Knut Borch-Johnsen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients: losartan intervention for endpoint reduction in hypertension study
    Hans Ibsen
    Glostrup University Hospital, Denmark
    Hypertension 45:198-202. 2005
  2. ncbi request reprint It is possible to help smokers in early motivational stages to quit. The Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Prev Med 40:278-84. 2005
  3. ncbi request reprint Waist circumference and weight following smoking cessation in a general population: the Inter99 study
    Charlotta Pisinger
    Charlotta Pisinger, Research Centre for Prevention and Health, Nordre Ringvej, Glostrup University, Hospital, Building 84 85, DK 2600 Glostrup, Copenhagen, Denmark
    Prev Med 44:290-5. 2007
  4. ncbi request reprint Weight concerns and smoking in a general population: the Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, Nordre Ringvej, Glostrup University Hospital, Building 84 85, DK 2600 Glostrup, Denmark
    Prev Med 44:283-9. 2007
  5. ncbi request reprint Is there a health benefit of reduced tobacco consumption? A systematic review
    Charlotta Pisinger
    Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark
    Nicotine Tob Res 9:631-46. 2007
  6. ncbi request reprint Smoking reduction intervention in a large population-based study. The Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Prev Med 40:112-8. 2005
  7. ncbi request reprint Acceptance of the smoking cessation intervention in a large population-based study: the Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, Nordre Ringvej, Glostrup University Hospital, Glostrup, Denmark
    Scand J Public Health 33:138-45. 2005
  8. ncbi request reprint Smoking cessation intervention in a large randomised population-based study. The Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, Nordre Ringvej, DK 2600 Glostrup University Hospital, Glostrup, Denmark
    Prev Med 40:285-92. 2005
  9. ncbi request reprint Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Pharmacogenetics 13:417-23. 2003
  10. ncbi request reprint Does albuminuria predict cardiovascular outcome on treatment with losartan versus atenolol in hypertension with left ventricular hypertrophy? A LIFE substudy
    Hans Ibsen
    Glostrup University Hospital, Denmark
    J Hypertens 22:1805-11. 2004

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients: losartan intervention for endpoint reduction in hypertension study
    Hans Ibsen
    Glostrup University Hospital, Denmark
    Hypertension 45:198-202. 2005
    ..If albuminuria is not decreased by the patient's current antihypertensive and other treatment, further intervention directed toward blood pressure control and other modifiable risks should be considered...
  2. ncbi request reprint It is possible to help smokers in early motivational stages to quit. The Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Prev Med 40:278-84. 2005
    ..In a population-based sample of smokers in early motivational stages, we found a high acceptance of smoking cessation groups...
  3. ncbi request reprint Waist circumference and weight following smoking cessation in a general population: the Inter99 study
    Charlotta Pisinger
    Charlotta Pisinger, Research Centre for Prevention and Health, Nordre Ringvej, Glostrup University, Hospital, Building 84 85, DK 2600 Glostrup, Copenhagen, Denmark
    Prev Med 44:290-5. 2007
    ..Central obesity is an independent risk factor of mortality. Change in waist circumference after smoking cessation has not been previously reported in a population-based prospective study of both sexes...
  4. ncbi request reprint Weight concerns and smoking in a general population: the Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, Nordre Ringvej, Glostrup University Hospital, Building 84 85, DK 2600 Glostrup, Denmark
    Prev Med 44:283-9. 2007
    ..No previous studies have explored weight concerns in relation to smoking habits, or investigated how weight concerns affect smoking cessation in a general population...
  5. ncbi request reprint Is there a health benefit of reduced tobacco consumption? A systematic review
    Charlotta Pisinger
    Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark
    Nicotine Tob Res 9:631-46. 2007
    ..A substantial reduction in smoking seems to have a small health benefit, but more studies are needed to determine the long-term effects of smoking reduction...
  6. ncbi request reprint Smoking reduction intervention in a large population-based study. The Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Prev Med 40:112-8. 2005
    ..Smoking reduction has been introduced as an alternative to smokers unable or unwilling to quit but has never been implemented in a population-based intervention...
  7. ncbi request reprint Acceptance of the smoking cessation intervention in a large population-based study: the Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, Nordre Ringvej, Glostrup University Hospital, Glostrup, Denmark
    Scand J Public Health 33:138-45. 2005
    ..Potential exists for improving the impact of quit-smoking programmes, by recruiting smokers in early motivational stages, by using active recruitment strategies, and by offering professional assistance to quit...
  8. ncbi request reprint Smoking cessation intervention in a large randomised population-based study. The Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, Nordre Ringvej, DK 2600 Glostrup University Hospital, Glostrup, Denmark
    Prev Med 40:285-92. 2005
    ..Several large and well-conducted community interventions have failed to detect an effect on prevalence of smoking...
  9. ncbi request reprint Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Pharmacogenetics 13:417-23. 2003
    ..In conclusion, the Leu162Val polymorphism of PPARalpha is associated with a decreased level of fasting serum triglyceride in glucose tolerant white subjects...
  10. ncbi request reprint Does albuminuria predict cardiovascular outcome on treatment with losartan versus atenolol in hypertension with left ventricular hypertrophy? A LIFE substudy
    Hans Ibsen
    Glostrup University Hospital, Denmark
    J Hypertens 22:1805-11. 2004
    ....
  11. ncbi request reprint The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes 52:573-7. 2003
    ..49, P = 0.00022). In conclusion, the widespread E23K polymorphism may have a diabetogenic effect by impairing glucose-induced insulin release and increasing BMI...
  12. ncbi request reprint Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population
    Marit E Jørgensen
    Centre for Health Research in Greenland, National Institute of Public Health, Copenhagen, Denmark
    Am J Clin Nutr 84:29-36. 2006
    ..Whether such differences in obesity-related risk factors exist within population groups of the same genetic origin but with differences in lifestyle remains to be determined...
  13. doi request reprint Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:1136-42. 2008
    ..Due to the previous inconclusive quantitative trait associations, we also did studies of intermediate quantitative phenotypes...
  14. doi request reprint Microvascular retinopathy in subjects without diabetes: the Inter99 Eye Study
    Inger Christine Munch
    Department of Ophthalmology, Glostrup Hospital, Copenhagen, Denmark
    Acta Ophthalmol 90:613-9. 2012
    ..In theory, these lesions could be a consequence of past hyperglycaemia. We examined the prevalence and risk factors for retinopathy, including lens fluorescence, a biomarker of cumulative life-time glycaemia in adults without diabetes...
  15. ncbi request reprint Diabetes and impaired glucose tolerance among the inuit population of Greenland
    Marit E Jørgensen
    Steno Diabetes Centre, Gentofte, Denmark National Institute of Public Health, Copenhagen, Denmark
    Diabetes Care 25:1766-71. 2002
    ..To assess the prevalence of diabetes and impaired glucose tolerance (IGT) among the Inuit population of Greenland and to determine risk factors for developing glucose intolerance...
  16. ncbi request reprint N-terminal pro brain natriuretic peptide is inversely related to metabolic cardiovascular risk factors and the metabolic syndrome
    Michael H Olsen
    Research Center for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Hypertension 46:660-6. 2005
    ..The metabolic syndrome was associated with lower Nt-proBNP levels and shifted the positive relationship between Nt-proBNP and pulse pressure to the right, creating a possible link between the metabolic syndrome and hypertension...
  17. ncbi request reprint A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99
    Torben Jørgensen
    Research Centre for Prevention and Health, Copenhagen County, Glostrup University Hospital, Glostrup, Denmark
    Eur J Cardiovasc Prev Rehabil 10:377-86. 2003
    ..The article describes the study and baseline results...
  18. doi request reprint Abdominal obesity has the highest impact on metabolic profile in an overweight African population
    Line N Handlos
    Department of International Health, University of Copenhagen, Copenhagen, Denmark
    Ann Hum Biol 39:530-3. 2012
    ..The aim of this study was to determine the association between different anthropometric parameters and metabolic profile in an overweight, adult, black Kenyan population...
  19. doi request reprint Variation in the gene encoding Krüppel-like factor 7 influences body fat: studies of 14 818 Danes
    Dorit P Zobel
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Copenhagen, Denmark
    Eur J Endocrinol 160:603-9. 2009
    ....
  20. ncbi request reprint Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study
    Kristian Wachtell
    Department of Medicine, Glostrup University Hospital, Glostrup, Denmark
    Ann Intern Med 139:901-6. 2003
    ..The partition values for urine albumin-creatinine ratio (UACR) used to identify microalbuminuria have been based on studies that predicted risk in diabetic patients...
  21. ncbi request reprint Microalbuminuria in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study
    Kristian Wachtell
    Copenhagen County University Hospital, Glostrup, Denmark
    J Hypertens 20:405-12. 2002
    ....
  22. ncbi request reprint A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro
    Søren M Echwald
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    Diabetes 51:1-6. 2002
    ..7 (CI 1.26-10.93, P = 0.02) genotype relative risk of type 2 diabetes in the examined population of Danish Caucasian subjects and results in impaired in vitro serine phosphorylation of the PTP-1B peptide...
  23. ncbi request reprint High-sensitivity C-reactive protein is only weakly related to cardiovascular damage after adjustment for traditional cardiovascular risk factors
    Michael H Olsen
    Research Center for Prevention and Health, Glostrup University, Denmark
    J Hypertens 24:655-61. 2006
    ....
  24. ncbi request reprint Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites
    Yasmin H Hamid
    Steno Diabetes Center, Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes 53:3342-5. 2004
    ..In conclusion, the Asp358Ala polymorphism of the IL6R associates with type 2 diabetes in Danish whites...
  25. ncbi request reprint Gender differences in the association between westernization and metabolic risk among Greenland Inuit
    Marit Eika Jørgensen
    Centre for Health Research in Greenland, National Institute of Public Health, Øster Farimagsgade 5A, Copenhagen, 1399, Denmark
    Eur J Epidemiol 21:741-8. 2006
    ..The aim was to analyze metabolic risk factors among Inuit in Greenland and Denmark and their relation to westernization...
  26. doi request reprint The impact of a population-based multi-factorial lifestyle intervention on changes in long-term dietary habits: the Inter99 study
    Ulla Toft
    Research Centre for Prevention and Health, Glostrup University Hospital, Building 84 85, DK 2600 Glostrup, Denmark
    Prev Med 47:378-83. 2008
    ..To evaluate the effectiveness of a population-based multi-factorial lifestyle intervention on long-term changes in dietary habits compared to a non-intervention control group...
  27. ncbi request reprint Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    J Mol Med (Berl) 83:353-61. 2005
    ..02) and altered fasting plasma glucose (P=0.03). However, these later findings could not be replicated in additional studies. In conclusion, variants in CDKN1C may contribute to the inter-individual variation in birth weight...
  28. ncbi request reprint Cardiovascular risk amongst migrant and non-migrant Greenland Inuit in a gender perspective
    Peter Bjerregaard
    National Institute of Public Health, Copenhagen, Denmark
    Scand J Public Health 35:380-6. 2007
    ..The purpose of the present study was to analyse the association of migration from Greenland to Denmark with cardiovascular risk factors in a gender-specific perspective...
  29. ncbi request reprint Urine albumin/creatinine ratio and echocardiographic left ventricular structure and function in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study. Losartan Intervention for Endpoint Reduction
    Kristian Wachtell
    Laboratory of Cardiology, Department of Medicine, Copenhagen County University Hospital, Glostrup, Denmark
    Am Heart J 143:319-26. 2002
    ..However, the relationship between these markers of cardiovascular damage has not been evaluated in a large hypertensive population...
  30. ncbi request reprint Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites
    Dorit P Jensen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Copenhagen, Denmark
    Mol Genet Metab 89:360-7. 2006
    ....
  31. ncbi request reprint Studies of the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) gene in Danish subjects with the metabolic syndrome
    Louise Ambye
    Department of Clinical Biochemistry, Hvidovre University Hospital, Kettegaards Alle 30, DK 2650 Hvidovre, Copenhagen, Denmark
    Diabetes Res Clin Pract 67:175-9. 2005
    ..In conclusion, the Gly482Ser polymorphism of the PGC-1alpha gene is not associated with the metabolic syndrome, related quantitative traits or cardiac hypertrophy among Danish Caucasian subjects...
  32. pmc The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population
    Lise Lotte N Husemoen
    Research Centre for Prevention and Health, Glostrup, Denmark
    PLoS ONE 5:e11735. 2010
    ..The underlying mechanisms are not clear. The aim was to examine the association between alcohol intake and diabetes and intermediate CHD risk factors in relation to selected ADH and ALDH gene variants...
  33. doi request reprint A randomized multifactorial intervention study for prevention of ischaemic heart disease (Inter99): the long-term effect on physical activity
    Lisa von Huth Smith
    Research Centre for Prevention and Health, Glostrup, Denmark
    Scand J Public Health 36:380-8. 2008
    ..To examine the effect of a randomized multiple risk factor intervention study for prevention of ischaemic heart disease (IHD) on the development in physical activity over a 36-month period...
  34. pmc The effect of adding group-based counselling to individual lifestyle counselling on changes in dietary intake. The Inter99 study--a randomized controlled trial
    Ulla Toft
    Research Centre for Prevention and Health, Glostrup University Hospital, Building 84 85, DK 2600 Glostrup, Denmark
    Int J Behav Nutr Phys Act 5:59. 2008
    ..The purpose was to investigate the effect of adding group-based diet and exercise counselling to individual life-style counselling on long-term changes in dietary habits...
  35. ncbi request reprint Commuting physical activity is favourably associated with biological risk factors for cardiovascular disease
    Lisa von Huth Smith
    Research Centre for Prevention and Health, Glostrup Hospital, Building 84 85, Glostrup 2600, Denmark
    Eur J Epidemiol 22:771-9. 2007
    ..We examined the associations between commuting, leisure time and total physical activity and biological risk factors for CVD. Design A cross-sectional study of men and women, who participated in a health screening programme...
  36. pmc Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e5469. 2009
    ..The aim of the present study was to investigate the putative association between SNPs and haplotype blocks of CHI3LI and T2D and T2D related quantitative traits...
  37. ncbi request reprint High risk strategy in smoking cessation is feasible on a population-based level. The Inter99 study
    Charlotta Pisinger
    Research Centre for Prevention and Health, The Capital Region of Denmark, Denmark
    Prev Med 46:579-84. 2008
    ..A high risk strategy is one of more strategies in public health. Smoking remains the most important contributor to the burden of disease in developed countries...
  38. doi request reprint Screening for risk of cardiovascular disease is not associated with mental distress: the Inter99 study
    Torben Jørgensen
    Research Centre for Prevention and Health, Building 84 85, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Prev Med 48:242-6. 2009
    ..To analyze mental distress in relation to participation in lifestyle intervention...
  39. ncbi request reprint Representativeness in population-based studies: a detailed description of non-response in a Danish cohort study
    Thomas Drivsholm
    Copenhagen County Research Centre for Prevention and Health, University of Copenhagen, Copenhagen, Denmark
    Scand J Public Health 34:623-31. 2006
    ..Consequently, estimates of possible differences between participants and non-participants are increasingly important for the interpretation of study results and generalization to the background population...
  40. pmc Moving to an A1C-based diagnosis of diabetes has a different impact on prevalence in different ethnic groups
    Dirk L Christensen
    Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 33:580-2. 2010
    ..K. study were of the same magnitude as between-country comparisons. CONCLUSIONS A shift to an A1C-based diagnosis for diabetes will have substantially different consequences for diabetes prevalence across ethnic groups and populations...
  41. pmc Associations between features of glucose exposure and A1C: the A1C-Derived Average Glucose (ADAG) study
    Rikke Borg
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 59:1585-90. 2010
    ....
  42. pmc Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes
    Camilla H Andreasen
    Steno Diabetes Center, Copenhagen, Denmark
    PLoS ONE 3:e2872. 2008
    ..We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors...
  43. doi request reprint Obesity and regional fat distribution in Kenyan populations: impact of ethnicity and urbanization
    Dirk L Christensen
    Steno Diabetes Center, Gentofte, Denmark, University of Copenhagen, Frederiksberg, Denmark
    Ann Hum Biol 35:232-49. 2008
    ..Obesity is increasing rapidly in Africa, and may not be associated with the same changes in body composition among different ethnic groups in Africa...
  44. doi request reprint Cumulative glycemia and microangiopathy in subjects with impaired glucose regulation in the Inter99 study
    Inger Christine Munch
    Department of Ophthalmology, Glostrup Hospital, Copenhagen, Denmark
    Diabetes Res Clin Pract 91:226-32. 2011
    ..To assess cumulative glycemia, microvascular characteristics, and associated risk factors for diabetes in subjects with impaired glucose regulation...
  45. ncbi request reprint Does albuminuria predict cardiovascular outcomes on treatment with losartan versus atenolol in patients with diabetes, hypertension, and left ventricular hypertrophy? The LIFE study
    Hans Ibsen
    Medical Department M, Glostrup Hospital, DK 2600 Glostrup, Denmark
    Diabetes Care 29:595-600. 2006
    ....
  46. ncbi request reprint Screening for diabetic retinopathy using a digital non-mydriatic camera compared with standard 35-mm stereo colour transparencies
    Anja B Hansen
    Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Acta Ophthalmol Scand 82:656-65. 2004
    ....
  47. ncbi request reprint Model simulation of the patient flow through a screening centre for diabetic retinopathy
    Anja B Hansen
    Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Acta Ophthalmol Scand 83:678-86. 2005
    ..To construct a quantitative, flexible and simplified mathematical model of the patient flow through the Eye Clinic at the Steno Diabetes Centre (SDC) in order to enable rational dimensioning and assess the effects of modifications...
  48. ncbi request reprint Diabetic retinopathy screening using digital non-mydriatic fundus photography and automated image analysis
    Anja B Hansen
    Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark
    Acta Ophthalmol Scand 82:666-72. 2004
    ..To investigate the use of automated image analysis for the detection of diabetic retinopathy (DR) in fundus photographs captured with and without pharmacological pupil dilation using a digital non-mydriatic camera...
  49. ncbi request reprint High prevalence of markers of coronary heart disease among Greenland Inuit
    Marit Eika Jørgensen
    Centre for Health Research in Greenland, National Institute of Public Health, Copenhagen, Denmark
    Atherosclerosis 196:772-8. 2008
    ..The aim of this study was to assess the prevalence of markers of CHD among Greenland Inuit, and to study associations between markers of CHD and behavioral and biological variables...
  50. doi request reprint Prevalence of age-related maculopathy and age-related macular degeneration among the inuit in Greenland. The Greenland Inuit Eye Study
    Mads Varis Nis Andersen
    Department of Ophthalmology, Rigshospitalet, University Hospital of Copenhagen and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Ophthalmology 115:700-707.e1. 2008
    ..To examine the age- and gender-specific prevalence and describe the common phenotype of early age-related maculopathy (ARM) and late-stage age-related macular degeneration (AMD) among the Inuit in Greenland...
  51. ncbi request reprint Increased transvascular lipoprotein transport in diabetes: association with albuminuria and systolic hypertension
    Jan Skov Jensen
    Department of Nephrology and Endocrinology P, The National University Hospital, Copenhagen, Denmark
    J Clin Endocrinol Metab 90:4441-5. 2005
    ..Diabetes is associated with a highly increased risk of atherosclerosis, especially if hypertension or albuminuria is present...
  52. ncbi request reprint Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes
    Klaus Klausen
    Copenhagen City Heart Study, Epidemiological Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark
    Circulation 110:32-5. 2004
    ..Microalbuminuria has been suggested as an atherosclerotic risk factor. However, the lower cutoff level of urinary albumin excretion is unknown. It is also unknown whether impaired renal function confounds the association...
  53. pmc Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:2534-40. 2008
    ....
  54. ncbi request reprint Increased transvascular low density lipoprotein transport in insulin dependent diabetes: a mechanistic model for development of atherosclerosis
    Karen Kornerup
    Department of Nephrology and Endocrinology P, The National University Hospital, Copenhagen, Denmark
    Atherosclerosis 170:163-8. 2003
    ..We hypothesized that transvascular lipoprotein transport may be increased in patients with diabetes, possibly explaining increased intimal lipoprotein accumulation and thus atherosclerosis...
  55. doi request reprint Combination of the electrocardiographic strain pattern and albuminuria for the prediction of new-onset heart failure in hypertensive patients: the LIFE study
    Peter M Okin
    Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, New York, USA
    Am J Hypertens 21:273-9. 2008
    ..Although albuminuria and the electrocardiographic (ECG) strain pattern each predict development of heart failure (HF), whether combining albuminuria and strain improves prediction of new HF is unclear...
  56. ncbi request reprint A Danish diabetes risk score for targeted screening: the Inter99 study
    Charlotte Glümer
    Steno Diabetes Centre, Gentofte, Denmark
    Diabetes Care 27:727-33. 2004
    ..To develop a simple self-administered questionnaire identifying individuals with undiagnosed diabetes with a sensitivity of 75% and minimizing the high-risk group needing subsequent testing...
  57. ncbi request reprint [European practice guidelines on prevention of cardiovascular diseases: executive summary]
    Ian Graham
    European Society of Cardiology
    G Ital Cardiol (Rome) 9:11-59. 2008
  58. doi request reprint The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes
    Trine Nielsen
    Steno Diabetes Center, Gentofte, Denmark
    J Hypertens 26:2142-6. 2008
    ..The previous studies have, however, been conflicting, and the aim of the present study was to clarify the impact of the Glu65Lys polymorphism on hypertension at the population level of middle-aged people...
  59. ncbi request reprint European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force Of European and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of eight societies and by invit
    Guy De Backer
    University Hospital, Ghent, Belgium
    Arch Mal Coeur Vaiss 97:1019-30. 2004
  60. ncbi request reprint A statistical approach based on substitution of macronutrients provides additional information to models analyzing single dietary factors in relation to type 2 diabetes in danish adults: the Inter99 study
    Kristine Faerch
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    J Nutr 135:1177-82. 2005
    ..Hence, the statistical approach based on substitution of macronutrients provided additional information to the model analyzing single dietary factors...
  61. ncbi request reprint PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Hypertension 45:565-70. 2005
    ..001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women...
  62. ncbi request reprint Diabetes among Inuit migrants in Denmark
    Helene Moustgaard
    Steno Diabetes Center, Gentofte, Denmark
    Int J Circumpolar Health 64:354-64. 2005
    ..Further, we analyzed determinants for diabetes and impaired glucose metabolism...
  63. ncbi request reprint Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
    Camilla H Andreasen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Denmark
    Diabetes 57:95-101. 2008
    ..In the present study, the effect of FTO variation on metabolic traits including obesity, type 2 diabetes, and related quantitative phenotypes was examined...
  64. ncbi request reprint Risk scores for type 2 diabetes can be applied in some populations but not all
    Charlotte Glümer
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Diabetes Care 29:410-4. 2006
    ..This study evaluated the performance of one risk score in nine populations of diverse ethnic origin...
  65. ncbi request reprint Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study
    Lars H Lindholm
    Steno Diabetes Centre, Gentofte, Denmark
    J Hypertens 20:1879-86. 2002
    ..There has been uncertainty about the risk of new-onset diabetes in hypertensive individuals treated with different blood pressure-decreasing drugs...
  66. ncbi request reprint Association between dietary glycemic index, glycemic load, and body mass index in the Inter99 study: is underreporting a problem?
    Cathrine Lau
    Steno Diabetes Center, Gentofte, Denmark
    Am J Clin Nutr 84:641-5. 2006
    ..The few studies examining the potential associations between glycemic index (GI), glycemic load (GL), and body mass index (BMI) have provided no clear pictures. Underreporting of energy intake may be one explanation for this...
  67. ncbi request reprint [Microalbuminuria is associated with a fourfold increased risk of ischemic heart disease among hypertensive patients]
    Jan Skov Jensen
    Kardiologisk Klinik B, Hjertecentret, H S Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 164:3773-7. 2002
    ..The aim of this population-based, follow-up study of hypertensive patients was to assess the predictive impact of a slightly elevated urinary excretion of albumin, i.e. microalbuminuria, on ischaemic heart disease...
  68. ncbi request reprint Prevalences of diabetes and impaired glucose regulation in a Danish population: the Inter99 study
    Charlotte Glümer
    Steno Diabetes Centre, Gentofte, Denmark
    Diabetes Care 26:2335-40. 2003
    ....
  69. ncbi request reprint European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  70. ncbi request reprint European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by r
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Doublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:E1-40. 2007
  71. ncbi request reprint European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  72. ncbi request reprint European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice
    Guy De Backer
    University Hospital, DePintelaan 185, B 9000 Ghent, Belgium
    Eur Heart J 24:1601-10. 2003
  73. ncbi request reprint Effect of losartan on sudden cardiac death in people with diabetes: data from the LIFE study
    Lars H Lindholm
    Department of Public Health and Clinical Medicine, Umea University Hospital, SE 901 85, Umea, Sweden
    Lancet 362:619-20. 2003
    ..Our results suggest losartan affords better protection against cardiac death from arrhythmias for patients with diabetes mellitus than does atenolol. Importantly, our analyses were exploratory and require confirmation...
  74. ncbi request reprint The impact of severe hypoglycemia and impaired awareness of hypoglycemia on relatives of patients with type 1 diabetes
    Hanne V Jørgensen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 26:1106-9. 2003
    ..The aim of this study was to compare patients' and relatives' assessments of rates of severe hypoglycemia and state of awareness and to explore the influence on involvement and concern of relatives...
  75. ncbi request reprint European guidelines on cardiovascular disease and prevention in clinical practice
    Guy De Backer
    Atherosclerosis 171:145-55. 2003
  76. ncbi request reprint Dietary glycemic index, glycemic load, fiber, simple sugars, and insulin resistance: the Inter99 study
    Cathrine Lau
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes Care 28:1397-403. 2005
    ..To examine the relationship between daily glycemic index, daily glycemic load, simple sugars, dietary fiber, and the prevalence of a measure of insulin resistance in 30- to 60-year-old nondiabetic Danish men and women...
  77. ncbi request reprint The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
    Dorit P Jensen
    Steno Diabetes Center, Niels Steensens Vej 2, 2820, Gentofte, Denmark
    J Mol Med (Berl) 85:445-9. 2007
    ..In conclusion, in a large study sample, we were unable to find robust evidence of an association of the Pro129Thr FAAH variant with overweight, obesity, and any related quantitative traits among the examined whites...
  78. ncbi request reprint Screen-detected diabetes, hypertension and hypercholesterolemia as predictors of cardiovascular mortality in five populations of Asian origin: the DECODA study
    Tomoko Nakagami
    Diabetes Center, Tokyo Women s Medical University, Tokyo, Japan
    Eur J Cardiovasc Prev Rehabil 13:555-61. 2006
    ..The aims of this study were to assess the predictive value of glucose tolerance status as a risk factor for CVD and identify a high-risk group for fatal CVD in population-based studies of Asians...
  79. ncbi request reprint Growth in the first year of life and the risk of type 1 diabetes in a Danish population
    Jannet Svensson
    Steno Diabetes Centre, Gentofte, Denmark
    Paediatr Perinat Epidemiol 21:44-8. 2007
    ..Thus the increasing incidence of T1D could not be explained by changes in growth parameters at birth or at age 1 year...
  80. ncbi request reprint Predictions of type 2 diabetes and complications in Greenland in 2014
    Nina Martinsen
    Steno Diabetes Center, Gentofte, Denmark
    Int J Circumpolar Health 65:243-52. 2006
    ..The predictions were based on changes in demographic variables and obesity...
  81. ncbi request reprint The metabolic syndrome in a global perspective. The public health impact--secondary publication
    Knut Borch-Johnsen
    Steno Diabetes Center, Niels Stensensvej 2, 2820 Gentofte, Denmark
    Dan Med Bull 54:157-9. 2007
    ..Preventive action is urgently needed, and studies in China and India have proven to be effective...
  82. pmc An education and training course in motivational interviewing influence: GPs' professional behaviour--ADDITION Denmark
    Sune Rubak
    Department of Paediatrics, Skejby University, Vennelyst Boulevard 6, DK 8000 Aarhus C, Denmark
    Br J Gen Pract 56:429-36. 2006
    ..However, data concerning implementation and aspects regarding the use of motivational interviewing in general practice is missing...
  83. ncbi request reprint Early childhood risk factors associated with type 1 diabetes--is gender important?
    Jannet Svensson
    Steno Diabetes Centre, Gentofte, Denmark
    Eur J Epidemiol 20:429-34. 2005
    ..A total of 1490 non-diabetic healthy children matched by gender and date of birth were randomly selected from the Danish population register. In addition a combination of national register data and questionnaire data was used...
  84. doi request reprint The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    J Clin Endocrinol Metab 93:2294-9. 2008
    ..Hepatic lipase plays a pivotal role in the metabolism of high-density lipoprotein (HDL) and low-density lipoprotein by involvement in reverse cholesterol transport and the formation of atherogenic small dense low-density lipoprotein...
  85. doi request reprint Comparisons of metabolic syndrome definitions in four populations of the Asia-Pacific region
    Crystal Man Ying Lee
    The George Institute for International Health, University of Sydney, Sydney, Australia
    Metab Syndr Relat Disord 6:37-46. 2008
    ..To compare the prevalence of metabolic syndrome (MetS) by four MetS definitions in four Asia-Pacific populations, and to compare the prevalence of individual metabolic components...
  86. ncbi request reprint Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    Agnar Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 39:218-25. 2007
    ....