Angela Fago

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. pmc Oxygen binding to partially nitrosylated hemoglobin
    Angela Fago
    Department of Bioscience, Aarhus University, DK 8000 Aarhus, Denmark
    Biochim Biophys Acta 1834:1894-900. 2013
  2. doi request reprint Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach
    Angela Fago
    Zoophysiology, Department of Bioscience, Aarhus University, Aarhus C, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 162:1-6. 2012
  3. pmc Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties
    Eva Geuens
    Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    BMC Biochem 11:17. 2010
  4. ncbi request reprint Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance
    Angela Fago
    Department of Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, Aarhus University, DK 8000 Aarhus C, Denmark
    J Biol Chem 279:44417-26. 2004
  5. ncbi request reprint Functional properties of neuroglobin and cytoglobin. Insights into the ancestral physiological roles of globins
    Angela Fago
    Department of Zoophysiology, Institute of Biological Sciences, Aarhus University, Aarhus C, Denmark
    IUBMB Life 56:689-96. 2004
  6. pmc Lack of conventional oxygen-linked proton and anion binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobin
    Roy E Weber
    Zoophysiology, Department of Bioscience, Aarhus University, Aarhus, Denmark
    Am J Physiol Regul Integr Comp Physiol 305:R300-12. 2013
  7. doi request reprint Myoglobin-dependent O2 consumption of the hypoxic trout heart
    Signe Helbo
    Department of Bioscience, C F Møllers Allé 3, Bldg 1131, 8000 Aarhus University, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 165:40-5. 2013
  8. ncbi request reprint Critical redox and allosteric aspects of nitric oxide interactions with hemoglobin
    Celia Bonaventura
    Nicholas School of the Environment and Earth Sciences, Duke University Marine Laboratory, Beaufort, NC 28516, USA
    Antioxid Redox Signal 6:979-91. 2004
  9. ncbi request reprint The reactions of neuroglobin with CO: evidence for two forms of the ferrous protein
    Angela Fago
    Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, Aarhus University, DK 8000 Aarhus C, Denmark
    J Inorg Biochem 100:1339-43. 2006
  10. pmc Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) with different altitudinal ranges
    Inge G Revsbech
    Zoophysiology, Department of Bioscience, Aarhus University, C F Møllers Allé 3, DK 8000 Aarhus C, Denmark
    J Exp Biol 216:4264-71. 2013

Collaborators

Detail Information

Publications44

  1. pmc Oxygen binding to partially nitrosylated hemoglobin
    Angela Fago
    Department of Bioscience, Aarhus University, DK 8000 Aarhus, Denmark
    Biochim Biophys Acta 1834:1894-900. 2013
    ..This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. ..
  2. doi request reprint Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach
    Angela Fago
    Zoophysiology, Department of Bioscience, Aarhus University, Aarhus C, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 162:1-6. 2012
    ..It also highlights the need and potential for a comparative approach of study and collaborative effort to identify potential link(s) between the signaling pathways involving NO, nitrite and H(2)S in the whole-body responses to hypoxia...
  3. pmc Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties
    Eva Geuens
    Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    BMC Biochem 11:17. 2010
    ..No information is available on the physicochemical properties and the in vivo expression...
  4. ncbi request reprint Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance
    Angela Fago
    Department of Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, Aarhus University, DK 8000 Aarhus C, Denmark
    J Biol Chem 279:44417-26. 2004
    ..In contrast, the lower O2 affinity in NGB does not appear compatible with a physiological role involving mitochondrial O2 supply at the low O2 tensions found within neurons...
  5. ncbi request reprint Functional properties of neuroglobin and cytoglobin. Insights into the ancestral physiological roles of globins
    Angela Fago
    Department of Zoophysiology, Institute of Biological Sciences, Aarhus University, Aarhus C, Denmark
    IUBMB Life 56:689-96. 2004
    ..The O2 binding properties of cytoglobin, which is upregulated upon hypoxia, are consistent with a role for this protein in O2-requiring reactions, such as those catalysed by hydroxylases...
  6. pmc Lack of conventional oxygen-linked proton and anion binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobin
    Roy E Weber
    Zoophysiology, Department of Bioscience, Aarhus University, Aarhus, Denmark
    Am J Physiol Regul Integr Comp Physiol 305:R300-12. 2013
    ..palpebrosus Hb provides a unique opportunity for studies on structure-function coupling and the evolution of compensatory mechanisms for maintaining tissue O2 delivery in Hbs that lack conventional effector-binding residues. ..
  7. doi request reprint Myoglobin-dependent O2 consumption of the hypoxic trout heart
    Signe Helbo
    Department of Bioscience, C F Møllers Allé 3, Bldg 1131, 8000 Aarhus University, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 165:40-5. 2013
    ..Taken together, these results show that O2 consumption of the hypoxic rainbow trout heart is dependent on the function of Mb as intracellular O2 carrier...
  8. ncbi request reprint Critical redox and allosteric aspects of nitric oxide interactions with hemoglobin
    Celia Bonaventura
    Nicholas School of the Environment and Earth Sciences, Duke University Marine Laboratory, Beaufort, NC 28516, USA
    Antioxid Redox Signal 6:979-91. 2004
    ..In spite of low levels of NO-Hb and SNO-Hb found in vivo, recent findings do not rule out participation of NO-Hb or SNO-Hb in NO-dependent signaling reactions...
  9. ncbi request reprint The reactions of neuroglobin with CO: evidence for two forms of the ferrous protein
    Angela Fago
    Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, Aarhus University, DK 8000 Aarhus C, Denmark
    J Inorg Biochem 100:1339-43. 2006
    ..Our data suggests that, unlike many other heme proteins, neuroglobin displays complex reactivity with ligands in the ferrous form due to heme rotational disorder, as has previously been reported for the ferric form of the protein...
  10. pmc Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) with different altitudinal ranges
    Inge G Revsbech
    Zoophysiology, Department of Bioscience, Aarhus University, C F Møllers Allé 3, DK 8000 Aarhus C, Denmark
    J Exp Biol 216:4264-71. 2013
    ....
  11. pmc Hemoglobin isoform differentiation and allosteric regulation of oxygen binding in the turtle, Trachemys scripta
    Christian Damsgaard
    Zoophysiology, Department of Bioscience, Aarhus University, Aarhus, Denmark
    Am J Physiol Regul Integr Comp Physiol 305:R961-7. 2013
    ..This is the first extensive study on freshwater turtle Hb isoforms, providing molecular evidence for adaptive changes in O2 transport associated with acclimation to severe hypoxia. ..
  12. doi request reprint Roles of nitric oxide, nitrite and myoglobin on myocardial efficiency in trout (Oncorhynchus mykiss) and goldfish (Carassius auratus): implications for hypoxia tolerance
    Claus Lunde Pedersen
    Department of Biological Sciences, Universitetsparken, Aarhus University, DK 8000, Aarhus C, Denmark
    J Exp Biol 213:2755-62. 2010
    ....
  13. doi request reprint Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation
    Rasmus Aamand
    Department of Biological Sciences, Universitetsparken Bldg 1131, Aarhus University, DK 8000 Aarhus C, Denmark
    Am J Physiol Heart Circ Physiol 297:H2068-74. 2009
    ..The CA-mediated NO production may be important to the correlation between blood flow and metabolic activity in tissues, as occurring for instance in active areas of the brain...
  14. ncbi request reprint Oxygen binding properties of non-mammalian nerve globins
    Christian Hundahl
    Zoophysiology, Institute of Biological Sciences, University of Aarhus, Denmark
    FEBS J 273:1323-9. 2006
    ..These results demonstrate a remarkable diversity in oxygenation characteristics of vertebrate and invertebrate nerve haemoglobins that clearly reflect distinct physiological roles...
  15. doi request reprint Circulating nitric oxide metabolites and cardiovascular changes in the turtle Trachemys scripta during normoxia, anoxia and reoxygenation
    Søren B Jacobsen
    Zoophysiology, Department of Bioscience, Aarhus University, DK 8000 Aarhus C, Denmark
    J Exp Biol 215:2560-6. 2012
    ....
  16. ncbi request reprint Functional adaptation and its molecular basis in vertebrate hemoglobins, neuroglobins and cytoglobins
    Roy E Weber
    Department of Zoophysiology, Institute of Biological Sciences, University of Aarhus, C F Møllers Alle 131, DK 8000 Aarhus C, Denmark
    Respir Physiol Neurobiol 144:141-59. 2004
    ..This review deals with the functional adaptations and the underlying molecular mechanisms in globins and presents case examples of molecular adaptations encountered in vertebrates and agnathans...
  17. doi request reprint Thermodynamics of oxygenation-linked proton and lactate binding govern the temperature sensitivity of O2 binding in crustacean (Carcinus maenas) hemocyanin
    Roy E Weber
    Zoophysiology, Department of Biological Sciences, University of Aarhus, CF Møllers Alle 1131, DK 8000 Aarhus, Denmark
    J Exp Biol 211:1057-62. 2008
    ..The data demonstrate governing roles for lactate and proton ions in determining the temperature sensitivity of hemocyanin-O2 affinity in crustaceans...
  18. ncbi request reprint Allosteric effect of water in fish and human hemoglobins
    Christian Hundahl
    Department of Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 278:42769-73. 2003
    ..Addition of cofactors strongly increases the number of water molecules bound to eel hemoglobin A (as in human hemoglobin) but only weakly affects water binding to eel hemoglobin C...
  19. ncbi request reprint The reaction of neuroglobin with potential redox protein partners cytochrome b5 and cytochrome c
    Angela Fago
    Department of Biological Sciences, C F Møllers Alle 1131, Aarhus University, DK 8000 Aarhus C, Denmark
    FEBS Lett 580:4884-8. 2006
    ..Based on this data we propose that ferrous neuroglobin may well play a role in preventing apoptosis...
  20. pmc The case of the missing NO-hemoglobin: spectral changes suggestive of heme redox reactions reflect changes in NO-heme geometry
    Angela Fago
    Nicholas School of the Environment and Earth Sciences, Duke University, Beaufort, NC 28516, USA
    Proc Natl Acad Sci U S A 100:12087-92. 2003
    ....
  21. doi request reprint Functional differentiation of myoglobin isoforms in hypoxia-tolerant carp indicates tissue-specific protective roles
    Signe Helbo
    Department of Bioscience, Aarhus University, Denmark
    Am J Physiol Regul Integr Comp Physiol 302:R693-701. 2012
    ..This property might be of particular significance during reoxygenation following extended periods of hypoxia, when production of H(2)O(2) and other ROS is highest...
  22. ncbi request reprint Effects of water activity on oxygen-binding in high-molecular weight, extracellular invertebrate hemoglobin and hemocyanin
    Christian Hundahl
    Department of Zoophysiology, Institute of Biology, Building 131, University of Aarhus, Aarhus C DK 8000, Denmark
    Comp Biochem Physiol B Biochem Mol Biol 136:83-90. 2003
    ....
  23. doi request reprint Molecular and functional characterization of hemocyanin of the giant African millipede, Archispirostreptus gigas
    Christian Damsgaard
    Zoophysiology, Deparment of Bioscience, Aarhus University, DK 8000 Aarhus, Denmark
    J Exp Biol 216:1616-23. 2013
    ..4, and the number of interacting O2-binding sites (q) is markedly increased by binding Ca(2+). The data are discussed in the light of the mutually supplementary roles of Hc and the tracheal system for tissue O2 supply...
  24. doi request reprint Expression patterns and adaptive functional diversity of vertebrate myoglobins
    Signe Helbo
    Department of Bioscience, Aarhus University, Denmark
    Biochim Biophys Acta 1834:1832-9. 2013
    ..This article is part of a special issue entitled: Oxygen Binding and Sensing Proteins. ..
  25. doi request reprint ATP-induced temperature independence of hemoglobin-O2 affinity in heterothermic billfish
    Roy E Weber
    Zoophysiology, Department of Biological Sciences, Aarhus University, Bygning 1131, C F Møllers Allé 3, DK 8000 Aarhus, Denmark
    J Exp Biol 213:1579-85. 2010
    ..The mechanism underlying this reduction in oxygenation enthalpy differs fundamentally from that in tuna, supporting independent evolution of this trait in these scombroid lineages...
  26. ncbi request reprint Functional properties of myoglobins from five whale species with different diving capacities
    Signe Helbo
    Department of Bioscience, Aarhus University, 8000 Aarhus C, Denmark
    J Exp Biol 215:3403-10. 2012
    ..In conclusion, Mb concentration rather than specific functional reactivities may support whale diving performance...
  27. ncbi request reprint Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities
    Thomas Dalsgaard
    Department of Biological Sciences, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Heart Circ Physiol 292:H3072-8. 2007
    ..Possible reaction mechanisms for nitrite vasoactivity, including formation of S-nitrosothiols within the arterial smooth muscle, are discussed...
  28. ncbi request reprint Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions
    Morten Gjerning Petersen
    Department of Biological Sciences, University of Aarhus, Building 1131, Universitetsparken, DK 8000 Aarhus C, Denmark
    J Inorg Biochem 102:1777-82. 2008
    ..The possible biological significance of the reaction between nitrite and neuroglobin in vivo under brain hypoxia is discussed...
  29. doi request reprint Decrease in the red cell cofactor 2,3-diphosphoglycerate increases hemoglobin oxygen affinity in the hibernating brown bear Ursus arctos
    Inge G Revsbech
    Zoophysiology, Department of Bioscience, Aarhus University, Denmark
    Am J Physiol Regul Integr Comp Physiol 304:R43-9. 2013
    ..Calculations show that the increase in Hb-O(2) affinity and decrease in cooperativity resulting from decreased red cell DPG may be crucial in maintaining a fairly constant tissue oxygen tension during hibernation in vivo...
  30. doi request reprint Allosteric modulation by S-nitrosation in the low-O₂ affinity myoglobin from rainbow trout
    Signe Helbo
    Department of Biological Sciences, Aarhus University, Denmark
    Am J Physiol Regul Integr Comp Physiol 300:R101-8. 2011
    ....
  31. ncbi request reprint Enhancing effects of acetazolamide on neuronal activity correlate with enhanced visual processing ability in humans
    Rasmus Aamand
    Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
    Neuropharmacology 61:900-8. 2011
    ..g. opening of Ca(2+) activated K(+) channels and inhibition of Ca(2+) channels...
  32. ncbi request reprint Modulation of red cell glycolysis: interactions between vertebrate hemoglobins and cytoplasmic domains of band 3 red cell membrane proteins
    Roy E Weber
    Zoophysiology Department, Institute of Biological Sciences, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Regul Integr Comp Physiol 287:R454-64. 2004
    ....
  33. doi request reprint Nitric oxide increases myocardial efficiency in the hypoxia-tolerant turtle Trachemys scripta
    Mikkel Misfeldt
    Department of Biological Sciences, Building 1131, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Exp Biol 212:954-60. 2009
    ..This effect was particularly pronounced under O2 deficiency and may therefore contribute towards preserving cardiac function and to the overall excellent hypoxic tolerance of the turtle...
  34. ncbi request reprint Water regulates oxygen binding in hagfish (Myxine glutinosa) hemoglobin
    Gabriele Müller
    Department of Zoophysiology, Institute of Biology, Building 131, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Exp Biol 206:1389-95. 2003
    ..Our data show that water may act as an allosteric effector for hemoglobin within intact red cells and even in animals that do not experience large variations in blood osmolality...
  35. ncbi request reprint Novel mechanism for high-altitude adaptation in hemoglobin of the Andean frog Telmatobius peruvianus
    Roy E Weber
    Department of Zoophysiology, University of Aarhus, 131 C F Møllers Alle, DK 8000 Aarhus C, Denmark
    Am J Physiol Regul Integr Comp Physiol 283:R1052-60. 2002
    ..The findings are discussed in relation to other strategies for high-altitude adaptations in amphibians...
  36. ncbi request reprint Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation
    Inge G Revsbech
    Department of Bioscience, Aarhus University, 8000 Aarhus C, Denmark
    Free Radic Biol Med 73:349-57. 2014
    ..Our findings reveal that remodeling of H2S metabolism and enhanced intracellular GSH levels are hallmarks of the aerobic metabolic suppression of hibernating bears. ..
  37. ncbi request reprint Enthalpic partitioning of the reduced temperature sensitivity of O2 binding in bovine hemoglobin
    Roy E Weber
    Zoophysiology, Department of Bioscience, Aarhus University, DK 8000 Aarhus C, Denmark Electronic address
    Comp Biochem Physiol A Mol Integr Physiol 176:20-5. 2014
    ....
  38. pmc Oxygen-linked S-nitrosation in fish myoglobins: a cysteine-specific tertiary allosteric effect
    Signe Helbo
    Department of Bioscience, Aarhus University, Aarhus, Denmark
    PLoS ONE 9:e97012. 2014
    ..The importance of S-nitrosation of Mb in vivo is confirmed by the observation that Mb-SNO is present in trout hearts and that its level can be significantly reduced by anoxic conditions. ..
  39. ncbi request reprint Reactions of peroxynitrite with globin proteins and their possible physiological role
    Susanna Herold
    Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Comp Biochem Physiol A Mol Integr Physiol 142:124-9. 2005
    ....
  40. ncbi request reprint Reactivity studies of the Fe(III) and Fe(II)NO forms of human neuroglobin reveal a potential role against oxidative stress
    Susanna Herold
    Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 279:22841-7. 2004
    ..Taken together, our data indicate that human neuroglobin may be an efficient scavenger of reactive oxidizing species and thus may play a role in the cellular defense against oxidative stress...
  41. ncbi request reprint The nerve hemoglobin of the bivalve mollusc Spisula solidissima: molecular cloning, ligand binding studies, and phylogenetic analysis
    Sylvia Dewilde
    Department of Biomedical Sciences, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B 2610 Antwerp, Belgium
    J Biol Chem 281:5364-72. 2006
    ..They most likely fulfill a myoglobin-like function and enhance oxygen supply to the neurons...
  42. ncbi request reprint Characterization of a globin-coupled oxygen sensor with a gene-regulating function
    Liesbet Thijs
    Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610, Antwerp, Belgium
    J Biol Chem 282:37325-40. 2007
    ..Besides sensing ligands, in vitro data suggest that AvGReg(178) may have a role in O(2)-mediated NO-detoxification, yielding metAvGReg(178) and nitrate...
  43. doi request reprint A role for neuroglobin: resetting the trigger level for apoptosis in neuronal and retinal cells
    Angela Fago
    Department of Biological Sciences, University of Aarhus, Aarhus, Denmark
    IUBMB Life 60:398-401. 2008
    ....
  44. ncbi request reprint Neuroglobin and cytoglobin in search of their role in the vertebrate globin family
    Thomas Hankeln
    Institute of Molecular Genetics, Johannes Gutenberg University of Mainz, D 55099 Mainz, Germany
    J Inorg Biochem 99:110-9. 2005
    ..Cytoglobin is predominantly expressed in fibroblasts and related cell types, but also in distinct nerve cell populations. Much less is known about its function, although in fibroblasts it might be involved in collagen synthesis...