Flemming Dela

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle
    R Boushel
    Department of Exercise Science, Concordia University, Montreal, QC, Canada
    Diabetologia 50:790-6. 2007
  2. ncbi request reprint Physical training may enhance beta-cell function in type 2 diabetes
    Flemming Dela
    Copenhagen Muscle Research Centre, The Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark
    Am J Physiol Endocrinol Metab 287:E1024-31. 2004
  3. ncbi request reprint Other adaptations to training/inactivity in type 2 diabetics and other groups with insulin resistance: emphasis on prevention of CHD
    Flemming Dela
    Department of Medical Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
    Appl Physiol Nutr Metab 32:602-6. 2007
  4. pmc Impact of physical inactivity on subcutaneous adipose tissue metabolism in healthy young male offspring of patients with type 2 diabetes
    Lise Højbjerre
    Department of Biomedical Sciences, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    Diabetes 59:2790-8. 2010
  5. doi request reprint High-fat feeding inhibits exercise-induced increase in mitochondrial respiratory flux in skeletal muscle
    Mette Skovbro
    Xlab, Center for Healthy Aging, Dept of Biomedical Sciences, Faculty of Health Sciences, Bldg 12 4 7, Univ of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen N, Denmark
    J Appl Physiol (1985) 110:1607-14. 2011
  6. doi request reprint Impaired endothelial function and insulin action in first-degree relatives of patients with type 2 diabetes mellitus
    Mette P Sonne
    Department of Biomedical Sciences, Section of Systems Biology Research, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
    Metabolism 58:93-101. 2009
  7. doi request reprint Effect of 10 days of bedrest on metabolic and vascular insulin action: a study in individuals at risk for type 2 diabetes
    Mette P Sonne
    Center for Healthy Ageing, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 108:830-7. 2010
  8. doi request reprint Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss
    Rasmus Rabøl
    Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Metabolism 58:1145-52. 2009
  9. pmc Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization
    Clara Prats
    Copenhagen Muscle Research Center, Center for Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    J Biol Chem 284:15692-700. 2009
  10. doi request reprint Endothelial function after 10 days of bed rest in individuals at risk for type 2 diabetes and cardiovascular disease
    Mette P Sonne
    Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Exp Physiol 96:1000-9. 2011

Collaborators

Detail Information

Publications69

  1. pmc Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle
    R Boushel
    Department of Exercise Science, Concordia University, Montreal, QC, Canada
    Diabetologia 50:790-6. 2007
    ....
  2. ncbi request reprint Physical training may enhance beta-cell function in type 2 diabetes
    Flemming Dela
    Copenhagen Muscle Research Centre, The Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark
    Am J Physiol Endocrinol Metab 287:E1024-31. 2004
    ..The improved beta-cell function does not require changes in insulin sensitivity and Hb A(1c) concentration...
  3. ncbi request reprint Other adaptations to training/inactivity in type 2 diabetics and other groups with insulin resistance: emphasis on prevention of CHD
    Flemming Dela
    Department of Medical Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
    Appl Physiol Nutr Metab 32:602-6. 2007
    ..The mechanism for the positive effect of physical training may be a reduction of known risk factors for atherosclerosis, but a direct effect on the atherosclerotic process per se cannot be excluded...
  4. pmc Impact of physical inactivity on subcutaneous adipose tissue metabolism in healthy young male offspring of patients with type 2 diabetes
    Lise Højbjerre
    Department of Biomedical Sciences, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    Diabetes 59:2790-8. 2010
    ..Using a positive family history of type 2 diabetes as a marker of increased genetic risk, the aim of this study was to investigate the impact of physical inactivity on adipose tissue (AT) metabolism in FDR subjects...
  5. doi request reprint High-fat feeding inhibits exercise-induced increase in mitochondrial respiratory flux in skeletal muscle
    Mette Skovbro
    Xlab, Center for Healthy Aging, Dept of Biomedical Sciences, Faculty of Health Sciences, Bldg 12 4 7, Univ of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen N, Denmark
    J Appl Physiol (1985) 110:1607-14. 2011
    ..The effect of HFD is present even without effects on insulin sensitivity and intramyocellular lipid accumulation. An isocaloric high-fat diet does not cause insulin resistance...
  6. doi request reprint Impaired endothelial function and insulin action in first-degree relatives of patients with type 2 diabetes mellitus
    Mette P Sonne
    Department of Biomedical Sciences, Section of Systems Biology Research, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
    Metabolism 58:93-101. 2009
    ..It remains to be established whether FDR also demonstrate impaired insulin-stimulated microvascular function...
  7. doi request reprint Effect of 10 days of bedrest on metabolic and vascular insulin action: a study in individuals at risk for type 2 diabetes
    Mette P Sonne
    Center for Healthy Ageing, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 108:830-7. 2010
    ..The changes were most pronounced in the CON group. In the FDR group, insulin resistance was already present before bedrest, but even this group displayed a high sensitivity to changes in daily physical activity...
  8. doi request reprint Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss
    Rasmus Rabøl
    Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Metabolism 58:1145-52. 2009
    ....
  9. pmc Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization
    Clara Prats
    Copenhagen Muscle Research Center, Center for Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    J Biol Chem 284:15692-700. 2009
    ..After overnight low muscle glycogen level and/or in response to exhausting exercise-induced glycogenolysis, GS is associated with spherical structures at the I-band of sarcomeres...
  10. doi request reprint Endothelial function after 10 days of bed rest in individuals at risk for type 2 diabetes and cardiovascular disease
    Mette P Sonne
    Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Exp Physiol 96:1000-9. 2011
    ..In FDR, a further deterioration of FBF with inactivity is not possible...
  11. doi request reprint Impaired mitochondrial function in chronically ischemic human heart
    Nis Stride
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Heart Circ Physiol 304:H1407-14. 2013
    ..Diminished mitochondrial respiration capacity and excessive ROS production demonstrate an impaired mitochondrial function in ischemic human heart muscle. No chronic ischemic preconditioning effect was found...
  12. doi request reprint Cardiovascular disease markers in type 2 diabetes: the effects of a moderate home-based exercise training programme
    Celena Scheede-Bergdahl
    Centre for Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, Denmark
    Diab Vasc Dis Res 6:291-6. 2009
    ....
  13. ncbi request reprint Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance
    Camilla Skov-Jensen
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Kbh N, Denmark
    Appl Physiol Nutr Metab 32:115-24. 2007
    ..Humans with IGT are resistant to insulin-stimulated but not to exercise-induced glucose uptake...
  14. doi request reprint Effect of gender on lipid-induced insulin resistance in obese subjects
    Bodil Vistisen
    Department of Biomedical Sciences, The Panum Institute, The Copenhagen Muscle Research Centre, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Eur J Endocrinol 158:61-8. 2008
    ..However, neither the lipid-induced reduction of glucose disposal nor the intramyocellular lipid deposition has been compared directly in obese females and males...
  15. ncbi request reprint Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients
    Flemming Dela
    Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 299:E80-91. 2010
    ..Maximal GU rates are similar between groups and increases with physical training...
  16. doi request reprint Skeletal muscle mitochondrial function in polycystic ovarian syndrome
    Rasmus Rabøl
    Department of Biomedical Sciences, Faculty of Health Sciences, Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen N, Denmark
    Eur J Endocrinol 165:631-7. 2011
    ..We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry...
  17. doi request reprint Insulin and non-insulin mediated vasodilation and glucose uptake in patients with type 2 diabetes
    Celena Scheede-Bergdahl
    Centre for Healthy Aging, Department of Biomedical Sciences, Section of Systems Biology Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Diabetes Res Clin Pract 85:243-51. 2009
    ....
  18. doi request reprint Increased lipolysis but diminished gene expression of lipases in subcutaneous adipose tissue of healthy young males with intrauterine growth retardation
    Lise Højbjerre
    Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Appl Physiol (1985) 111:1863-70. 2011
    ..Subjects with IUGR exhibit primary defects in adipose tissue metabolism...
  19. doi request reprint Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance
    Steen Larsen
    Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Am Coll Cardiol 61:44-53. 2013
    ....
  20. doi request reprint Effect of hyperglycemia on mitochondrial respiration in type 2 diabetes
    Rasmus Rabøl
    Department of Biomedical Sciences, Faculty of Health Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    J Clin Endocrinol Metab 94:1372-8. 2009
    ..Whether hyperglycemia inhibits mitochondrial biogenesis and/or function is unknown. This study examined the effect of different levels of glycemia on skeletal muscle mitochondrial function in patients with T2DM...
  21. ncbi request reprint Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes
    Mads K Holten
    Department of Medical Physiology, The Panum Institute, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 53:294-305. 2004
    ..The adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade...
  22. doi request reprint Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction
    Nis Stride
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen, Denmark
    Eur J Heart Fail 15:150-7. 2013
    ..The study aim was to test mitochondrial OXPHOS capacity in LVSD myocardium compared with OXPHOS capacity in a comparable patient group without LVSD...
  23. pmc Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice
    Jonas M Kristensen
    Section of Molecular Physiology Group, August Krogh Centre, Department of Nutrition, Exercise and Sport Sciences, University of Copenhagen, Denmark
    PLoS ONE 8:e53533. 2013
    ..The improvement seems to be unrelated to AMPK, and does not involve changes in key mitochondrial proteins...
  24. pmc Impact of physical inactivity on adipose tissue low-grade inflammation in first-degree relatives of type 2 diabetic patients
    Lise Højbjerre
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 34:2265-72. 2011
    ..We investigated whether subjects who are nonobese FDRs show signs of low-grade inflammation before or after exposure to short-term physical inactivity...
  25. pmc Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity
    Regitze Kraunsøe
    Center for Healthy Ageing, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Physiol 588:2023-32. 2010
    ..Oxidative phosphorylation has a higher relative activity in visceral compared with subcutaneous adipose tissue...
  26. pmc Glucose clearance is higher in arm than leg muscle in type 2 diabetes
    David B Olsen
    Copenhagen Muscle Research Centre, University Hospital Rigshospitalet, Section 7652, DK 2100 Copenhagen, Denmark
    J Physiol 565:555-62. 2005
    ..In conclusion, this study shows that glucose clearance is higher in arm than leg muscles, regardless of insulin resistance, which may indicate better preserved insulin sensitivity in arm than leg muscle in type 2 diabetes...
  27. pmc Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans
    Carsten Juel
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    J Physiol 556:297-304. 2004
    ..Conclusions: MCT1 content in skeletal muscle in Type 2 is lower compared with healthy men. Strength training increases MCT1 content in healthy men and in Type 2, thus normalizing the content in Type 2...
  28. ncbi request reprint Effects of physical training on endothelial function and limb blood flow in type 2 diabetes
    Mette Paulli Sonne
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, Section of Systems Biology, University of Copenhagen, Blegdamsvej 3, 2200 Kbh N, Denmark
    Appl Physiol Nutr Metab 32:936-41. 2007
    ..In general, physical training can improve endothelial function when this is impaired. However, physical training does not seem to have any effect on endothelial function when this is normal...
  29. doi request reprint Increase in IL-6, TNF-α, and MMP-9, but not sICAM-1, concentrations depends on exercise duration
    Dace Reihmane
    Xlab, Department of Biomedical Sciences, Faculty of Health Sciences, Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark
    Eur J Appl Physiol 113:851-8. 2013
    ....
  30. doi request reprint Immobilization increases interleukin-6, but not tumour necrosis factor-α, release from the leg during exercise in humans
    Dace Reihmane
    Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen N, Denmark
    Exp Physiol 98:778-83. 2013
    ..Neither immobilization nor exercise had an effect on TNF-α release in the working legs...
  31. ncbi request reprint Are blood flow and lipolysis in subcutaneous adipose tissue influenced by contractions in adjacent muscles in humans?
    Bente Stallknecht
    Department of Medical Physiology, The Panum Institute, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Am J Physiol Endocrinol Metab 292:E394-9. 2007
    ..05). In conclusion, blood flow and lipolysis are generally higher in SCAT adjacent to contracting than adjacent to resting muscle irrespective of exercise intensity. Thus specific exercises can induce "spot lipolysis" in adipose tissue...
  32. ncbi request reprint Metallothionein-mediated antioxidant defense system and its response to exercise training are impaired in human type 2 diabetes
    Celena Scheede-Bergdahl
    The Copenhagen Muscle Research Centre, The Panum Institute, Department of Medical Physiology, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Diabetes 54:3089-94. 2005
    ..This study presents a novel candidate in the pathogenesis of complications related to oxidative stress in type 2 diabetes...
  33. doi request reprint Altered mitochondrial regulation in quadriceps muscles of patients with COPD
    Ashley I Naimi
    Centre for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Denmark
    Clin Physiol Funct Imaging 31:124-31. 2011
    ..These results indicate that quadriceps muscle mitochondrial function is altered in patients with COPD. The regulatory mechanisms underlying these functional abnormalities remain to be uncovered...
  34. ncbi request reprint Effect of training on muscle triacylglycerol and structural lipids: a relation to insulin sensitivity?
    Jørn W Helge
    Department of Medical Physiology, Copenhagen Muscle Research Centre, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Diabetes 52:1881-7. 2003
    ..In contrast, training induced a minor increase in the content of phospholipid fatty acid membrane polyunsaturates, which may indicate that membrane lipids may have a role in the training-induced increase in insulin sensitivity...
  35. ncbi request reprint Resistance training, insulin sensitivity and muscle function in the elderly
    Flemming Dela
    Institute for Biomedical Sciences, University of Copenhagen, Denmark
    Essays Biochem 42:75-88. 2006
    ....
  36. doi request reprint Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue
    Ninna Bo Nielsen
    Department of Biomedical Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Regul Pept 155:39-45. 2009
    ..Furthermore, subcutaneous adipose tissue has a marked production of pro-inflammatory adipokines...
  37. pmc 5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes
    Jørgen F P Wojtaszewski
    The Institute of Exercise and Sport Sciences, The Copenhagen Muscle Research Centre, University of Copenhagen, 13 Universitetsparken, 2100 Copenhagen, Denmark
    J Physiol 564:563-73. 2005
    ....
  38. pmc An optimized histochemical method to assess skeletal muscle glycogen and lipid stores reveals two metabolically distinct populations of type I muscle fibers
    Clara Prats
    Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e77774. 2013
    ..Exhaustive exercise lead to glycogen depletion in type IIA and IIX fibers, a reduction in lipid droplets density in both type I-1 and I-2 fibers, and a decrease in the size of lipid droplets exclusively in type I-1 fibers. ..
  39. ncbi request reprint Effect of intermittent fasting and refeeding on insulin action in healthy men
    Nils Halberg
    Dept of Muscle Research Centre, The Panum Institute, University of Copenhagen, Denmark
    J Appl Physiol (1985) 99:2128-36. 2005
    ..3,860 +/- 784 ng/ml, P = 0.02). This experiment is the first in humans to show that intermittent fasting increases insulin-mediated glucose uptake rates, and the findings are compatible with the thrifty gene concept...
  40. ncbi request reprint [Physical activity and chronic disease I. Heart disease and hypertension]
    Peter Magnusson
    H S Bispebjerg Hospital, Medicinsk Center
    Ugeskr Laeger 166:1543-7. 2004
  41. ncbi request reprint [Physical activity and chronic disease II. Type 2 diabetes, obesity and cancer]
    Peter Magnusson
    H S Bispebjerg Hospital, Medicinsk Center
    Ugeskr Laeger 166:1547-51. 2004
  42. ncbi request reprint [Physical activity and chronic disease III. Musculoskeletal diseases and lung diseases]
    Peter Magnusson
    H S Bispebjerg Hospital, Medicinsk Center
    Ugeskr Laeger 166:1552-7. 2004
  43. ncbi request reprint [Physical training in the treatment of metabolic syndrome]
    Flemming Dela
    Center for Muskelforskning, Medicinsk Fysiologisk Institut, Panum Instituttet 12 4 7, Københavns Universitet, DK 2200 København N
    Ugeskr Laeger 164:2147-52. 2002
    ..The results are more doubtful for the dyslipidaemia and hypertension, but if the training is combined with an appropriate diet, these abnormalities are also correctable...
  44. doi request reprint Ceramide content is higher in type I compared to type II fibers in obesity and type 2 diabetes mellitus
    Ditte Kristensen
    Center of Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark
    Acta Diabetol 50:705-12. 2013
    ..In human skeletal muscle, ceramide content was higher in type I than in type II fibers in patients with type 2 diabetes and in obese subjects, but overall ceramide muscle fiber content was not different compared to controls. ..
  45. ncbi request reprint Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects
    Lise Højbjerre
    Department of Biomedical Sciences, The Panum Institute, The Copenhagen Muscle Research Centre, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Eur J Endocrinol 157:613-23. 2007
    ..We studied how an acute bout of exercise influences expression and concentration of adiponectin and regulators of adiponectin in adipose tissue and plasma...
  46. ncbi request reprint Mitochondrial oxidative function and type 2 diabetes
    Rasmus Rabøl
    The Copenhagen Muscle Research Centre, The Panum Institute, Department of Medical Physiology, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Appl Physiol Nutr Metab 31:675-83. 2006
    ..Specific effects of regular physical training and muscular work on mitochondrial function and plasticity in type 2 diabetes remain an important area of research...
  47. doi request reprint Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
    Michael Taulo Lund
    Department of Biomedical Sciences, Center for Healthy Aging, Xlab, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark
    Eur J Appl Physiol 113:2737-47. 2013
    ..Satiety measures did not differ between groups throughout the test. It is possible that in aerobically T subjects, a lower GIP release is partly responsible for a lower postprandial incretin stimulated insulin secretion...
  48. doi request reprint Insulin resistance and mitochondrial function in skeletal muscle
    Flemming Dela
    Xlab, Center for Healthy Aging, Faculty of Medicine, University of Copenhagen, Denmark
    Int J Biochem Cell Biol 45:11-5. 2013
    ..In this review we will present the prevailing view-points and argue for the unlikelihood of this scenario being instrumental in human insulin resistance. This article is part of a Directed Issue entitled: Bioenergetic dysfunction...
  49. ncbi request reprint Effect of resistance training on Na,K pump and Na+/H+ exchange protein densities in muscle from control and patients with type 2 diabetes
    Flemming Dela
    Department of Medical Physiology, University of Copenhagen, Copenhagen, Denmark
    Pflugers Arch 447:928-33. 2004
    ..06) in trained compared to untrained leg in the diabetics. Thus, a limited amount of strength-training is able to increase the Na,K-pump subunit and isoform content both in controls and in patients with type 2 diabetes...
  50. ncbi request reprint Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes
    Maria Pedersen
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Mech Ageing Dev 124:495-502. 2003
    ..Furthermore, TNF-alpha was related to lower ASM and BCM, suggesting that TNF-alpha contributes to sarcopenia in ageing...
  51. ncbi request reprint Physical inactivity and muscle oxidative capacity in humans
    Martin Gram
    a Xlab, Department of Biomedical Sciences, Center for Healthy Ageing, University of Copenhagen, Blegdamsvej 3b, Denmark
    Eur J Sport Sci 14:376-83. 2014
    ..Thus, it is concluded that studies on the effect of physical inactivity per se on muscle oxidative capacity in functional human skeletal muscle are warranted. ..
  52. ncbi request reprint Cardiovascular control during exercise: insights from spinal cord-injured humans
    Flemming Dela
    Department of Medical Physiology, The Panum Institute, Building 12 4 7, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Circulation 107:2127-33. 2003
    ..We studied the role of the central nervous system, neural feedback from contracting skeletal muscles, and sympathetic activity to the heart in the control of heart rate and blood pressure during 2 levels of dynamic exercise...
  53. doi request reprint Educating health professionals: the Avicenna project
    David Gordon
    Faculty of Health Sciences, University of Copenhagen, Copenhagen DK 2200, Denmark
    Lancet 371:966-7. 2008
  54. ncbi request reprint The outcome of bone mineral density measurements on patients referred from general practice
    Sofia Inez Iqbal
    Depart of Medical Physiology Copenhagen Muscle Research Centre, Section of Pathophysiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    J Clin Densitom 8:178-82. 2005
    ..A low BMI is a good indicator for referral of women less than 60 yr for measurements of bone density. Forty-five percent of the referred women from general practitioners had a normal BMD...
  55. ncbi request reprint Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-alpha, and FFAs to low-dose endotoxemia in humans
    Rikke Krogh-Madsen
    Professor of Internal Medicine, Dept of Infectious Diseases 7641, Univ Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Physiol Endocrinol Metab 286:E766-72. 2004
    ....
  56. ncbi request reprint Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes
    Kurt Højlund
    Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Denmark
    J Biol Chem 278:10436-42. 2003
    ....
  57. ncbi request reprint Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight
    Christine B Jensen
    Department of Endocrinology and Clinical Research Unit, Hvidovre University Hospital, Hvidovre, Denmark
    Diabetes 51:1271-80. 2002
    ..We propose that reduced insulin-stimulated glycolysis precedes overt insulin resistance in LBW men. A lower insulin secretion may contribute to impaired glucose tolerance and ultimately lead to diabetes...
  58. ncbi request reprint Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    Eur J Endocrinol 152:103-12. 2005
    ..Aiming to provide a detailed description of the metabolic adverse effects of HIV-lipodystrophy, we investigated several aspects of glucose metabolism, lipid metabolism and beta-cell function in lipodystrophic HIV-infected patients...
  59. pmc The effect of caffeine on glucose kinetics in humans--influence of adrenaline
    Danielle S Battram
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Physiol 569:347-55. 2005
    ....
  60. ncbi request reprint Insulin secretion and cellular glucose metabolism after prolonged low-grade intralipid infusion in young men
    Christine B Jensen
    Department of Endocrinology and Clinical Research Unit, Hvidovre University Hospital, 2650 Hvidovre, Denmark
    J Clin Endocrinol Metab 88:2775-83. 2003
    ..Moreover, insulin hypersecretion perfectly countered the free-fatty acid-induced insulin resistance. Future studies are needed to determine the role of a prolonged moderate lipid load in subjects at increased risk of developing diabetes...
  61. ncbi request reprint Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    J Infect 54:89-97. 2007
    ..However, the correlation between fasting lactate and mitochondrial DNA may be weak or absent, implicating that other factors e.g. glucose turnover may contribute to hyperlactatemia...
  62. ncbi request reprint [Eating for top performance in sports?]
    Jørn Wulff Helge
    Københavns Universitet, Medicinsk Fysiologisk Institut, København N
    Ugeskr Laeger 168:4510. 2006
  63. ncbi request reprint Tumor necrosis factor alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, DK 2650 Copenhagen, Denmark
    Metabolism 55:175-82. 2006
    ..Furthermore, FFA may be a major determinant of LIPOX in HIV-infected patients on highly active antiretroviral therapy...
  64. ncbi request reprint [Prevention of obesity among children and adolescents--proposal for a strategy]
    Christian Mølgaard
    Motions og Ernaeringsrådet, Søborg
    Ugeskr Laeger 169:2314-6. 2007
    ....
  65. ncbi request reprint Insulin secretion in lipodystrophic HIV-infected patients is associated with high levels of nonglucose secretagogues and insulin resistance of beta-cells
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 287:E677-85. 2004
    ....
  66. ncbi request reprint The CSF and arterial to internal jugular venous hormonal differences during exercise in humans
    Mads K Dalsgaard
    Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Exp Physiol 89:271-7. 2004
    ..The results support the notion that the exercise-induced changes in brain metabolism are controlled by factors intrinsic to the brain...
  67. ncbi request reprint Depleted skeletal muscle mitochondrial DNA, hyperlactatemia, and decreased oxidative capacity in HIV-infected patients on highly active antiretroviral therapy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    J Med Virol 77:29-38. 2005
    ..Further, HIV may deplete sm-mtDNA of NAIVE, which in part could be mediated through an enhanced pro-inflammatory response...
  68. ncbi request reprint Young, low-birth-weight men are not more susceptible to the diabetogenic effects of a prolonged free fatty acid exposure than matched controls
    Christine B Jensen
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Metabolism 54:1398-406. 2005
    ..We reproduced our previous finding of lower insulin-stimulated glycolysis in this population...
  69. ncbi request reprint Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle
    Eveline Hutter
    Department for Molecular and Cellular Biology, Institute for Biomedical Aging Research of the Austrian Academy of Sciences, 6020 Innsbruck, Austria
    Aging Cell 6:245-56. 2007
    ..The data support a model, where ROS-induced molecular damage is continuously removed, preventing the accumulation of dysfunctional mitochondria despite ongoing ROS production...