Jakob Christensen

..FPIA also proved precise and accurate, and there was a high agreement with the LC/MS/MS assay in plasma and CSF. Either method displayed sufficient precision and accuracy and may thus be implemented in daily routine...

..Despite several interventions used to prevent posttraumatic epilepsy, the only proven "intervention" to date is to prevent TBI from occurring...

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..This study evaluates the pharmacokinetic interaction between sertraline and lamotrigine in psychiatric patients...

..The goal of the study described here was to study the risk for epilepsy in parents exposed to severe stress caused by loss of a child...

..To estimate the occurrence of epilepsy in Denmark between 1977 and 2002, taking gender, age, and secular trends into consideration...

..To validate the diagnosis of epilepsy in the Danish National Hospital Register...

..Studies have linked epilepsy with an increased suicide risk, but the association might be modified by psychiatric, demographic, and socioeconomic factors...

..This study evaluates the effect of oral contraceptives on lamotrigine (LTG) plasma concentrations and urine excretion of LTG metabolites in a double-blind, placebo-controlled, crossover study in patients with epilepsy...

..0016), being 72% (SD = 13%) in the first trimester, 74% (SD = 17%) in the second trimester, 64% (SD = 6%) in the third trimester, and 108% (SD = 18%) after pregnancy vs the dose-corrected concentration before pregnancy...

..Plasma levels of cabergoline were analyzed in one of the patients and increased to approximately 300% during treatment with itraconazole, which paralleled major clinical improvement...

..To establish the concentration response of topiramate in patients with refractory focal epilepsy...

..The aim of this study was to look at gender differences in unselected populations of patients with epilepsy classified according to the 1989 International League Against Epilepsy (ILAE) criteria...

..Most injury studies have focused on proximal causes; few have examined the role of neonatal characteristics such as birth weight and gestational age...

..To examine whether prenatal exposure to maternal bereavement is associated with an increased risk of epilepsy in the first decades of life...

..No studies have had sufficient size to estimate mortality in children with febrile seizures. We studied mortality after febrile seizures in a large population-based cohort of children in Denmark with up to 28 years of follow-up...

..We asked whether breastfeeding reduces the risk of epilepsy in childhood...

..The results are exploratory, however, and need to be replicated...

..We studied congenital abnormalities following exposure to phenytoin, phenobarbital, and diazepam in early pregnancy, i.e., second and third month, compared to mid-pregnancy, i.e., fifth and sixth month of pregnancy...

..In Denmark, acellular pertussis vaccine has been included in the combined diphtheria-tetanus toxoids-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine since September 2002...

..We aimed to examine whether prenatal stress exposure after maternal bereavement is associated with an increased risk of autism later in life...

..Eclampsia has been found to be a strong risk factor for epilepsy in the offspring, but it is unclear whether the risk also applies to the preceding condition, preeclampsia...

..Only few studies have addressed the long-term neurological outcomes of children born by subfertile couples. We studied the risk of epilepsy and febrile seizures in children of treated and untreated subfertile couples...

..To estimate if maternal intake of n-3 long-chain polyunsaturated fatty acids (LCPUFA) during pregnancy is related to the risk of epilepsy in the offspring...

..The risk was higher for those who had a family history of epilepsy, cerebral palsy, or low Apgar scores at 5 minutes...

..0-39.4°C (IRR = 2.79, 95% CI 1.60, 4.84). Our findings do not support a strong association between hyperthermia and epilepsy but the associations between underlying causes of fever, especially prenatal infections, call for more research...

..Febrile seizure is a benign condition for most children, but experiments in animals and neuroimaging studies in humans suggest that some febrile seizures may damage the hippocampus, a brain area of possible importance in schizophrenia...

..We examined the quality and completeness of the discharge diagnosis of febrile seizures in the Danish National Hospital Register (DNHR)...

..In conclusion, short gestational age, low birth weight, and intrauterine growth restriction are associated with an increased risk of epilepsy...

..We aimed to assess the risk of epilepsy up to 10 years or longer after traumatic brain injury, taking into account sex, age, severity, and family history...

..Febrile seizure is a common condition with a benign outcome for the vast majority of children. Genes and environmental factors operating in early life seem to play a causal role...

..0001), indicating that LTG plasma levels are reduced by >50% during OC co-medication. It is advisable to monitor LTG plasma levels in conjunction with initiation or withdrawal of OC in women on LTG therapy...

..We estimated the association between prenatal exposure to maternal infections and the subsequent risk for epilepsy in childhood...

..The specialist service should include a multidisciplinary team. Epilepsy surgery should be considered early in patients with refractory focal epilepsy...

..Low Apgar scores are associated with high risk of neonatal death, cerebral palsy, and mental retardation, but the association between Apgar scores and long-term risk of epilepsy remains unresolved...

..The calibration models showed that the signal separation due the analytes 2,4-dinitrophenol (2,4-DNP) and 4-nitrophenol (4-NP) was possible with a prediction concentration error of 1.4 microM and 72 microM, respectively...