Karsten S Buschard

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells
    Karsten Buschard
    Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark
    Diabetes 51:2514-21. 2002
  2. ncbi C16:0 sulfatide inhibits insulin secretion in rat beta-cells by reducing the sensitivity of KATP channels to ATP inhibition
    Karsten Buschard
    Bartholin Instituttet, Rigshospitalet, 2100 Copenhagen, Denmark
    Diabetes 55:2826-34. 2006
  3. ncbi Self-glycolipids modulate dendritic cells changing the cytokine profiles of committed autoreactive T cells
    Karsten Buschard
    Bartholin Instituttet, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 7:e52639. 2012
  4. ncbi Uptake of the glycosphingolipid sulfatide in the gastrointestinal tract and pancreas in vivo and in isolated islets of Langerhans
    Maria Blomqvist
    Institute of Neuroscience and Physiology, Psychiatry and Neurochemistry Section, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital Molndal, SE 431 80 Molndal, Sweden
    Lipids Health Dis 5:26. 2006
  5. ncbi What causes type 1 diabetes? Lessons from animal models
    Karsten Buschard
    Bartholin Instituttet, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    APMIS Suppl 132:1-19. 2011
  6. ncbi Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice
    Karsten Buschard
    Bartholin Instituttet, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 6:e17931. 2011
  7. ncbi Neonatal treatment with beta-cell stimulatory agents reduces the incidence of diabetes in BB rats
    K Buschard
    Bartholin Institutet, Kommunehospitalet, Copenhagen, Denmark
    Int J Exp Diabetes Res 1:1-8. 2000
  8. ncbi Involvement of sulfatide in beta cells and type 1 and type 2 diabetes
    K Buschard
    Bartholin Institute, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    Diabetologia 48:1957-62. 2005
  9. ncbi [Gluten and type 1 diabetes mellitus]
    Karsten S Buschard
    Kommunehospitalet, Bartholin Instituttet,
    Ugeskr Laeger 166:2542-3. 2004
  10. ncbi Treatment with sulfatide or its precursor, galactosylceramide, prevents diabetes in NOD mice
    K Buschard
    Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark
    Autoimmunity 34:9-17. 2001

Detail Information

Publications20

  1. ncbi Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells
    Karsten Buschard
    Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark
    Diabetes 51:2514-21. 2002
    ..Our data suggest that sulfatide is important for the control of glucose-induced insulin secretion and that both an increase and a decrease in the sulfatide content have an impact on the secretory capacity of the individual beta-cells...
  2. ncbi C16:0 sulfatide inhibits insulin secretion in rat beta-cells by reducing the sensitivity of KATP channels to ATP inhibition
    Karsten Buschard
    Bartholin Instituttet, Rigshospitalet, 2100 Copenhagen, Denmark
    Diabetes 55:2826-34. 2006
    ..We conclude that a major mechanism by which the predominant sulfatide isoform in beta-cells, C16:0 sulfatide, inhibits glucose-induced insulin secretion is by reducing the K(ATP) channel sensitivity to the ATP block...
  3. ncbi Self-glycolipids modulate dendritic cells changing the cytokine profiles of committed autoreactive T cells
    Karsten Buschard
    Bartholin Instituttet, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 7:e52639. 2012
    ....
  4. ncbi Uptake of the glycosphingolipid sulfatide in the gastrointestinal tract and pancreas in vivo and in isolated islets of Langerhans
    Maria Blomqvist
    Institute of Neuroscience and Physiology, Psychiatry and Neurochemistry Section, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital Molndal, SE 431 80 Molndal, Sweden
    Lipids Health Dis 5:26. 2006
    ..p. administration of radioactive sulfatide in mice, and in vitro in isolated rat islets. Isolated tissue/islets were analysed by scintillation counting, autoradiography and thin-layer chromatography-ELISA...
  5. ncbi What causes type 1 diabetes? Lessons from animal models
    Karsten Buschard
    Bartholin Instituttet, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    APMIS Suppl 132:1-19. 2011
    ..Neutralization of any one of these factors is capable of stopping T1D development, as lessons are learned from the animal models...
  6. ncbi Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice
    Karsten Buschard
    Bartholin Instituttet, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 6:e17931. 2011
    ..Ethanol ('alcohol') is a partly hydrophobic detergent that may affect the accessibility of glycolipids thereby influencing immunological effects of these molecules...
  7. ncbi Neonatal treatment with beta-cell stimulatory agents reduces the incidence of diabetes in BB rats
    K Buschard
    Bartholin Institutet, Kommunehospitalet, Copenhagen, Denmark
    Int J Exp Diabetes Res 1:1-8. 2000
    ..The theory behind the study, that the treatment accelerates beta-cell maturation leading to increased immunological tolerance towards beta cells, is discussed...
  8. ncbi Involvement of sulfatide in beta cells and type 1 and type 2 diabetes
    K Buschard
    Bartholin Institute, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    Diabetologia 48:1957-62. 2005
    ..Glycosphingolipids in general, and sulfatide in particular, appear relevant to both type 1 and type 2 diabetes...
  9. ncbi [Gluten and type 1 diabetes mellitus]
    Karsten S Buschard
    Kommunehospitalet, Bartholin Instituttet,
    Ugeskr Laeger 166:2542-3. 2004
  10. ncbi Treatment with sulfatide or its precursor, galactosylceramide, prevents diabetes in NOD mice
    K Buschard
    Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark
    Autoimmunity 34:9-17. 2001
    ..001). A robust proliferative response to sulfatide, but none to GM1, was observed when spleen cells were rechallenged with glycosphingolipid in vitro. Thus, like insulin and GAD, sulfatide is able to prevent diabetes in NOD mice...
  11. ncbi Iodine and tri-iodo-thyronine reduce the incidence of type 1 diabetes mellitus in the autoimmune prone BB rats
    Marie Louise Hartoft-Nielsen
    Department of Endocrinology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Autoimmunity 42:131-8. 2009
    ..In Wistar rats T3 treatment increased the beta cell mass per bodyweight. The modulation of thyroid function during postnatal development may thus affect the precipitation of T1DM in genetically susceptible individuals...
  12. ncbi Antidiabetogenic effect of fusidic acid in diabetes prone BB rats: a sex-dependent organ accumulation of the drug is seen
    Ida Hageman
    Bartholin Institute, Kommunehospitalet, Copenhagen, Denmark
    Pharmacol Toxicol 91:123-8. 2002
    ..Fusidin accumulates substantially more in female rats which may be due to the steroid structure of fusidin. Whether the same phenomenon takes place in human beings is not known...
  13. ncbi Genetic background determines the size and structure of the endocrine pancreas
    Troels Bock
    Research Laboratory for Stereology and Neuroscience, H S Bispebjerg Hospital, Copenhagen University Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    Diabetes 54:133-7. 2005
    ..We also conclude that inbred mice could be a valuable resource to identify the genes responsible for the size and structure of the endocrine pancreas...
  14. ncbi Periodontitis deteriorates metabolic control in type 2 diabetic Goto-Kakizaki rats
    Carla C Pontes Andersen
    Department of Periodontology, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, and Bartholin Instituttet, Rigshospitalet, Copenhagen, Denmark
    J Periodontol 77:350-6. 2006
    ..The aim of this study was to gain knowledge on the effect of PD on diabetes metabolic control in a new model for type 2 diabetes-associated PD (i.e., the Goto-Kakizaki [GK] rat)...
  15. ncbi Periodontitis is associated with aggravation of prediabetes in Zucker fatty rats
    Carla C Pontes Andersen
    Department of Periodontology, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Periodontol 78:559-65. 2007
    ..The aim of the present study was to investigate whether periodontitis affects the prediabetic state of ZFRs...
  16. ncbi Increased islet volume but unchanged islet number in ob/ob mice
    Troels Bock
    H S Bartholin Institute, Copenhagen University Hospital, Copenhagen, Denmark
    Diabetes 52:1716-22. 2003
    ..Cells within the existing islets are presumably the most important sources for islet cell hyperplasia during expansion of the total islet mass...
  17. ncbi Renal alterations in prediabetic rats with periodontitis
    Carla C Pontes Andersen
    Department of Periodontology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Periodontol 79:684-90. 2008
    ..The aim of the present study was to investigate whether periodontitis influences kidney changes in ZFRs...
  18. ncbi Postnatal development of beta-cells in rats. Proposed explanatory model
    Kirsten Svenstrup
    Bartholin Instituttet, H:S Kommunehospitalet, H:S Bispebjerg Hospital, Copenhagen, Denmark
    APMIS 110:372-8. 2002
    ....
  19. ncbi The endocrine pancreas in non-diabetic rats after short-term and long-term treatment with the long-acting GLP-1 derivative NN2211
    Troels Bock
    H S Bartholin Instituttet, Copenhagen University Hospital, Copenhagen, Denmark
    APMIS 111:1117-24. 2003
    ....
  20. ncbi Relationship between periodontitis and diabetes: lessons from rodent studies
    Carla C Pontes Andersen
    Department of Periodontology, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Periodontol 78:1264-75. 2007
    ..The association between periodontitis and diabetes has been discussed in several reviews over the past years; however, none has focused on the use and contribution of rodent models...