Søren E Degn

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. doi request reprint Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44
    Søren E Degn
    Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark
    J Immunol 191:1334-45. 2013
  2. doi request reprint Humoral pattern recognition and the complement system
    S E Degn
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Scand J Immunol 78:181-93. 2013
  3. doi request reprint Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor
    Søren E Degn
    Department of Biomedicine, Aarhus University, DK 8000 Aarhus C, Denmark
    Protein Expr Purif 88:173-82. 2013
  4. doi request reprint Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function
    Søren E Degn
    Department of Biomedicine, Aarhus University, DK 8000 Aarhus C, Denmark
    J Immunol 189:3957-69. 2012
  5. doi request reprint MAp19, the alternative splice product of the MASP2 gene
    Søren E Degn
    Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 4, DK 8000 Aarhus C, Denmark
    J Immunol Methods 373:89-101. 2011
  6. doi request reprint Assay interference caused by antibodies reacting with rat kappa light-chain in human sera
    Søren E Degn
    Department of Medical Microbiology and Immunology, Aarhus University, Wilhelm Meyers Allé 4, DK 8000 Aarhus C, Denmark
    J Immunol Methods 372:204-8. 2011
  7. pmc Disease-causing mutations in genes of the complement system
    Søren E Degn
    Department of Medical Microbiology and Immunology, Aarhus University, Wilhelm Meyers Allé 4, 8000 Aarhus C, DK Denmark
    Am J Hum Genet 88:689-705. 2011
  8. doi request reprint Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system
    Søren E Degn
    Department of Medical Microbiology and Immunology, Aarhus University, Wilhelm Meyers Allé 4, 8000 Arhus C, Denmark
    J Immunol Methods 361:37-50. 2010
  9. ncbi request reprint New perspectives on mannan-binding lectin-mediated complement activation
    Søren E Degn
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Immunobiology 212:301-11. 2007
  10. doi request reprint MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation
    Søren E Degn
    Departments of Medical Microbiology and Immunology, University of Aarhus, Arhus, Denmark
    J Immunol 183:7371-8. 2009

Collaborators

Detail Information

Publications12

  1. doi request reprint Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44
    Søren E Degn
    Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark
    J Immunol 191:1334-45. 2013
    ..We present support for this contention...
  2. doi request reprint Humoral pattern recognition and the complement system
    S E Degn
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Scand J Immunol 78:181-93. 2013
    ....
  3. doi request reprint Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor
    Søren E Degn
    Department of Biomedicine, Aarhus University, DK 8000 Aarhus C, Denmark
    Protein Expr Purif 88:173-82. 2013
    ..We have generalized the concept to the expression also of MASP-2 entirely in its zymogen form and with improved yields. We suggest a general advantage of expressing aggressive, autocatalytic proteases with their cognate inhibitors...
  4. doi request reprint Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function
    Søren E Degn
    Department of Biomedicine, Aarhus University, DK 8000 Aarhus C, Denmark
    J Immunol 189:3957-69. 2012
    ..Hence, in functional terms, it appears that MASP-1 and MASP-2 act in a manner analogous to that of C1r and C1s of the classical pathway...
  5. doi request reprint MAp19, the alternative splice product of the MASP2 gene
    Søren E Degn
    Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 4, DK 8000 Aarhus C, Denmark
    J Immunol Methods 373:89-101. 2011
    ..Immunohistochemical analyses combined with qRT-PCR revealed that both MAp19 and MASP-2 were mainly expressed in hepatocytes. High levels of MAp19 were found in urine, where MASP-2 was absent...
  6. doi request reprint Assay interference caused by antibodies reacting with rat kappa light-chain in human sera
    Søren E Degn
    Department of Medical Microbiology and Immunology, Aarhus University, Wilhelm Meyers Allé 4, DK 8000 Aarhus C, Denmark
    J Immunol Methods 372:204-8. 2011
    ..Our results highlight a major pitfall of potential relevance to many sandwich-type assays, as well as an approach to rectify such problems...
  7. pmc Disease-causing mutations in genes of the complement system
    Søren E Degn
    Department of Medical Microbiology and Immunology, Aarhus University, Wilhelm Meyers Allé 4, 8000 Aarhus C, DK Denmark
    Am J Hum Genet 88:689-705. 2011
    ..Here, we compare the functional immunologic consequences of "conventional" complement deficiencies with these newly described developmental roles...
  8. doi request reprint Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system
    Søren E Degn
    Department of Medical Microbiology and Immunology, Aarhus University, Wilhelm Meyers Allé 4, 8000 Arhus C, Denmark
    J Immunol Methods 361:37-50. 2010
    ..Thus, neither of the two proteins behaves as a classical acute phase protein...
  9. ncbi request reprint New perspectives on mannan-binding lectin-mediated complement activation
    Søren E Degn
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Immunobiology 212:301-11. 2007
    ..The emerging picture of the complement system is more that of a small "scale-free" network where C3 acts as the main hub, than that of three linear pathways converging in a common terminal pathway...
  10. doi request reprint MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation
    Søren E Degn
    Departments of Medical Microbiology and Immunology, University of Aarhus, Arhus, Denmark
    J Immunol 183:7371-8. 2009
    ..MAp44 competes with MASP-2 for binding to MBL and ficolins, resulting in inhibition of complement activation. Our results add a novel mechanism to those known to control the innate immune system...
  11. pmc Mitochondria and the lectin pathway of complement
    Christel R Brinkmann
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, DK 8000 Aarhus C, Denmark
    J Biol Chem 288:8016-27. 2013
    ..Thus, we report here the first indication of involvement of the lectin pathway in mitochondrial immune handling...
  12. doi request reprint The lectin pathway and its implications in coagulation, infections and auto-immunity
    Søren E Degn
    Department of Medical Microbiology and Immunology, Aarhus University, and Medical Research Laboratories, Clinical Institute and Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
    Curr Opin Organ Transplant 16:21-7. 2011
    ..To give a comprehensive overview of the recently published studies on the role of the lectin pathway in coagulation, infections and auto-immunity...