Ismail Gogenur

..The objective of this study was to examine the profile of melatonin, cortisol and core body temperature rhythms before and after major surgery...

..The daytime sleep pattern of patients after major general surgery has not been investigated before. We decided to study the circadian distribution of sleep phases before and after surgery...

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..The consequences will probably be that the amount of research will decline as a result of the new laws. We describe what the basic requirements for clinical researchers are today...

..Circadian rhythmicity as assessed by aMT6s excretion was disturbed after surgery but we were unable to show an association with POCD. Strategies to improve postoperative sleep quality should be investigated in the future...

..The rate has been reduced dramatically since the introduction of TME, but up to 5% of patients still suffer from permanent bladder dysfunction and complete impotence...

..The methods in themselves are promising, though, and will probably have a natural position in the future treatment of GERD...

..Fasting did not affect the surgical skills, but resulted in increased foetor ex ore. Abstaining from eating and drinking during the daytime does probably not negatively affect surgical skills, but increases foetor ex ore...

..Episodic hypoxaemia, cardiac arrhythmias, and myocardial ischaemia may be related after major abdominal surgery...

..In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort...

..There was a significant drop in ascorbic acid at 1 hour and 6 hours after the first abdominal incision (P=0.002) for all 19 patients. Laparoscopic surgery was not found to be associated with reduced oxidative stress...

..We studied the safety and prophylactic effect of placing a newly designed polypropylene mesh in an onlay position at the primary operation...

..This review summarizes the results of animal and human studies wherein melatonin was shown to modulate oxidative stress; this discussion emphasizes the stress response related to surgery...

..We hypothesized that patients with the PER3(5/5) genotype would have an increased risk of postoperative cognitive dysfunction (POCD) 1 week after noncardiac surgery...

..The objective of this study was to evaluate the long-term recurrence rate as well as surgical complications in a consecutive group of patients undergoing open repair using an onlay mesh technique...

..We investigated the impact of surgical experience on surgeons' stress levels and how perioperative sleep quality may influence surgical performance...

..In this paper, we review the current evidence regarding the analgesic properties of melatonin in animals and humans with chronic pain...

..We recommend that diclofenac and celecoxib be omitted from analgesic regimens after colorectal surgery involving an anastomosis...

..The aim of this study was to examine whether optimized ergonomics and technical aids within a modern operating room (OR) affect psychological and physiological stress in experienced laparoscopic surgeons...

..Data regarding the long-term hernia risk after laparoscopic colonic surgery are lacking in the literature. In the present study we compared the long-term hernia incidence after laparoscopic versus open sigmoid resection...

..The purpose of this study was to evaluate the incidence of per- and postoperative complications of low anterior resection and Hartmann's operation (HO) for rectal cancer. The study was performed in a department with a high frequency of HO...

..Melatonin has not been used in adult patients with acute oxidative stress. A potential beneficial effect of melatonin in patients after surgery is possible and should be investigated in the future...

..The aim of the study was to evaluate the quality of buffy-coat reduced red cells in SAG-M additive solution, by assessing biomarkers of oxidative and inflammatory stress during a storage period of 35 days...

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..Melatonin may decrease oxidative damage resulting from surgery, but randomized clinical trials are required before definitive conclusions can be drawn regarding the clinical benefit of melatonin in surgical situations...

..It may be indicated in subgroups or if other perioperative treatment algorithms were used, but this has to be investigated in future trials...

..After diclofenac was removed from the postoperative analgesic regimen, the frequency dropped. This study aimed to evaluate the influence of diclofenac on the risk of developing anastomotic leakage after laparoscopic colorectal surgery...

..Learning is a complex process, and the interpretation of learning curves is not straight-forward. This paper addresses the problems concerning the analysis of learning curves in surgery...

..Studies show an effect in favour of medication with melatonin with regards to sedation and anxiety but the effect on analgesia has yet to be clarified with further clinical studies...

..There is no evidence to support a conversion of the postoperative antibiotic regimen from intravenous to oral administration in patients with acute perforated appendicitis...

..International experience with nurse endoscopists has shown good results, with safety, sensitivity and specificity comparable to doctors'. This paper discusses the possibilities for nurses' performing endoscopy...

..To evaluate the effect of postoperative use of non-steroidal anti-inflammatory drugs (NSAIDs) on anastomotic leakage requiring reoperation after colorectal resection...

..The aim of this study was to compare a rapidly resorbable suture with a non-resorbable suture in experimental colorectal anastomoses...

..The PER3 genotype is also to be determined in blood samples...

..The aim of this review was to give an overview of the literature for this new approach and to determine the safety compared with Hartmann's procedure for patients with acute complicated sigmoid diverticulitis...

..Most sudden postoperative deaths occur during the night and we conjectured that this was associated with circadian variations in the autonomic nervous tone, reflected in heart rate variability...

..The model is well suited for future interventional studies...

..Ultrasound examination after 1 year revealed a polypoid gallbladder mass. Immunohistochemical examination confirmed the metastasis diagnosis originating from the primary kidney tumour...