Jesper Hallas

..A recent meta-analysis has suggested an increased risk of cancer among users of angiotensin receptor blockers...

..We hypothesized that existing scoring systems would have a low level of evidence and only few systems would have been externally validated...

..To examine the prognostic significance of fulfilling at least one of the Appropriateness Evaluation Protocol (AEP) criteria...

..Prescribed ephedrine/caffeine was not associated with a substantially increased risk of adverse cardiovascular outcomes in this study...

..We undertook this case-control study to clarify whether long-term users of valproate had a reduced cancer incidence. If so, it would support HDAC inhibition as a pharmacologic principle in chemoprevention...

..Each measure may be incorporated into an integral matrix that reflects various traits in utilization of every drug or drug class, thereby possibly finding abnormalities that suggest sub-optimal prescribing...

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..We performed a population-based case-control study to estimate the risk of intracerebral hemorrhage, subarachnoid hemorrhage, and ischemic stroke in users of NSAIDs...

..We aimed to evaluate the effect of statin use on acute nonvariceal UGB alone or in combinations with low-dose aspirin and other antithrombotic drugs...

..Increased awareness towards pain treatment, with earlier initiation of opioid treatment and higher doses to the cancer patients, could be major explanations for the increase in the cancer patients' use of opioids...

..Recent studies have suggested an increased risk of upper gastrointestinal bleeding (UGB) in spironolactone users. The aim was to confirm the association, identify the risk factors and quantify the absolute risk...

..To investigate whether the use of antiepileptic drugs (AEDs) increases the risk of hip fracture...

..We conducted this case-control study to assess if Helicobacter pylori (H. pylori) potentiates the risk of serious UGB in SSRI users...

..The factors underlying the choice of opioids for cancer patients in primary care are largely unknown. Our aim was to describe cancer patients' first treatment episode with opioids in relation to disease characteristics and clinical course...

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..It is controversial whether use of SSRIs is a cause of clinically important bleeding; results from observational studies have been equivocal...

..To assess adverse events with use of antiepileptic drugs (AEDs) by the method of sequence symmetry analysis...

..Objectives of this study were to evaluate the significance of comorbidity and age ≥70 years on receiving cytoreductive surgery, standard combination chemotherapy (TC), adherence to TC treatment, and prognosis...

..Several case-control studies have reported that the use of fluoroquinolone increases the risk of rupture of the Achilles tendon. Our aim was to estimate this risk by means of a population-based cohort approach...

..In specific situations, pharmacy dispensing data without diagnostic information can be used to assess the association between drug use and adverse effects in a prescription symmetry design...

..Cancer patients' consumption of strong opioids increased dramatically in 1996-1997, almost accounting for the entire increase in the whole population's consumption of strong opioids...

..The objective was to assess whether the concurrent use of tramadol and vitamin K antagonists (VKAs) leads to an increased risk of excessive anticoagulation...

..We used population-based data to estimate the risk of hemorrhagic and ischemic stroke in users of SSRIs...

..The aim of this study was to describe development in the number of patients undergoing first-time endoscopies and their use of antisecretory medication...

..CONCLUSION: The risk of esophageal adenocarcinoma is increased fivefold in patients with previously diagnosed esophagitis, but most of the adenocarcinomas occurred among patients with Barrett's esophagus...

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..We validated a new method of identifying patients with incident myasthenia in automated Danish registers for the purpose of conducting epidemiological studies of the disorder...

..The only peer-reviewed study in a Danish setting estimated an intervention rate of 2.3 per 1,000 prescriptions. With the introduction of a new tool for registration, we hypothesized that a better estimate could be obtained...

..This study aimed to assess the effect of community H. pylori screening and treatment on the prevalence of dyspepsia, and as secondary outcomes, the effect on dyspepsia-related health-care consumption and quality of life over 5 yr...

..Recently, the use of proton pump inhibitors (PPIs) has been associated with an increased risk of pneumonia. We aimed to confirm this association and to identify the risk factors...

..We investigated if past use of antibiotics active against CP is associated with a decreased risk of developing MI...

..Two papers report a multiplicative interaction for combined treatment with non-steroidal anti-inflammatory drugs (NSAIDs) and SSRIs. We conclude that SSRIs should be used with caution in patients with an increased risk of bleeding...

..We thus found it of interest to review a large case series to characterize the underlying causes of excessive anticoagulation...

..We wanted to test whether we, by using data on thousands of prescriptions, could answer a prosaic yet very timely question: Which penicillin is most widely accepted?..

..In this study, we investigated the possible association between the use of cardiovascular drugs and suicide using population-based register data...

..The aim of this study was to describe the risk of treatment failures over the last 10 years...

..Treatment with antiplatelet drugs is a key element of secondary stroke prevention. We investigated long-term antiplatelet drug use in stroke patients with a focus on non-persistence...

..We have assessed this overview by measuring the 'fidelity coefficient', a measure of the extent to which a drug user has a preference for one prescriber or one pharmacy...

..This population-based longitudinal study aimed to investigate trends in use of inhaled corticosteroids (ICS) and determinants of ICS use in young Danish adults with asthma...

..Methylphenidate exposure during pregnancy does not appear to be associated with a substantially (i.e. more than twofold) increased risk of congenital malformations...

..The purpose of the study was to characterize the utilization of medication against attention deficit hyperactivity disorder (ADHD) in Denmark between 1995 and 2011 from a national perspective, by using population-based prescription data...

..A common extrapulmonary effect to chronic obstructive pulmonary disease (COPD) is osteoporosis...

..The overall acceptance rate was 80%, albeit varying from 99% for generic substitution to 25% for change of administration route...

..6 (9.6-13.9), 4.0 (3.6-4.4), and 2.5 (2.3-2.7). CONCLUSION:During the period, incidence of peptic ulcers decreased and an increasing proportion was related to NSAID. Mortality is high...

..The antiplatelet effect of clopidogrel is not attenuated by concomitant treatment with a CYP3A4 metabolized statin in patients with clinical stable ischemic heart disease...

..Persons who have had an appendectomy are less prone to develop ulcerative colitis than those who have not. The underlying mechanism and the clinical use of this finding are unknown...

..Most observational studies on HRT are based on self-reported data, although data on the validity of HRT in postmenopausal women are sparse...

..We describe epidemiological, prophylactic, and clinical aspects of imported malaria in the county of Funen, 1987-1999...

..The aim of the study was to estimate the incidence of gastroesophageal cancer with or without pre-endoscopic treatment with antisecretory medication...