristics]
    Torben Hansen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte
    Ugeskr Laeger 164:2017-22. 2002
    ..The identification of MODY genes also opens new perspectives in the understanding of the molecular basis of diabetes and may probably contribute to the definition of novel targets for drug development and gene therapy...
  41. pmc Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function
    Bernadette Neve
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8090, Institute Pasteur de Lille, F 59019 Lille, France
    Proc Natl Acad Sci U S A 102:4807-12. 2005
    ..Thus, both functional and genetic analyses reveal that KLF11 plays a role in the regulation of pancreatic beta cell physiology, and its variants may contribute to the development of diabetes...
  42. ncbi request reprint The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance
    Torben Hansen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes Care 30:257-62. 2007
    ....
  43. ncbi request reprint Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
    Camilla H Andreasen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Denmark
    Diabetes 57:95-101. 2008
    ..In the present study, the effect of FTO variation on metabolic traits including obesity, type 2 diabetes, and related quantitative phenotypes was examined...
  44. doi request reprint The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 40:217-24. 2008
    ..These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases...
  45. doi request reprint The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes
    Trine Nielsen
    Steno Diabetes Center, Gentofte, Denmark
    J Hypertens 26:2142-6. 2008
    ..The previous studies have, however, been conflicting, and the aim of the present study was to clarify the impact of the Glu65Lys polymorphism on hypertension at the population level of middle-aged people...
  46. doi request reprint AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 12, DK 2820 Gentofte, Denmark
    Diabetes 57:1427-32. 2008
    ..We related seven frequent AHSG tag single nucleotide polymorphisms to a range of metabolic traits, including type 2 diabetes, obesity, and dyslipidemia...
  47. ncbi request reprint Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses
    Takafumi Tsuchiya
    Departments of Medicine and Human Genetics, The University of Chicago, 5841 S Maryland Ave, MC1027, Chicago, IL 60637, USA
    Mol Genet Metab 89:174-84. 2006
    ..68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans...
  48. ncbi request reprint [Genetics in non-autoimmune diabetes. The Danish Society of Endocrinology]
    Torben Hansen
    Steno Diabetes Center, DK 2820 Gentofte
    Ugeskr Laeger 170:1021. 2008
  49. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  50. ncbi request reprint Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits
    Gitte Andersen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 52:2445-8. 2003
    ..However, the codon 206 polymorphism may be related to the interindividual variation in fasting and oral glucose-induced serum insulin levels...
  51. ncbi request reprint Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene
    Leen M 't Hart
    Leiden University Medical Center, Department of Molecular Cell Biology, Wassenaarseweg 72, 2333 AL Leiden, Netherlands
    Diabetes 54:1892-5. 2005
    ..This is the first report of association between an aminoacyl tRNA synthetase gene and disease. Our results further highlight the important role of mitochondria in glucose homeostasis...
  52. ncbi request reprint Novel variants in the putative peroxisome proliferator-activated receptor {gamma} promoter and relationships with obesity in men
    Thomas M Larsen
    Department of Human Nutrition, LMC Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Denmark
    Obes Res 13:953-8. 2005
    ..In conclusion, the identified novel variants in the PPARgamma2 promoter region do not explain the reported discrepancies in the association of previously identified variants with obesity and type 2 diabetes...
  53. ncbi request reprint Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes
    Signe S Torekov
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820, Gentofte, Denmark
    Diabetes 54:2261-5. 2005
    ..03), and a lower insulinogenic index (P = 0.01). In conclusion, the common Arg allele of the PYY Arg72Thr variant modestly associates with type 2 diabetes and with type 2 diabetes-related quantitative traits...
  54. ncbi request reprint Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes
    Sara K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:3629-37. 2005
    ..In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes...
  55. ncbi request reprint Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites
    Dorit P Jensen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Copenhagen, Denmark
    Mol Genet Metab 89:360-7. 2006
    ....
  56. ncbi request reprint Grey-box modelling of pharmacokinetic/pharmacodynamic systems
    Christoffer W Tornøe
    Informatics and Mathematical Modelling, Technical University of Denmark, Lyngby, Denmark
    J Pharmacokinet Pharmacodyn 31:401-17. 2004
    ....
  57. ncbi request reprint Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 92:363-6. 2007
    ..A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been reported to associate with insulin resistance...
  58. ncbi request reprint Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people
    Thomas Sparsø
    Steno Diabetes Center, 521, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Mol Genet Metab 90:205-9. 2007
    ..If replicated, the Val162Val variant may, however, confer an increase in fasting levels of serum lipids...
  59. ncbi request reprint Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites
    Yasmin H Hamid
    Steno Diabetes Center, Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes 53:3342-5. 2004
    ..In conclusion, the Asp358Ala polymorphism of the IL6R associates with type 2 diabetes in Danish whites...
  60. ncbi request reprint The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
    Dorit P Jensen
    Steno Diabetes Center, Niels Steensens Vej 2, 2820, Gentofte, Denmark
    J Mol Med (Berl) 85:445-9. 2007
    ..In conclusion, in a large study sample, we were unable to find robust evidence of an association of the Pro129Thr FAAH variant with overweight, obesity, and any related quantitative traits among the examined whites...
  61. ncbi request reprint Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes
    Lesli H Larsen
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    Clin Biochem 38:420-4. 2005
    ..To investigate the preproghrelin gene for variants and their association with obesity and type 2 diabetes...
  62. pmc Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus
    Gitte Andersen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Diabetes 53:2992-7. 2004
    ..Thus, variation in the coding region of NCB5OR is not a major contributor in the pathogenesis of nonautoimmune diabetes...
  63. ncbi request reprint A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    Valgerdur Steinthorsdottir
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:770-5. 2007
    ..The insulin response for homozygotes was approximately 20% lower than for heterozygotes or noncarriers, suggesting that this variant confers risk of T2D through reduced insulin secretion...
  64. pmc A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis
    Ingrid Dahlman
    Department of Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Am J Hum Genet 80:1115-24. 2007
    ..The latter involves a cross-talk between GPR74 and beta -adrenoceptor signaling to lipolysis in fat cells...
  65. ncbi request reprint Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis
    Irena Hainerova
    Department of Pediatrics and Center for Research of Diabetes, Metabolism, and Nutrition, Third Faculty of Medicine, Charles University, 100 34 Prague 10, Czech Republic
    J Clin Endocrinol Metab 92:3689-96. 2007
    ..Mutations in the melanocortin 4 receptor gene (MC4R) represent the most common known cause of monogenic human obesity...
  66. ncbi request reprint A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro
    Søren M Echwald
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    Diabetes 51:1-6. 2002
    ..7 (CI 1.26-10.93, P = 0.02) genotype relative risk of type 2 diabetes in the examined population of Danish Caucasian subjects and results in impaired in vitro serine phosphorylation of the PTP-1B peptide...