Pia S Hansen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins
    Pia Skov Hansen
    Department of Endocrinology M, Odense University Hospital, and The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 89:1181-7. 2004
  2. ncbi request reprint The impact of a TSH receptor gene polymorphism on thyroid-related phenotypes in a healthy Danish twin population
    Pia Skov Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 66:827-32. 2007
  3. ncbi request reprint Genetic and environmental interrelations between measurements of thyroid function in a healthy Danish twin population
    Pia Skov Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Denmark
    Am J Physiol Endocrinol Metab 292:E765-70. 2007
  4. pmc Yersinia enterocolitica infection does not confer an increased risk of thyroid antibodies: evidence from a Danish twin study
    P S Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Exp Immunol 146:32-8. 2006
  5. ncbi request reprint The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity: a study of healthy Danish twins
    Pia S Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Eur J Endocrinol 154:29-38. 2006
  6. ncbi request reprint The relative importance of genetic and environmental factors in the aetiology of thyroid nodularity: a study of healthy Danish twins
    Pia Skov Hansen
    Department of Endocrinology M, Odense University Hospital, Odense C, Denmark
    Clin Endocrinol (Oxf) 62:380-6. 2005
  7. ncbi request reprint Genetic and environmental causes of individual differences in thyroid size: a study of healthy Danish twins
    Pia Skov Hansen
    Department of Endocrinology M, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 89:2071-7. 2004
  8. doi request reprint The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study
    Thomas H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 73:666-70. 2010
  9. ncbi request reprint Low birth weight is not associated with thyroid autoimmunity: a population-based twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Sdr Boulevard 29, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 91:3499-502. 2006
  10. pmc Preliminary evidence of a noncausal association between the X-chromosome inactivation pattern and thyroid autoimmunity: a twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Eur J Hum Genet 18:254-7. 2010

Detail Information

Publications20

  1. ncbi request reprint Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins
    Pia Skov Hansen
    Department of Endocrinology M, Odense University Hospital, and The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 89:1181-7. 2004
    ..Whether this is of importance when treating individuals in whom pituitary-thyroid function has been disrupted by, e.g. hypo- or hyperthyroidism, remains to be clarified...
  2. ncbi request reprint The impact of a TSH receptor gene polymorphism on thyroid-related phenotypes in a healthy Danish twin population
    Pia Skov Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 66:827-32. 2007
    ....
  3. ncbi request reprint Genetic and environmental interrelations between measurements of thyroid function in a healthy Danish twin population
    Pia Skov Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Denmark
    Am J Physiol Endocrinol Metab 292:E765-70. 2007
    ..In conclusion, thyroid hormone levels are partly genetically correlated genes that affect free T4 levels and exert pleiotropic effects on free T3 levels, although most of the genetic variance for these measurements is trait specific...
  4. pmc Yersinia enterocolitica infection does not confer an increased risk of thyroid antibodies: evidence from a Danish twin study
    P S Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Exp Immunol 146:32-8. 2006
    ..In conclusion, Yersinia infection does not confer an increased risk of thyroid antibodies. The genetic contribution in the acquisition of Yersinia infection is modest...
  5. ncbi request reprint The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity: a study of healthy Danish twins
    Pia S Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Eur J Endocrinol 154:29-38. 2006
    ..We aimed to estimate the relative importance of genetic and environmental effects for the presence of thyroid autoantibodies in euthyroid subjects...
  6. ncbi request reprint The relative importance of genetic and environmental factors in the aetiology of thyroid nodularity: a study of healthy Danish twins
    Pia Skov Hansen
    Department of Endocrinology M, Odense University Hospital, Odense C, Denmark
    Clin Endocrinol (Oxf) 62:380-6. 2005
    ..Factors such as age, gender, iodine intake, smoking and parity are associated with nodularity of the thyroid. Whether there is a genetic susceptibility is unclear...
  7. ncbi request reprint Genetic and environmental causes of individual differences in thyroid size: a study of healthy Danish twins
    Pia Skov Hansen
    Department of Endocrinology M, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 89:2071-7. 2004
    ..This fits the observation that goiter may be seen also in the absence of evident environmental goitrogens such as iodine deficiency and that not all individuals develop goiter even in iodine-deficient areas...
  8. doi request reprint The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study
    Thomas H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 73:666-70. 2010
    ..Theoretically, as shown for autoimmune thyroid disease, the pattern of X chromosome inactivation (XCI) could offer a novel explanation for the observed variability of the PTA set point in women...
  9. ncbi request reprint Low birth weight is not associated with thyroid autoimmunity: a population-based twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Sdr Boulevard 29, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 91:3499-502. 2006
    ..The effect of these confounders can be minimized through investigation of twin pairs...
  10. pmc Preliminary evidence of a noncausal association between the X-chromosome inactivation pattern and thyroid autoimmunity: a twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Eur J Hum Genet 18:254-7. 2010
    ..More likely, XCI and TPOAb are influenced by shared genetic determinants...
  11. ncbi request reprint Establishment of reference distributions and decision values for thyroid antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TgAb) and the thyrotropin receptor (TRAb)
    Esther A Jensen
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Clin Chem Lab Med 44:991-8. 2006
    ..However, some young men without any of the risk factors have autoantibodies, and cannot be identified by the present tools. A model for reference intervals and cut-off values should not be influenced by the prevalence of risk factors...
  12. doi request reprint Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves' disease: evidence from a twin case-control study
    Thomas H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 69:491-6. 2008
    ..This potential confounding can be minimized by investigation of twin pairs discordant for GD...
  13. doi request reprint X Chromosome inactivation pattern is not associated with interindividual variations in thyroid volume: a study of euthyroid Danish female twins
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Denmark
    Twin Res Hum Genet 12:502-6. 2009
    ..In conclusion, in a sample of euthyroid Danish female twins, we found no evidence of a relationship between XCI pattern and thyroid volume...
  14. ncbi request reprint Aggregation of thyroid autoantibodies in first-degree relatives of patients with autoimmune thyroid disease is mainly due to genes: a twin study
    Thomas Heiberg Brix
    Department of Endocrinology M, Odense University Hospital, Denmark
    Clin Endocrinol (Oxf) 60:329-34. 2004
    ..However, family studies cannot determine whether the observed familial aggregation of these antibodies is due to shared genes or shared environment...
  15. doi request reprint Aggregation of thyroid autoantibodies in twins from opposite-sex pairs suggests that microchimerism may play a role in the early stages of thyroid autoimmunity
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 94:4439-43. 2009
    ..Microchimerism has recently been proposed to play a role in the pathogenesis of thyroid autoimmunity. In that case, twins from opposite-sex pairs (OS) should have an increased risk of thyroid autoantibodies (TA)...
  16. doi request reprint Identification and consequences of polymorphisms in the thyroid hormone receptor alpha and beta genes
    Helena Gásdal Sørensen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Thyroid 18:1087-94. 2008
    ..However, little is known about SNPs in the THRA (17q11.2) and THRB (3p24.2) genes. The aim of this study was to map THRA and THRB for the occurrence and frequencies of SNPs and relate these to thyroid parameters...
  17. ncbi request reprint Establishment of a serum thyroid stimulating hormone (TSH) reference interval in healthy adults. The importance of environmental factors, including thyroid antibodies
    Esther Jensen
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Clin Chem Lab Med 42:824-32. 2004
    ..Consequently, a common reference interval for serum TSH of 0.58-4.07 mlU/l for all adults between 17 and 66 years of age was established. This reference interval is much higher than expected from the NACB-guidelines...
  18. doi request reprint No link between X chromosome inactivation pattern and simple goiter in females: evidence from a twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Thyroid 19:165-9. 2009
    ....
  19. ncbi request reprint Improved sensitivity of a thyrotropin receptor antibody assay
    Esther Jensen
    Department of Clinical Biochemistry, Odense University Hospital, Denmark
    Clin Chem 51:2186-7. 2005
  20. doi request reprint Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Center, Room Ee 502, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocrinology 149:5307-14. 2008
    ..In conclusion, OATP1C1 mediates transport of T4, T4S, and rT3 and increases the access of these substrates to the intracellular active sites of the deiodinases. No effect of genetic variation on the function of OATP1C1 was observed...