Ditlev E Brodersen

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. ncbi Crystal structure of the VapBC toxin-antitoxin complex from Shigella flexneri reveals a hetero-octameric DNA-binding assembly
    Christian Dienemann
    Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    J Mol Biol 414:713-22. 2011
  2. ncbi The structural basis for mRNA recognition and cleavage by the ribosome-dependent endonuclease RelE
    Cajetan Neubauer
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Cell 139:1084-95. 2009
  3. ncbi The social life of ribosomal proteins
    Ditlev E Brodersen
    Centre for Structural Biology, Department of Molecular Biology, University of Aarhus, Denmark
    FEBS J 272:2098-108. 2005
  4. ncbi Origins and activities of the eukaryotic exosome
    Søren Lykke-Andersen
    Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, C F Møllers Allé 1130, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Cell Sci 122:1487-94. 2009
  5. ncbi Cyanobacteria contain a structural homologue of the Hfq protein with altered RNA-binding properties
    Andreas Bøggild
    Centre for mRNP Biogenesis and Metabolism, University of Aarhus, Denmark
    FEBS J 276:3904-15. 2009
  6. ncbi Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants
    Jannie Assenholt
    Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, The Faculty of Science, Aarhus University, DK 8000 Aarhus C, Denmark
    RNA 14:2305-13. 2008
  7. ncbi Take the "A" tail--quality control of ribosomal and transfer RNA
    Kasper R Andersen
    Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    Biochim Biophys Acta 1779:532-7. 2008
  8. ncbi The 1.4-A crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzyme
    Anette Thyssen Jonstrup
    Centre for Structural Biology, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Arhus C, Denmark
    Nucleic Acids Res 35:3153-64. 2007
  9. ncbi Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA
    Ditlev E Brodersen
    Laboratory of Molecular Biology, MRC, Hills Road, Cambridge CB2 2QH, UK
    J Mol Biol 316:725-68. 2002
  10. ncbi Shape can be seductive
    Ditlev E Brodersen
    Nat Struct Biol 10:78-80. 2003

Collaborators

  • Torben Heick Jensen
  • Poul Valentin-Hansen
  • Poul Nissen
  • VENKATRAMAN RAMAKRISHNAN
  • Kasper R Andersen
  • Andreas Bøggild
  • Christian Dienemann
  • Kenn Gerdes
  • Søren Lykke-Andersen
  • Cajetan Neubauer
  • Jannie Assenholt
  • Anette Thyssen Jonstrup
  • Christine M Dunham
  • Ann C Kelley
  • Jesper S Nielsen
  • Sabine Petry
  • Kristoffer S Winther
  • Yong Gui Gao
  • Jendrik Hentschel
  • Martin Overgaard
  • John Mouaikel
  • Domenico Libri
  • Gorm Nielsen
  • Lan B Van
  • Anders Boysen
  • Christian B F Andersen
  • Frank V Murphy
  • Michael J Tarry
  • Maria Selmer

Detail Information

Publications13

  1. ncbi Crystal structure of the VapBC toxin-antitoxin complex from Shigella flexneri reveals a hetero-octameric DNA-binding assembly
    Christian Dienemann
    Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    J Mol Biol 414:713-22. 2011
    ..The structure gives new insights into the inhibition of VapC toxins by VapB and provides the molecular basis for understanding transcriptional regulation through VapB dimerization...
  2. ncbi The structural basis for mRNA recognition and cleavage by the ribosome-dependent endonuclease RelE
    Cajetan Neubauer
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Cell 139:1084-95. 2009
    ..These structures provide detailed insight into the translational regulation on the bacterial ribosome by mRNA cleavage...
  3. ncbi The social life of ribosomal proteins
    Ditlev E Brodersen
    Centre for Structural Biology, Department of Molecular Biology, University of Aarhus, Denmark
    FEBS J 272:2098-108. 2005
    ..In this review we highlight some of the many known and important functions of ribosomal proteins, both during translation on the ribosome and in a wider context...
  4. ncbi Origins and activities of the eukaryotic exosome
    Søren Lykke-Andersen
    Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, C F Møllers Allé 1130, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Cell Sci 122:1487-94. 2009
    ....
  5. ncbi Cyanobacteria contain a structural homologue of the Hfq protein with altered RNA-binding properties
    Andreas Bøggild
    Centre for mRNP Biogenesis and Metabolism, University of Aarhus, Denmark
    FEBS J 276:3904-15. 2009
    ..The results have implications for our understanding of the evolution of the Sm fold and the Hfq proteins in the bacterial kingdom in general...
  6. ncbi Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants
    Jannie Assenholt
    Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, The Faculty of Science, Aarhus University, DK 8000 Aarhus C, Denmark
    RNA 14:2305-13. 2008
    ..Our data show that exonucleolytic attack by the nuclear exosome is needed both for provoking mRNP QC and for its ensuing elimination of faulty RNA...
  7. ncbi Take the "A" tail--quality control of ribosomal and transfer RNA
    Kasper R Andersen
    Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    Biochim Biophys Acta 1779:532-7. 2008
    ..Nonetheless, our knowledge about the controlled degradation of both stable and labile RNAs is now converging into a unified picture that points to the poly(A) tail as a key discriminator of RNA quality in both bacteria and eukaryotes...
  8. ncbi The 1.4-A crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzyme
    Anette Thyssen Jonstrup
    Centre for Structural Biology, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Arhus C, Denmark
    Nucleic Acids Res 35:3153-64. 2007
    ....
  9. ncbi Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA
    Ditlev E Brodersen
    Laboratory of Molecular Biology, MRC, Hills Road, Cambridge CB2 2QH, UK
    J Mol Biol 316:725-68. 2002
    ..We attempt to correlate the structure with a large body of biochemical and genetic data on the 30 S subunit...
  10. ncbi Shape can be seductive
    Ditlev E Brodersen
    Nat Struct Biol 10:78-80. 2003
  11. ncbi Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon
    Sabine Petry
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Cell 123:1255-66. 2005
    ..Finally, this work demonstrates the feasibility of crystallizing ribosomes with bound factors at a defined state along the translational pathway...
  12. ncbi An Hfq-like protein in archaea: crystal structure and functional characterization of the Sm protein from Methanococcus jannaschii
    Jesper S Nielsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    RNA 13:2213-23. 2007
    ..Functional analysis reveals that Escherichia coli and M. jannaschii Hfqs display very similar biochemical and biological properties. It thus appears that the archaeal and bacterial Hfq proteins are largely functionally interchangeable...