Claus H Gravholt

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Dehydroepiandrosterone substitution in female adrenal failure: no impact on endothelial function and cardiovascular parameters despite normalization of androgen status
    Jens Juel Christiansen
    Medical Department M, Aarhus Sygehus, Aarhus University Hospital, Denmark
    Clin Endocrinol (Oxf) 66:426-33. 2007
  2. doi request reprint Clinical review: Klinefelter syndrome--a clinical update
    Kristian A Groth
    Department of Molecular Medicine, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 98:20-30. 2013
  3. doi request reprint Coagulation and fibrinolytic disturbances are related to carotid intima thickness and arterial blood pressure in Turner syndrome
    Claus H Gravholt
    Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus Hospital NBG, Aarhus University Hospital, Aarhus C, Demmark
    Clin Endocrinol (Oxf) 76:649-56. 2012
  4. ncbi request reprint Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue
    C H Gravhølt
    Department of Endocrinology M and Medical Research Laboratories, Arhus University Hospital, DK 8000 Aarhus C, Denmark
    Am J Physiol 277:E848-54. 1999
  5. ncbi request reprint Turner syndrome and the heart: cardiovascular complications and treatment strategies
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Kommunehospital, Aarhus University Hospital, Aarhus, Denmark
    Am J Cardiovasc Drugs 2:401-13. 2002
  6. ncbi request reprint The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Kommunehospital, Arhus University Hospital, 8000 Arhus C, Denmark
    Eur J Endocrinol 150:355-62. 2004
  7. ncbi request reprint Protein metabolism in Turner syndrome and the impact of hormone replacement therapy
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Sygehus NBG, Aarhus University Hospital, Aarhus C, Denmark
    Clin Endocrinol (Oxf) 67:413-8. 2007
  8. ncbi request reprint Quantitative liver functions in Turner syndrome with and without hormone replacement therapy
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes, Aarhus Sygehus, Nørrebrogade, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 156:679-86. 2007
  9. ncbi request reprint The GH-IGF-IGFBP axis is changed in Turner syndrome: partial normalization by HRT
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Sygehus NBG, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Growth Horm IGF Res 16:332-9. 2006
  10. ncbi request reprint Clinical and epidemiological description of aortic dissection in Turner's syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Sygehus, Arhus University Hospital, Denmark
    Cardiol Young 16:430-6. 2006

Detail Information

Publications77

  1. ncbi request reprint Dehydroepiandrosterone substitution in female adrenal failure: no impact on endothelial function and cardiovascular parameters despite normalization of androgen status
    Jens Juel Christiansen
    Medical Department M, Aarhus Sygehus, Aarhus University Hospital, Denmark
    Clin Endocrinol (Oxf) 66:426-33. 2007
    ..A putative DHEA receptor in vascular endothelium has been described and in vitro studies have shown involvement of DHEA in NO dependent pathways...
  2. doi request reprint Clinical review: Klinefelter syndrome--a clinical update
    Kristian A Groth
    Department of Molecular Medicine, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 98:20-30. 2013
    ..We review aspects of epidemiology, endocrinology, metabolism, body composition, and neuropsychology with reference to recent genetic discoveries...
  3. doi request reprint Coagulation and fibrinolytic disturbances are related to carotid intima thickness and arterial blood pressure in Turner syndrome
    Claus H Gravholt
    Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus Hospital NBG, Aarhus University Hospital, Aarhus C, Demmark
    Clin Endocrinol (Oxf) 76:649-56. 2012
    ..Turner syndrome (TS) is characterized by growth retardation, hypogonadism and a high risk of cardiovascular complications and atherosclerosis; case reports suggest that thrombo-embolic complications may be present...
  4. ncbi request reprint Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue
    C H Gravhølt
    Department of Endocrinology M and Medical Research Laboratories, Arhus University Hospital, DK 8000 Aarhus C, Denmark
    Am J Physiol 277:E848-54. 1999
    ..The peak glycerol increments after GH were higher in abdominal adipose tissue, perhaps due to a higher basal rate of lipolysis in this region...
  5. ncbi request reprint Turner syndrome and the heart: cardiovascular complications and treatment strategies
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Kommunehospital, Aarhus University Hospital, Aarhus, Denmark
    Am J Cardiovasc Drugs 2:401-13. 2002
    ..Recommendations for clinical practice are given, including life-long surveillance of cardiac function, aortic diameter and blood pressure...
  6. ncbi request reprint The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Kommunehospital, Arhus University Hospital, 8000 Arhus C, Denmark
    Eur J Endocrinol 150:355-62. 2004
    ....
  7. ncbi request reprint Protein metabolism in Turner syndrome and the impact of hormone replacement therapy
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Sygehus NBG, Aarhus University Hospital, Aarhus C, Denmark
    Clin Endocrinol (Oxf) 67:413-8. 2007
    ..Ovarian failure necessitates substitution with female hormone replacement therapy (HRT), and HRT induces favourable changes in body composition. It is unknown how HRT affects protein metabolism...
  8. ncbi request reprint Quantitative liver functions in Turner syndrome with and without hormone replacement therapy
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes, Aarhus Sygehus, Nørrebrogade, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 156:679-86. 2007
    ..Studies have documented elevated levels of liver enzymes in many females with Turner syndrome (TS). Histology has shown a range of changes. Treatment with female hormone replacement therapy (HRT) reduces liver enzymes...
  9. ncbi request reprint The GH-IGF-IGFBP axis is changed in Turner syndrome: partial normalization by HRT
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Sygehus NBG, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Growth Horm IGF Res 16:332-9. 2006
    ....
  10. ncbi request reprint Clinical and epidemiological description of aortic dissection in Turner's syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Sygehus, Arhus University Hospital, Denmark
    Cardiol Young 16:430-6. 2006
    ..Women with Turner's syndrome have an increased risk of congenital cardiac malformations, ischaemic heart disease, hypertension and stroke. Aortic dissection seems to occur with increased frequency...
  11. ncbi request reprint Effect of growth hormone and 17beta-oestradiol treatment on metabolism and body composition in girls with Turner syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Sygehus, Aarhus University Hospital, Aarhus C, Denmark
    Clin Endocrinol (Oxf) 62:616-22. 2005
    ..Girls with Turner syndrome (TS) receive GH treatment during childhood, and in adolescence this treatment may be combined with oestradiol. We have studied the effects of this combined treatment on metabolism and body composition...
  12. ncbi request reprint Clinical practice in Turner syndrome
    Claus H Gravholt
    Medical Department M at Aarhus Sygehus, Aarhus University Hospital, Denmark
    Nat Clin Pract Endocrinol Metab 1:41-52. 2005
    ..Currently no firm guidelines for diagnosis exist. In conclusion, TS is a condition associated with a number of diseases and conditions that are reviewed in the present paper. Individuals with TS need life-long medical attention...
  13. ncbi request reprint Epidemiological, endocrine and metabolic features in Turner syndrome
    Claus Højbjerg Gravholt
    Medical Department, Aarhus University Hospital, Aarhus, Denmark
    Arq Bras Endocrinol Metabol 49:145-56. 2005
    ..In summary, Turner syndrome is a condition associated with a number of disease and conditions which are reviewed in present paper...
  14. ncbi request reprint Nocturnal hypertension and impaired sympathovagal tone in Turner syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes, Arhus, Arhus University Hospital, Arhus, Denmark
    J Hypertens 24:353-60. 2006
    ..We hypothesized that altered heart rate variability is present in TS in comparison with controls, and can be influenced by hormonal replacement therapy (HRT)...
  15. ncbi request reprint Turner syndrome in adulthood
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Sygehus, Arhus University Hospital, Arhus, Denmark
    Horm Res 64:86-93. 2005
    ..Since the risk of cardiovascular and endocrinological disease is clearly elevated, proper care during adulthood is crucial. Cognition and social functioning are altered in Turner syndrome...
  16. ncbi request reprint Short-term growth hormone treatment in girls with Turner syndrome decreases fat mass and insulin sensitivity: a randomized, double-blind, placebo-controlled, crossover study
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Kommunehospital, Aarhus University Hospital, Aarhus, Denmark
    Pediatrics 110:889-96. 2002
    ..Most girls with Turner syndrome (TS) receive growth hormone (GH) treatment during childhood and adolescence, but controlled data on the effects on body composition and glucose metabolism are lacking...
  17. ncbi request reprint Medical problems of adult Turner's syndrome
    C H Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Kommunehospital, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Horm Res 56:44-50. 2001
    ..Since general physicians only encounter these patients infrequently, it is recommended that the care and treatment of Turner's syndrome be centralized...
  18. ncbi request reprint Reduced free IGF-I and increased IGFBP-3 proteolysis in Turner syndrome: modulation by female sex steroids
    C H Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 280:E308-14. 2001
    ..During sex steroid treatment, IGFBP-3 proteolysis normalized, without any change in free IGF-I...
  19. ncbi request reprint Physiological levels of glucagon do not influence lipolysis in abdominal adipose tissue as assessed by microdialysis
    C H Gravholt
    Department of Endocrinology M and Medical Research Laboratories, Arhus University Hospital, Denmark
    J Clin Endocrinol Metab 86:2085-9. 2001
    ....
  20. ncbi request reprint Muscle fiber composition and capillary density in Turner syndrome: evidence of increased muscle fiber size related to insulin resistance
    C H Gravholt
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Diabetes Care 24:1668-73. 2001
    ..To assess muscle fiber composition and capillary density in Turner syndrome, a condition linked with insulin resistance and increased frequency of type 2 diabetes, and link these findings with insulin sensitivity and physical fitness...
  21. ncbi request reprint Occurrence of gonadoblastoma in females with Turner syndrome and Y chromosome material: a population study
    C H Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Kommunehospital, Denmark
    J Clin Endocrinol Metab 85:3199-202. 2000
    ..This study emphasizes the need for prospective unbiased studies...
  22. ncbi request reprint Aspects of the treatment of Turner syndrome
    C H Gravholt
    Medical Department M Endocrinology and Diabetes and Medcal Research Laboratories, Aarhus Kommunehospital, Aarhus University Hospital, Aarhus, Denmark
    Expert Opin Pharmacother 2:1633-47. 2001
    ..Since general physicians encounter Turner patients infrequently, it is recommended that the care and treatment of Turner syndrome is centralised...
  23. ncbi request reprint Body composition is distinctly altered in Turner syndrome: relations to glucose metabolism, circulating adipokines, and endothelial adhesion molecules
    Claus Højbjerg Gravholt
    Medical Research Laboratories, Medical Department M Endocrinology and Diabetes, Aarhus Sygehus NBG, Denmark
    Eur J Endocrinol 155:583-92. 2006
    ..Body composition in Turner syndrome (TS) is altered with final height of TS decreased; anthropometry and bone mass distinctly changed...
  24. ncbi request reprint Marked disproportionality in bone size and mineral, and distinct abnormalities in bone markers and calcitropic hormones in adult turner syndrome: a cross-sectional study
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 87:2798-808. 2002
    ....
  25. ncbi request reprint Inhibin A and B in adolescents and young adults with Turner's syndrome and no sign of spontaneous puberty
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Kommunehospital, Arhus University Hospital, DK 8000 Arhus C, Denmark E mail
    Hum Reprod 17:2049-53. 2002
    ..The aim of this study was to assess levels of inhibin A and B, FSH and LH in Turner's syndrome (TS) without signs of spontaneous ovarian activity...
  26. ncbi request reprint Preferential stimulation of abdominal subcutaneous lipolysis after prednisolone exposure in humans
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus University Hospital, Arhus C, Denmark
    Obes Res 10:774-81. 2002
    ..The role of cortisol in the regulation of lipolysis is not clear. This study was undertaken to explore whether a standard dose of prednisolone for 1 week would influence lipolysis in abdominal and femoral tissue...
  27. pmc Delayed β-cell response and glucose intolerance in young women with Turner syndrome
    Britta E Hjerrild
    Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus Sygehus NBG, Aarhus University Hospital, Denmark
    BMC Endocr Disord 11:6. 2011
    ..To investigate glucose homeostasis in detail in Turner syndrome (TS), where impaired glucose tolerance (IGT) and type 2 diabetes are frequent...
  28. ncbi request reprint Lp(a) and lipids in adult Turner's syndrome: impact of treatment with 17beta-estradiol and norethisterone
    C H Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus University Hospital, DK 8000, Aarhus, Denmark
    Atherosclerosis 150:201-8. 2000
    ..Replacement therapy with female sex hormones lowered Lp(a), HDL cholesterol and apolipoprotein A-I...
  29. doi request reprint Body composition, metabolic syndrome and type 2 diabetes in Klinefelter syndrome
    Claus H Gravholt
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Sygehus NBG, Denmark
    Acta Paediatr 100:871-7. 2011
    ....
  30. ncbi request reprint The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism
    Anders Bojesen
    Medical Department M, Endocrinology and Diabetes, Aarhus University Hospital, Noerrebrogade 42 44, DK 8000, Aarhus C, Denmark
    Diabetes Care 29:1591-8. 2006
    ..We analyzed differences between patients with untreated Klinefelter's syndrome and control subjects and subsequently analyzed differences between testosterone-treated and untreated Klinefelter's syndrome patients...
  31. pmc Dilation of the ascending aorta in Turner syndrome - a prospective cardiovascular magnetic resonance study
    Kristian H Mortensen
    Department of Endocrinology, Aarhus Hospital NBG, Aarhus University Hospital, Aarhus, Denmark
    J Cardiovasc Magn Reson 13:24. 2011
    ..Unfortunately, risk stratification is inadequate due to a lack of insight into the natural course of the syndrome-associated aortopathy. Therefore, this study aimed to prospectively assess aortic dimensions in TS...
  32. pmc Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study
    Britta E Hjerrild
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Sygehus NBG, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Cardiovasc Magn Reson 12:12. 2010
    ..To investigate aortic dimensions in women with Turner syndrome (TS) in relation to aortic valve morphology, blood pressure, karyotype, and clinical characteristics...
  33. doi request reprint Discontinuation of hormone replacement therapy in young GH-treated hypopituitary women increases liver enzymes
    Christian Høst
    Medical Department M, Diabetes and Endocrinology and the Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Growth Horm IGF Res 20:26-30. 2010
    ..We investigated the effect of HRT on liver enzymes, lipid levels and measures of insulin sensitivity 26 in hypopituitary women...
  34. pmc Independent Effects of Testosterone on Lipid Oxidation and VLDL-TG Production: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
    Christian Høst
    Department of Endocrinology and Internal Medicine and the Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Aarhus, Denmark
    Diabetes 62:1409-16. 2013
    ..T is not a major determinant of resting VLDL-TG kinetics in men...
  35. doi request reprint Sex hormone replacement in Turner syndrome
    Christian Trolle
    Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Endocrine 41:200-19. 2012
    ..In this review, we will discuss the effects of estrogen and androgen insufficiency as well as the effects of sex HRT on morbidity and mortality with special emphasis on evidence based research and areas needing further studies...
  36. ncbi request reprint Clinical care of adult Turner syndrome--new aspects
    Christian Trolle
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Pediatr Endocrinol Rev 9:739-49. 2012
    ..In summary, TS is a condition associated with a number of diseases and conditions which need the attention of a multi-disciplinary team during adulthood...
  37. ncbi request reprint Effects of cortisol on carbohydrate, lipid, and protein metabolism: studies of acute cortisol withdrawal in adrenocortical failure
    Jens Juel Christiansen
    Medical Department M, Aarhus Sygehus NBG, Arhus University Hospital, DK 8000 C Arhus, Denmark
    J Clin Endocrinol Metab 92:3553-9. 2007
    ..Cortisol is an important catabolic hormone, but little is known about the metabolic effects of acute cortisol deficiency...
  38. ncbi request reprint Discontinuation of estrogen replacement therapy in GH-treated hypopituitary women alters androgen status and IGF-I
    Jens Juel Christiansen
    Medical Department M, Arhus Sygehus, Arhus University Hospital, Nørrebrogade 44, DK 8000 Arhus C, Denmark
    Eur J Endocrinol 152:719-26. 2005
    ..Twenty six patients were studied twice: with estrogen replacement and after 28 days of estrogen discontinuation in a randomised design...
  39. ncbi request reprint Very short term dehydroepiandrosterone treatment in female adrenal failure: impact on carbohydrate, lipid and protein metabolism
    Jens Juel Christiansen
    Medical Department M, Arhus Sygehus, Arhus University Hospital, Arhus, Denmark
    Eur J Endocrinol 152:77-85. 2005
    ..In female adrenal insufficiency, dehydroepiandrosterone (DHEA) secretion is impaired and circulating androgen levels are severely reduced. We wanted to analyse the acute effects of physiological DHEA substitution on substrate metabolism...
  40. ncbi request reprint Epidemiological, endocrine and metabolic features in Turner syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Sygehus, Aarhus University Hospital, DK 8000 Arhus C, Denmark
    Eur J Endocrinol 151:657-87. 2004
    ..In summary, Turner syndrome is a condition associated with a number of diseases and conditions which are reviewed in the present paper...
  41. doi request reprint Ambulatory arterial stiffness index in Turner syndrome: the impact of sex hormone replacement therapy
    Kristian H Mortensen
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus University Hospital NBG, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Horm Res 72:184-9. 2009
    ..Morbidity and mortality from congenital and acquired cardiovascular (CV) disease is increased in Turner syndrome (TS), where traditional indices of CV risk are widely present but the single most common feature remains estrogen deficiency...
  42. ncbi request reprint Morbidity in Klinefelter syndrome: a Danish register study based on hospital discharge diagnoses
    Anders Bojesen
    Medical Department M Diabetes and Endocrinology, Aarhus Sygehus, Aarhus University Hospital, Noerrebrogade 42 44, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 91:1254-60. 2006
    ..Our current knowledge of morbidity in KS is based on observational studies and case reports and therefore is limited...
  43. doi request reprint Long-term DHEA substitution in female adrenocortical failure, body composition, muscle function, and bone metabolism: a randomized trial
    Jens J Christiansen
    Department of Endocrinology and Internal Medicine MEA Aarhus Sygehus NBG Aarhus Sygehus THG, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 165:293-300. 2011
    ..Adrenal derived androgens are low in women with adrenal failure. The physiological consequences of substitution therapy are uncertain...
  44. doi request reprint Hypothyroidism secondary to hypothalamic-pituitary dysfunction may be part of the phenotype in klinefelter syndrome: a case-control study
    Anne Mette Bay Bjørn
    Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, DK 9000 Aalborg, Denmark
    J Clin Endocrinol Metab 94:2478-81. 2009
    ..Klinefelter syndrome (KS) may involve a number of abnormalities besides the characteristic testicular insufficiency. Some studies have suggested that thyroid abnormalities may be common, but this has not been clarified...
  45. ncbi request reprint Elevated regional lipolysis in hyperthyroidism
    Anne Lene Dalkjaer Riis
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital and Institute of Experimental Clinical Science, Aarhus University, Aarhus 8000, Denmark
    J Clin Endocrinol Metab 87:4747-53. 2002
    ..01), 166 +/- 21(CTR) (P < 0.01)]. These results suggest that femoral and abdominal adipose tissue contribute equally to the excessive rate of lipolysis in hyperthyroidism and that both tissues are resistant to the actions of insulin...
  46. ncbi request reprint Incidence of GH deficiency - a nationwide study
    Kirstine Stochholm
    Medical Department M Endocrinology and Diabetes, Aarhus Sygehus, NBG, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 155:61-71. 2006
    ..Data on incidence rates are scarce in GH deficiency (GHD). Here, we estimate the incidence rate in childhood onset (CO) and adult onset (AO) GHD in Denmark...
  47. doi request reprint Cardiovascular phenotype in Turner syndrome--integrating cardiology, genetics, and endocrinology
    Kristian H Mortensen
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark
    Endocr Rev 33:677-714. 2012
    ....
  48. pmc Diagnosis and mortality in 47,XYY persons: a registry study
    Kirstine Stochholm
    Department of Internal Medicine and Endocrinology, Aarhus Sygehus, Aarhus University Hospital, Denmark
    Orphanet J Rare Dis 5:15. 2010
    ..Sex chromosomal abnormalities are relatively common, yet many aspects of these syndromes remain unexplored. For instance epidemiological data in 47,XYY persons are still limited...
  49. doi request reprint Acute estrogen exposure does not affect basal very low-density lipoprotein-triglyceride production or oxidation in postmenopausal women
    Lars C Gormsen
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Eur J Endocrinol 163:421-6. 2010
    ..There are indications that this effect of estrogens may be immediate...
  50. ncbi request reprint Klinefelter syndrome in clinical practice
    Anders Bojesen
    Department of Clinical Genetics, Vejle Hospital, Aarhus University Hospital, Denmark
    Nat Clin Pract Urol 4:192-204. 2007
    ....
  51. ncbi request reprint Increased mortality in Klinefelter syndrome
    Anders Bojesen
    Medical Department M Diabetes and Endocrinology, Aarhus Sygehus, Aarhus University Hospital, Denmark
    J Clin Endocrinol Metab 89:3830-4. 2004
    ..Whether this increase is caused by the syndrome per se (i.e. hypogonadism) or other factors, e.g. socioeconomic, are involved is presently unknown...
  52. doi request reprint Turner syndrome and clinical treatment
    Britta E Hjerrild
    Medical Department M Endocrinology and Diabetes, Arhus Kommunehospital, DK 8000 Aarhus C, Denmark
    Br Med Bull 86:77-93. 2008
    ..The average intellectual performance is within the normal range. New insight into genetics, epidemiology, cardiology, endocrinology and metabolism from a number of recent studies will be included in this review...
  53. doi request reprint Klinefelter's syndrome, type 2 diabetes and the metabolic syndrome: the impact of body composition
    Anders Bojesen
    Department of Clinical Genetics, Vejle Hospital, Sygehus Lillebaelt, DK 7100 Vejle, Denmark
    Mol Hum Reprod 16:396-401. 2010
    ..Despite the lack of such studies in KS, we recommend testosterone treatment to KS patients with low serum testosterone or increased LH and change in body composition...
  54. pmc Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries
    Ole Frøbert
    Department of Cardiology B, Skejby Sygehus, University Hospital Aarhus, Denmark
    J Physiol 539:277-84. 2002
    ..The lactate concentration may affect, but is not essential for, hypoxia-induced vasodilatation in porcine coronary arteries...
  55. ncbi request reprint Insulin increases glycolysis without further vasodilation in porcine coronary arteries exposed to hypoxia
    Ole Frøbert
    Department of Cardiology S, Aalborg University Hospital, DK 900 Aalborg, Denmark
    Clin Sci (Lond) 107:213-20. 2004
    ..Our findings suggest that insulin increases arterial glycolysis, but treatment with insulin, propranolol, or both, is not associated with enhanced coronary vasodilation during hypoxia...
  56. doi request reprint Morbidity and mortality in Klinefelter syndrome (47,XXY)
    Anders Bojesen
    Department of Clinical Genetics, Vejle Hospital, Sygehus Lillebaelt, Denmark
    Acta Paediatr 100:807-13. 2011
    ..The risk of being admitted to hospital with any diagnosis was increased by 70%. The underlying reason for the poorer health in KS may be caused by interaction of genetic, hormonal and socio-economic factors...
  57. ncbi request reprint Elevated levels of mannan-binding lectin in patients with type 1 diabetes
    Troels Krarup Hansen
    Medical Department M, Aarhus University Hospital, Aarhus University, DK 8000 Aarhus, Denmark
    J Clin Endocrinol Metab 88:4857-61. 2003
    ..036). In conclusion, our data demonstrate that circulating MBL concentrations are significantly elevated in patients with type 1 diabetes and suggest a possible role of MBL in the pathogenesis of renovascular complications in diabetes...
  58. ncbi request reprint Dose dependency of the pharmacokinetics and acute lipolytic actions of growth hormone
    Troels Krarup Hansen
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    J Clin Endocrinol Metab 87:4691-8. 2002
    ..Taken together, our findings suggest that differences in GH-binding protein concentrations, which possibly reflect GHR expression, determine GH pharmacokinetics rather than age or body composition per se...
  59. ncbi request reprint Circadian variation of holo-transcobalamin (holo-TC) and related markers
    Anne Mette Hvas
    Department of Clinical Biochemistry, SKS, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 43:760-4. 2005
    ..This supports the view that holo-TC is a marker of long-term vitamin B(12) status, and that samples may also be obtained from non-fasting subjects...
  60. ncbi request reprint Dehydroepiandrosterone supplementation in women with adrenal failure: impact on twenty-four hour GH secretion and IGF-related parameters
    Jens Juel Christiansen
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital and Institute of Experimental Clinical Research, Aarhus University, Aarhus, Denmark
    Clin Endocrinol (Oxf) 60:461-9. 2004
    ..In women, GH secretion is strongly influenced by oestrogen status, whereas the role of androgens is unclear. We, therefore, examined GH secretory dynamics during low vs. normalized androgen levels in women with adrenal failure...
  61. ncbi request reprint Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study
    Anders Bojesen
    Medical Department M, Diabetes and Endocrinology, Aarhus Kommunehospital, Aarhus University Hospital, Denmark
    J Clin Endocrinol Metab 88:622-6. 2003
    ..There is a marked delay in diagnosis of the syndrome. A delay in treatment with testosterone may lead to decreased muscle and bone mass with subsequent risk of osteoporosis...
  62. ncbi request reprint Mortality and GH deficiency: a nationwide study
    Kirstine Stochholm
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, Aarhus Sygehus, NBG, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 157:9-18. 2007
    ..To estimate the mortality in Denmark in patients suffering from GH deficiency (GHD)...
  63. doi request reprint Mortality and incidence in women with 47,XXX and variants
    Kirstine Stochholm
    Medical Department M Endocrinology and Diabetes, Aarhus Sygehus, Aarhus University Hospital, Aarhus C, Denmark
    Am J Med Genet A 152:367-72. 2010
    ..Better delineation of the clinical phenotype of 47,XXX is needed; available information does not readily explain the increased mortality...
  64. doi request reprint Mortality and reduced growth hormone secretion
    Kirstine Stochholm
    Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Horm Res 68:173-6. 2007
    ..Furthermore, differences in mortality rates in females and males have been reported...
  65. doi request reprint Morbidity and GH deficiency: a nationwide study
    Kirstine Stochholm
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, Aarhus Sygehus, NBG, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 158:447-57. 2008
    ..To estimate morbidity in Denmark in all patients with GH deficiency (GHD)...
  66. ncbi request reprint Glycemia, lipidemia and systolic left ventricular function evaluated by myocardial strain rate: a tissue Doppler echocardiographic study
    Niels Holmark Andersen
    Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark
    Ultrasound Med Biol 34:151-4. 2008
    ..In conclusion, LV systolic function seems significantly related to fasting levels of glucose and LDL cholesterol in normal subjects...
  67. pmc Long QT Interval in Turner Syndrome - A High Prevalence of LQTS Gene Mutations
    Christian Trolle
    Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 8:e69614. 2013
    ..This study set out to explore the presence of known long QT mutations in Turner syndrome and to examine the corrected QT-interval (QTc) over time and relate the findings to the Turner syndrome phenotype...
  68. ncbi request reprint Prevalence, incidence, diagnostic delay, and mortality in Turner syndrome
    Kirstine Stochholm
    Medical Department M Endocrinology and Diabetes, Aarhus Sygehus, Nørrebrogade, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 91:3897-902. 2006
    ..Our aim was to study prevalence, incidence, age at diagnosis, and mortality in Turner syndrome (TS) in Denmark...
  69. ncbi request reprint Increased fracture rates in Turner's syndrome: a nationwide questionnaire survey
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Denmark
    Clin Endocrinol (Oxf) 59:89-96. 2003
    ..A total of 322 patients (51%) and 1169 controls (62%) returned the questionnaire...
  70. doi request reprint Poor socio-economic status in 47,XXX --an unexpected effect of an extra X chromosome
    Kirstine Stochholm
    Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Eur J Med Genet 56:286-91. 2013
    ..The affected socio-economic status suggests that the presence of an extra X chromosome has more detrimental effects than previously appreciated...
  71. ncbi request reprint Myocardial injury with biomarker elevation in diabetic ketoacidosis
    Niels Moller
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, Aarhus DK 8000, Denmark
    J Diabetes Complications 19:361-3. 2005
    ....
  72. ncbi request reprint Continuous glucose monitoring in interstitial subcutaneous adipose tissue and skeletal muscle reflects excursions in cerebral cortex
    Jannik Kruse Nielsen
    Medical Department M Endocrinology and Diabetes, Arhus Sygehus, Arhus University Hospital, DK 8000 Arhus C, Denmark
    Diabetes 54:1635-9. 2005
    ..The reduced magnitude of glucose excursions in the brain suggests that different mechanisms of glucose transport are operative in CNS compared with subcutaneous adipose tissue and muscle...
  73. pmc Adenosine concentration in the porcine coronary artery wall and A2A receptor involvement in hypoxia-induced vasodilatation
    Ole Frøbert
    Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Denmark
    J Physiol 570:375-84. 2006
    ..We conclude that hypoxia-induced coronary artery dilatation is not mediated by increased adenosine produced within the artery wall but might be facilitated by increased adenosine sensitivity at the A(2A) receptor level...
  74. ncbi request reprint Thyroid hormone increases mannan-binding lectin levels
    Anne Lene Dalkjaer Riis
    Medical Department M, Aarhus University Hospital, Denmark
    Eur J Endocrinol 153:643-9. 2005
    ..Mannan-binding lectin (MBL), a protein of the innate immune system, may constitute a connection between these fields...
  75. doi request reprint Socioeconomic trajectories affect mortality in Klinefelter syndrome
    Anders Bojesen
    Department of Clinical Genetics, Vejle Hospital, Sygehus Lillebaelt, 7100 Vejle, Denmark
    J Clin Endocrinol Metab 96:2098-104. 2011
    ..Morbidity and mortality are increased and the causes behind remain unknown. Is it the chromosome aberration or is it caused by postulated poorer socioeconomic status?..
  76. doi request reprint Repeated spontaneous pregnancies in 45,X Turner syndrome
    Kristian Havmand Mortensen
    Medical Department M Diabetes and Endocrinology and Research Laboratories, Aarhus University Hospital, Denmark
    Obstet Gynecol 115:446-9. 2010
    ..Spontaneous pregnancy rarely occurs in women with Turner syndrome, and poor maternal outcomes are prominent in these women...
  77. doi request reprint Abnormalities of the major intrathoracic arteries in Turner syndrome as revealed by magnetic resonance imaging
    Kristian Havmand Mortensen
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus University Hospital, Aarhus Hospital NBG, Noerrebrogade 44, Aarhus, Denmark
    Cardiol Young 20:191-200. 2010
    ..Ectatic aortopathy and arterial abnormalities cause excess morbidity and mortality in Turner syndrome, where a state of vasculopathy seemingly extends into the major head and neck branch arteries...