L Christiansen

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. pmc A prospective study of twinning and perinatal mortality in urban Guinea-Bissau
    Morten Bjerregaard-Andersen
    Bandim Health Project, INDEPTH Network, Apartado 861, 1004, Bissau Codex, Guinea Bissau
    BMC Pregnancy Childbirth 12:140. 2012
  2. pmc Retrospective analysis of main and interaction effects in genetic association studies of human complex traits
    Qihua Tan
    Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark
    BMC Genet 8:70. 2007
  3. ncbi request reprint A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival
    L Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark
    Mech Ageing Dev 127:597-9. 2006
  4. ncbi request reprint Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population
    Lene Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Biol Psychiatry 61:223-30. 2007
  5. ncbi request reprint The catalase -262C/T promoter polymorphism and aging phenotypes
    Lene Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark
    J Gerontol A Biol Sci Med Sci 59:B886-9. 2004
  6. ncbi request reprint Paraoxonase 1 polymorphisms and survival
    L Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Eur J Hum Genet 12:843-7. 2004
  7. ncbi request reprint Modest implication of interleukin-6 promoter polymorphisms in longevity
    L Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Mech Ageing Dev 125:391-5. 2004
  8. ncbi request reprint Expression and characterization of six clinically relevant uroporphyrinogen decarboxylase gene mutations
    L Christiansen
    Department of Clinical Biochemistry and Clinical Genetics, Odense University Hospital, Odense, Denmark
    Scand J Clin Lab Invest 65:227-35. 2005
  9. ncbi request reprint Age- and sex-differences in the validity of questionnaire-based zygosity in twins
    Lene Christiansen
    The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 6:275-8. 2003
  10. pmc Candidate region linkage analysis in twins discordant or concordant for depression symptomatology
    L Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Am J Med Genet B Neuropsychiatr Genet 150:581-4. 2009

Collaborators

Detail Information

Publications23

  1. pmc A prospective study of twinning and perinatal mortality in urban Guinea-Bissau
    Morten Bjerregaard-Andersen
    Bandim Health Project, INDEPTH Network, Apartado 861, 1004, Bissau Codex, Guinea Bissau
    BMC Pregnancy Childbirth 12:140. 2012
    ..Despite twinning being common in Africa, few prospective twin studies have been conducted. We studied twinning rate, perinatal mortality and the clinical characteristics of newborn twins in urban Guinea-Bissau...
  2. pmc Retrospective analysis of main and interaction effects in genetic association studies of human complex traits
    Qihua Tan
    Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark
    BMC Genet 8:70. 2007
    ..Performance of our method in detecting interaction effect is compared with that of the case-only model...
  3. ncbi request reprint A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival
    L Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark
    Mech Ageing Dev 127:597-9. 2006
    ..To our knowledge, this is the first longitudinal study exploring the influence of GST gene polymorphisms on longevity and these data implies that GST gene copy numbers do affect mortality risk in the elderly...
  4. ncbi request reprint Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population
    Lene Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Biol Psychiatry 61:223-30. 2007
    ..Variations in genes included in the serotonin system have been suggested as risk factors for various psychiatric disorders but may also serve as candidates for normal variations in mood...
  5. ncbi request reprint The catalase -262C/T promoter polymorphism and aging phenotypes
    Lene Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark
    J Gerontol A Biol Sci Med Sci 59:B886-9. 2004
    ..The results raise the hypothesis that the catalase -262T allele serves as protection against neurodegenerative and physical decline, although replication in other studies is warranted for confirmation of these findings...
  6. ncbi request reprint Paraoxonase 1 polymorphisms and survival
    L Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Eur J Hum Genet 12:843-7. 2004
    ....
  7. ncbi request reprint Modest implication of interleukin-6 promoter polymorphisms in longevity
    L Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Mech Ageing Dev 125:391-5. 2004
    ..We found a modest, but significant, increase in the frequency of interleukin-6 -174GG homozygotes with age suggesting that this genotype is advantageous for longevity...
  8. ncbi request reprint Expression and characterization of six clinically relevant uroporphyrinogen decarboxylase gene mutations
    L Christiansen
    Department of Clinical Biochemistry and Clinical Genetics, Odense University Hospital, Odense, Denmark
    Scand J Clin Lab Invest 65:227-35. 2005
    ..Although the clinical manifestation of familial porphyria cutanea tarda is complex, the findings support the notion that different mutations may affect individuals differently...
  9. ncbi request reprint Age- and sex-differences in the validity of questionnaire-based zygosity in twins
    Lene Christiansen
    The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 6:275-8. 2003
    ..The results demonstrate that questionnaire based zygosity diagnosis can still be regarded as a valid and valuable classification method for most purposes...
  10. pmc Candidate region linkage analysis in twins discordant or concordant for depression symptomatology
    L Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Am J Med Genet B Neuropsychiatr Genet 150:581-4. 2009
    ..91 for marker D12S1634 located at 148 cM, and thus indicates that the previously identified disease locus at 12q24 is also a general vulnerability locus affecting the normal range of mood...
  11. ncbi request reprint Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Ann Hum Genet 67:598-607. 2003
    ..Application has shown that these methods can serve as useful tools in searching for important gene variations that contribute to human aging and longevity...
  12. ncbi request reprint Assessing genetic association with human survival at multi-allelic loci
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Biogerontology 5:89-97. 2004
    ..As an example, we apply the methods to empirical data on Renin gene polymorphism and longevity. We show that our models can serve as useful tools in searching for important genetic variations implicated in human aging and longevity...
  13. ncbi request reprint Association of mutations in the hemochromatosis gene with shorter life expectancy
    L Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Sdr Blvd 29, DK 5000 Odense C, Denmark
    Arch Intern Med 161:2441-4. 2001
    ..It is of value in the debate concerning screening for hereditary hemochromatosis to determine the significance of heterozygosity...
  14. pmc Genetic variants in the choline acetyltransferase (ChAT) gene are modestly associated with normal cognitive function in the elderly
    J Mengel-From
    The Danish Aging Research Center, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Genes Brain Behav 10:876-82. 2011
    ....
  15. ncbi request reprint Haplotype effects on human survival: logistic regression models applied to unphased genotype data
    Q Tan
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense C, Denmark
    Ann Hum Genet 69:168-75. 2005
    ..We show that our logistic regression based haplotype model can be a helpful tool for researchers interested in the genetics of human aging and longevity...
  16. ncbi request reprint Uroporphyrinogen decarboxylase gene mutations in Danish patients with porphyria cutanea tarda
    L Christiansen
    Department of Clinical Biochemistry and Clinical Genetics, Odense University Hospital, Denmark
    Scand J Clin Lab Invest 60:611-5. 2000
    ..However, possible disease-related UROD mutations were identified in 24% of the examined patients, indicating that genetic analysis of PCT patients may improve differentiation between familial and sporadic PCT cases...
  17. ncbi request reprint DGGE analysis of the coproporphyrinogen oxidase gene: two new mutations in DNA from Danish patients with hereditary coproporphyria
    N E Petersen
    Department for Clinical Biochemistry and Clinical Genetics, Odense University Hospital, Denmark
    Scand J Clin Lab Invest 60:617-25. 2000
    ....
  18. ncbi request reprint Association between CYP1A2 polymorphism and susceptibility to porphyria cutanea tarda
    L Christiansen
    Department of Clinical Biochemistry and Clinical Genetics, Odense University Hospital, Denmark
    Hum Genet 107:612-4. 2000
    ..The results demonstrate that the frequency of the highly inducible A/A genotype is increased in both familial and sporadic PCT. This suggests that inheritance of this genotype is a susceptibility factor in development of PCT...
  19. ncbi request reprint Screening for mutations in the uroporphyrinogen decarboxylase gene using denaturing gradient gel electrophoresis. Identification and characterization of six novel mutations associated with familial PCT
    L Christiansen
    Department of Clinical Biochemistry and Clinical Genetics, Odense University Hospital, Odense, Denmark
    Hum Mutat 14:222-32. 1999
    ..The DGGE assay presented greatly improves the genetic diagnosis of fPCT and HEP, thereby facilitating the detection of familial UROD deficient patients as well as the discrimination between familial and sporadic PCT cases...
  20. pmc Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project
    A Skytthe
    Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winsløws Vej 9B, Odense, Denmark
    Exp Gerontol 46:934-45. 2011
    ..Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity...
  21. doi request reprint Adult glucose metabolism in extremely birthweight-discordant monozygotic twins
    M Frost
    The Danish Twin Registry, Department of Epidemiology, University of Southern Denmark, JB Winsløvsvej 9, Odense C, Denmark
    Diabetologia 55:3204-12. 2012
    ..Low birthweight (BW) is associated with increased risk of type 2 diabetes. We compared glucose metabolism in adult BW-discordant monozygotic (MZ) twins, thereby controlling for genetic factors and rearing environment...
  22. ncbi request reprint Characterization of two isoalleles and three mutations in both isoforms of purified recombinant human porphobilinogen deaminase
    J Brøns-Poulsen
    DakoCytomation Norden A S, Glostrup, Denmark
    Scand J Clin Lab Invest 65:93-105. 2005
    ....
  23. ncbi request reprint Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly
    J C Lambert
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Mol Psychiatry 12:870-80. 2007
    ..Therefore, this genetic variant in S100beta increases the risk of low cognitive performance and dementia, possibly by favouring a splicing event increasing S100beta2 isoform expression in the brain...