Lise Bathum

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Genetic and environmental influences on plasma homocysteine: results from a Danish twin study
    Lise Bathum
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark
    Clin Chem 53:971-9. 2007
  2. ncbi request reprint Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians
    Lise Bathum
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, DK 5000 Odense C, Denmark
    J Gerontol A Biol Sci Med Sci 62:196-201. 2007
  3. ncbi request reprint Haplotype association analysis of human disease traits using genotype data of unrelated individuals
    Qihua Tan
    Department of Clinical Biochemistry and Genetics KKA, Odense University Hospital, Denmark
    Genet Res 86:223-31. 2005
  4. ncbi request reprint Apolipoprotein e genotypes: relationship to cognitive functioning, cognitive decline, and survival in nonagenarians
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    J Am Geriatr Soc 54:654-8. 2006
  5. pmc Genetic association analysis of human longevity in cohort studies of elderly subjects: an example of the PON1 gene in the Danish 1905 birth cohort
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, DK 5000 Odense, Denmark
    Genetics 172:1821-8. 2006
  6. ncbi request reprint Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population
    Lene Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Biol Psychiatry 61:223-30. 2007
  7. ncbi request reprint The Danish Twin Registry in the new millennium
    Axel Skytthe
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winløws Vej 9B, DK 5000 Odense C, Denmark
    Twin Res Hum Genet 9:763-71. 2006
  8. ncbi request reprint No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Eur J Hum Genet 13:1154-8. 2005
  9. ncbi request reprint Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin study
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, 5000, Denmark
    Osteoporos Int 15:659-64. 2004
  10. ncbi request reprint Estimating haplotype relative risks on human survival in population-based association studies
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, DK 5000 Odense, Denmark
    Hum Hered 59:88-97. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Genetic and environmental influences on plasma homocysteine: results from a Danish twin study
    Lise Bathum
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark
    Clin Chem 53:971-9. 2007
    ..We assessed the genetic and environmental influences on homocysteine in adult twins and tested the influence of 3 candidate polymorphisms...
  2. ncbi request reprint Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians
    Lise Bathum
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, DK 5000 Odense C, Denmark
    J Gerontol A Biol Sci Med Sci 62:196-201. 2007
    ..Two common polymorphisms in the genes coding for methylenetetrahydrofolate reductase (MTHFR 677C>T) and methionine synthase (MTR 2756A>G) have an impact on plasma homocysteine level...
  3. ncbi request reprint Haplotype association analysis of human disease traits using genotype data of unrelated individuals
    Qihua Tan
    Department of Clinical Biochemistry and Genetics KKA, Odense University Hospital, Denmark
    Genet Res 86:223-31. 2005
    ..We show, by applying the model to an empirical data set, that our method based on the well-known logistic regression model is a useful tool for haplotype association analysis of human disease traits...
  4. ncbi request reprint Apolipoprotein e genotypes: relationship to cognitive functioning, cognitive decline, and survival in nonagenarians
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    J Am Geriatr Soc 54:654-8. 2006
    ..To evaluate the extent to which relationships between apolipoprotein E, cognitive functioning, and survival in people aged 60 to 80 persist into advanced old age...
  5. pmc Genetic association analysis of human longevity in cohort studies of elderly subjects: an example of the PON1 gene in the Danish 1905 birth cohort
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, DK 5000 Odense, Denmark
    Genetics 172:1821-8. 2006
    ....
  6. ncbi request reprint Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population
    Lene Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Biol Psychiatry 61:223-30. 2007
    ..Variations in genes included in the serotonin system have been suggested as risk factors for various psychiatric disorders but may also serve as candidates for normal variations in mood...
  7. ncbi request reprint The Danish Twin Registry in the new millennium
    Axel Skytthe
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winløws Vej 9B, DK 5000 Odense C, Denmark
    Twin Res Hum Genet 9:763-71. 2006
    ..This paper summarizes the newest extension of the register and gives examples of new developments and phenotypes studied...
  8. ncbi request reprint No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Eur J Hum Genet 13:1154-8. 2005
    ....
  9. ncbi request reprint Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin study
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, 5000, Denmark
    Osteoporos Int 15:659-64. 2004
    ..In conclusion, we here provide evidence for a significant impact of the MTHFR genotype on the occurrence of fractures in an elderly Danish population...
  10. ncbi request reprint Estimating haplotype relative risks on human survival in population-based association studies
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, DK 5000 Odense, Denmark
    Hum Hered 59:88-97. 2005
    ..Results from both simulation and model application indicate that our survival analysis model is an efficient method for inferring haplotype effects on human survival in population-based association studies...
  11. doi request reprint The impact of the CAG repeat polymorphism of the androgen receptor gene on muscle and adipose tissues in 20-29-year-old Danish men: Odense Androgen Study
    Torben Leo Nielsen
    Department of Endocrinology Biochemistry, Odense University Hospital, Sdr Boulevard, 5000 Odense C, Denmark
    Eur J Endocrinol 162:795-804. 2010
    ..The number of CAG repeats (CAG(n)) within the CAG repeat polymorphism of the androgen receptor gene correlates inversely with the transactivation of the receptor...
  12. ncbi request reprint Genetic dissection of gene expression observed in whole blood samples of elderly Danish twins
    Qihua Tan
    Department of Clinical Biochemistry and Genetics KKA, Odense University Hospital, Sdr Boulevard 29, 5000 Odense C, Denmark
    Hum Genet 117:267-74. 2005
    ..In conclusion, the correlation patterns revealed in our twin data provide evidence of the existence of a heritable mechanism in gene expression regulation persistently functioning even in aged subjects...
  13. ncbi request reprint ACE genotype and physical training effects: a randomized study among elderly Danes
    Henrik Frederiksen
    Institute of Public Health, Epidemiology, University of Southern Denmark, Odense, Denmark
    Aging Clin Exp Res 15:284-91. 2003
    ..However, ACE studies have mainly been conducted among younger persons in excellent physical shape. In this study, we examine whether the level of PF, trainability, or rate-of-change are associated with the ACE genotype among the elderly...
  14. ncbi request reprint Apolipoprotein E genotype frequency patterns in aged Danes as revealed by logistic regression models
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Eur J Epidemiol 19:651-6. 2004
    ....
  15. ncbi request reprint Heritability of biochemical kidney markers and relation to survival in the elderly--results from a Danish population-based twin study
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Denmark
    Clin Chim Acta 349:143-50. 2004
    ..Furthermore, we tested the association between these biochemical values and mortality to examine the consequence of an abnormal biochemical kidney parameter in an aging population...
  16. ncbi request reprint Angiotensin I-converting enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival--a follow-up study of elderly Danish twins
    Henrik Frederiksen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Main Campus Odense University, Odense, Denmark
    Ann Epidemiol 13:57-65. 2003
    ..Using a longitudinal study of elderly twins we studied the association between ACE genotype and physical and cognitive functioning and survival in old age...
  17. doi request reprint Denaturing high-performance liquid chromatography mutation analysis in patients with reduced Protein S levels
    Lise Bathum
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Denmark
    Clin Chim Acta 390:76-81. 2008
    ..The aim was to design a high-throughput genetic analysis based on denaturing high-performance liquid chromatography to identify sequence variations in the gene coding for Protein S...
  18. ncbi request reprint Association between combined properdin and mannose-binding lectin deficiency and infection with Neisseria meningitidis
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Mol Immunol 43:473-9. 2006
    ..In this study we report our findings in a Danish family with a remarkably high incidence of meningococcal meningitis-in total four cases, one of them fatal...
  19. ncbi request reprint The catalase -262C/T promoter polymorphism and aging phenotypes
    Lene Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark
    J Gerontol A Biol Sci Med Sci 59:B886-9. 2004
    ..The results raise the hypothesis that the catalase -262T allele serves as protection against neurodegenerative and physical decline, although replication in other studies is warranted for confirmation of these findings...
  20. ncbi request reprint [Biobanks--a resource for the future. The Danish Society of Clinical Biochemistry]
    Lise Bathum
    Afdeling for Biokemi, Farmakologi og Genetik, Odense Universitetshospital, DK 5000 Odense C
    Ugeskr Laeger 168:1225. 2006
  21. pmc Telomere length and mortality: a study of leukocytes in elderly Danish twins
    Masayuki Kimura
    Center of Human Development and Aging, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Am J Epidemiol 167:799-806. 2008
    ..Leukocyte telomere dynamics might help explain the boundaries of the human life span...
  22. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  23. ncbi request reprint [Diagnosing lactose intolerance in adults]
    Mikala Klok Jørgensen
    Klinisk Biokemisk Afdeling, Slagelse Sygehus, DK 4200 Slagelse
    Ugeskr Laeger 170:3309-12. 2008
    ..Genotyping was implemented for routine testing of patients for primary lactose intolerance. We estimated the frequency of genotypes in a group of blood donors and compared it with the frequency among patients...
  24. ncbi request reprint Genetic influence on inflammation variables in the elderly
    Moniek P M de Maat
    Department for Thrombosis Research, University of Southern Denmark, Esbjerg, Denmark
    Arterioscler Thromb Vasc Biol 24:2168-73. 2004
    ....