PHILIPPE A GRANDJEAN

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. pmc Separation of risks and benefits of seafood intake
    Esben Budtz-Jørgensen
    Department of Biostatistics, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 115:323-7. 2007
  2. pmc Neurobehavioral deficits at age 7 years associated with prenatal exposure to toxicants from maternal seafood diet
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Neurotoxicol Teratol 34:466-72. 2012
  3. pmc Estimation of health effects of prenatal methylmercury exposure using structural equation models
    Esben Budtz-Jørgensen
    Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
    Environ Health 1:2. 2002
  4. pmc Organochlorine exposures influence on breast cancer risk and survival according to estrogen receptor status: a Danish cohort-nested case-control study
    A P Høyer
    The Copenhagen Center for Prospective Population Studies, Harsdorffsvej 1B, 2tv, DK 1874 Frederiksberg C, Denmark
    BMC Cancer 1:8. 2001
  5. ncbi request reprint Impact of contrast sensitivity performance on visually presented neurobehavioral tests in mercury-exposed children
    P Grandjean
    Institute of Public Health, University of Southern Denmark, DK 5000 Odense, Denmark
    Neurotoxicol Teratol 23:141-6. 2001
  6. ncbi request reprint Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls
    Philippe Grandjean
    Department of Environmental Health, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
    FASEB J 17:699-701. 2003
  7. ncbi request reprint Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Ambul Pediatr 3:18-23. 2003
  8. pmc The Matthew effect in environmental science publication: a bibliometric analysis of chemical substances in journal articles
    Philippe Grandjean
    Department of Environmental Medicine, and University Library, University of Southern Denmark, Odense, Denmark
    Environ Health 10:96. 2011
  9. ncbi request reprint Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants
    P Grandjean
    Institute of Public Health, University of Southern Denmark, Winslowparken 17, DK 5000 Odense, Denmark
    Neurotoxicol Teratol 23:305-17. 2001
  10. ncbi request reprint Non-precautionary aspects of toxicology
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Winslowparken 17, DK 5000 Odense C, Denmark
    Toxicol Appl Pharmacol 207:652-7. 2005

Detail Information

Publications45

  1. pmc Separation of risks and benefits of seafood intake
    Esben Budtz-Jørgensen
    Department of Biostatistics, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 115:323-7. 2007
    ..In resolving this conundrum, most epidemiologic studies provide little guidance because they address either nutrient benefits or mercury toxicity, not both...
  2. pmc Neurobehavioral deficits at age 7 years associated with prenatal exposure to toxicants from maternal seafood diet
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Neurotoxicol Teratol 34:466-72. 2012
    ..Thus, in the presence of elevated methylmercury exposure, PCB neurotoxicity may be difficult to detect, and PCB exposure does not explain the methylmercury neurotoxicity previously reported in this cohort...
  3. pmc Estimation of health effects of prenatal methylmercury exposure using structural equation models
    Esben Budtz-Jørgensen
    Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
    Environ Health 1:2. 2002
    ..This approach was used in a large epidemiological data set from a prospective study of developmental methyl-mercury toxicity...
  4. pmc Organochlorine exposures influence on breast cancer risk and survival according to estrogen receptor status: a Danish cohort-nested case-control study
    A P Høyer
    The Copenhagen Center for Prospective Population Studies, Harsdorffsvej 1B, 2tv, DK 1874 Frederiksberg C, Denmark
    BMC Cancer 1:8. 2001
    ..As estrogen receptor positive and negative breast cancer may represent different entities of the disease, this study was undertaken to evaluate organochlorines influence on breast cancer risk and survival according to receptor status...
  5. ncbi request reprint Impact of contrast sensitivity performance on visually presented neurobehavioral tests in mercury-exposed children
    P Grandjean
    Institute of Public Health, University of Southern Denmark, DK 5000 Odense, Denmark
    Neurotoxicol Teratol 23:141-6. 2001
    ..Visuospatial processing appears to be a determinant in contrast sensitivity performance, and careful consideration of whether to control for contrast sensitivity in future studies of neurotoxicant effects is therefore recommended...
  6. ncbi request reprint Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls
    Philippe Grandjean
    Department of Environmental Health, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
    FASEB J 17:699-701. 2003
    ..Thus, in communities with increased contaminant exposures, risks associated with lactational transfer of toxicants to the infant must be considered when judging the benefits of prolonged breast-feeding...
  7. ncbi request reprint Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Ambul Pediatr 3:18-23. 2003
    ..To examine whether the dose-effect relationship for developmental mercury neurotoxicity is affected by variable mercury exposure during pregnancy...
  8. pmc The Matthew effect in environmental science publication: a bibliometric analysis of chemical substances in journal articles
    Philippe Grandjean
    Department of Environmental Medicine, and University Library, University of Southern Denmark, Odense, Denmark
    Environ Health 10:96. 2011
    ..While environmental research addresses scientific questions of possible societal relevance, it is unclear to what degree research focuses on environmental chemicals in need of documentation for risk assessment purposes...
  9. ncbi request reprint Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants
    P Grandjean
    Institute of Public Health, University of Southern Denmark, Winslowparken 17, DK 5000 Odense, Denmark
    Neurotoxicol Teratol 23:305-17. 2001
    ..The limited PCB-related neurotoxicity in this cohort appears to be affected by concomitant methylmercury exposure...
  10. ncbi request reprint Non-precautionary aspects of toxicology
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Winslowparken 17, DK 5000 Odense C, Denmark
    Toxicol Appl Pharmacol 207:652-7. 2005
    ....
  11. pmc Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Environ Health Perspect 113:905-8. 2005
    ..Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered...
  12. ncbi request reprint Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    J Pediatr 144:169-76. 2004
    ..To determine whether heart function in childhood is affected by exposure to methylmercury (MeHg) from seafood...
  13. ncbi request reprint Neurodevelopmental toxicity risks due to occupational exposure to industrial chemicals during pregnancy
    Jordi Julvez
    Department of Environmental Health, Harvard School of Public Health, Landmark Building 3E 110, 401 Park Drive, Boston, MA 02215, USA
    Ind Health 47:459-68. 2009
    ..Due to the vulnerability of the brain during early development, a precautionary approach to neurodevelopmental toxicity needs to be applied in occupational health...
  14. doi request reprint Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease
    Maria Skaalum Petersen
    Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17, Odense C, Denmark
    Neurotoxicology 29:591-5. 2008
    ....
  15. pmc Total imprecision of exposure biomarkers: implications for calculating exposure limits
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Am J Ind Med 50:712-9. 2007
    ..Unrecognized imprecision leads to underestimation of the true toxicity of the exposure. We have assessed the total imprecision of exposure biomarkers and the implications for calculation of exposure limits...
  16. ncbi request reprint Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults
    Maria Skaalum Petersen
    Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winsløvparken 17, 5000 Odense C, Denmark
    Toxicol Appl Pharmacol 224:202-6. 2007
    ....
  17. pmc Adverse effects of methylmercury: environmental health research implications
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Environ Health Perspect 118:1137-45. 2010
    ....
  18. doi request reprint High latitude and marine diet: vitamin D status in elderly Faroese
    Christine Dalgård
    Department of Environmental Health, Institute of Public Health, University of Southern Denmark, JB Winslowsvej 17, 2nd Floor, 5000 Odense C, Denmark
    Br J Nutr 104:914-8. 2010
    ..Thus, even in a population with a high intake of marine food, the northern latitude causes a low vitamin D status. Efforts to improve vitamin D status in this population are warranted...
  19. pmc Direct assessment of cumulative aryl hydrocarbon receptor agonist activity in sera from experimentally exposed mice and environmentally exposed humans
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:693-8. 2010
    ..However, assessment of the significance of human exposures is hampered by an incomplete understanding of how complex mixtures affect AhR activation/inactivation...
  20. doi request reprint Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands
    Jónrit Halling
    Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Winslowparken, Odense C, Denmark
    Pharmacogenet Genomics 18:209-12. 2008
    ..To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased...
  21. pmc Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy
    Helle R Andersen
    Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Environ Health Perspect 116:566-72. 2008
    ..The aim of this prospective study was to investigate whether occupational pesticide exposure during pregnancy causes adverse effects on the reproductive development in the male infants...
  22. ncbi request reprint Arachidonic acid status during pregnancy is associated with polychlorinated biphenyl exposure
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense
    Am J Clin Nutr 77:715-9. 2003
    ..However, the nutritional benefits could be limited by polychlorinated biphenyl (PCB) contamination. In particular, inhibition of desaturase activities by PCBs may affect the maintenance of arachidonic acid (AA) status during development...
  23. pmc Xeno-oestrogenic activity in serum as marker of occupational pesticide exposure
    Helle Raun Andersen
    Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Occup Environ Med 64:708-14. 2007
    ..An increasing number of currently used pesticides are reported to possess oestrogen-like properties or to disturb the endocrine system in other ways...
  24. pmc Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-Screen bioassay to determine estrogenic response of serum extracts
    Thomas Høj Rasmussen
    Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Environ Health 2:12. 2003
    ..Thus, analysis of mixtures allows evaluation of combined effects of chemicals each present at low concentrations...
  25. ncbi request reprint Methylmercury toxicity and functional programming
    Philippe Grandjean
    Department of Environmental Health, Harvard School of Public Health, Landmark Center, 3 110E, 401 Park Drive, Boston, MA 02215, USA
    Reprod Toxicol 23:414-20. 2007
    ..This notion is considered from epidemiological evidence using developmental methylmercury neurotoxicity as an example...
  26. ncbi request reprint Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population
    Jónrit Halling
    Clinical Pharmacology, Faculty of Health Sciences, Institute of Public Health, University of Southern Denmark, Winslovparken 19, 5000 Odense C, Denmark
    Eur J Clin Pharmacol 61:491-7. 2005
    ..The purpose of the study was to study the distribution of poor and extensive metabolizers of CYP2C19 and CYP2D6 and to genotype for CYP2C8 and CYP2C9 among 312 randomly selected Faroese...
  27. ncbi request reprint Underestimation of risk due to exposure misclassification
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Int J Occup Med Environ Health 17:131-6. 2004
    ..When exposure measurement errors are overlooked or underestimated, decisions based on the precautionary principle will not appropriately reflect the degree of precaution that was intended...
  28. ncbi request reprint Implications of the Precautionary Principle in research and policy-making
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    Am J Ind Med 45:382-5. 2004
    ..Research approaches should be developed and strengthened to counteract innate ideological biases and to support our confidence in applying the PP for decision-making in the public policy arena...
  29. pmc Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:367-72. 2009
    ..Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality...
  30. pmc Potential developmental neurotoxicity of pesticides used in Europe
    Marina Bjørling-Poulsen
    Department of Environmental Medicine, University of Southern Denmark, Winslowparken 17, 5000 Odense, Denmark
    Environ Health 7:50. 2008
    ..While awaiting more definite evidence, existing uncertainties should be considered in light of the need for precautionary action to protect brain development...
  31. pmc Elimination half-lives of polychlorinated biphenyl congeners in children
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Winsløwparken 17, DK 5000 Odense, Denmark
    Environ Sci Technol 42:6991-6. 2008
    ..The longest half-lives correspond to elimination of the parent PCB solely with a daily fat excretion rate of 1-2 g, whereas shorter half-lives assume metabolic break-down...
  32. doi request reprint Impact of dietary exposure to food contaminants on the risk of Parkinson's disease
    Maria Skaalum Petersen
    Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17, Odense C, Denmark
    Neurotoxicology 29:584-90. 2008
    ..Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD...
  33. ncbi request reprint Effects of breast feeding on neuropsychological development in a community with methylmercury exposure from seafood
    Tina Kold Jensen
    Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    J Expo Anal Environ Epidemiol 15:423-30. 2005
    ..Although the advantage may be less, Faroese women can still safely breastfeed their children...
  34. pmc Late insights into early origins of disease
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Basic Clin Pharmacol Toxicol 102:94-9. 2008
    ..Additional emphasis should be placed on the question: what could be known, given our study opportunities and methodologies? Our late insights into the early disease origins may then benefit science and prevention...
  35. ncbi request reprint Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school children
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Pediatrics 117:e546-56. 2006
    ..To examine possible effects on blood pressure, neurological function, and neurobehavioral tests in school-aged children with and without prenatal pesticide exposure in an area where stunting is common...
  36. ncbi request reprint Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls
    Maria Skaalum Petersen
    Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Winslovparken 17, 5000 Odense C, Denmark
    Eur J Clin Pharmacol 62:1041-8. 2006
    ..Further, to investigate the effect of sex, smoking, and oral contraceptive use on the CYP1A2 activity...
  37. ncbi request reprint Criteria for skin notation in different countries
    Jesper B Nielsen
    Institute of Public Health, University of Southern Denmark, DK 5000 Odense C, Denmark
    Am J Ind Med 45:275-80. 2004
    ..However, risk is not a qualitative term, but needs a quantitative measure to be useful for prevention. For this reason, some countries have developed alternative criteria for assigning skin notations to industrial chemicals...
  38. ncbi request reprint Spermaturia and serum hormone concentrations at the age of puberty in boys prenatally exposed to polychlorinated biphenyls
    Nanette M Mol
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Eur J Endocrinol 146:357-63. 2002
    ..To determine whether prenatal exposure to polychlorinated biphenyls (PCBs) with possible hormone-disrupting effects is capable of affecting sexual differentiation in boys at the age of puberty...
  39. pmc Negative confounding in the evaluation of toxicity: the case of methylmercury in fish and seafood
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Crit Rev Toxicol 38:877-93. 2008
    ..Attention should also be paid to the occurrence of negative confounding in other connections...
  40. ncbi request reprint Developmental arsenic neurotoxicity in retrospect
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Epidemiology 18:25-6. 2007
  41. ncbi request reprint Implications of the Precautionary Principle for public health practice and research
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Int J Occup Med Environ Health 17:5-7. 2004
  42. ncbi request reprint The delayed appearance of a mercurial warning
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Epidemiology 19:10-1. 2008
    ..The delayed release of the 1971 results therefore reminds us as epidemiologists of our obligation, even in the presence of scientific uncertainty, to call attention to preventable risks...
  43. pmc Selenium as a potential protective factor against mercury developmental neurotoxicity
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Res 107:45-52. 2008
    ..Additional research is needed to determine the identity of the nutrients responsible for the beneficial effects...
  44. ncbi request reprint Implications of the precautionary principle for primary prevention and research
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Annu Rev Public Health 25:199-223. 2004
    ..From this perspective, current research is afflicted by important biases and insufficient focus on major environmental health problems...
  45. pmc Seven deadly sins of environmental epidemiology and the virtues of precaution
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Epidemiology 19:158-62. 2008
    ....