Jakob Christensen

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. ncbi request reprint Liquid chromatography tandem mass spectrometry assay for topiramate analysis in plasma and cerebrospinal fluid: validation and comparison with fluorescence-polarization immunoassay
    Jakob Christensen
    Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark
    Ther Drug Monit 24:658-64. 2002
  2. doi request reprint Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    JAMA 309:1696-703. 2013
  3. doi request reprint Traumatic brain injury: risks of epilepsy and implications for medicolegal assessment
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Epilepsia 53:43-7. 2012
  4. doi request reprint Epidemiology of epilepsy in adults: implementing the ILAE classification and terminology into population-based epidemiologic studies
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Epilepsia 53:14-7. 2012
  5. doi request reprint Lack of interaction between sertraline and lamotrigine in psychiatric patients: a retrospective study
    J Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Pharmacopsychiatry 45:119-21. 2012
  6. ncbi request reprint Incidence and prevalence of epilepsy in Denmark
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Epilepsy Res 76:60-5. 2007
  7. ncbi request reprint Validation of epilepsy diagnoses in the Danish National Hospital Register
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Epilepsy Res 75:162-70. 2007
  8. ncbi request reprint Epilepsy and risk of suicide: a population-based case-control study
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Denmark
    Lancet Neurol 6:693-8. 2007
  9. ncbi request reprint Oxcarbazepine concentrations during pregnancy: a retrospective study in patients with epilepsy
    Jakob Christensen
    Department of Clinical Pharmacology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Neurology 67:1497-9. 2006
  10. ncbi request reprint Stress and epilepsy: a population-based cohort study of epilepsy in parents who lost a child
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Norrebrogade 44, DK 8000, Aarhus C, Denmark
    Epilepsy Behav 11:324-8. 2007

Detail Information

Publications41

  1. ncbi request reprint Liquid chromatography tandem mass spectrometry assay for topiramate analysis in plasma and cerebrospinal fluid: validation and comparison with fluorescence-polarization immunoassay
    Jakob Christensen
    Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark
    Ther Drug Monit 24:658-64. 2002
    ..Comparison is made with the commercially available fluorescence-polarization immunoassay (FPIA)...
  2. doi request reprint Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    JAMA 309:1696-703. 2013
    ..Valproate is used for the treatment of epilepsy and other neuropsychological disorders and may be the only treatment option for women of childbearing potential. However, prenatal exposure to valproate may increase the risk of autism...
  3. doi request reprint Traumatic brain injury: risks of epilepsy and implications for medicolegal assessment
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Epilepsia 53:43-7. 2012
    ..Despite several interventions used to prevent posttraumatic epilepsy, the only proven "intervention" to date is to prevent TBI from occurring...
  4. doi request reprint Epidemiology of epilepsy in adults: implementing the ILAE classification and terminology into population-based epidemiologic studies
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Epilepsia 53:14-7. 2012
    ....
  5. doi request reprint Lack of interaction between sertraline and lamotrigine in psychiatric patients: a retrospective study
    J Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Pharmacopsychiatry 45:119-21. 2012
    ..This study evaluates the pharmacokinetic interaction between sertraline and lamotrigine in psychiatric patients...
  6. ncbi request reprint Incidence and prevalence of epilepsy in Denmark
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Epilepsy Res 76:60-5. 2007
    ..To estimate the occurrence of epilepsy in Denmark between 1977 and 2002, taking gender, age, and secular trends into consideration...
  7. ncbi request reprint Validation of epilepsy diagnoses in the Danish National Hospital Register
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Epilepsy Res 75:162-70. 2007
    ..To validate the diagnosis of epilepsy in the Danish National Hospital Register...
  8. ncbi request reprint Epilepsy and risk of suicide: a population-based case-control study
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Denmark
    Lancet Neurol 6:693-8. 2007
    ..Studies have linked epilepsy with an increased suicide risk, but the association might be modified by psychiatric, demographic, and socioeconomic factors...
  9. ncbi request reprint Oxcarbazepine concentrations during pregnancy: a retrospective study in patients with epilepsy
    Jakob Christensen
    Department of Clinical Pharmacology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Neurology 67:1497-9. 2006
    ..0016), being 72% (SD = 13%) in the first trimester, 74% (SD = 17%) in the second trimester, 64% (SD = 6%) in the third trimester, and 108% (SD = 18%) after pregnancy vs the dose-corrected concentration before pregnancy...
  10. ncbi request reprint Stress and epilepsy: a population-based cohort study of epilepsy in parents who lost a child
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Norrebrogade 44, DK 8000, Aarhus C, Denmark
    Epilepsy Behav 11:324-8. 2007
    ..The goal of the study described here was to study the risk for epilepsy in parents exposed to severe stress caused by loss of a child...
  11. ncbi request reprint Gender differences in epilepsy
    Jakob Christensen
    Department of Clinical Pharmacology, University of Aarhus, Aarhus, Denmark
    Epilepsia 46:956-60. 2005
    ..The aim of this study was to look at gender differences in unselected populations of patients with epilepsy classified according to the 1989 International League Against Epilepsy (ILAE) criteria...
  12. ncbi request reprint [Antiepileptic treatment of adults with epilepsy]
    Jakob Christensen
    Arhus Universitetshospital, Arhus Sygehus, Neurologisk afdeling
    Ugeskr Laeger 166:3929-31. 2004
  13. ncbi request reprint Randomized, concentration-controlled trial of topiramate in refractory focal epilepsy
    Jakob Christensen
    Department of Clinical Pharmacology, Aarhus University, Denmark
    Neurology 61:1210-8. 2003
    ..To establish the concentration response of topiramate in patients with refractory focal epilepsy...
  14. ncbi request reprint Cabergoline plasma concentration is increased during concomitant treatment with itraconazole
    Jakob Christensen
    Centre for Clinical Pharmacology, University of Aarhus, Aarhus, Denmark
    Mov Disord 17:1360-2. 2002
    ..Plasma levels of cabergoline were analyzed in one of the patients and increased to approximately 300% during treatment with itraconazole, which paralleled major clinical improvement...
  15. ncbi request reprint Oral contraceptives induce lamotrigine metabolism: evidence from a double-blind, placebo-controlled trial
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Epilepsia 48:484-9. 2007
    ..This study evaluates the effect of oral contraceptives on lamotrigine (LTG) plasma concentrations and urine excretion of LTG metabolites in a double-blind, placebo-controlled, crossover study in patients with epilepsy...
  16. doi request reprint Prenatal stress and epilepsy in later life: a nationwide follow-up study in Denmark
    Jiong Li
    Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus C, Denmark
    Epilepsy Res 81:52-7. 2008
    ..To examine whether prenatal exposure to maternal bereavement is associated with an increased risk of epilepsy in the first decades of life...
  17. doi request reprint Gestational age, birth weight, and risk for injuries in childhood
    Yuelian Sun
    Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark
    Epidemiology 21:650-7. 2010
    ..Most injury studies have focused on proximal causes; few have examined the role of neonatal characteristics such as birth weight and gestational age...
  18. doi request reprint Death in children with febrile seizures: a population-based cohort study
    Mogens Vestergaard
    Department of General Practice, Institute of Public Health, Aarhus University, Aarhus, Denmark
    Lancet 372:457-63. 2008
    ..No studies have had sufficient size to estimate mortality in children with febrile seizures. We studied mortality after febrile seizures in a large population-based cohort of children in Denmark with up to 28 years of follow-up...
  19. doi request reprint A nationwide study on the risk of autism after prenatal stress exposure to maternal bereavement
    Jiong Li
    Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark
    Pediatrics 123:1102-7. 2009
    ..We aimed to examine whether prenatal stress exposure after maternal bereavement is associated with an increased risk of autism later in life...
  20. doi request reprint Breastfeeding and risk of epilepsy in childhood: a birth cohort study
    Yuelian Sun
    Department of Epidemiology, School of Public Health, University of Aarhus, Aarhus, Denmark
    J Pediatr 158:924-9. 2011
    ..We asked whether breastfeeding reduces the risk of epilepsy in childhood...
  21. doi request reprint Binge drinking during pregnancy and risk of seizures in childhood: a study based on the Danish National Birth Cohort
    Yuelian Sun
    Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus C, Denmark
    Am J Epidemiol 169:313-22. 2009
    ..The results are exploratory, however, and need to be replicated...
  22. ncbi request reprint Epilepsy and febrile seizures in children of treated and untreated subfertile couples
    Yuelian Sun
    The Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark
    Hum Reprod 22:215-20. 2007
    ..Only few studies have addressed the long-term neurological outcomes of children born by subfertile couples. We studied the risk of epilepsy and febrile seizures in children of treated and untreated subfertile couples...
  23. ncbi request reprint Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study
    Dorte Kjaer
    The Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark
    Pharmacoepidemiol Drug Saf 16:181-8. 2007
    ..We studied congenital abnormalities following exposure to phenytoin, phenobarbital, and diazepam in early pregnancy, i.e., second and third month, compared to mid-pregnancy, i.e., fifth and sixth month of pregnancy...
  24. doi request reprint Risk of febrile seizures and epilepsy after vaccination with diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Haemophilus influenzae type B
    Yuelian Sun
    Department of Public Health, Aarhus University, Bartholins Alle 2, DK 8000 Aarhus C, Denmark
    JAMA 307:823-31. 2012
    ..In Denmark, acellular pertussis vaccine has been included in the combined diphtheria-tetanus toxoids-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine since September 2002...
  25. doi request reprint Intake of marine n-3 fatty acids during pregnancy and risk for epilepsy in the offspring: a population-based cohort study
    Yuelian Sun
    Department of Epidemiology, School of Public Health, University of Aarhus, Bartholins Alle 2, 8000 C, Aarhus, Denmark
    Epilepsy Res 91:267-72. 2010
    ..To estimate if maternal intake of n-3 long-chain polyunsaturated fatty acids (LCPUFA) during pregnancy is related to the risk of epilepsy in the offspring...
  26. doi request reprint Preeclampsia and risk for epilepsy in offspring
    Chun Sen Wu
    Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark
    Pediatrics 122:1072-8. 2008
    ..Eclampsia has been found to be a strong risk factor for epilepsy in the offspring, but it is unclear whether the risk also applies to the preceding condition, preeclampsia...
  27. ncbi request reprint The long-term risk of epilepsy after febrile seizures in susceptible subgroups
    Mogens Vestergaard
    Department of General Practice, Institute of Public Health, Aarhus University, Aarhus, Denmark
    Am J Epidemiol 165:911-8. 2007
    ..The risk was higher for those who had a family history of epilepsy, cerebral palsy, or low Apgar scores at 5 minutes...
  28. ncbi request reprint Febrile seizures and risk of schizophrenia
    Mogens Vestergaard
    The Danish Epidemiology Science Centre, Department of Epidemiology and Social Medicine, University of Aarhus, Vennelyst Boulevard 6, Building 260, DK 8000 Aarhus C, Denmark
    Schizophr Res 73:343-9. 2005
    ..Febrile seizure is a benign condition for most children, but experiments in animals and neuroimaging studies in humans suggest that some febrile seizures may damage the hippocampus, a brain area of possible importance in schizophrenia...
  29. ncbi request reprint The Danish National Hospital Register is a valuable study base for epidemiologic research in febrile seizures
    Mogens Vestergaard
    The Danish Epidemiology Science Center at the Department of Epidemiology and Social Medicine, University of Aarhus, Vennelyst Boulevard 6, DK 8000 Aarhus C, Denmark
    J Clin Epidemiol 59:61-6. 2006
    ..We examined the quality and completeness of the discharge diagnosis of febrile seizures in the Danish National Hospital Register (DNHR)...
  30. doi request reprint Prenatal exposure to elevated maternal body temperature and risk of epilepsy in childhood: a population-based pregnancy cohort study
    Yuelian Sun
    Department of Epidemiology, University of Aarhus, Aarhus, Denmark
    Paediatr Perinat Epidemiol 25:53-9. 2011
    ..0-39.4°C (IRR = 2.79, 95% CI 1.60, 4.84). Our findings do not support a strong association between hyperthermia and epilepsy but the associations between underlying causes of fever, especially prenatal infections, call for more research...
  31. pmc Gestational age, birth weight, intrauterine growth, and the risk of epilepsy
    Yuelian Sun
    Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark
    Am J Epidemiol 167:262-70. 2008
    ..In conclusion, short gestational age, low birth weight, and intrauterine growth restriction are associated with an increased risk of epilepsy...
  32. pmc Prenatal antidepressant exposure and risk of spontaneous abortion - a population-based study
    Maiken Ina Siegismund Kjaersgaard
    Department of Public Health, Section for Biostatistics, Aarhus University, Aarhus, Denmark
    PLoS ONE 8:e72095. 2013
    ..To estimate the risk of spontaneous abortion after use of antidepressant medication during pregnancy...
  33. doi request reprint Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Lancet 373:1105-10. 2009
    ..We aimed to assess the risk of epilepsy up to 10 years or longer after traumatic brain injury, taking into account sex, age, severity, and family history...
  34. doi request reprint Register-based studies on febrile seizures in Denmark
    Mogens Vestergaard
    Department of General Practice, Institute of Public Health, Aarhus University, Aarhus, Denmark
    Brain Dev 31:372-7. 2009
    ..Febrile seizure is a common condition with a benign outcome for the vast majority of children. Genes and environmental factors operating in early life seem to play a causal role...
  35. ncbi request reprint Oral contraceptives reduce lamotrigine plasma levels
    Anne Sabers
    Danish Epilepsy Hospital, University of Aarhus, Denmark
    Neurology 61:570-1. 2003
    ..0001), indicating that LTG plasma levels are reduced by >50% during OC co-medication. It is advisable to monitor LTG plasma levels in conjunction with initiation or withdrawal of OC in women on LTG therapy...
  36. ncbi request reprint [Danish clinical guidelines for epilepsy]
    Anne Sabers
    Amtssygehuset i Glostrup, Epilepsiklinikken, Arhus Universitetshospital, Arhus Sygehus, Neurologisk, Glostrup
    Ugeskr Laeger 168:773-6. 2006
    ..The specialist service should include a multidisciplinary team. Epilepsy surgery should be considered early in patients with refractory focal epilepsy...
  37. doi request reprint Prenatal exposure to maternal infections and epilepsy in childhood: a population-based cohort study
    Yuelian Sun
    Department of Epidemiology, University of Aarhus, Vennelyst Boulevard 6, Aarhus, 8000 C, Denmark
    Pediatrics 121:e1100-7. 2008
    ..We estimated the association between prenatal exposure to maternal infections and the subsequent risk for epilepsy in childhood...
  38. doi request reprint Post-stroke mortality, stroke severity, and preadmission antipsychotic medicine use - a population-based cohort study
    Anders Prior
    Research Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark Section for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark
    PLoS ONE 9:e84103. 2014
    ..It has been suggested that antipsychotic medication may be neuroprotective and may reduce post-stroke mortality, but studies are few and ambiguous. We aimed to investigate the post-stroke effects of preadmission antipsychotic use...
  39. ncbi request reprint [Morbidity and mortality in epilepsy]
    Bjarke à Rogvi-Hansen
    H S Rigshospitalet, Neurologisk Klinik, København
    Ugeskr Laeger 166:3945-7. 2004
  40. ncbi request reprint Multivariate analysis to separate the signal given by cross-reactants in immunoassay with sample matrix dilution
    Catalin Nistor
    Department of Analytical Chemistry, Lund University, P O Box 124, 221 00 Lund, Sweden
    Anal Bioanal Chem 380:898-907. 2004
    ..The calibration models showed that the signal separation due the analytes 2,4-dinitrophenol (2,4-DNP) and 4-nitrophenol (4-NP) was possible with a prediction concentration error of 1.4 microM and 72 microM, respectively...
  41. ncbi request reprint Apgar scores and long-term risk of epilepsy
    Yuelian Sun
    The Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, Aarhus
    Epidemiology 17:296-301. 2006
    ..Low Apgar scores are associated with high risk of neonatal death, cerebral palsy, and mental retardation, but the association between Apgar scores and long-term risk of epilepsy remains unresolved...