K Christensen

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. pmc Physical and cognitive functioning of people older than 90 years: a comparison of two Danish cohorts born 10 years apart
    Kaare Christensen
    Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark Max Planck Odense Center, University of Southern Denmark, Odense, Denmark Department of Clinical Genetics, Odense University Hospital, Odense, Denmark Department of Clinical biochemistry and pharmacology, Odense University Hospital, Odense, Denmark Electronic address
    Lancet 382:1507-13. 2013
  2. pmc A prospective study of twinning and perinatal mortality in urban Guinea-Bissau
    Morten Bjerregaard-Andersen
    Bandim Health Project, INDEPTH Network, Apartado 861, 1004, Bissau Codex, Guinea Bissau
    BMC Pregnancy Childbirth 12:140. 2012
  3. pmc The effects of oral clefts on hospital use throughout the lifespan
    George L Wehby
    Department of Health Management and Policy, College of Public Health, University of Iowa, 105 River Street, N248 CPHB, Iowa City, IA 52242, USA
    BMC Health Serv Res 12:58. 2012
  4. pmc Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918
    Kaare Christensen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    J Gerontol A Biol Sci Med Sci 67:489-94. 2012
  5. pmc Retrospective analysis of main and interaction effects in genetic association studies of human complex traits
    Qihua Tan
    Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark
    BMC Genet 8:70. 2007
  6. pmc Comparison of academic performance of twins and singletons in adolescence: follow-up study
    Kaare Christensen
    Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    BMJ 333:1095. 2006
  7. ncbi request reprint The correlation of fecundability among twins: evidence of a genetic effect on fertility?
    Kaare Christensen
    Epidemiology, Institute of Public Health, and The Danish Twin Registry, University of Southern Denmark, Odense, Denmark
    Epidemiology 14:60-4. 2003
  8. pmc The quest for genetic determinants of human longevity: challenges and insights
    Kaare Christensen
    Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winslows Vej 9B, 5000 Odense C, Denmark
    Nat Rev Genet 7:436-48. 2006
  9. ncbi request reprint Age trajectories of genetic variance in physical functioning: a longitudinal study of Danish twins aged 70 years and older
    Kaare Christensen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, DK 5000 Odense, Denmark
    Behav Genet 33:125-36. 2003
  10. pmc Exceptional longevity does not result in excessive levels of disability
    Kaare Christensen
    The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, DK 5000, Odense C, Denmark
    Proc Natl Acad Sci U S A 105:13274-9. 2008

Research Grants

  1. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2003
  2. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2004
  3. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2005
  4. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006

Collaborators

Detail Information

Publications124 found, 100 shown here

  1. pmc Physical and cognitive functioning of people older than 90 years: a comparison of two Danish cohorts born 10 years apart
    Kaare Christensen
    Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark Max Planck Odense Center, University of Southern Denmark, Odense, Denmark Department of Clinical Genetics, Odense University Hospital, Odense, Denmark Department of Clinical biochemistry and pharmacology, Odense University Hospital, Odense, Denmark Electronic address
    Lancet 382:1507-13. 2013
    ..To investigate this issue, we compared the cognitive and physical functioning of two cohorts of Danish nonagenarians, born 10 years apart...
  2. pmc A prospective study of twinning and perinatal mortality in urban Guinea-Bissau
    Morten Bjerregaard-Andersen
    Bandim Health Project, INDEPTH Network, Apartado 861, 1004, Bissau Codex, Guinea Bissau
    BMC Pregnancy Childbirth 12:140. 2012
    ..Despite twinning being common in Africa, few prospective twin studies have been conducted. We studied twinning rate, perinatal mortality and the clinical characteristics of newborn twins in urban Guinea-Bissau...
  3. pmc The effects of oral clefts on hospital use throughout the lifespan
    George L Wehby
    Department of Health Management and Policy, College of Public Health, University of Iowa, 105 River Street, N248 CPHB, Iowa City, IA 52242, USA
    BMC Health Serv Res 12:58. 2012
    ..However, not much is known about the long term effects of oral clefts on health and healthcare use of affected individuals. In this study, we evaluate the effects of oral clefts on hospital use throughout the lifespan...
  4. pmc Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918
    Kaare Christensen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    J Gerontol A Biol Sci Med Sci 67:489-94. 2012
    ..This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin...
  5. pmc Retrospective analysis of main and interaction effects in genetic association studies of human complex traits
    Qihua Tan
    Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark
    BMC Genet 8:70. 2007
    ..Performance of our method in detecting interaction effect is compared with that of the case-only model...
  6. pmc Comparison of academic performance of twins and singletons in adolescence: follow-up study
    Kaare Christensen
    Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    BMJ 333:1095. 2006
    ..To determine whether twins in recent cohorts show similar academic performance in adolescence to singletons and to test the effect of birth weight on academic performance in twins and singletons...
  7. ncbi request reprint The correlation of fecundability among twins: evidence of a genetic effect on fertility?
    Kaare Christensen
    Epidemiology, Institute of Public Health, and The Danish Twin Registry, University of Southern Denmark, Odense, Denmark
    Epidemiology 14:60-4. 2003
    ..Numerous rare genetic conditions are known to influence fecundability in both males and females. It is less clear to what extent more subtle genetic differences influence fecundability on a population level...
  8. pmc The quest for genetic determinants of human longevity: challenges and insights
    Kaare Christensen
    Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winslows Vej 9B, 5000 Odense C, Denmark
    Nat Rev Genet 7:436-48. 2006
    ..However, large-scale linkage studies of long-lived families, longitudinal candidate-gene association studies and the development of analytical methods provide the potential for future progress...
  9. ncbi request reprint Age trajectories of genetic variance in physical functioning: a longitudinal study of Danish twins aged 70 years and older
    Kaare Christensen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, DK 5000 Odense, Denmark
    Behav Genet 33:125-36. 2003
    ....
  10. pmc Exceptional longevity does not result in excessive levels of disability
    Kaare Christensen
    The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, DK 5000, Odense C, Denmark
    Proc Natl Acad Sci U S A 105:13274-9. 2008
    ..For the individual, long life brings an increasing risk of loss of independence. For society, mortality reductions are not expected to result in exceptional levels of disability in cohorts of the very old...
  11. pmc Register-based research on twins
    Kaare Christensen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Scand J Public Health 39:185-90. 2011
    ..The Danish Twin Registry (DTR) has for more than 50 years been based on surveys and clinical investigations and over the two last decades also on register linkage. Currently these two approaches are merged within Statistics Denmark...
  12. ncbi request reprint ["Looking your age"--genetics and mortality]
    Kaare Christensen
    Syddansk Universitet, Institut for Sundhedstjenesteforskning, Det Danske Tvillingregister, Epidemiologi
    Ugeskr Laeger 166:3500-1. 2004
  13. pmc Long term follow up study of survival associated with cleft lip and palate at birth
    Kaare Christensen
    Center for the Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, DK 5000 Odense, Denmark
    BMJ 328:1405. 2004
    ..To assess the overall and cause specific mortality of people from birth to 55 years with cleft lip and palate...
  14. pmc Ageing populations: the challenges ahead
    Kaare Christensen
    Danish Ageing Research Centre, University of Southern Denmark, Odense, Denmark
    Lancet 374:1196-208. 2009
    ..This finding, together with technological and medical development and redistribution of work, will be important for our chances to meet the challenges of ageing populations...
  15. pmc Perceived age as clinically useful biomarker of ageing: cohort study
    Kaare Christensen
    Danish Twin Registry and Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, DK 5000 Odense C, Denmark
    BMJ 339:b5262. 2009
    ..To determine whether perceived age correlates with survival and important age related phenotypes...
  16. ncbi request reprint Facial clefting and psychiatric diseases: a follow-up of the Danish 1936-1987 Facial Cleft cohort
    Kaare Christensen
    Center for the Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Cleft Palate Craniofac J 39:392-6. 2002
    ..This study assesses whether patients with facial cleft have an increased risk of psychiatric diseases...
  17. ncbi request reprint Genetic contribution to rate of change in functional abilities among Danish twins aged 75 years or more
    Kaare Christensen
    Danish Twin Registry, Institute of Public Health, University of Southern Denmark, DK 5000 Odense, Denmark
    Am J Epidemiol 155:132-9. 2002
    ....
  18. pmc Why Danes are smug: comparative study of life satisfaction in the European Union
    Kaare Christensen
    Epidemiology, Institute of Public Health, University of Southern Denmark, JB Winslowsvej 9B, DK 5000 Odense C, Denmark
    BMJ 333:1289-91. 2006
  19. ncbi request reprint Cardiovascular mortality in twins and the fetal origins hypothesis
    K Christensen
    The Danish Twin Registry, University of Southern Denmark, Denmark
    Twin Res 4:344-9. 2001
    ....
  20. ncbi request reprint The X chromosome and the female survival advantage: an example of the intersection between genetics, epidemiology and demography
    K Christensen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, and the Danish Center for Demographic Research, University of Southern Denmark, Odense
    Ann N Y Acad Sci 954:175-83. 2001
    ....
  21. ncbi request reprint [Health and mortality in men and women--a paradox]
    Kaare Christensen
    Syddansk Universitet, Institut for Sundhedsforskning, Epidemiologi, Odense C
    Ugeskr Laeger 169:2395-7. 2007
    ..The reason for this paradox is undoubtedly multifactorial with biological (hormonal, immunological, genetic), behavioural (smoking, risk behaviour, sickness behaviour), and social (the male role) factors...
  22. pmc Do genetic factors contribute to the association between birth weight and blood pressure?
    K Christensen
    Institute of Public Health, Epidemiology, and Institute for Demography and Statistics, University of Southern Denmark, Odense, Denmark
    J Epidemiol Community Health 55:583-7. 2001
    ..To evaluate whether genetic factors contribute to the association between low birth weight and increased blood pressure among adolescents...
  23. ncbi request reprint Evaluation of two putative susceptibility loci for oral clefts in the Danish population
    L E Mitchell
    Department of Biostatistics, and Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Epidemiol 153:1007-15. 2001
    ..However, there is no evidence that the risk of CL+/-P or CP is influenced by gene-environment interactions involving MSX1 or TGFB3 and either first trimester exposure to maternal cigarette smoke or alcohol consumption...
  24. ncbi request reprint Genetic and environmental influences on functional abilities in Danish twins aged 75 years and older
    K Christensen
    Epidemiology, Institute of Public Health, and the Danish Center for Demographic Research, University of Southern Denmark, Odense
    J Gerontol A Biol Sci Med Sci 55:M446-52. 2000
    ..This study estimates the relative importance of genetic and environmental factors to variation in functional abilities in elderly persons...
  25. ncbi request reprint Functional status and self-rated health in 2,262 nonagenarians: the Danish 1905 Cohort Survey
    H Nybo
    Danish Center for Demographic Research and Epidemiology, Institute of Public Health and Aging Research Center, University of Southern Denmark, Odense University, Odense, Denmark
    J Am Geriatr Soc 49:601-9. 2001
    ..Nevertheless, the majority of the participants considered their health to be good and were satisfied with their lives...
  26. ncbi request reprint Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Ann Hum Genet 67:598-607. 2003
    ..Application has shown that these methods can serve as useful tools in searching for important gene variations that contribute to human aging and longevity...
  27. ncbi request reprint Assessing genetic association with human survival at multi-allelic loci
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Biogerontology 5:89-97. 2004
    ..As an example, we apply the methods to empirical data on Renin gene polymorphism and longevity. We show that our models can serve as useful tools in searching for important genetic variations implicated in human aging and longevity...
  28. ncbi request reprint Genetic and environmental contributions to back pain in old age: a study of 2,108 danish twins aged 70 and older
    Jan Hartvigsen
    Nordic Institute of Chiropractic and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
    Spine (Phila Pa 1976) 29:897-901; discussion 902. 2004
    ..Self-reported 1-month prevalence of back pain in older twins assessed at intake in a population-based longitudinal survey...
  29. ncbi request reprint Declining physical abilities with age: a cross-sectional study of older twins and centenarians in Denmark
    K Andersen-Ranberg
    Ageing Research Centre and Epidemiology, Institute of Public Health, Odense, Denmark
    Age Ageing 28:373-7. 1999
    ..To evaluate whether physical disability reaches a plateau in the oldest age groups...
  30. ncbi request reprint Risk of stroke associated with nonsteroidal anti-inflammatory drugs: a nested case-control study
    Søren Bak
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Stroke 34:379-86. 2003
    ..We performed a population-based case-control study to estimate the risk of intracerebral hemorrhage, subarachnoid hemorrhage, and ischemic stroke in users of NSAIDs...
  31. ncbi request reprint Long-term effects of migraine on cognitive function: a population-based study of Danish twins
    D Gaist
    Danish Twin Register and Epidemiology, Institute of Public Health, University of Southern Denmark
    Neurology 64:600-7. 2005
    ..To investigate the cognitive functioning of migraineurs vs nonmigraineurs in a large population-based sample of middle-aged twins where headache diagnoses were established by neurologists...
  32. ncbi request reprint Genetic influence on thrombotic risk markers in the elderly--a Danish twin study
    E M Bladbjerg
    Department for Thrombosis Research, University of Southern Denmark, Ribe County Hospital, Esbjerg, Denmark
    J Thromb Haemost 4:599-607. 2006
    ..The genetic contribution to cardiovascular disease (CVD) decreases with increasing age, and it is therefore important to determine the heritability of hemostasis also in the elderly...
  33. ncbi request reprint Small effect of genetic factors on neck pain in old age: a study of 2,108 Danish twins 70 years of age and older
    Jan Hartvigsen
    Nordic Institute of Chiropractic and Clinical Biomechanics, Odense C, Denmark
    Spine (Phila Pa 1976) 30:206-8. 2005
    ..Classic twin study...
  34. ncbi request reprint Genetic influence on inflammation variables in the elderly
    Moniek P M de Maat
    Department for Thrombosis Research, University of Southern Denmark, Esbjerg, Denmark
    Arterioscler Thromb Vasc Biol 24:2168-73. 2004
    ....
  35. ncbi request reprint Between nurture and nature: the shifting determinants of female fertility in Danish twin cohorts
    Hans Peter Kohler
    Population Studies Center, University of Pennsylvania, 3718 Locust Walk, Philadelphia, PA 19104 6299, USA
    Soc Biol 49:218-48. 2002
    ..Moreover, our results emphasize the need for socially and contextually informed analyses of nature and nurture that allow both factors to influence human reproductive behavior over time...
  36. pmc Sex differences in health and mortality in Moscow and Denmark
    A Oksuzyan
    Max Planck Odense Center on the Biodemography of Aging, Winsloews Vej 9B, 5000, Odense, Denmark
    Eur J Epidemiol 29:243-52. 2014
    ....
  37. pmc Genetic variants in the choline acetyltransferase (ChAT) gene are modestly associated with normal cognitive function in the elderly
    J Mengel-From
    The Danish Aging Research Center, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Genes Brain Behav 10:876-82. 2011
    ....
  38. ncbi request reprint Haplotype effects on human survival: logistic regression models applied to unphased genotype data
    Q Tan
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense C, Denmark
    Ann Hum Genet 69:168-75. 2005
    ..We show that our logistic regression based haplotype model can be a helpful tool for researchers interested in the genetics of human aging and longevity...
  39. pmc Back pain remains a common symptom in old age. a population-based study of 4486 Danish twins aged 70-102
    Jan Hartvigsen
    Nordic Institute of Chiropractic and Clinical Biomechanics, Klosterbakken 20, 5000, Odense C, Denmark
    Eur Spine J 12:528-34. 2003
    ..We conclude that BP is a common symptom in old age; however, the prevalence does not change with increasing age. BP may be part of a more general syndrome of poor health among the old...
  40. ncbi request reprint Selective serotonin reuptake inhibitors and the risk of stroke: a population-based case-control study
    Søren Bak
    Departments of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Stroke 33:1465-73. 2002
    ..We used population-based data to estimate the risk of hemorrhagic and ischemic stroke in users of SSRIs...
  41. pmc Candidate region linkage analysis in twins discordant or concordant for depression symptomatology
    L Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Am J Med Genet B Neuropsychiatr Genet 150:581-4. 2009
    ..91 for marker D12S1634 located at 148 cM, and thus indicates that the previously identified disease locus at 12q24 is also a general vulnerability locus affecting the normal range of mood...
  42. ncbi request reprint The 20th century Danish facial cleft population--epidemiological and genetic-epidemiological studies
    K Christensen
    Institute of Public Health, Epidemiology, Odense University, Denmark
    Cleft Palate Craniofac J 36:96-104. 1999
    ..The review also points toward the excellent opportunities for continued etiological CLP research in Denmark in the 21st century using already established resources and an on-going prospective cohort study of 100,000 pregnant women...
  43. ncbi request reprint A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival
    L Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark
    Mech Ageing Dev 127:597-9. 2006
    ..To our knowledge, this is the first longitudinal study exploring the influence of GST gene polymorphisms on longevity and these data implies that GST gene copy numbers do affect mortality risk in the elderly...
  44. ncbi request reprint Power of non-parametric linkage analysis in mapping genes contributing to human longevity in long-lived sib-pairs
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Genet Epidemiol 26:245-53. 2004
    ....
  45. pmc Marital status and twins' health and behavior: an analysis of middle-aged Danish twins
    Merete Osler
    Danish Ageing Research Center Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Psychosom Med 70:482-7. 2008
    ..We compared health status among same-sex male and female twin pairs who lived together during childhood and were discordant or concordant on adult marital status...
  46. ncbi request reprint Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts
    T H Brix
    Department of Endocrinology, Odense University Hospital, Denmark
    J Clin Endocrinol Metab 86:930-4. 2001
    ..In conclusion, our study strongly supports the idea that genetic factors play a major role in the etiology of GD and suggest that a further search for susceptibility genes is worthwhile...
  47. ncbi request reprint Evidence for a substantial genetic influence on biochemical liver function tests: results from a population-based Danish twin study
    L Bathum
    Department of Clinical Biochemistry, Odense University Hospital, DK 5000 Odense C, Denmark
    Clin Chem 47:81-7. 2001
    ..The aim of the present study was to estimate the relative importance of genetic and environmental factors to variations in these tests among the elderly...
  48. ncbi request reprint No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Eur J Hum Genet 13:1154-8. 2005
    ....
  49. ncbi request reprint Estimating haplotype relative risks on human survival in population-based association studies
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, DK 5000 Odense, Denmark
    Hum Hered 59:88-97. 2005
    ..Results from both simulation and model application indicate that our survival analysis model is an efficient method for inferring haplotype effects on human survival in population-based association studies...
  50. ncbi request reprint Hair loss among elderly men: etiology and impact on perceived age
    Helle Rexbye
    The Danish Twin Registry, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    J Gerontol A Biol Sci Med Sci 60:1077-82. 2005
    ..Here we used a population-based twin study of men aged 70+ to assess the magnitude of the genetic component affecting hair loss and to examine the association between baldness and perceived age...
  51. pmc Lifetime according to health status among the oldest olds in Denmark
    Henrik Brønnum-Hansen
    National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5 A, DK 1399, Copenhagen, Denmark
    Age Ageing 38:47-51. 2009
    ..The purpose of this study was to quantify the average lifetime according to health status among the oldest olds in Denmark...
  52. ncbi request reprint Apolipoprotein e genotypes: relationship to cognitive functioning, cognitive decline, and survival in nonagenarians
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    J Am Geriatr Soc 54:654-8. 2006
    ..To evaluate the extent to which relationships between apolipoprotein E, cognitive functioning, and survival in people aged 60 to 80 persist into advanced old age...
  53. pmc Genetic association analysis of human longevity in cohort studies of elderly subjects: an example of the PON1 gene in the Danish 1905 birth cohort
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, DK 5000 Odense, Denmark
    Genetics 172:1821-8. 2006
    ....
  54. ncbi request reprint Predictors of mortality in 2,249 nonagenarians--the Danish 1905-Cohort Survey
    Hanne Nybo
    Danish Center for Demographic Research, Epidemiology, Institute of Public Health and Aging Research Center, University of Southern Denmark, Odense
    J Am Geriatr Soc 51:1365-73. 2003
    ..To elucidate whether well-known predictions of mortality are reduced or even reversed, or whether mortality is a stochastic process in the oldest old...
  55. ncbi request reprint Back and neck pain exhibit many common features in old age: a population-based study of 4,486 Danish twins 70-102 years of age
    Jan Hartvigsen
    Nordic Institute of Chiropractic and Clinical Biomechanics, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    Spine (Phila Pa 1976) 29:576-80. 2004
    ..Cross-sectional and longitudinal analysis of data comprising 4486 Danish twins 70-102 years of age...
  56. ncbi request reprint The danish twin registry: past and present
    Bent Harvald
    The Danish Twin Registry, Epidemiology, Department of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 7:318-35. 2004
    ..The Danish Twin Registry was established formally in 1954 and thus celebrates its 50th anniversary in 2004. Here we give an account of its founding and the early years, and a brief summary of more recent progress...
  57. ncbi request reprint Self-rated health and age: a cross-sectional and longitudinal study of 11,000 Danes aged 45-102
    Frank Krarup Andersen
    Epidemiology, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    Scand J Public Health 35:164-71. 2007
    ..The aim of this study was to explore and describe self-rated health in middle-aged and elderly Danes using both a cross-sectional and a longitudinal design. Global and (age) comparative self-rated health are examined and compared...
  58. doi request reprint Adult glucose metabolism in extremely birthweight-discordant monozygotic twins
    M Frost
    The Danish Twin Registry, Department of Epidemiology, University of Southern Denmark, JB Winsløvsvej 9, Odense C, Denmark
    Diabetologia 55:3204-12. 2012
    ..Low birthweight (BW) is associated with increased risk of type 2 diabetes. We compared glucose metabolism in adult BW-discordant monozygotic (MZ) twins, thereby controlling for genetic factors and rearing environment...
  59. ncbi request reprint Early exposure to smoking and future fecundity among Danish twins
    T K Jensen
    Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Int J Androl 29:603-13. 2006
    ..65; 95% CI 0.47-0.91). This study supports that smoking is hazardous to the female fetus not only in the short term but also affects her future ability to conceive and makes it even more important to advise pregnant women to stop smoking...
  60. ncbi request reprint Paraoxonase 1 polymorphisms and survival
    L Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Eur J Hum Genet 12:843-7. 2004
    ....
  61. ncbi request reprint Genetic and environmental influences on self-reported reduced hearing in the old and oldest old
    K Christensen
    Danish Twin Registry, Institute of Public Health, and the Danish Center for Demographic Research, Odense
    J Am Geriatr Soc 49:1512-7. 2001
    ....
  62. ncbi request reprint Genetic and environmental factors in epilepsy: a population-based study of 11900 Danish twin pairs
    M J Kjeldsen
    Department of Neurology, Odense University Hospital, Odense, Denmark
    Epilepsy Res 44:167-78. 2001
    ..In conclusion, this study has confirmed the substantial impact, which genetic factors have in the etiology of epilepsy. The heritability of epilepsy is high and seems to increase with age...
  63. pmc Risk of subarachnoid haemorrhage in first degree relatives of patients with subarachnoid haemorrhage: follow up study based on national registries in Denmark
    D Gaist
    Epidemiology, Institute of Public Health, Universtity of Southern Denmark, Odense University, DK 5000 Odense C, Denmark
    BMJ 320:141-5. 2000
    ..To estimate the risk of occurrence of subarachnoid haemorrhage in first degree relatives (parents, siblings, children) of patients with subarachnoid haemorrhage...
  64. pmc Infertility, infertility treatment and twinning: the Danish National Birth Cohort
    Jin Liang Zhu
    Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus C, Denmark
    Hum Reprod 22:1086-90. 2007
    ..By using updated information, we assessed the frequencies of dizygotic (DZ) and monozygotic (MZ) twin deliveries as a function of infertility (TTP > 12 months), as well as infertility treatment...
  65. ncbi request reprint Genetic variation in estrogen receptor, C-reactive protein and fibrinogen does not predict the plasma levels of inflammation markers after longterm hormone replacement therapy
    Moniek P M de Maat
    Department for Thrombosis Research, Institute of Public Health, University of Southern Denmark, Denmark
    Thromb Haemost 97:234-9. 2007
    ..In conclusion, higher plasma levels of CRP and lower plasma levels of fibrinogen were observed in women using HRT; however, genetic polymorphisms in ESR1, CRP and FGB were not associated with these effects of HRT...
  66. ncbi request reprint Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians
    Lise Bathum
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, DK 5000 Odense C, Denmark
    J Gerontol A Biol Sci Med Sci 62:196-201. 2007
    ..Two common polymorphisms in the genes coding for methylenetetrahydrofolate reductase (MTHFR 677C>T) and methionine synthase (MTR 2756A>G) have an impact on plasma homocysteine level...
  67. ncbi request reprint Leukocyte telomere length is inversely correlated with plasma Von Willebrand factor
    Jacob v B Hjelmborg
    The Danish Aging Research Center and Research unit of Biostatistics, Institute of Public Health, University of Southern Denmark
    Thromb Res 125:e339-42. 2010
    ..Such a process would heighten the rate of age-dependent LTL attrition, ultimately resulting in shortened LTL...
  68. ncbi request reprint Influence of environmental factors on facial ageing
    Helle Rexbye
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, DK 5000 Odense, Denmark
    Age Ageing 35:110-5. 2006
    ..A recent twin study has shown that 'looking old for one's age' is associated with increased mortality. Approximately 40% of the variation in perceived age is due to non-genetic factors...
  69. ncbi request reprint Genetic factors in seizures: a population-based study of 47,626 US, Norwegian and Danish twin pairs
    Marianne J Kjeldsen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res Hum Genet 8:138-47. 2005
    ..This sample is likely to provide an important resource for studying the genetics of epilepsy subtypes and febrile seizures...
  70. doi request reprint Early-life environment influencing susceptibility to cytomegalovirus infection: evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins
    L H Mortensen
    Unit of Epidemiology, University of Southern Denmark, Odense, Denmark
    Epidemiol Infect 140:835-41. 2012
    ..Our findings suggest that susceptibility to CMV infection--even under continuous within-partnership exposure--appears to be more strongly influenced by early-life environment than by genetic factors and adult environment...
  71. ncbi request reprint Modest implication of interleukin-6 promoter polymorphisms in longevity
    L Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Mech Ageing Dev 125:391-5. 2004
    ..We found a modest, but significant, increase in the frequency of interleukin-6 -174GG homozygotes with age suggesting that this genotype is advantageous for longevity...
  72. ncbi request reprint Analysis of functional abilities for elderly Danish twins using GEE models
    Maria Iachina
    Department of Statistics and Demography, University of Southern Denmark, Odense
    Twin Res 5:289-93. 2002
    ....
  73. pmc Back and neck pain in seniors-prevalence and impact
    Jan Hartvigsen
    Nordic Institute of Chiropractic and Clinical Biomechanics, Research, Odense C, Denmark
    Eur Spine J 15:802-6. 2006
    ..NP and BP in seniors are probably associated with difficulty but not inability to perform daily activities...
  74. ncbi request reprint Stroke research in GenomEUtwin
    David Gaist
    Danish Twin Registry, University of Southern Denmark, Denmark
    Twin Res 6:442-7. 2003
    ..This information illustrates that the number of affected sib pairs for linkage studies is relatively limited, but the sample sizes are promising for association studies...
  75. ncbi request reprint Physical and mental function and incident low back pain in seniors: a population-based two-year prospective study of 1387 Danish Twins aged 70 to 100 years
    Jan Hartvigsen
    Nordic Institute of Chiropractic and Clinical Biomechanics, Clinical Locomotion Science, Odense, Denmark
    Spine (Phila Pa 1976) 31:1628-32. 2006
    ..Prospective cohort study...
  76. ncbi request reprint Angiotensin I-converting enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival--a follow-up study of elderly Danish twins
    Henrik Frederiksen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Main Campus Odense University, Odense, Denmark
    Ann Epidemiol 13:57-65. 2003
    ..Using a longitudinal study of elderly twins we studied the association between ACE genotype and physical and cognitive functioning and survival in old age...
  77. ncbi request reprint Apolipoprotein E genotype frequency patterns in aged Danes as revealed by logistic regression models
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Eur J Epidemiol 19:651-6. 2004
    ....
  78. pmc Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project
    A Skytthe
    Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winsløws Vej 9B, Odense, Denmark
    Exp Gerontol 46:934-45. 2011
    ..Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity...
  79. ncbi request reprint The influence of genetic factors on physical functioning and exercise in second half of life
    H Frederiksen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, DK 5000 Odense, Denmark
    Scand J Med Sci Sports 13:9-18. 2003
    ..Here, we summarise the evidence currently available for a genetic influence on physical functioning and disposition to leisure time physical activity with a focus on recent Danish twin data...
  80. ncbi request reprint Association of mutations in the hemochromatosis gene with shorter life expectancy
    L Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Sdr Blvd 29, DK 5000 Odense C, Denmark
    Arch Intern Med 161:2441-4. 2001
    ..It is of value in the debate concerning screening for hereditary hemochromatosis to determine the significance of heterozygosity...
  81. pmc Increased effect of the ApoE gene on survival at advanced age in healthy and long-lived Danes: two nationwide cohort studies
    Rune Jacobsen
    Danish Aging Research Center, Epidemiology, University of Southern Denmark, JB Winsløws Vej 9B, DK 5000 Odense C, Denmark
    Aging Cell 9:1004-9. 2010
    ....
  82. pmc Cross-national comparison of sex differences in health and mortality in Denmark, Japan and the US
    Anna Oksuzyan
    The Danish Aging Research Center, Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winsløws Vej 9B, 5000, Odense, Denmark
    Eur J Epidemiol 25:471-80. 2010
    ..The present study revealed consistent sex differentials in survival and physical health, self-rated health and cognition at older ages, whereas the pattern of sex differences in depressive symptoms was country-specific...
  83. pmc Recurrence risk for offspring of twins discordant for oral cleft: a population-based cohort study of the Danish 1936-2004 cleft twin cohort
    Dorthe Grosen
    Department of Epidemiology, University of Southern Denmark, Odense, Denmark
    Am J Med Genet A 152:2468-74. 2010
    ..This provides further evidence for a genetic component in cleft etiology and is useful information for genetic counseling of twin pairs discordant for clefting...
  84. doi request reprint Good semen quality and life expectancy: a cohort study of 43,277 men
    Tina Kold Jensen
    Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Winsloewsparken 17, 5000 Odense C, Denmark
    Am J Epidemiol 170:559-65. 2009
    ..Semen quality may therefore be a fundamental biomarker of overall male health...
  85. pmc Power for genetic association study of human longevity using the case-control design
    Qihua Tan
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense C, Denmark
    Am J Epidemiol 168:890-6. 2008
    ..Power is drastically reduced when nonagenarians are considered cases, with a more than 5-fold difference in the size of the case sample required to achieve comparable power as that found with centenarians...
  86. pmc Sex differential in mortality trends of old-aged Danes: a nation wide study of age, period and cohort effects
    Rune Jacobsen
    Institute of Public Health, Epidemiology, University of Southern Denmark, Odense C, Denmark
    Eur J Epidemiol 23:723-30. 2008
    ..This can provide clues for where to search for causes behind the changes in sex differential in mortality seen in many Western countries during the last decades...
  87. pmc Cohort changes in cognitive function among Danish centenarians. A comparative study of 2 birth cohorts born in 1895 and 1905
    Henriette Engberg
    Danish Aging Research Center, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Dement Geriatr Cogn Disord 26:153-60. 2008
    ..The objective was to examine cohort changes in cognitive function in 2 cohorts of centenarians born 10 years apart...
  88. pmc Differential and correlation analyses of microarray gene expression data in the CEPH Utah families
    Qihua Tan
    Department of Biochemistry, Pharmacology, and Genetics, Odense University Hospital, Denmark
    Genomics 92:94-100. 2008
    ..In addition, we observe an interesting pattern of sibship correlation on gene expression that increases exponentially with the mean of gene expression reflecting the enhanced genetic control over the functionally active genes...
  89. ncbi request reprint Epileptic seizures and syndromes in twins: the importance of genetic factors
    Marianne Juel Kjeldsen
    Department of Neurology, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense C, Denmark
    Epilepsy Res 55:137-46. 2003
    ....
  90. ncbi request reprint Characteristics of middle-aged and elderly women with urinary incontinence
    Gitte Rohr
    Research Unit for General Practice, Institute of Public Health, University of Southern Denmark, J B Winsløws Vej 9A, 5000 Odense C, Denmark
    Scand J Prim Health Care 23:203-8. 2005
    ..To describe the prevalence of urinary incontinence and to find characteristics useful in general practice for identifying middle-aged and elderly women with the problem...
  91. ncbi request reprint Age- and sex-differences in the validity of questionnaire-based zygosity in twins
    Lene Christiansen
    The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 6:275-8. 2003
    ..The results demonstrate that questionnaire based zygosity diagnosis can still be regarded as a valid and valuable classification method for most purposes...
  92. pmc Cancer risk in persons with oral cleft--a population-based study of 8,093 cases
    Camilla Bille
    Center for the Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Am J Epidemiol 161:1047-55. 2005
    ..14, 6.78), and primary lung cancer among males born with both cleft lip and cleft palate (SIR = 2.49, 95% CI: 1.00, 5.14). The results do not provide evidence for an increased overall cancer risk for individuals born with oral clefts...
  93. ncbi request reprint The catalase -262C/T promoter polymorphism and aging phenotypes
    Lene Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark
    J Gerontol A Biol Sci Med Sci 59:B886-9. 2004
    ..The results raise the hypothesis that the catalase -262T allele serves as protection against neurodegenerative and physical decline, although replication in other studies is warranted for confirmation of these findings...
  94. ncbi request reprint Genetic and environmental influences on urinary incontinence: a Danish population-based twin study of middle-aged and elderly women
    Gitte Rohr
    Research Unit of General Practice, University of Southern Denmark, Odense, Denmark
    Acta Obstet Gynecol Scand 83:978-82. 2004
    ..Familial clustering has been reported for urinary incontinence (stress and urge), but different etiologies for the two types of incontinence have been suggested...
  95. ncbi request reprint Cessation of smoking after first-ever stroke: a follow-up study
    Søren Bak
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark
    Stroke 33:2263-9. 2002
    ..We used data from a prospective follow-up study to assess modification of smoking habits and to identify predictors of persistent smoking after first-ever stroke...
  96. ncbi request reprint Socioeconomic position and twins' health: a life-course analysis of 1266 pairs of middle-aged Danish twins
    Merete Osler
    Institute of Public Health Epidemiology, University of Southern Denmark, JB Winsløws Vej 9B, 5000 Odense C, Denmark
    Int J Epidemiol 36:77-83. 2007
    ....
  97. ncbi request reprint Oral clefts and life style factors--a case-cohort study based on prospective Danish data
    Camilla Bille
    Center for the Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, J B Winsløwsvej 9B, 5000 Odense C, Denmark
    Eur J Epidemiol 22:173-81. 2007
    ..The present study found an association between oral clefts and smoking and, although not conclusive, supports an association of oral cleft with alcohol...
  98. pmc Power assessment for genetic association study of human longevity using offspring of long-lived subjects
    Qihua Tan
    Epidemiology, Institute of Public Health, University of Southern Denmark, Winsløws Vej 9B, 5000, Odense, Denmark
    Eur J Epidemiol 25:501-6. 2010
    ..In conclusion, the indirect design can be a good choice for studying longevity in comparison with other alternatives, when relatively large sample size is available...
  99. pmc Does the association of education with breast cancer replicate within twin pairs? A register-based study on Danish female twins
    M Madsen
    Unit of Epidemiology, University of Southern Denmark, The Danish Twin Registry, DARC, University of Southern Denmark
    Br J Cancer 104:520-3. 2011
    ..A positive association between socio-economic position and breast cancer has been widely observed, but not hitherto within twin pairs, where shared familial factors were adjusted for...
  100. ncbi request reprint Comparison of assessment methods for self-reported alcohol consumption in health interview surveys
    O Ekholm
    National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Eur J Clin Nutr 62:286-91. 2008
    ..To select a simple method for assessing alcohol consumption and to compare how different reference periods and response categories influence the self-reported frequency of binge drinking...
  101. pmc Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway
    S Dato
    Department of Biology, Ecology and Heart Sciences, University of Calabria, Ponte Pietro Bucci cubo 4C, 87036 Rende, CS, Italy The Danish Aging Research Center, Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winslows Vej 9B, 5000 Odense C, Denmark Electronic address
    Exp Gerontol 52:23-9. 2014
    ..Overall, our work supports the evidence that genes belonging to the pro-anti-oxidant pathway are able to modulate physical and cognitive performance after the ninth decade of life, finally influencing extreme survival. ..

Research Grants4

  1. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2003
    ..This study will provide a new level of understanding for a complex birth defect trait. ..
  2. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2004
    ..This study will provide a new level of understanding for a complex birth defect trait. ..
  3. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2005
    ..This study will provide a new level of understanding for a complex birth defect trait. ..
  4. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006
    ..This study will provide a new level of understanding for a complex birth defect trait. ..