Camilla Foged

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen O, Denmark
    Int J Pharm 331:160-6. 2007
  2. ncbi request reprint Antiplasmodial and prehemolytic activities of alpha-peptide-beta-peptoid chimeras
    Line Vedel
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Chembiochem 8:1781-4. 2007
  3. ncbi request reprint Subunit vaccines of the future: the need for safe, customized and optimized particulate delivery systems
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    Ther Deliv 2:1057-77. 2011
  4. ncbi request reprint siRNA delivery with lipid-based systems: promises and pitfalls
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Curr Top Med Chem 12:97-107. 2012
  5. ncbi request reprint License to kill: Formulation requirements for optimal priming of CD8(+) CTL responses with particulate vaccine delivery systems
    Camilla Foged
    University of Copenhagen, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, Universitetsparken 2, DK 2100 Copenhagen Ø, Denmark
    Eur J Pharm Sci 45:482-91. 2012
  6. ncbi request reprint Cellular uptake and membrane-destabilising properties of alpha-peptide/beta-peptoid chimeras: lessons for the design of new cell-penetrating peptides
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1778:2487-95. 2008
  7. ncbi request reprint Cell-penetrating peptides for drug delivery across membrane barriers
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Faculty of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen O, Denmark
    Expert Opin Drug Deliv 5:105-17. 2008
  8. ncbi request reprint Phospholipase A2 sensitive liposomes for delivery of small interfering RNA (siRNA)
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Liposome Res 17:191-6. 2007
  9. doi request reprint Calcipotriol delivery into the skin with PEGylated liposomes
    Nina Østergaard Knudsen
    Department of Pharmacy, University of Copenhagen, Copenhagen Ø, Denmark
    Eur J Pharm Biopharm 81:532-9. 2012
  10. doi request reprint High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: quality by design optimization and characterization
    Dongmei Cun
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen Ø, Denmark
    Eur J Pharm Biopharm 77:26-35. 2011

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen O, Denmark
    Int J Pharm 331:160-6. 2007
    ..We hypothesize that the SL can be used to target siRNA to inflammed tissue for silencing of cytokine expression in rheumatoid arthritis...
  2. ncbi request reprint Antiplasmodial and prehemolytic activities of alpha-peptide-beta-peptoid chimeras
    Line Vedel
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Chembiochem 8:1781-4. 2007
  3. ncbi request reprint Subunit vaccines of the future: the need for safe, customized and optimized particulate delivery systems
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    Ther Deliv 2:1057-77. 2011
    ....
  4. ncbi request reprint siRNA delivery with lipid-based systems: promises and pitfalls
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Curr Top Med Chem 12:97-107. 2012
    ..In addition, pitfalls related to immune activation and side effects are discussed, and possible ways to overcome them are highlighted...
  5. ncbi request reprint License to kill: Formulation requirements for optimal priming of CD8(+) CTL responses with particulate vaccine delivery systems
    Camilla Foged
    University of Copenhagen, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, Universitetsparken 2, DK 2100 Copenhagen Ø, Denmark
    Eur J Pharm Sci 45:482-91. 2012
    ....
  6. ncbi request reprint Cellular uptake and membrane-destabilising properties of alpha-peptide/beta-peptoid chimeras: lessons for the design of new cell-penetrating peptides
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1778:2487-95. 2008
    ..The alpha-peptide/beta-peptoid chimeras described herein exhibit promising cellular uptake properties, and thus represent proteolytically stable alternatives to currently known cell-penetrating peptides...
  7. ncbi request reprint Cell-penetrating peptides for drug delivery across membrane barriers
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Faculty of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen O, Denmark
    Expert Opin Drug Deliv 5:105-17. 2008
    ....
  8. ncbi request reprint Phospholipase A2 sensitive liposomes for delivery of small interfering RNA (siRNA)
    Camilla Foged
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Liposome Res 17:191-6. 2007
    ....
  9. doi request reprint Calcipotriol delivery into the skin with PEGylated liposomes
    Nina Østergaard Knudsen
    Department of Pharmacy, University of Copenhagen, Copenhagen Ø, Denmark
    Eur J Pharm Biopharm 81:532-9. 2012
    ..In conclusion, PEGylation is therefore a promising approach for stabilising calcipotriol-containing liposomal dispersions without compromising their favourable skin accumulation properties...
  10. doi request reprint High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: quality by design optimization and characterization
    Dongmei Cun
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen Ø, Denmark
    Eur J Pharm Biopharm 77:26-35. 2011
    ..These results enable careful understanding and definition of optimal process parameters for preparation of PLGA nanoparticles encapsulating high amounts of siRNA with immediate and long-term sustained release properties...
  11. doi request reprint Designing CAF-adjuvanted dry powder vaccines: spray drying preserves the adjuvant activity of CAF01
    Pall Thor Ingvarsson
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    J Control Release 167:256-64. 2013
    ..These data demonstrate the importance of liposome stabilization via optimization of formulation and processing conditions in the engineering of dry powder liposome formulations...
  12. ncbi request reprint Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues
    Xiaona Jing
    Department of Pharmacy, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    Biochim Biophys Acta 1818:2660-8. 2012
    ..Together, the findings provide an improved understanding on the behavior of cell-penetrating peptidomimetics in the presence of lipid bilayers and live cells...
  13. doi request reprint Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake
    Xiaona Jing
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Langmuir 28:5167-75. 2012
    ....
  14. doi request reprint Preparation and characterization of poly(DL-lactide-co-glycolide) nanoparticles for siRNA delivery
    Dongmei Cun
    Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Int J Pharm 390:70-5. 2010
    ..The integrity of siRNA was preserved during the preparation. Preparation of core-loaded siRNA-NPs based on PLGA and no cationic excipient seems possible and promising for delivery of siRNA...
  15. ncbi request reprint Engineering of an inhalable DDA/TDB liposomal adjuvant: a quality-by-design approach towards optimization of the spray drying process
    Pall Thor Ingvarsson
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100, Copenhagen O, Denmark
    Pharm Res 30:2772-84. 2013
    ....
  16. doi request reprint Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded plga microparticles via spray-drying
    Feng Wan
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark
    Pharm Res 30:1065-76. 2013
    ..We investigated how the solvent power and volatility influence the texture and surface chemistry of celecoxib-loaded poly (lactic-co-glycolic acid) (PLGA) microparticles prepared by spray-drying...
  17. doi request reprint The physical stability of the recombinant tuberculosis fusion antigens h1 and h56
    Mette Hamborg
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Ø, Denmark
    J Pharm Sci 102:3567-78. 2013
    ..This study provides important information about the biophysical properties of H1 and H56 and highlights the analytical challenges of characterizing complex vaccine formulations...
  18. doi request reprint Protein antigen adsorption to the DDA/TDB liposomal adjuvant: effect on protein structure, stability, and liposome physicochemical characteristics
    Mette Hamborg
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Denmark
    Pharm Res 30:140-55. 2013
    ..We studied the interactions between three model protein antigens and the clinically tested cationic liposomal adjuvant composed of dimethyldioctadecylammonium (DDA) and trehalose 6,6'-dibehenate (TDB)...
  19. doi request reprint Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin α₂β₁ receptor
    Nina Ø Knudsen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen Ø, Denmark
    Int J Pharm 428:171-7. 2012
    ..In conclusion, the 12 amino acid head-to-tail cyclic RKKH peptide seems promising for targeting of liposomes to the integrin α(2)β(1) receptor...
  20. doi request reprint Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo
    Pernille Nordly
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen Ø, Denmark
    Eur J Pharm Biopharm 77:89-98. 2011
    ..Thus, incorporation of 31 mol% MMG-1 into DDA liposomes results in an adjuvant system with favorable physical as well as immunological properties...
  21. ncbi request reprint Elucidating the molecular mechanism of PAMAM-siRNA dendriplex self-assembly: effect of dendrimer charge density
    Linda B Jensen
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen Ø, Denmark
    Int J Pharm 416:410-8. 2011
    ..The flexible G1 displayed the highest entropic penalty followed by the rigid G7, making the intermediate G4 the most suitable for dendriplex formation, showing favorable charge density for siRNA binding...
  22. doi request reprint Evaluation of carrier-mediated siRNA delivery: lessons for the design of a stem-loop qPCR-based approach for quantification of intracellular full-length siRNA
    Stefano Colombo
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen O, Denmark
    J Control Release 166:220-6. 2013
    ..The outcome of the present study is a thoroughly discussed analytical protocol generally applicable to characterize carrier-mediated siRNA delivery processes...
  23. ncbi request reprint Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA
    Ditte Krohn Jensen
    University of Copenhagen, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, Universitetsparken 2, DK 2100 Copenhagen Ø, Denmark
    J Control Release 157:141-8. 2012
    ..This study demonstrates that spray-drying is an excellent technique for engineering dry powder formulations of siRNA nanoparticles, which might enable the local delivery of biologically active siRNA directly to the lung tissue...
  24. doi request reprint Immunity by formulation design: induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method
    Pernille Nordly
    Faculty of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen Ø, Denmark
    J Control Release 150:307-17. 2011
    ..These data emphasize the importance of improving the quality of the vaccine formulation to indeed overcome some of the major obstacles for using CD8-inducing agents such as poly(I:C) in future subunit vaccines...
  25. ncbi request reprint Targeting of liposome-associated calcipotriol to the skin: effect of liposomal membrane fluidity and skin barrier integrity
    Nina Østergaard Knudsen
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen Ø, Denmark
    Int J Pharm 416:478-85. 2011
    ..This suggests that the liposome-mediated delivery of calcipotriol to the epidermis of diseased skin is affected by the fluidity of the liposomal membrane...
  26. doi request reprint Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/TDB liposomes: physico-chemical characterization and induction of CD8+ T-cell responses in vivo
    Pernille Nordly
    Department of Pharmaceutics and Analytical Chemistry The Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100, Copenhagen Ø, Denmark
    Pharm Res 28:553-62. 2011
    ....
  27. doi request reprint Stabilization of liposomes during drying
    Pall Thor Ingvarsson
    University of Copenhagen, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen Ø, Denmark
    Expert Opin Drug Deliv 8:375-88. 2011
    ..In this context, the development of dry formulations of liposomes is important to ensure a more stable drug product and to avoid the use of the 'cold chain' during distribution...
  28. doi request reprint Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation
    Ditte Marie Krohn Jensen
    Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen O, Denmark
    J Control Release 142:138-45. 2010
    ..In conclusion, the present results show that spray drying is a suitable technique for producing nanocomposite microparticles comprising siRNA-containing PLGA NPs for potential use in inhalation therapy...
  29. ncbi request reprint NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen, Denmark
    Eur J Pharm Biopharm 70:914-20. 2008
    ..These studies therefore suggest that NIR can be used for real-time process control analysis in the production of CAF01 liposomes...
  30. ncbi request reprint Status and future prospects of lipid-based particulate delivery systems as vaccine adjuvants and their combination with immunostimulators
    Pernille Nordly
    University of Copenhagen, Department of Pharmaceutics and Analytical Chemistry, Universitetsparken 2, DK 2100 Copenhagen O, Denmark
    Expert Opin Drug Deliv 6:657-72. 2009
    ..Formulations, adjuvant mechanisms and alternative administration routes are highlighted...
  31. pmc The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes
    Karen Smith Korsholm
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Immunology 121:216-26. 2007
    ..10 T cells. Our data therefore suggest that the primary adjuvant mechanism of cationic DDA liposomes is to target the cell membrane of antigen-presenting cells, which subsequently leads to enhanced uptake and presentation of antigen...
  32. doi request reprint Molecular characterization of the interaction between siRNA and PAMAM G7 dendrimers by SAXS, ITC, and molecular dynamics simulations
    Linda B Jensen
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Biomacromolecules 11:3571-7. 2010
    ..This study demonstrates the unique complementarity of SAXS, ITC, and modeling for the detailed description of the molecular interactions between dendrimers and siRNA during dendriplex formation...
  33. ncbi request reprint The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models
    Pall Thor Ingvarsson
    Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
    Eur J Pharm Biopharm 87:480-8. 2014
    ..Our in vitro results thus indicate that DDA/TDB liposomes might be efficiently and safely used as an adjuvant system for vaccines targeting the mucus-covered epithelium of the upper respiratory tract and the conducting airways. ..
  34. doi request reprint Comparison of polymeric siRNA nanocarriers in a murine LPS-activated macrophage cell line: gene silencing, toxicity and off-target gene expression
    Linda B Jensen
    Department of Pharmaceutics and Analytical Chemistry Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen O, Denmark
    Pharm Res 29:669-82. 2012
    ..We aimed to identify polymeric nanocarriers for anti-TNF-α siRNA with optimal efficacy and minimal off-target effects in vitro...
  35. ncbi request reprint Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model
    Camilla Foged
    Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Int J Pharm 298:315-22. 2005
    ..Whether increased particle uptake is correlated with increased immune responses, remains to be established...
  36. ncbi request reprint alpha,alpha'-trehalose 6,6'-dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Adjuvant Research, DK 2300 Copenhagen S, Denmark
    Biochim Biophys Acta 1778:1365-73. 2008
    ..Furthermore the results indicate that direct interaction with liposome surfaces is necessary for trehalose to enable protection during freeze-drying...
  37. ncbi request reprint Trehalose preserves DDA/TDB liposomes and their adjuvant effect during freeze-drying
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Adjuvant Research, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Biochim Biophys Acta 1768:2120-9. 2007
    ....
  38. ncbi request reprint Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition
    Camilla Foged
    Division of Hematology, Centre for Molecular Medicine, Karolinska Hospital and Institute, S 17176 Stockholm, Sweden
    Vaccine 22:1903-13. 2004
    ..In conclusion, liposome bilayer composition has an important effect on interaction with DCs and might be critical for the vaccination outcome...
  39. ncbi request reprint Targeting vaccines to dendritic cells
    Camilla Foged
    Department of Pharmaceutics, The Royal Danish School of Pharmacy, Copenhagen
    Pharm Res 19:229-38. 2002
    ..This paper will review the current knowledge of DC physiology as well as the progress in the field of novel vaccination strategies that directly or indirectly aim at targeting DC...