Affiliation: University of Aarhus
- Oxygen binding to partially nitrosylated hemoglobinAngela Fago
Department of Bioscience, Aarhus University, DK 8000 Aarhus, Denmark
Biochim Biophys Acta 1834:1894-900. 2013..This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. ..
- Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approachAngela Fago
Zoophysiology, Department of Bioscience, Aarhus University, Aarhus C, Denmark
Comp Biochem Physiol A Mol Integr Physiol 162:1-6. 2012..It also highlights the need and potential for a comparative approach of study and collaborative effort to identify potential link(s) between the signaling pathways involving NO, nitrite and H(2)S in the whole-body responses to hypoxia...
- Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural propertiesEva Geuens
Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
BMC Biochem 11:17. 2010..No information is available on the physicochemical properties and the in vivo expression...
- Functional properties of neuroglobin and cytoglobin. Insights into the ancestral physiological roles of globinsAngela Fago
Department of Zoophysiology, Institute of Biological Sciences, Aarhus University, Aarhus C, Denmark
IUBMB Life 56:689-96. 2004..The O2 binding properties of cytoglobin, which is upregulated upon hypoxia, are consistent with a role for this protein in O2-requiring reactions, such as those catalysed by hydroxylases...
- Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significanceAngela Fago
Department of Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, Aarhus University, DK 8000 Aarhus C, Denmark
J Biol Chem 279:44417-26. 2004..In contrast, the lower O2 affinity in NGB does not appear compatible with a physiological role involving mitochondrial O2 supply at the low O2 tensions found within neurons...
- Myoglobin-dependent O2 consumption of the hypoxic trout heartSigne Helbo
Department of Bioscience, C F Møllers Allé 3, Bldg 1131, 8000 Aarhus University, Denmark
Comp Biochem Physiol A Mol Integr Physiol 165:40-5. 2013..Taken together, these results show that O2 consumption of the hypoxic rainbow trout heart is dependent on the function of Mb as intracellular O2 carrier...
- Critical redox and allosteric aspects of nitric oxide interactions with hemoglobinCelia Bonaventura
Nicholas School of the Environment and Earth Sciences, Duke University Marine Laboratory, Beaufort, NC 28516, USA
Antioxid Redox Signal 6:979-91. 2004..In spite of low levels of NO-Hb and SNO-Hb found in vivo, recent findings do not rule out participation of NO-Hb or SNO-Hb in NO-dependent signaling reactions...
- The reactions of neuroglobin with CO: evidence for two forms of the ferrous proteinAngela Fago
Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, Aarhus University, DK 8000 Aarhus C, Denmark
J Inorg Biochem 100:1339-43. 2006..Our data suggests that, unlike many other heme proteins, neuroglobin displays complex reactivity with ligands in the ferrous form due to heme rotational disorder, as has previously been reported for the ferric form of the protein...
- Roles of nitric oxide, nitrite and myoglobin on myocardial efficiency in trout (Oncorhynchus mykiss) and goldfish (Carassius auratus): implications for hypoxia toleranceClaus Lunde Pedersen
Department of Biological Sciences, Universitetsparken, Aarhus University, DK 8000, Aarhus C, Denmark
J Exp Biol 213:2755-62. 2010....
- Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilationRasmus Aamand
Department of Biological Sciences, Universitetsparken Bldg 1131, Aarhus University, DK 8000 Aarhus C, Denmark
Am J Physiol Heart Circ Physiol 297:H2068-74. 2009..The CA-mediated NO production may be important to the correlation between blood flow and metabolic activity in tissues, as occurring for instance in active areas of the brain...
- Oxygen binding properties of non-mammalian nerve globinsChristian Hundahl
Zoophysiology, Institute of Biological Sciences, University of Aarhus, Denmark
FEBS J 273:1323-9. 2006..These results demonstrate a remarkable diversity in oxygenation characteristics of vertebrate and invertebrate nerve haemoglobins that clearly reflect distinct physiological roles...
- Circulating nitric oxide metabolites and cardiovascular changes in the turtle Trachemys scripta during normoxia, anoxia and reoxygenationSøren B Jacobsen
Zoophysiology, Department of Bioscience, Aarhus University, DK 8000 Aarhus C, Denmark
J Exp Biol 215:2560-6. 2012....
- Functional adaptation and its molecular basis in vertebrate hemoglobins, neuroglobins and cytoglobinsRoy E Weber
Department of Zoophysiology, Institute of Biological Sciences, University of Aarhus, C F Møllers Alle 131, DK 8000 Aarhus C, Denmark
Respir Physiol Neurobiol 144:141-59. 2004..This review deals with the functional adaptations and the underlying molecular mechanisms in globins and presents case examples of molecular adaptations encountered in vertebrates and agnathans...
- Thermodynamics of oxygenation-linked proton and lactate binding govern the temperature sensitivity of O2 binding in crustacean (Carcinus maenas) hemocyaninRoy E Weber
Zoophysiology, Department of Biological Sciences, University of Aarhus, CF Møllers Alle 1131, DK 8000 Aarhus, Denmark
J Exp Biol 211:1057-62. 2008..The data demonstrate governing roles for lactate and proton ions in determining the temperature sensitivity of hemocyanin-O2 affinity in crustaceans...
- The reaction of neuroglobin with potential redox protein partners cytochrome b5 and cytochrome cAngela Fago
Department of Biological Sciences, C F Møllers Alle 1131, Aarhus University, DK 8000 Aarhus C, Denmark
FEBS Lett 580:4884-8. 2006..Based on this data we propose that ferrous neuroglobin may well play a role in preventing apoptosis...
- Allosteric effect of water in fish and human hemoglobinsChristian Hundahl
Department of Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, University of Aarhus, DK 8000 Aarhus C, Denmark
J Biol Chem 278:42769-73. 2003..Addition of cofactors strongly increases the number of water molecules bound to eel hemoglobin A (as in human hemoglobin) but only weakly affects water binding to eel hemoglobin C...
- The case of the missing NO-hemoglobin: spectral changes suggestive of heme redox reactions reflect changes in NO-heme geometryAngela Fago
Nicholas School of the Environment and Earth Sciences, Duke University, Beaufort, NC 28516, USA
Proc Natl Acad Sci U S A 100:12087-92. 2003....
- Functional differentiation of myoglobin isoforms in hypoxia-tolerant carp indicates tissue-specific protective rolesSigne Helbo
Department of Bioscience, Aarhus University, Denmark
Am J Physiol Regul Integr Comp Physiol 302:R693-701. 2012..This property might be of particular significance during reoxygenation following extended periods of hypoxia, when production of H(2)O(2) and other ROS is highest...
- Effects of water activity on oxygen-binding in high-molecular weight, extracellular invertebrate hemoglobin and hemocyaninChristian Hundahl
Department of Zoophysiology, Institute of Biology, Building 131, University of Aarhus, Aarhus C DK 8000, Denmark
Comp Biochem Physiol B Biochem Mol Biol 136:83-90. 2003....
- ATP-induced temperature independence of hemoglobin-O2 affinity in heterothermic billfishRoy E Weber
Zoophysiology, Department of Biological Sciences, Aarhus University, Bygning 1131, C F Møllers Allé 3, DK 8000 Aarhus, Denmark
J Exp Biol 213:1579-85. 2010..The mechanism underlying this reduction in oxygenation enthalpy differs fundamentally from that in tuna, supporting independent evolution of this trait in these scombroid lineages...
- Functional properties of myoglobins from five whale species with different diving capacitiesSigne Helbo
Department of Bioscience, Aarhus University, 8000 Aarhus C, Denmark
J Exp Biol 215:3403-10. 2012..In conclusion, Mb concentration rather than specific functional reactivities may support whale diving performance...
- Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activitiesThomas Dalsgaard
Department of Biological Sciences, University of Aarhus, DK 8000 Aarhus C, Denmark
Am J Physiol Heart Circ Physiol 292:H3072-8. 2007..Possible reaction mechanisms for nitrite vasoactivity, including formation of S-nitrosothiols within the arterial smooth muscle, are discussed...
- Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditionsMorten Gjerning Petersen
Department of Biological Sciences, University of Aarhus, Building 1131, Universitetsparken, DK 8000 Aarhus C, Denmark
J Inorg Biochem 102:1777-82. 2008..The possible biological significance of the reaction between nitrite and neuroglobin in vivo under brain hypoxia is discussed...
- Decrease in the red cell cofactor 2,3-diphosphoglycerate increases hemoglobin oxygen affinity in the hibernating brown bear Ursus arctosInge G Revsbech
Zoophysiology, Department of Bioscience, Aarhus University, Denmark
Am J Physiol Regul Integr Comp Physiol 304:R43-9. 2013..Calculations show that the increase in Hb-O(2) affinity and decrease in cooperativity resulting from decreased red cell DPG may be crucial in maintaining a fairly constant tissue oxygen tension during hibernation in vivo...
- Allosteric modulation by S-nitrosation in the low-O₂ affinity myoglobin from rainbow troutSigne Helbo
Department of Biological Sciences, Aarhus University, Denmark
Am J Physiol Regul Integr Comp Physiol 300:R101-8. 2011....
- Enhancing effects of acetazolamide on neuronal activity correlate with enhanced visual processing ability in humansRasmus Aamand
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Neuropharmacology 61:900-8. 2011..g. opening of Ca(2+) activated K(+) channels and inhibition of Ca(2+) channels...
- Nitric oxide increases myocardial efficiency in the hypoxia-tolerant turtle Trachemys scriptaMikkel Misfeldt
Department of Biological Sciences, Building 1131, University of Aarhus, DK 8000 Aarhus C, Denmark
J Exp Biol 212:954-60. 2009..This effect was particularly pronounced under O2 deficiency and may therefore contribute towards preserving cardiac function and to the overall excellent hypoxic tolerance of the turtle...
- Water regulates oxygen binding in hagfish (Myxine glutinosa) hemoglobinGabriele Müller
Department of Zoophysiology, Institute of Biology, Building 131, University of Aarhus, DK 8000 Aarhus C, Denmark
J Exp Biol 206:1389-95. 2003..Our data show that water may act as an allosteric effector for hemoglobin within intact red cells and even in animals that do not experience large variations in blood osmolality...
- Molecular and functional characterization of hemocyanin of the giant African millipede, Archispirostreptus gigasChristian Damsgaard
Zoophysiology, Deparment of Bioscience, Aarhus University, DK 8000 Aarhus, Denmark
J Exp Biol 216:1616-23. 2013..4, and the number of interacting O2-binding sites (q) is markedly increased by binding Ca(2+). The data are discussed in the light of the mutually supplementary roles of Hc and the tracheal system for tissue O2 supply...
- Novel mechanism for high-altitude adaptation in hemoglobin of the Andean frog Telmatobius peruvianusRoy E Weber
Department of Zoophysiology, University of Aarhus, 131 C F Møllers Alle, DK 8000 Aarhus C, Denmark
Am J Physiol Regul Integr Comp Physiol 283:R1052-60. 2002..The findings are discussed in relation to other strategies for high-altitude adaptations in amphibians...
- Modulation of red cell glycolysis: interactions between vertebrate hemoglobins and cytoplasmic domains of band 3 red cell membrane proteinsRoy E Weber
Zoophysiology Department, Institute of Biological Sciences, University of Aarhus, DK 8000 Aarhus, Denmark
Am J Physiol Regul Integr Comp Physiol 287:R454-64. 2004....
- Lack of conventional oxygen-linked proton and anion binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobinRoy E Weber
Zoophysiology, Department of Bioscience, Aarhus University, Aarhus, Denmark
Am J Physiol Regul Integr Comp Physiol 305:R300-12. 2013..palpebrosus Hb provides a unique opportunity for studies on structure-function coupling and the evolution of compensatory mechanisms for maintaining tissue O2 delivery in Hbs that lack conventional effector-binding residues. ..
- Expression patterns and adaptive functional diversity of vertebrate myoglobinsSigne Helbo
Department of Bioscience, Aarhus University, Denmark
Biochim Biophys Acta 1834:1832-9. 2013..This article is part of a special issue entitled: Oxygen Binding and Sensing Proteins. ..
- Reactivity studies of the Fe(III) and Fe(II)NO forms of human neuroglobin reveal a potential role against oxidative stressSusanna Herold
Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule Honggerberg, CH 8093 Zurich, Switzerland
J Biol Chem 279:22841-7. 2004..Taken together, our data indicate that human neuroglobin may be an efficient scavenger of reactive oxidizing species and thus may play a role in the cellular defense against oxidative stress...
- Neuroglobin and cytoglobin in search of their role in the vertebrate globin familyThomas Hankeln
Institute of Molecular Genetics, Johannes Gutenberg University of Mainz, D 55099 Mainz, Germany
J Inorg Biochem 99:110-9. 2005..Cytoglobin is predominantly expressed in fibroblasts and related cell types, but also in distinct nerve cell populations. Much less is known about its function, although in fibroblasts it might be involved in collagen synthesis...
- Reactions of peroxynitrite with globin proteins and their possible physiological roleSusanna Herold
Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule, ETH Honggerberg, CH 8093 Zurich, Switzerland
Comp Biochem Physiol A Mol Integr Physiol 142:124-9. 2005....
- The nerve hemoglobin of the bivalve mollusc Spisula solidissima: molecular cloning, ligand binding studies, and phylogenetic analysisSylvia Dewilde
Department of Biomedical Sciences, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B 2610 Antwerp, Belgium
J Biol Chem 281:5364-72. 2006..They most likely fulfill a myoglobin-like function and enhance oxygen supply to the neurons...
- Characterization of a globin-coupled oxygen sensor with a gene-regulating functionLiesbet Thijs
Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610, Antwerp, Belgium
J Biol Chem 282:37325-40. 2007..Besides sensing ligands, in vitro data suggest that AvGReg(178) may have a role in O(2)-mediated NO-detoxification, yielding metAvGReg(178) and nitrate...
- A role for neuroglobin: resetting the trigger level for apoptosis in neuronal and retinal cellsAngela Fago
Department of Biological Sciences, University of Aarhus, Aarhus, Denmark
IUBMB Life 60:398-401. 2008....