Lars Hansen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients
    Lars Hansen
    Novo Nordisk A S, D M S C, Krogshoejvej 53A, 9E2 48, DK 2880 Bagsvaerd, Denmark
    J Clin Endocrinol Metab 91:3446-50. 2006
  2. ncbi request reprint Mutation analysis of the WFS1 gene in seven Danish Wolfram syndrome families; four new mutations identified
    Lars Hansen
    The Wilhelm Johannsen Centre for Functional Genome Research, Institute of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Copenhagen N, Denmark
    Eur J Hum Genet 13:1275-84. 2005
  3. doi request reprint Comprehensive mutational screening in a cohort of Danish families with hereditary congenital cataract
    Lars Hansen
    Wilhelm Johannsen Centre for Functional Genome Research, Institute of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
    Invest Ophthalmol Vis Sci 50:3291-303. 2009
  4. ncbi request reprint Genetic heterogeneity in microcornea-cataract: five novel mutations in CRYAA, CRYGD, and GJA8
    Lars Hansen
    Wilhelm Johannsen Centre for Functional Genome Research, Department G, Institute of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Invest Ophthalmol Vis Sci 48:3937-44. 2007
  5. ncbi request reprint A 72-year-old Danish puzzle resolved--comparative analysis of phenotypes in families with different-sized HOXD13 polyalanine expansions
    Klaus W Kjaer
    Department of Medical Biochemistry and Genetics, Wilhelm Johannsen Centre for Functional Genome Research, University of Copenhagen, Denmark
    Am J Med Genet A 138:328-39. 2005
  6. ncbi request reprint Novel MAF mutation in a family with congenital cataract-microcornea syndrome
    Lars Hansen
    The Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Copenhagen N, Denmark
    Mol Vis 13:2019-22. 2007
  7. doi request reprint Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression
    Hans Eiberg
    Department of Cellular and Molecular Medicine, Section IV Build 24 4, Panum Institute, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark
    Hum Genet 123:177-87. 2008
  8. ncbi request reprint A novel nonsense mutation in PAX9 is associated with marked variability in number of missing teeth
    Lars Hansen
    Department of Cellular and Molecular Medicine and The Wilhelm Johannsen Center for Functional Genome Research, The Panum Insitute, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen N, Denmark
    Eur J Oral Sci 115:330-3. 2007
  9. ncbi request reprint Male-to-male transmission in Laurin-Sandrow syndrome and exclusion of RARB and RARG
    Klaus W Kjaer
    Department of Medical Biochemistry and Genetics, Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Panum Institute 24 4, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Am J Med Genet A 137:148-52. 2005
  10. ncbi request reprint Mapping of hereditary trichilemmal cyst (TRICY1) to chromosome 3p24-p21.2 and exclusion of beta-CATENIN and MLH1
    Hans Eiberg
    Department of Medical Biochemistry and Genetics, University of Copenhagen, Copenhagen, Denmark
    Am J Med Genet A 133:44-7. 2005

Collaborators

Detail Information

Publications34

  1. ncbi request reprint The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients
    Lars Hansen
    Novo Nordisk A S, D M S C, Krogshoejvej 53A, 9E2 48, DK 2880 Bagsvaerd, Denmark
    J Clin Endocrinol Metab 91:3446-50. 2006
    ..Clinically, however, fluid retention and edema are worrying side effects with these drugs...
  2. ncbi request reprint Mutation analysis of the WFS1 gene in seven Danish Wolfram syndrome families; four new mutations identified
    Lars Hansen
    The Wilhelm Johannsen Centre for Functional Genome Research, Institute of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Copenhagen N, Denmark
    Eur J Hum Genet 13:1275-84. 2005
    ..In contrast, diabetes insipidus was present in two subjects only. Various degrees and types of hearing impairment were diagnosed in six individuals and cataract was observed in five subjects...
  3. doi request reprint Comprehensive mutational screening in a cohort of Danish families with hereditary congenital cataract
    Lars Hansen
    Wilhelm Johannsen Centre for Functional Genome Research, Institute of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
    Invest Ophthalmol Vis Sci 50:3291-303. 2009
    ..Seven families have been published previously, and the data of the remaining 21 families are presented together with an overview of the results in all families...
  4. ncbi request reprint Genetic heterogeneity in microcornea-cataract: five novel mutations in CRYAA, CRYGD, and GJA8
    Lars Hansen
    Wilhelm Johannsen Centre for Functional Genome Research, Department G, Institute of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Invest Ophthalmol Vis Sci 48:3937-44. 2007
    ..To unravel the molecular genetic background in families with congenital cataract in association with microcornea (CCMC, OMIM 116150)...
  5. ncbi request reprint A 72-year-old Danish puzzle resolved--comparative analysis of phenotypes in families with different-sized HOXD13 polyalanine expansions
    Klaus W Kjaer
    Department of Medical Biochemistry and Genetics, Wilhelm Johannsen Centre for Functional Genome Research, University of Copenhagen, Denmark
    Am J Med Genet A 138:328-39. 2005
    ..Thus, our data have added evidence to the phenotype-genotype correlation previously reported, which was further extended to include lesser involvement of bones in ray 1, 2, and 5...
  6. ncbi request reprint Novel MAF mutation in a family with congenital cataract-microcornea syndrome
    Lars Hansen
    The Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Copenhagen N, Denmark
    Mol Vis 13:2019-22. 2007
    ..To further unravel the molecular genetic background for the association congenital cataract-microcornea (CCMC)...
  7. doi request reprint Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression
    Hans Eiberg
    Department of Cellular and Molecular Medicine, Section IV Build 24 4, Panum Institute, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark
    Hum Genet 123:177-87. 2008
    ..In addition, an LOD score of Z = 4.21 between hair color and D14S72 was obtained in the large family, indicating that RABGGTA is a candidate gene for hair color...
  8. ncbi request reprint A novel nonsense mutation in PAX9 is associated with marked variability in number of missing teeth
    Lars Hansen
    Department of Cellular and Molecular Medicine and The Wilhelm Johannsen Center for Functional Genome Research, The Panum Insitute, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen N, Denmark
    Eur J Oral Sci 115:330-3. 2007
    ..The family showed a marked phenotypic variability in the number of missing teeth, ranging from 2 to 15 missing teeth. The highest frequency of missing teeth was found for second molars followed by second premolars...
  9. ncbi request reprint Male-to-male transmission in Laurin-Sandrow syndrome and exclusion of RARB and RARG
    Klaus W Kjaer
    Department of Medical Biochemistry and Genetics, Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Panum Institute 24 4, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Am J Med Genet A 137:148-52. 2005
    ..However, it was located 83 bp from exon 2, suggesting it is a rare polymorphism which does not account for the phenotype. No other mutations were found. This suggests that another yet unknown gene is responsible for the condition...
  10. ncbi request reprint Mapping of hereditary trichilemmal cyst (TRICY1) to chromosome 3p24-p21.2 and exclusion of beta-CATENIN and MLH1
    Hans Eiberg
    Department of Medical Biochemistry and Genetics, University of Copenhagen, Copenhagen, Denmark
    Am J Med Genet A 133:44-7. 2005
    ..69; theta(M = F) = 0.08) spanning 10.3 Mb on chromosome 3p24-p21.2. We sequenced two candidate genes previously reported in inherited hair defects, CTNNB1 and MLH1 but failed to detect mutations in exons and intron-exon bounders...
  11. ncbi request reprint The congenital "ant-egg" cataract phenotype is caused by a missense mutation in connexin46
    Lars Hansen
    The Wilhelm Johannsen Centre for Functional Genome Research, Institute of Medical Biochemistry and Genetics, University of Copenhagen, Copenhagen, Denmark
    Mol Vis 12:1033-9. 2006
    ..We retrieved the family and performed linkage analysis to determine the disease locus and identify the mutated gene...
  12. pmc Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment
    Nanna D Rendtorff
    Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, Denmark
    Am J Med Genet A 155:1298-313. 2011
    ..R445H mutation in OPA1. Our findings suggest that patients who are heterozygous for WFS1 missense mutations should be carefully clinically examined for OA and other manifestations of Wolfram syndrome...
  13. pmc Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disability
    Lars Hansen
    Wilhelm Johannsen Centre for Functional Genome Research, The Panum Institute, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen N, Denmark
    Am J Hum Genet 92:575-83. 2013
    ..GPI-anchor deficiencies can be interpreted within the concept of a disease family, and we propose that the severity of the phenotype is dependent on the location of the altered protein in the biosynthesis chain...
  14. ncbi request reprint Mutation analysis of the Sonic hedgehog promoter and putative enhancer elements in Parkinson's disease patients
    Mads Bak
    Wilhelm Johannsen Centre for Functional Genome Research, Department of Medical Genetics G, Institute of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Blegdamsvej 3, Bldg 24 4, DK 2200N Copenhagen, Denmark
    Brain Res Mol Brain Res 126:207-11. 2004
    ..None of the identified sequence variations were present at a significantly different frequency in PD patients compared to healthy individuals, suggesting that they are not involved in the pathogenesis of PD...
  15. ncbi request reprint Determination of the 'critical region' for cat-like cry of Cri-du-chat syndrome and analysis of candidate genes by quantitative PCR
    Qingfa Wu
    Department of Medical Genetics, Institute of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Copenhagen N, Denmark
    Eur J Hum Genet 13:475-85. 2005
    ..The other two genes are expressed uniformly in all tissues tested, which suggest that they are housekeeping genes...
  16. pmc Complex multi-block analysis identifies new immunologic and genetic disease progression patterns associated with the residual β-cell function 1 year after diagnosis of type 1 diabetes
    Marie Louise Max Andersen
    Department of Pediatrics, Herlev Hospital, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e64632. 2013
    ..0005). These results demonstrate that Latent Factor Modelling can identify associating patterns in clinical prospective data--future functional studies will be needed to clarify the relevance of these patterns...
  17. ncbi request reprint Novel Connexin 43 (GJA1) mutation causes oculo-dento-digital dysplasia with curly hair
    Klaus W Kjaer
    Wilhelm Johannsen Centre for Functional Genome Research, The Panum Institute Building 24 4, Department of Medical Genetics, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen N, Denmark
    Am J Med Genet A 127:152-7. 2004
    ..We provide an easy method for mutation detection by use of the restriction enzyme Nde1 and discuss possible pathogenetic mechanisms, arguing that loss of function cannot be excluded. This is the second article reporting ODDD mutations...
  18. pmc Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
    Camilla Helene Sandholt
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e23531. 2011
    ..Moreover, we want to investigate if these loci associate with type 2 diabetes and to elucidate potential underlying metabolic mechanisms...
  19. ncbi request reprint The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
    Dorit P Jensen
    Steno Diabetes Center, Niels Steensens Vej 2, 2820, Gentofte, Denmark
    J Mol Med (Berl) 85:445-9. 2007
    ..In conclusion, in a large study sample, we were unable to find robust evidence of an association of the Pro129Thr FAAH variant with overweight, obesity, and any related quantitative traits among the examined whites...
  20. ncbi request reprint Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Pharmacogenetics 13:417-23. 2003
    ..In conclusion, the Leu162Val polymorphism of PPARalpha is associated with a decreased level of fasting serum triglyceride in glucose tolerant white subjects...
  21. ncbi request reprint Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians
    Søren K Rasmussen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 51:3561-7. 2002
    ....
  22. ncbi request reprint The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes 52:573-7. 2003
    ..49, P = 0.00022). In conclusion, the widespread E23K polymorphism may have a diabetogenic effect by impairing glucose-induced insulin release and increasing BMI...
  23. ncbi request reprint Candidate genes and late-onset type 2 diabetes mellitus. Susceptibility genes or common polymorphisms?
    Lars Hansen
    Steno Diabetes Center, Gentofte, Denmark
    Dan Med Bull 50:320-46. 2003
    ..Reviewed in context of the existing data our studies support the candidate gene approach as a feasible method for directly either identifying or excluding any gene as a diabetes-susceptibility gene ("diabetogene")...
  24. doi request reprint A novel mutation in IRF6 resulting in VWS-PPS spectrum disorder with renal aplasia
    Filipe de Medeiros
    Department of Plastic and Reconstructive Surgery and Burns Unit, University Hospital of Copenhagen, Rigshospitalet, Denmark
    Am J Med Genet A 146:1605-8. 2008
    ..The patient and his brother were both conceived by in vitro fertilization (IVF). It is discussed whether the renal malformation in the patient is related to the IVF procedure or to the IRF6 mutation...
  25. doi request reprint Cone dystrophy with supernormal rod response is strictly associated with mutations in KCNV2
    Bernd Wissinger
    Molecular Genetics Laboratory, Institute for Ophthalmic Research, Centre for Ophthalmology, University Clinics Tübingen, Germany
    Invest Ophthalmol Vis Sci 49:751-7. 2008
    ..Mutations in PDE6H and in KCNV2 have been described in CDSRR. A combined clinical and genetic study was conducted in a cohort of patients with CDSRR, to substantiate these prior..
  26. ncbi request reprint A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Clin Biochem 37:660-5. 2004
    ....
  27. ncbi request reprint Genetics of type 2 diabetes mellitus: status and perspectives
    Lars Hansen
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes Obes Metab 7:122-35. 2005
    ..The results of these efforts are likely to be the platform for major progress in the development of personalized antidiabetic drugs with higher efficacy and few side effects...
  28. ncbi request reprint Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
    Camilla H Andreasen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Denmark
    Diabetes 57:95-101. 2008
    ..In the present study, the effect of FTO variation on metabolic traits including obesity, type 2 diabetes, and related quantitative phenotypes was examined...
  29. ncbi request reprint Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    J Mol Med (Berl) 83:353-61. 2005
    ..02) and altered fasting plasma glucose (P=0.03). However, these later findings could not be replicated in additional studies. In conclusion, variants in CDKN1C may contribute to the inter-individual variation in birth weight...
  30. ncbi request reprint Significant difference in knowledge between English and Danish psychiatrists
    Lars Hansen
    Department of Psychiatry, University of Southampton, Brintons Terrace, Southampton SO14 0YG, UK
    Eur Psychiatry 20:287-90. 2005
    ..This is important in the context of the free (and growing) movement of the medical workforce across European Union (EU) countries' borders...
  31. ncbi request reprint Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes
    Lotte B Nielsen
    Department of Paediatrics, Glostrup University Hospital, Ndr Ringvej 57, DK 2600 Glostrup, Denmark
    Eur J Endocrinol 156:663-71. 2007
    ..2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes...
  32. ncbi request reprint [Prenatal diagnosis of congenital insulin-resistant diabetes (Donohue's syndrome)]
    Sven Pörksen
    Diabetesambulatoriet, Glostrup Hospital, Børneafdeling L, Glostrup
    Ugeskr Laeger 169:827-8. 2007
    ..The family received genetic counselling, and chorion villus sampling was performed early in pregnancy. Genotyping showed that the child in utero was heterozygous for the mutation. Subsequently the mother gave birth to a healthy boy...
  33. ncbi request reprint [Pharmacogenetic/regulatory aspects seen from the viewpoint of the industry]
    Lars Hansen
    Novo Nordisk A S, Måløv
    Ugeskr Laeger 167:2160-4. 2005
  34. ncbi request reprint [Chasing the genetic determinants of the presumed polygenic forms of type 2 diabetes. Status and perspectives]
    Oluf Borbye Pedersen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte
    Ugeskr Laeger 164:2163-6. 2002