Robert A Fenton

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. doi request reprint Urea transporters and renal function: lessons from knockout mice
    Robert A Fenton
    Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Curr Opin Nephrol Hypertens 17:513-8. 2008
  2. doi request reprint New insights into regulated aquaporin-2 function
    Robert A Fenton
    Department of Biomedicine, Aarhus University and Center for Interactions of Proteins in Epithelial Transport, Aarhus University, Aarhus, Denmark
    Curr Opin Nephrol Hypertens 22:551-8. 2013
  3. ncbi request reprint Molecular physiology of the medullary collecting duct
    Robert A Fenton
    Department of Anatomy and the Water and Salt Research Center, Aarhus University, Aarhus, Denmark
    Compr Physiol 1:1031-56. 2011
  4. pmc Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC
    L L Rosenbaek
    Department of Biomedicine, Aarhus University, DK 8000 Aarhus, Denmark
    J Physiol 590:6121-39. 2012
  5. ncbi request reprint Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Am J Physiol Renal Physiol 293:F748-60. 2007
  6. ncbi request reprint Role of collecting duct urea transporters in the kidney--insights from mouse models
    R A Fenton
    The Water and Salt Research Center, Institute of Anatomy, Building 1233, University of Aarhus, DK 8000, Aarhus, Denmark
    J Membr Biol 212:119-31. 2006
  7. ncbi request reprint Urea and renal function in the 21st century: insights from knockout mice
    Robert A Fenton
    Water and Salt Research Center, Institute of Anatomy, Building 233 234, University of Aarhus, DK 8000 Aarhus, Denmark
    J Am Soc Nephrol 18:679-88. 2007
  8. ncbi request reprint Gamble's "economy of water" revisited: studies in urea transporter knockout mice
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Hearth, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, and Faculty of Life Sciences, University of Manchester, UK
    Am J Physiol Renal Physiol 291:F148-54. 2006
  9. pmc UT-A urea transporter promoter, UT-Aalpha, targets principal cells of the renal inner medullary collecting duct
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 290:F188-95. 2006
  10. pmc Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 105:3134-9. 2008

Collaborators

Detail Information

Publications51

  1. doi request reprint Urea transporters and renal function: lessons from knockout mice
    Robert A Fenton
    Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Curr Opin Nephrol Hypertens 17:513-8. 2008
    ..In this brief review, the new insights in our understanding of the role of urea in the urinary concentrating mechanism and kidney function resulting from studies in these mice are discussed...
  2. doi request reprint New insights into regulated aquaporin-2 function
    Robert A Fenton
    Department of Biomedicine, Aarhus University and Center for Interactions of Proteins in Epithelial Transport, Aarhus University, Aarhus, Denmark
    Curr Opin Nephrol Hypertens 22:551-8. 2013
    ..In this article, we highlight some of the new insights into AQP2 function that have developed recently, with particular focus on the cell biological aspects of AQP2 regulation...
  3. ncbi request reprint Molecular physiology of the medullary collecting duct
    Robert A Fenton
    Department of Anatomy and the Water and Salt Research Center, Aarhus University, Aarhus, Denmark
    Compr Physiol 1:1031-56. 2011
    ..Knowledge gained from studies in knockout mice is also discussed...
  4. pmc Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC
    L L Rosenbaek
    Department of Biomedicine, Aarhus University, DK 8000 Aarhus, Denmark
    J Physiol 590:6121-39. 2012
    ..In novel tetracycline-inducible MDCKII-NCC cell lines, S124A and S124D mutants were able to traffic to the plasma membrane similarly to wildtype NCC...
  5. ncbi request reprint Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Am J Physiol Renal Physiol 293:F748-60. 2007
    ..Confocal microscopy of isolated inner medullary collecting duct tubules showed that the V2R is expressed both intracellularly and in basolateral membrane domains...
  6. ncbi request reprint Role of collecting duct urea transporters in the kidney--insights from mouse models
    R A Fenton
    The Water and Salt Research Center, Institute of Anatomy, Building 1233, University of Aarhus, DK 8000, Aarhus, Denmark
    J Membr Biol 212:119-31. 2006
    ....
  7. ncbi request reprint Urea and renal function in the 21st century: insights from knockout mice
    Robert A Fenton
    Water and Salt Research Center, Institute of Anatomy, Building 233 234, University of Aarhus, DK 8000 Aarhus, Denmark
    J Am Soc Nephrol 18:679-88. 2007
    ....
  8. ncbi request reprint Gamble's "economy of water" revisited: studies in urea transporter knockout mice
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Hearth, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, and Faculty of Life Sciences, University of Manchester, UK
    Am J Physiol Renal Physiol 291:F148-54. 2006
    ....
  9. pmc UT-A urea transporter promoter, UT-Aalpha, targets principal cells of the renal inner medullary collecting duct
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 290:F188-95. 2006
    ..These results demonstrate that 4.2 kb of the UT-Aalpha promoter is sufficient to drive expression of a heterologous reporter gene in a tissue-specific and cell-specific fashion in transgenic mice...
  10. pmc Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 105:3134-9. 2008
    ..Overall, our results are consistent with a dynamic effect of AVP on the phosphorylation and subcellular distribution of AQP2...
  11. doi request reprint Essential role of vasopressin-regulated urea transport processes in the mammalian kidney
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Denmark
    Pflugers Arch 458:169-77. 2009
    ....
  12. ncbi request reprint Mouse models and the urinary concentrating mechanism in the new millennium
    Robert A Fenton
    Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Physiol Rev 87:1083-112. 2007
    ....
  13. pmc Quantitative analysis of aquaporin-2 phosphorylation
    Luke Xie
    Epithelial Systems Biology Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 298:F1018-23. 2010
    ..We suggest from these studies that Ser269 phosphorylation may be a more consistent indicator of vasopressin action and AQP2 membrane abundance than is Ser256 phosphorylation...
  14. pmc Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transporters
    Shelly Hwang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 299:F559-67. 2010
    ..The findings add to prior evidence for vasopressin-induced phosphorylation of UT-A1, providing evidence that UT-A3 may be regulated by phosphorylation as well...
  15. pmc Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus
    Emma T B Olesen
    Department of Biomedicine, Water and Salt Research Center, Aarhus University, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 108:12949-54. 2011
    ..Furthermore, EP2 selective agonists can partially compensate for a nonfunctional V2R, providing a rationale for new treatment strategies for hereditary nephrogenic diabetes insipidus...
  16. doi request reprint Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction
    Anja M Jensen
    The Water and Salt Research Center, Institute of Clinical Medicine, Univ of Aarhus, Dept of Clinical Physiology and Nuclear Medicine, Aarhus Univ Hospital Skejby, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
    Am J Physiol Renal Physiol 296:F127-34. 2009
    ..In addition, we have shown that angiotensin II regulates the V2 receptor complex and pS256-AQP2 in postobstructive kidney IM, probably by stimulating cAMP generation...
  17. pmc Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2
    Jason D Hoffert
    NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    J Biol Chem 283:24617-27. 2008
    ..The data support a model in which vasopressin-mediated phosphorylation of AQP2 at Ser269:(a) depends on prior PKA-mediated phosphorylation of Ser256 and (b) enhances apical plasma membrane retention of AQP2...
  18. pmc Renal phenotype of UT-A urea transporter knockout mice
    Robert A Fenton
    Laboratory of Kidney Electrolyte Metabolism, National Heart, Lung and Blood Institutes, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
    J Am Soc Nephrol 16:1583-92. 2005
    ..These results support our conclusion that the urinary concentrating defect in UT-A1/3(-/-) mice is caused by a failure of urea transport from the IMCD lumen to the inner medullary interstitium, resulting in osmotic diuresis...
  19. ncbi request reprint The basolateral expression of mUT-A3 in the mouse kidney
    Gavin S Stewart
    School of Biological Sciences, University of Manchester, M13 9PT, UK
    Am J Physiol Renal Physiol 286:F979-87. 2004
    ..In conclusion, our study indicates that mUT-A3 is a basolateral membrane transporter expressed in IMCD cells...
  20. pmc Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells
    Hanne B Moeller
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Kidney Int 75:295-303. 2009
    ..Our results show that S269 phosphorylated aquaporin-2 is exclusively associated with the apical plasma membrane, where it escapes endocytosis to remain at the cell surface...
  21. doi request reprint Liver-specific Aquaporin 11 knockout mice show rapid vacuolization of the rough endoplasmic reticulum in periportal hepatocytes after amino acid feeding
    Aleksandra Rojek
    Water and Salt Research Center, Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Am J Physiol Gastrointest Liver Physiol 304:G501-15. 2013
    ..In conclusion, in the liver, deletion of AQP11 results in disrupted RER homeostasis and increased sensitivity to RER injury upon metabolic challenge with amino acids...
  22. pmc Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions
    Hanne B Moeller
    Water and Salt Research Center, Department of Anatomy, Aarhus University, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 107:424-9. 2010
    ....
  23. pmc Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 101:7469-74. 2004
    ..Thus, these results do not corroborate the predictions of passive medullary concentrating models stating that NaCl accumulation in the inner medulla depends on rapid vasopressin-regulated urea transport across the IMCD epithelium...
  24. pmc Assessment of the effect of 24-hour aldosterone administration on protein abundance in fluorescence-sorted mouse distal renal tubules by mass spectrometry
    Thomas B Jensen
    Department of Biomedicine and the Water and Salt Research Center, Aarhus University HEALTH, Aarhus, Denmark
    Nephron Physiol 121:p9-15. 2012
    ..Aldosterone exerts multiple long-term effects on the distal renal tubules. The aim of this study was to establish a method for identifying proteins in these tubules that change in abundance by only 24-hour aldosterone administration...
  25. doi request reprint Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes
    Sabina Jelen
    The Water and Salt Research Center, Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Am J Physiol Gastrointest Liver Physiol 303:G1279-87. 2012
    ..We conclude that AQP9 and unidentified UT-A urea channels constitute primary but redundant urea facilitators in murine hepatocytes...
  26. doi request reprint Regulation of the water channel aquaporin-2 by posttranslational modification
    Hanne B Moeller
    The Water and Salt Research Center, Dept of Anatomy, Aarhus Univ, Denmark
    Am J Physiol Renal Physiol 300:F1062-73. 2011
    ....
  27. ncbi request reprint Increased collecting duct urea transporter expression in Dahl salt-sensitive rats
    Robert A Fenton
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and BIood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 285:F143-51. 2003
    ....
  28. doi request reprint Recent discoveries in vasopressin-regulated aquaporin-2 trafficking
    Robert A Fenton
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Prog Brain Res 170:571-9. 2008
    ..Determining how AQP-2 trafficking occurs at the molecular level is fundamental to understanding the physiology of water balance regulation and the pathophysiology of water balance disorders...
  29. doi request reprint Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule
    Nis B Pedersen
    The Water and Salt Research Center, Department of Anatomy, Aarhus University, Aarhus C, Denmark
    Kidney Int 78:160-9. 2010
    ..Our results show that AVP is a potent regulator of NCC activity...
  30. pmc Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating
    Hanne B Moeller
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Am J Physiol Renal Physiol 296:F649-57. 2009
    ..In contrast, AQP2 S261 phosphorylation is independent of the phosphorylation status of S256...
  31. pmc Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation
    Jakob Nielsen
    Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 105:3634-9. 2008
    ..This study provides a comprehensive analysis of the proteins affected by lithium treatment in the IMCD and, as such, provides clues to potential lithium targets in the brain...
  32. pmc Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry
    Nicholas A Zwang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Proteome Res 8:1540-54. 2009
    ..These results suggest that phosphorylation of AQP2 at Ser-256 may regulate AQP2 trafficking in part by mediating differential binding of hsp70 family proteins to the COOH-terminal tail...
  33. pmc Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities
    Vinitha A Jacob
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Kidney Int 74:1202-8. 2008
    ..Our studies show that real time imaging of renal pelvic structure in genetically manipulated mice provides a tool for the non-destructive, temporal evaluation of kidney structure...
  34. pmc Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct
    Jason D Hoffert
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:13624-30. 2005
    ..These studies demonstrate the importance of calmodulin in the regulation of collecting duct adenylyl cyclase activity and transport function...
  35. doi request reprint Differential water permeability and regulation of three aquaporin 4 isoforms
    Robert A Fenton
    The Water and Salt Research Center, Department of Anatomy, University of Aarhus, 8000, Aarhus, Denmark
    Cell Mol Life Sci 67:829-40. 2010
    ..The M23 isoform was more sensitive to PKC regulation than the longer isoforms and was internalized significantly faster. Our results suggest a specific role for square array formation...
  36. pmc Phosphorylation decreases ubiquitylation of the thiazide-sensitive cotransporter NCC and subsequent clathrin-mediated endocytosis
    Lena L Rosenbaek
    From the Department of Biomedicine and Center for Interactions of Proteins in Epithelial Transport, Aarhus University, Aarhus DK 8000, Denmark
    J Biol Chem 289:13347-61. 2014
    ....
  37. ncbi request reprint Aquaporin-1 is not expressed in descending thin limbs of short-loop nephrons
    Xiao Yue Zhai
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Arhus C, Denmark
    J Am Soc Nephrol 18:2937-44. 2007
    ..Likewise, the roles of aquaporin-1 and UT-A2 in the countercurrent multiplier and water conversation may need to be readdressed...
  38. pmc Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice
    Aleksandra M Rojek
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 104:3609-14. 2007
    ..Thus, AQP9 is important for hepatic glycerol metabolism and may play a role in glycerol and glucose metabolism in diabetes mellitus...
  39. ncbi request reprint A current view of the mammalian aquaglyceroporins
    Aleksandra Rojek
    Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
    Annu Rev Physiol 70:301-27. 2008
    ..This review comprehensively discusses the recent discoveries in the field of aquaglyceroporins, alongside a brief overview of the so-called unorthodox aquaporins...
  40. ncbi request reprint Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells
    Qi Cai
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 291:F341-9. 2006
    ....
  41. pmc Distal Renal Tubules Are Deficient in Aggresome Formation and Autophagy upon Aldosterone Administration
    Muhammad Umar Cheema
    Department of Biomedicine, Membranes Center and InterPrET Pilot Center, Health, Aarhus University, Aarhus, Denmark
    PLoS ONE 9:e101258. 2014
    ..We conclude that aldosterone induces protein accumulation in distal renal tubules; these aggregates are not cleared by autophagy that may lead to early renal tubular damage. ..
  42. ncbi request reprint Renal aquaporins and water balance disorders
    Marleen L A Kortenoeven
    Department of Biomedicine, Aarhus University, Aarhus, Denmark Center for Interactions of Proteins in Epithelial Transport InterPrET, Aarhus University, Aarhus, Denmark Electronic address
    Biochim Biophys Acta 1840:1533-49. 2014
    ..Eight AQPs are expressed in the kidney of which five have been shown to play a role in body water balance; AQP1, AQP2, AQP3, AQP4 and AQP7. AQP2 in particular is regulated by vasopressin...
  43. doi request reprint Is there a role for PGE2 in urinary concentration?
    Emma T B Olesen
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    J Am Soc Nephrol 24:169-78. 2013
    ..PGE2 has an intricate role in urinary concentration, and we now suggest how targeting specific prostanoid receptor signaling pathways could be exploited for the treatment of disorders in water balance...
  44. doi request reprint Cell biology of vasopressin-regulated aquaporin-2 trafficking
    Hanne B Moeller
    Department of Biomedicine and Center for Interactions of Proteins in Epithelial Transport InterPrET, Aarhus University, Bldg 1233 Wilhelm Meyers Alle, Aarhus, 8000, Denmark
    Pflugers Arch 464:133-44. 2012
    ..Insight into the molecular mechanisms responsible for regulated AQP2 trafficking is proving to be fundamental for development of novel therapies for water balance disorders...
  45. ncbi request reprint Long-term regulation of ENaC expression in kidney by angiotensin II
    Kathleen T Beutler
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Hypertension 41:1143-50. 2003
    ..The results support the view that the angiotensin II receptor regulates ENaC abundance, consistent with a role for angiotensin II in regulation of collecting duct function...
  46. doi request reprint Fluorescence isolation of mouse late distal convoluted tubules and connecting tubules: effects of vasopressin and vitamin D3 on Ca2+ signaling
    Marlene V Hofmeister
    Institute of Anatomy and The Water and Salt Research Center, Univ of Aarhus, Wilhelm Meyers Alle, Bldg 1 234, 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 296:F194-203. 2009
    ....
  47. pmc Genetic ablation of aquaporin-2 in the mouse connecting tubules results in defective renal water handling
    Marleen L A Kortenoeven
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
    J Physiol 591:2205-19. 2013
    ..Our studies indicate that the CNT plays a role in regulating body water balance under basal conditions, but not for maximal concentration of the urine during antidiuresis...
  48. doi request reprint 17β-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1
    Marlene Vind Hofmeister
    Dept of Biomedicine, The Water and Salt Research Center, Aarhus Univ, Aarhus C, Denmark
    Am J Physiol Renal Physiol 302:F358-68. 2012
    ..We propose that E2 via GPER1 evokes [Ca(2+)](i) transients and increases H(+)-ATPase activity in intercalated cells in mouse DCT2/CNT/iCCD...
  49. pmc Aldosterone and angiotensin II induce protein aggregation in renal proximal tubules
    Muhammad U Cheema
    Department of Biomedicine, Membranes and InterPrET, Health, Aarhus University Aarhus, Denmark
    Physiol Rep 1:e00064. 2013
    ..Despite an increase in aggregation-prone protein load in these tubules during hormone treatment, renal proximal tubules seem to have sufficient capacity for removing protein aggregates from the cells. ..
  50. pmc Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment
    Hanne B Moeller
    Department of Biomedicine, Aarhus University, and Department of Pediatrics, Aarhus University Hospital, Wilhelm Meyers Allé 3, Building 1234, Aarhus 8000, Denmark
    Endocr Rev 34:278-301. 2013
    ..Additionally, we provide an overview of the exciting new treatment strategies that have been recently proposed for alleviating the symptoms of some forms of the disease and for bypassing G protein-coupled receptor signaling...
  51. doi request reprint Treatment with the vascular disrupting agent combretastatin is associated with impaired AQP2 trafficking and increased urine output
    Anja B Bohn
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade, Denmark
    Am J Physiol Regul Integr Comp Physiol 303:R186-98. 2012
    ..The CA4P-mediated increase in urine output seems to be a local effect in the collecting ducts due to reduced AQP2 trafficking to the apical plasma membrane...