T H Brix

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. ncbi request reprint Preliminary evidence of genetic anticipation in Graves' disease
    Thomas Heiberg Brix
    Department of Endocrinology, Odense University Hospital, Denmark
    Thyroid 13:447-51. 2003
  2. ncbi request reprint Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts
    T H Brix
    Department of Endocrinology, Odense University Hospital, Denmark
    J Clin Endocrinol Metab 86:930-4. 2001
  3. ncbi request reprint A population-based study of chronic autoimmune hypothyroidism in Danish twins
    T H Brix
    Department of Endocrinology M, Odense University Hospital, Denmark
    J Clin Endocrinol Metab 85:536-9. 2000
  4. ncbi request reprint Major role of genes in the etiology of simple goiter in females: a population-based twin study
    T H Brix
    Department of Endocrinology M, Odense University Hospital, Odense University, Odense C, Denmark
    J Clin Endocrinol Metab 84:3071-5. 1999
  5. ncbi request reprint Cigarette smoking and risk of clinically overt thyroid disease: a population-based twin case-control study
    T H Brix
    Department of Endocrinology, Odense University Hospital, Odense University, Denmark
    Arch Intern Med 160:661-6. 2000
  6. doi request reprint Twins as a tool for evaluating the influence of genetic susceptibility in thyroid autoimmunity
    T H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
    Ann Endocrinol (Paris) 72:103-7. 2011
  7. ncbi request reprint Low birth weight is not associated with clinically overt thyroid disease: a population based twin case-control study
    T H Brix
    Department of Endocrinology, Odense University Hospital The Danish Twin Register, Odense University, Odense, Denmark
    Clin Endocrinol (Oxf) 53:171-6. 2000
  8. ncbi request reprint Validity of self-reported hyperthyroidism and hypothyroidism: comparison of self-reported questionnaire data with medical record review
    T H Brix
    Department of Endocrinology M, Odense University Hospital, Denmark
    Thyroid 11:769-73. 2001
  9. pmc Yersinia enterocolitica infection does not confer an increased risk of thyroid antibodies: evidence from a Danish twin study
    P S Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Exp Immunol 146:32-8. 2006
  10. ncbi request reprint Relationship between cigarette smoking and Graves' ophthalmopathy
    L Hegediüs
    Department of Endocrinology and Metabolism M, Odense University Hospital, Odense, Denmark
    J Endocrinol Invest 27:265-71. 2004

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Preliminary evidence of genetic anticipation in Graves' disease
    Thomas Heiberg Brix
    Department of Endocrinology, Odense University Hospital, Denmark
    Thyroid 13:447-51. 2003
    ..In conclusion, our data suggest that patients in the second affected generation seem to acquire their disease at an earlier time in life in familial cases of Graves' disease, indicating that genetic anticipation might occur...
  2. ncbi request reprint Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts
    T H Brix
    Department of Endocrinology, Odense University Hospital, Denmark
    J Clin Endocrinol Metab 86:930-4. 2001
    ..In conclusion, our study strongly supports the idea that genetic factors play a major role in the etiology of GD and suggest that a further search for susceptibility genes is worthwhile...
  3. ncbi request reprint A population-based study of chronic autoimmune hypothyroidism in Danish twins
    T H Brix
    Department of Endocrinology M, Odense University Hospital, Denmark
    J Clin Endocrinol Metab 85:536-9. 2000
    ..However, the fact that the concordance rate among MZ twins was below 1 suggests that environmental factors also are of etiological importance...
  4. ncbi request reprint Major role of genes in the etiology of simple goiter in females: a population-based twin study
    T H Brix
    Department of Endocrinology M, Odense University Hospital, Odense University, Odense C, Denmark
    J Clin Endocrinol Metab 84:3071-5. 1999
    ..We conclude that the etiology of clinically overt simple goiter is multifactorial. Genetic factors play a major role in the etiology of simple goiter in females, but environmental factors are also of importance...
  5. ncbi request reprint Cigarette smoking and risk of clinically overt thyroid disease: a population-based twin case-control study
    T H Brix
    Department of Endocrinology, Odense University Hospital, Odense University, Denmark
    Arch Intern Med 160:661-6. 2000
    ..The effects of cigarette smoking on the thyroid gland have been studied for years. However, the effect of smoking on thyroid function and size is still controversial...
  6. doi request reprint Twins as a tool for evaluating the influence of genetic susceptibility in thyroid autoimmunity
    T H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
    Ann Endocrinol (Paris) 72:103-7. 2011
    ..Future twin studies will incorporate information on genetic and epigenetic variation making it possible to quantify the precise effect of specific susceptibility genes and/or epigenetic variation on estimates of heritability...
  7. ncbi request reprint Low birth weight is not associated with clinically overt thyroid disease: a population based twin case-control study
    T H Brix
    Department of Endocrinology, Odense University Hospital The Danish Twin Register, Odense University, Odense, Denmark
    Clin Endocrinol (Oxf) 53:171-6. 2000
    ..The aim of the present study was to investigate the impact of birth weight and several other birth characteristics on the development of clinically overt thyroid disease...
  8. ncbi request reprint Validity of self-reported hyperthyroidism and hypothyroidism: comparison of self-reported questionnaire data with medical record review
    T H Brix
    Department of Endocrinology M, Odense University Hospital, Denmark
    Thyroid 11:769-73. 2001
    ..However, by combining self-reports with valid retrospective data on diagnostic findings it can be used as a sampling method in large epidemiological or genetic studies...
  9. pmc Yersinia enterocolitica infection does not confer an increased risk of thyroid antibodies: evidence from a Danish twin study
    P S Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Exp Immunol 146:32-8. 2006
    ..In conclusion, Yersinia infection does not confer an increased risk of thyroid antibodies. The genetic contribution in the acquisition of Yersinia infection is modest...
  10. ncbi request reprint Relationship between cigarette smoking and Graves' ophthalmopathy
    L Hegediüs
    Department of Endocrinology and Metabolism M, Odense University Hospital, Odense, Denmark
    J Endocrinol Invest 27:265-71. 2004
    ..The possibility of hindering GO or attenuating its course suggests that counselling on smoking cessation should be an integral part of the treatment of any patient with GD...
  11. ncbi request reprint High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity
    Thomas Heiberg Brix
    Department of Endocrinology, Odense University Hospital, Sonder Boulevard 29, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 90:5949-53. 2005
    ..They are characterized by loss of immunological self-tolerance and female preponderance. Theoretically, X chromosome inactivation (XCI) and resultant tissue chimerism could offer an explanation for the female predisposition to AITD...