Research Topics
Species | A DirksenSummaryAffiliation: University of Copenhagen Country: Denmark Publications
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Detail Information
Publications
Quantitative computed tomography and aerosol morphometry in COPD and alpha1-antitrypsin deficiencyS B Shaker
Dept of Respiratory Medicine, post 58, Gentofte University Hospital, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
Eur Respir J 25:23-30. 2005....
Identification of patients with chronic obstructive pulmonary disease (COPD) by measurement of plasma biomarkersSaher B Shaker
Department of Cardiology and Respiratory Medicine, Hvidovre University Hospital, Copenhagen, Denmark
Clin Respir J 2:17-25. 2008..Inflammation is an important constituent of the pathology of chronic obstructive pulmonary disease (COPD), leading to alveolar destruction and airway remodelling...- The effect of inhaled corticosteroids on the development of emphysema in smokers assessed by annual computed tomographySaher B Shaker
Department of Respiratory Medicine, Gentofte University Hospital, Hellerup, Denmark
COPD 6:104-11. 2009.... - The extent of emphysema in patients with COPDSaher Burhan Shaker
Department of Cardiology and Respiratory Medicine, Hvidovre Hospital, Copenhagen, Denmark
Clin Respir J 3:15-21. 2009..The objective of this study was to apply CT to assess the extent of emphysema in patients with chronic obstructive pulmonary disease (COPD) and relate this extent to the GOLD stage of airway obstruction... - Imaging in chronic obstructive pulmonary diseaseSaher B Shaker
Department of Respiratory Medicine, Gentofte University Hospital, Hellerup, Denmark
COPD 4:143-61. 2007..However, recent studies using Multi-detector row CT (MDCT) reported more reproducible assessment of air wall thickening... 
Alpha1-antitrypsin deficiency. 7: Computed tomographic imaging in alpha1-antitrypsin deficiencyS B Shaker
Department of Respiratory Medicine, Gentofte Hospital, DK 2900 Hellerup, Denmark
Thorax 59:986-91. 2004..Computed tomographic scanning may replace lung function tests as the golden standard for assessing the response to known and novel treatments for alpha1-antitrypsin deficiency...- Short-term reproducibility of computed tomography-based lung density measurements in alpha-1 antitrypsin deficiency and smokers with emphysemaS B Shaker
Department of Respiratory Medicine, Gentofte Hospital, Hellerup, Denmark
Acta Radiol 45:424-30. 2004..To study the short-term reproducibility of lung density measurements by multi-slice computed tomography (CT) using three different radiation doses and three reconstruction algorithms... - Volume adjustment of lung density by computed tomography scans in patients with emphysemaS B Shaker
Department of Respiratory Medicine, Gentofte Hospital, Hellerup, Denmark
Acta Radiol 45:417-23. 2004..To determine how to adjust lung density measurements for the volume of the lung calculated from computed tomography (CT) scans in patients with emphysema... - [Emphysema: a high-resolution CT diagnosis]Saher B Shaker
Amtssygehuset i Gentofte, Lungemedicinsk afdeling, , Hellerup
Ugeskr Laeger 166:2466-7. 2004 - Rapid fall in lung density following smoking cessation in COPDSaher B Shaker
Gentofte University Hospital, Dept of Respiratory Medicine, Hellerup, Denmark
COPD 8:2-7. 2011..Whether smoking-induced lung inflammation subsides after smoking cessation is currently a matter of debate. We used computed tomography (CT) to evaluate the effect of smoking cessation on lung density in patients with COPD... - A randomized clinical trial of alpha(1)-antitrypsin augmentation therapyA Dirksen
Department of Respiratory Medicine, The Rigshospital, Copenhagen, Denmark
Am J Respir Crit Care Med 160:1468-72. 1999..We conclude that lung density measurements by CT may facilitate future randomized clinical trials of investigational drugs for a disease in which little progress in therapy has been made in the past 30 yr... - Allergic contact sensitization in an adult Danish population: two cross-sectional surveys eight years apart (the Copenhagen Allergy Study)N H Nielsen
Department of Dermatology, Gentofte Hospital, Hellerup, Denmark
Acta Derm Venereol 81:31-4. 2001..4% in 1990 to 5.8% in 1998 (odds ratio 2.44, 95% confidence interval 1.04-5.73). The prevalence of contact sensitivity to cosmetic-related allergens has been doubled between 1990 and 1998... - Exploring the role of CT densitometry: a randomised study of augmentation therapy in alpha1-antitrypsin deficiencyA Dirksen
Gentofte Hospital, Copenhagen University, Hellerup, Denmark
Eur Respir J 33:1345-53. 2009..In patients with alpha(1)-AT deficiency, CT is a more sensitive outcome measure of emphysema-modifying therapy than physiology and health status, and demonstrates a trend of treatment benefit from alpha(1)-AT augmentation... - Airborne chemicals cause respiratory symptoms in individuals with contact allergyJ Elberling
The National Allergy Research Centre, Department of Dermatology, Gentofte University Hospital, Gentofte, Denmark
Contact Dermatitis 52:65-72. 2005..Bronchial hyperreactivity, female sex and psychological vulnerability were independently associated with symptoms, but no association was found between prick test reactivity to proteins and the symptoms elicited by airborne chemicals... - Lung nodule volumetry: segmentation algorithms within the same software package cannot be used interchangeablyH Ashraf
Department of Radiology, Gentofte Hospital, Copenhagen University, Hellerup, Denmark
Eur Radiol 20:1878-85. 2010..We examined the reproducibility of lung nodule volumetry software that offers three different volumetry algorithms... - Transmitting genetic risk information in families: attitudes about disclosing the identity of relativesJ T Wilcke
Department of Respiratory Medicine, Rigshospitalet, Copenhagen, Denmark
Am J Hum Genet 65:902-9. 1999..Our findings imply that fully informing all relatives about the disorder and about who is actually ill should be the principal rule... - Reversible and irreversible airflow obstruction as predictor of overall mortality in asthma and chronic obstructive pulmonary diseaseE F Hansen
Department of Pulmonary Medicine, Copenhagen University Hospital, Copenhagen, Denmark
Am J Respir Crit Care Med 159:1267-71. 1999..However, reversibility per se does not influence survival in subjects with moderate to severe asthma or COPD... - Combined use of positron emission tomography and volume doubling time in lung cancer screening with low-dose CT scanningH Ashraf
Department of Radiology, Gentofte University Hospital, Niels Andersens Vej 65, 2900 Hellerup, Denmark
Thorax 66:315-9. 2011..This study evaluates the ability of positron emission tomography (PET) and volume doubling time (VDT) to discriminate between benign and malignant nodules... - Exposure of eyes to perfume: a double-blind, placebo-controlled experimentJ Elberling
The National Allergy Research Centre, Gentofte University Hospital, Gentofte, Denmark
Indoor Air 16:276-81. 2006..Vapors of perfume provoked symptoms in the relevant eye in some patients and healthy control persons, but under our exposure conditions, ocular chemesthesis failed to elicit respiratory symptoms... - Distribution of serum IgE in children and adolescents aged 7 to 16 years in Copenhagen, in relation to factors of importanceV Backer
Department of Medicine B, State University Hospital, Copenhagen, Denmark
Allergy 47:484-9. 1992..In conclusion, total IgE is highly influenced by allergen skin reactivity. Further, this study suggests that normal IgE values were within 330 kU/l, although the range was wide... - Increased release of histamine in patients with respiratory symptoms related to perfumeJ Elberling
The Danish Research Centre for Chemical Sensitivities, Gentofte University Hospital, Gentofte, Denmark
Clin Exp Allergy 37:1676-80. 2007..The study aimed to investigate whether basophils from patients with respiratory symptoms related to perfume released more histamine in the presence of perfume as compared with healthy volunteers... - Persistence of contact allergy among Danish adults: an 8-year follow-up studyN H Nielsen
Department of Dermatology, Gentofte Hospital, DK-2900 Hellerup, Denmark
Contact Dermatitis 45:350-3. 2001..Nickel allergy persisted in 79%. Allergen avoidance should probably be lifelong to prevent elicitation of contact dermatitis... - Risk of hospital admission for obstructive pulmonary disease in alpha(1)-antitrypsin heterozygotes of phenotype PiMZN Seersholm
Respiratory Department Y, Gentofte Hospital, Hellerup and Respiratory Clinic, Rigshospitalet, Copenhagen, Denmark
Am J Respir Crit Care Med 161:81-4. 2000.... - Preoperative staging of lung cancer with combined PET-CTBarbara Fischer
Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
N Engl J Med 361:32-9. 2009..The purpose of this randomized study was to evaluate the clinical effect of combined positron-emission tomography and computed tomography (PET-CT) on preoperative staging of NSCLC... - Quantitative assessment of regional emphysema distribution in patients with chronic obstructive pulmonary disease (COPD)T Stavngaard
Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Acta Radiol 47:914-21. 2006..To compare objective and subjective assessment of the distribution of emphysema in unselected patients with chronic obstructive pulmonary disease (COPD)... - Effect of CT screening on smoking habits at 1-year follow-up in the Danish Lung Cancer Screening Trial (DLCST)H Ashraf
Gentofte Hospital, Hellerup, Denmark
Thorax 64:388-92. 2009..The effect of low-dose CT screening for lung cancer on smoking habits has not been reported in large randomised controlled trials... - Incidence of allergic contact sensitization in Danish adults between 1990 and 1998; the Copenhagen Allergy Study, DenmarkN H Nielsen
Department of Dermatology K, Gentofte Hospital, University of Copenhagen, 65, Niels Andersens Vej, DK 2900 Hellerup, Denmark
Br J Dermatol 147:487-92. 2002..Studies of incidence of contact allergy in a general population have not been reported. Data from incidence studies may support and direct strategies for prevention of contact allergy and allergic contact dermatitis... - Office spirometry: temperature conversion of volumes measured by the Vitalograph-R bellows spirometer is not necessaryF Madsen
Department of Internal Medicine B, University of Copenhagen at Frederiksberg, Denmark
Respir Med 93:685-8. 1999..The use of the BTPS correction based on ambient temperature seems unjustified at office temperatures close to 23 degrees C and at extreme temperatures the conversion of volume will introduce significant over or underestimation... - [Sample size and number needed to treat--a statistical case study]K Møller
Epidemiafdeling M, H S Rigshospitalet
Ugeskr Laeger 163:6140-1. 2001..The number of persons needed to be vaccinated to prevent one episode of pneumococcal sepsis can be similarly calculated from the observed incidences with and without vaccine... - Is the increase in allergic respiratory disease caused by a cohort effect?A Linneberg
Centre for Preventive Medicine, Glostrup University Hospital, Glostrup, Denmark
Clin Exp Allergy 32:1702-5. 2002..This could reflect the natural course of allergic sensitization. Alternatively, this could reflect that the increase in sensitization is caused by a cohort effect, i.e. an increase among subjects born during recent decades... - The relationship of alcohol consumption to total immunoglobulin E and the development of immunoglobulin E sensitization: the Copenhagen Allergy StudyA Linneberg
Centre for Preventive Medicine, Glostrup University Hospital, Glostrup, Denmark
Clin Exp Allergy 33:192-8. 2003..Furthermore, we have previously reported a positive association between alcohol consumption and the prevalence of skin prick test (SPT positivity) to inhalant allergens in a population-based cross-sectional study... - Progression of emphysema evaluated by MRI using hyperpolarized (3)He (HP (3)He) measurements in patients with alpha-1-antitrypsin (A1AT) deficiency compared with CT and lung function testsT Stavngaard
Danish Research Center for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
Acta Radiol 50:1019-26. 2009..However, FEV(1) is insensitive in detecting mild/slow progression of emphysema because of low reproducibility as compared to yearly decline... - [Is polysaccharide pneumococcal vaccine effective in adults?]K Møller
Epidemiafdeling M, H S Rigshospitalet
Ugeskr Laeger 163:6112-7. 2001..There is insufficient evidence to support mass vaccination of risk groups, including elderly people, with polysaccharide PC vaccine... - Peak flow as predictor of overall mortality in asthma and chronic obstructive pulmonary diseaseE F Hansen
Department of Respiratory Medicine 223, H S Hvidovre Hospital, Hvidovre, Denmark
Am J Respir Crit Care Med 163:690-3. 2001..e., chronic bronchitis, small airways disease, and emphysema. Furthermore, extrapulmonary components such as muscle mass and general "vigour" probably affect PEF to a greater extent than they affect FEV1... - Risk of Mycobacterium tuberculosis transmission in a low-incidence country due to immigration from high-incidence areasT Lillebaek
International Reference Laboratory for Mycobacteriology, Statens Serum Institut, National Institute for Prevention and Control of Infectious Diseases and Congenital Disorders, 5 Artillerivej, 2300 Copenhagen S, Denmark
J Clin Microbiol 39:855-61. 2001..The higher transmission rates between nationalities found in the Netherlands do not apply to the situation in Denmark and not necessarily elsewhere, since many different factors may influence the magnitude of active transmission... - Monitoring the progress of emphysema by repeat computed tomography scans with focus on noise reductionAsger Dirksen
Department of Respiratory Medicine, Gentofte University Hospital, Copenhagen, Denmark
Proc Am Thorac Soc 5:925-8. 2008..Work remains to be done to standardize and validate CT lung density, before it can become established as the primary outcome measure in clinical trials of new treatments for chronic obstructive pulmonary disease... - [Centralisation within the field of pulmonary medicine]Niels Jørgen Seersholm
Amtssygehuset i Gentofte, Lungemedicinsk afdeling Y, Hellerup
Ugeskr Laeger 168:1553-5. 2006..Correct indication and follow up is better for patients who received LTOT by pulmonary specialists with a higher patient compliance. We conclude that LTOT should be centralised and treated by pulmonary specialists only... - Endoscopic ultrasound guided biopsy performed routinely in lung cancer staging spares futile thoracotomies: preliminary results from a randomised clinical trialSoeren S Larsen
Department of Surgical Gasteroenterology, Gentofte University Hospital, Copenhagen, Denmark
Lung Cancer 49:377-85. 2005..However, no randomised trials have been performed, in which a staging strategy with EUS-FNA performed in all patients is compared with a conventional workup... - Quantitative assessment of emphysema distribution in smokers and patients with alpha1-antitrypsin deficiencyTrine Stavngaard
Department of Clinical Physiology and Nuclear Medicine, University of Copenhagen, Rigshospitalet, 4011, Blegdamsvej 9, 2100 Copenhagen, Denmark
Respir Med 100:94-100. 2006..Identification of upper lobe emphysema is mandatory before lung volume reduction surgery (LVRS). Here we introduce a CT-based objective model for describing the distribution of different types of emphysema... - [Screening and prevention. Danish Society of Pulmonary Medicine]Philip Tønnesen
Lungemedicinsk afdeling Y, Amtssygehuset i Gentofte, DK 2900 Hellerup
Ugeskr Laeger 167:1395. 2005 - The association between contact allergy and hand eczema in 2 cross-sectional surveys 8 years apartNiels Henrik Nielsen
Departments of Dermatology, Gentofte and Bispebjerg Hospital, Hellerup, Denmark
Contact Dermatitis 47:71-7. 2002..It was indicated that it might be possible to prevent the hand eczema related to nickel allergy by exposure regulation, public education or both... - Hyperpolarized 3He MRI and 81mKr SPECT in chronic obstructive pulmonary diseaseTrine Stavngaard
Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Denmark
Eur J Nucl Med Mol Imaging 32:448-57. 2005..The aim of this study was to compare ventilation imaging methods in 26 patients with chronic obstructive pulmonary disease (COPD) and nine lung healthy volunteers... - Endoscopic ultrasound guided biopsy versus mediastinoscopy for analysis of paratracheal and subcarinal lymph nodes in lung cancer stagingSoeren S Larsen
Department of Cardio Thoracic Surgery, Gentofte University Hospital, Copenhagen, Denmark
Lung Cancer 48:85-92. 2005..The aim of this study was to assess and compare the diagnostic value of MS and EUS-FNA with regard to mediastinal malignancy in the paratracheal- and subcarinal-regions... - [Increasing prevalence of specific IgE against aeroallergens in an adult Danish population--two cross-sectional studies in 1990 and 1998]Allan R Linneberg
Københavns Amts Center for Sygdomsforebyggelse, Amtssygehuset i Glostrup, DK 2600 Glostrup
Ugeskr Laeger 164:4061-5. 2002..We investigated whether the prevalence of specific IgE to aeroallergens had increased in an adult general population over an 8-year period... - A link between skin and airways regarding sensitivity to fragrance products?J Elberling
The National Allergy Reseasrch Centre for Consumer Products, Department of Dermatology, Gentofte University Hospital, Ledreborg Alle 40, 1, DK 2820 Gentofte, Denmark
Br J Dermatol 151:1197-203. 2004..Skin exposure to fragrances is known to cause perfume contact allergy and eczema, but it is unknown whether eye or airway symptoms elicited by fragrance products are associated with contact allergy or eczema... - Positron emission tomography of incidentally detected small pulmonary nodulesB M Fischer
Department of Clinical Physiology and Nuclear Medicine, Diagnostic Centre, Rigshopitalet, Copenhagen, Denmark
Nucl Med Commun 25:3-9. 2004..FDG PET also increases the possibility of an early diagnosis as compared to the strategy of watchful waiting... - A dominant Mycobacterium tuberculosis strain emerging in DenmarkT Lillebaek
International Reference Laboratory of Mycobacteriology, Statens Serum Institute, Copenhagen, Denmark
Int J Tuberc Lung Dis 8:1001-6. 2004..Denmark, a high-income country with a low prevalence of tuberculosis... - Phenotypes of individuals affected by airborne chemicals in the general populationNikolaj Drimer Berg
The Danish Research Centre for Chemical Sensitivities, Gentofte Hospital, University of Copenhagen, Ledreborg Alle 40, Gentofte, Denmark
Int Arch Occup Environ Health 82:509-17. 2009..To characterise the chemical exposures and symptoms affecting individuals with subsequent adjustments of social life or occupational conditions, and further characterise these severely affected individuals... - Prevalence of self-reported symptoms and consequences related to inhalation of airborne chemicals in a Danish general populationNikolaj Drimer Berg
The Danish Research Centre for Chemical Sensitivities, Gentofte Hospital, University of Copenhagen, Ledreborg Alle 40, 2 th, 2820 Gentofte, Denmark
Int Arch Occup Environ Health 81:881-7. 2008..To estimate the prevalence and consequences of self-reported symptoms related to inhalation of airborne chemicals in a Danish general population... - Variability in densitometric assessment of pulmonary emphysema with computed tomographyM Els Bakker
Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands, and the Department of Respiratory Medicine, Gentofte Hospital, Hellerup, Denmark
Invest Radiol 40:777-83. 2005.... - Persistent high incidence of tuberculosis in immigrants in a low-incidence countryTroels Lillebaek
International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark
Emerg Infect Dis 8:679-84. 2002..The decline was described by an exponential function with a half-time of 5.7 (95% confidence interval 4.0 to 9.7) years. This finding seriously challenges the adequacy of the customary practice of screening solely on arrival... - Is CT a new research tool for COPD?A Dirksen
Department of Respiratory Medicine, Gentofte Hospital, Hellerup, Denmark
Clin Respir J 2:76-83. 2008.... - Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivityJ Elberling
The National Allergy Research Centre, Gentofte University Hospital, Denmark
Clin Exp Allergy 35:75-81. 2005..Exposure to perfume and fragrance products may, in some individuals, cause symptoms from the eyes and airways. The localization, character and risk factors of such symptoms in the general population are unknown... - Mycobacterium tuberculosis Beijing genotypeTroels Lillebaek
National Institute for Prevention and Control of Infectious Diseases and Congenital Disorders, Copenhagen, Denmark
Emerg Infect Dis 9:1553-7. 2003..The true prevalence of Beijing strains worldwide is unknown because only a fraction of global strains have been analyzed... - The capsaicin cough reflex in eczema patients with respiratory symptoms elicited by perfumeJesper Elberling
The National Allergy Research Centre, and Deparment of Respiratory Medicine Y, Gentofte University Hospital, Denmark
Contact Dermatitis 54:158-64. 2006.... - Stability of DNA patterns and evidence of Mycobacterium tuberculosis reactivation occurring decades after the initial infectionTroels Lillebaek
International Reference Laboratory of Mycobacteriology, Statens Serum Institut, the National Institute for Prevention and Control of Infectious Diseases and Congenital Disorders, Rigshospitalet University Hospital, Copenhagen, Denmark
J Infect Dis 188:1032-9. 2003..This has important implications for the interpretation of clustering, especially for the extent of recent transmission... - [Screening for lung cancer with low-dosage CT]Jesper Holst Pedersen
Thoraxkirurgisk afdeling R, Lungemedicinsk afdeling Y, Amtssygehuset i Gentofte
Ugeskr Laeger 164:167-70. 2002 - A new staging strategy for chronic obstructive pulmonary diseaseMartin R Miller
Department of Medicine, University Hospital Birmingham NHS Trust, Birmingham, UK
Int J Chron Obstruct Pulmon Dis 2:657-63. 2007.... - Progression parameters for emphysema: a clinical investigationJan Stolk
Department of Pulmonology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Respir Med 101:1924-30. 2007..5-fold more sensitive using lung densitometry than by using currently recommended lung function parameters. Our results support CT scan as an efficacious test for novel drugs for emphysema... - IgG antibodies against microorganisms and atopic disease in Danish adults: the Copenhagen Allergy StudyAllan Linneberg
Centre for Preventive Medicine, Glostrup University Hospital, Denmark
J Allergy Clin Immunol 111:847-53. 2003..These findings raise the hypothesis that different groups of food-borne and orofecal microorganisms may have different effects on the risk of atopy... - Comparison of the sensitivities of 5 different computed tomography scanners for the assessment of the progression of pulmonary emphysema: a phantom studyBerend C Stoel
Division of Image Processing, Department of Radiology and dagger Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
Invest Radiol 39:1-7. 2004..To compare the sensitivities of 5 different computed tomography scanners (4 multislice CT [MSCT] and 1 single-slice CT) in the assessment of the progression of pulmonary emphysema... - [Incidental findings in connection with computer tomography and magnetic resonance imaging]Asger Dirksen
Ugeskr Laeger 170:3445; author reply 3445. 2008 - [Screening--what information should potential participants receive?]Asger Dirksen
Lungemedicinsk afdeling Y 58, Amtssygehuset i Gentofte, DK 2900 Hellerup
Ugeskr Laeger 164:145-7. 2002 - [Chronic obstructive pulmonary disease--an overlooked life style disease]Lars C Laursen
Ugeskr Laeger 165:3497. 2003