Research Topics
Genomes and Genes | Robert A FentonSummaryAffiliation: University of Aarhus Country: Denmark Publications
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Publications
Urea transporters and renal function: lessons from knockout miceRobert A Fenton
Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
Curr Opin Nephrol Hypertens 17:513-8. 2008..In this brief review, the new insights in our understanding of the role of urea in the urinary concentrating mechanism and kidney function resulting from studies in these mice are discussed...
Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCCL L Rosenbaek
Department of Biomedicine, Aarhus University, DK 8000 Aarhus, Denmark
J Physiol 590:6121-39. 2012..In novel tetracycline-inducible MDCKII-NCC cell lines, S124A and S124D mutants were able to traffic to the plasma membrane similarly to wildtype NCC...
Role of collecting duct urea transporters in the kidney--insights from mouse modelsR A Fenton
The Water and Salt Research Center, Institute of Anatomy, Building 1233, University of Aarhus, DK 8000, Aarhus, Denmark
J Membr Biol 212:119-31. 2006....- Mouse models and the urinary concentrating mechanism in the new millenniumRobert A Fenton
Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
Physiol Rev 87:1083-112. 2007.... - Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidneyRobert A Fenton
The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
Am J Physiol Renal Physiol 293:F748-60. 2007..Confocal microscopy of isolated inner medullary collecting duct tubules showed that the V2R is expressed both intracellularly and in basolateral membrane domains... - Urea and renal function in the 21st century: insights from knockout miceRobert A Fenton
Water and Salt Research Center, Institute of Anatomy, Building 233 234, University of Aarhus, DK 8000 Aarhus, Denmark
J Am Soc Nephrol 18:679-88. 2007.... - Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressinRobert A Fenton
The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
Proc Natl Acad Sci U S A 105:3134-9. 2008..Overall, our results are consistent with a dynamic effect of AVP on the phosphorylation and subcellular distribution of AQP2... - Gamble's "economy of water" revisited: studies in urea transporter knockout miceRobert A Fenton
Laboratory of Kidney and Electrolyte Metabolism, National Hearth, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, and Faculty of Life Sciences, University of Manchester, UK
Am J Physiol Renal Physiol 291:F148-54. 2006.... - UT-A urea transporter promoter, UT-Aalpha, targets principal cells of the renal inner medullary collecting ductRobert A Fenton
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Am J Physiol Renal Physiol 290:F188-95. 2006..These results demonstrate that 4.2 kb of the UT-Aalpha promoter is sufficient to drive expression of a heterologous reporter gene in a tissue-specific and cell-specific fashion in transgenic mice... - Essential role of vasopressin-regulated urea transport processes in the mammalian kidneyRobert A Fenton
The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Denmark
Pflugers Arch 458:169-77. 2009.... - Quantitative analysis of aquaporin-2 phosphorylationLuke Xie
Epithelial Systems Biology Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Physiol Renal Physiol 298:F1018-23. 2010..We suggest from these studies that Ser269 phosphorylation may be a more consistent indicator of vasopressin action and AQP2 membrane abundance than is Ser256 phosphorylation... - Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transportersShelly Hwang
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Am J Physiol Renal Physiol 299:F559-67. 2010..The findings add to prior evidence for vasopressin-induced phosphorylation of UT-A1, providing evidence that UT-A3 may be regulated by phosphorylation as well... - Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidusEmma T B Olesen
Department of Biomedicine, Water and Salt Research Center, Aarhus University, DK 8000 Aarhus C, Denmark
Proc Natl Acad Sci U S A 108:12949-54. 2011..Furthermore, EP2 selective agonists can partially compensate for a nonfunctional V2R, providing a rationale for new treatment strategies for hereditary nephrogenic diabetes insipidus... - Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2Jason D Hoffert
NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
J Biol Chem 283:24617-27. 2008..The data support a model in which vasopressin-mediated phosphorylation of AQP2 at Ser269:(a) depends on prior PKA-mediated phosphorylation of Ser256 and (b) enhances apical plasma membrane retention of AQP2... - Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstructionAnja M Jensen
The Water and Salt Research Center, Institute of Clinical Medicine, Univ of Aarhus, Dept of Clinical Physiology and Nuclear Medicine, Aarhus Univ Hospital Skejby, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
Am J Physiol Renal Physiol 296:F127-34. 2009..In addition, we have shown that angiotensin II regulates the V2 receptor complex and pS256-AQP2 in postobstructive kidney IM, probably by stimulating cAMP generation... - Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cellsHanne B Moeller
The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
Kidney Int 75:295-303. 2009..Our results show that S269 phosphorylated aquaporin-2 is exclusively associated with the apical plasma membrane, where it escapes endocytosis to remain at the cell surface... - The basolateral expression of mUT-A3 in the mouse kidneyGavin S Stewart
School of Biological Sciences, University of Manchester, M13 9PT, UK
Am J Physiol Renal Physiol 286:F979-87. 2004..In conclusion, our study indicates that mUT-A3 is a basolateral membrane transporter expressed in IMCD cells... - Renal phenotype of UT-A urea transporter knockout miceRobert A Fenton
Laboratory of Kidney Electrolyte Metabolism, National Heart, Lung and Blood Institutes, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
J Am Soc Nephrol 16:1583-92. 2005..These results support our conclusion that the urinary concentrating defect in UT-A1/3(-/-) mice is caused by a failure of urea transport from the IMCD lumen to the inner medullary interstitium, resulting in osmotic diuresis... - Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting ductRobert A Fenton
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
Proc Natl Acad Sci U S A 101:7469-74. 2004..Thus, these results do not corroborate the predictions of passive medullary concentrating models stating that NaCl accumulation in the inner medulla depends on rapid vasopressin-regulated urea transport across the IMCD epithelium... - Regulation of the water channel aquaporin-2 by posttranslational modificationHanne B Moeller
The Water and Salt Research Center, Dept of Anatomy, Aarhus Univ, Denmark
Am J Physiol Renal Physiol 300:F1062-73. 2011.... - Increased collecting duct urea transporter expression in Dahl salt-sensitive ratsRobert A Fenton
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and BIood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
Am J Physiol Renal Physiol 285:F143-51. 2003.... - Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytesSabina Jelen
The Water and Salt Research Center, Department of Biomedicine, Aarhus University, Aarhus, Denmark
Am J Physiol Gastrointest Liver Physiol 303:G1279-87. 2012..We conclude that AQP9 and unidentified UT-A urea channels constitute primary but redundant urea facilitators in murine hepatocytes... - Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactionsHanne B Moeller
Water and Salt Research Center, Department of Anatomy, Aarhus University, DK 8000 Aarhus C, Denmark
Proc Natl Acad Sci U S A 107:424-9. 2010.... - Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometryNicholas A Zwang
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Proteome Res 8:1540-54. 2009..These results suggest that phosphorylation of AQP2 at Ser-256 may regulate AQP2 trafficking in part by mediating differential binding of hsp70 family proteins to the COOH-terminal tail... - Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gatingHanne B Moeller
The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
Am J Physiol Renal Physiol 296:F649-57. 2009..In contrast, AQP2 S261 phosphorylation is independent of the phosphorylation status of S256... - Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubuleNis B Pedersen
The Water and Salt Research Center, Department of Anatomy, Aarhus University, Aarhus C, Denmark
Kidney Int 78:160-9. 2010..Our results show that AVP is a potent regulator of NCC activity... - Recent discoveries in vasopressin-regulated aquaporin-2 traffickingRobert A Fenton
The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
Prog Brain Res 170:571-9. 2008..Determining how AQP-2 trafficking occurs at the molecular level is fundamental to understanding the physiology of water balance regulation and the pathophysiology of water balance disorders... - Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferationJakob Nielsen
Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
Proc Natl Acad Sci U S A 105:3634-9. 2008..This study provides a comprehensive analysis of the proteins affected by lithium treatment in the IMCD and, as such, provides clues to potential lithium targets in the brain... - Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalitiesVinitha A Jacob
Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
Kidney Int 74:1202-8. 2008..Our studies show that real time imaging of renal pelvic structure in genetically manipulated mice provides a tool for the non-destructive, temporal evaluation of kidney structure... - Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting ductJason D Hoffert
Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 280:13624-30. 2005..These studies demonstrate the importance of calmodulin in the regulation of collecting duct adenylyl cyclase activity and transport function... - Differential water permeability and regulation of three aquaporin 4 isoformsRobert A Fenton
The Water and Salt Research Center, Department of Anatomy, University of Aarhus, 8000, Aarhus, Denmark
Cell Mol Life Sci 67:829-40. 2010..The M23 isoform was more sensitive to PKC regulation than the longer isoforms and was internalized significantly faster. Our results suggest a specific role for square array formation... - Assessment of the effect of 24-hour aldosterone administration on protein abundance in fluorescence-sorted mouse distal renal tubules by mass spectrometryThomas B Jensen
Department of Biomedicine and the Water and Salt Research Center, Aarhus University HEALTH, Aarhus, Denmark
Nephron Physiol 121:p9-15. 2012..Aldosterone exerts multiple long-term effects on the distal renal tubules. The aim of this study was to establish a method for identifying proteins in these tubules that change in abundance by only 24-hour aldosterone administration... - A current view of the mammalian aquaglyceroporinsAleksandra Rojek
Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
Annu Rev Physiol 70:301-27. 2008..This review comprehensively discusses the recent discoveries in the field of aquaglyceroporins, alongside a brief overview of the so-called unorthodox aquaporins... - Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cellsQi Cai
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
Am J Physiol Renal Physiol 291:F341-9. 2006.... - Aquaporin-1 is not expressed in descending thin limbs of short-loop nephronsXiao Yue Zhai
Department of Cell Biology, Institute of Anatomy, University of Aarhus, Arhus C, Denmark
J Am Soc Nephrol 18:2937-44. 2007..Likewise, the roles of aquaporin-1 and UT-A2 in the countercurrent multiplier and water conversation may need to be readdressed... - Defective glycerol metabolism in aquaporin 9 (AQP9) knockout miceAleksandra M Rojek
The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
Proc Natl Acad Sci U S A 104:3609-14. 2007..Thus, AQP9 is important for hepatic glycerol metabolism and may play a role in glycerol and glucose metabolism in diabetes mellitus... - Is there a role for PGE2 in urinary concentration?Emma T B Olesen
Department of Biomedicine, Aarhus University, Aarhus, Denmark
J Am Soc Nephrol 24:169-78. 2013..PGE2 has an intricate role in urinary concentration, and we now suggest how targeting specific prostanoid receptor signaling pathways could be exploited for the treatment of disorders in water balance... - Liver-specific Aquaporin 11 knockout mice show rapid vacuolization of the rough endoplasmic reticulum in periportal hepatocytes after amino acid feedingAleksandra Rojek
Water and Salt Research Center, Department of Biomedicine, Aarhus University, Aarhus, Denmark
Am J Physiol Gastrointest Liver Physiol 304:G501-15. 2013..In conclusion, in the liver, deletion of AQP11 results in disrupted RER homeostasis and increased sensitivity to RER injury upon metabolic challenge with amino acids... - Cell biology of vasopressin-regulated aquaporin-2 traffickingHanne B Moeller
Department of Biomedicine and Center for Interactions of Proteins in Epithelial Transport InterPrET, Aarhus University, Bldg 1233 Wilhelm Meyers Alle, Aarhus, 8000, Denmark
Pflugers Arch 464:133-44. 2012..Insight into the molecular mechanisms responsible for regulated AQP2 trafficking is proving to be fundamental for development of novel therapies for water balance disorders... - Long-term regulation of ENaC expression in kidney by angiotensin IIKathleen T Beutler
Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, MD 20892-1603, USA
Hypertension 41:1143-50. 2003..The results support the view that the angiotensin II receptor regulates ENaC abundance, consistent with a role for angiotensin II in regulation of collecting duct function... - Fluorescence isolation of mouse late distal convoluted tubules and connecting tubules: effects of vasopressin and vitamin D3 on Ca2+ signalingMarlene V Hofmeister
Institute of Anatomy and The Water and Salt Research Center, Univ of Aarhus, Wilhelm Meyers Alle, Bldg 1 234, 8000 Aarhus C, Denmark
Am J Physiol Renal Physiol 296:F194-203. 2009.... - 17β-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1Marlene Vind Hofmeister
Dept of Biomedicine, The Water and Salt Research Center, Aarhus Univ, Aarhus C, Denmark
Am J Physiol Renal Physiol 302:F358-68. 2012..We propose that E2 via GPER1 evokes [Ca(2+)](i) transients and increases H(+)-ATPase activity in intercalated cells in mouse DCT2/CNT/iCCD... - Treatment with the vascular disrupting agent combretastatin is associated with impaired AQP2 trafficking and increased urine outputAnja B Bohn
Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade, Denmark
Am J Physiol Regul Integr Comp Physiol 303:R186-98. 2012..The CA4P-mediated increase in urine output seems to be a local effect in the collecting ducts due to reduced AQP2 trafficking to the apical plasma membrane...