Jiri Bartek

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
    Niels Mailand
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Mol Cell 23:307-18. 2006
  2. ncbi Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours
    J Bartkova
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Oncogene 20:5897-902. 2001
  3. pmc Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
    Shizhou Liu
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell Biol 26:6056-64. 2006
  4. doi RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
    Carsten Doil
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell 136:435-46. 2009
  5. ncbi E2F activity is essential for survival of Myc-overexpressing human cancer cells
    Eric Santoni-Rugiu
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, 2100 Copenhagen E, Denmark
    Oncogene 21:6498-509. 2002
  6. ncbi Chk1 and Chk2 kinases in checkpoint control and cancer
    Jiri Bartek
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Cancer Cell 3:421-9. 2003
  7. ncbi CHK2 kinase--a busy messenger
    J Bartek
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Nat Rev Mol Cell Biol 2:877-86. 2001
  8. ncbi Mammalian G1- and S-phase checkpoints in response to DNA damage
    J Bartek
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Curr Opin Cell Biol 13:738-47. 2001
  9. ncbi Checking on DNA damage in S phase
    Jiri Bartek
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Rev Mol Cell Biol 5:792-804. 2004
  10. ncbi Pathways governing G1/S transition and their response to DNA damage
    J Bartek
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    FEBS Lett 490:117-22. 2001

Detail Information

Publications112 found, 100 shown here

  1. ncbi Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
    Niels Mailand
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Mol Cell 23:307-18. 2006
    ..Our data suggest that degradation of Claspin facilitates timely reversal of the checkpoint response and delineates the period permissive for Chk1 activation during cell cycle progression...
  2. ncbi Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours
    J Bartkova
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Oncogene 20:5897-902. 2001
    ....
  3. pmc Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
    Shizhou Liu
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell Biol 26:6056-64. 2006
    ..Together, these results suggest that while TopBP1 is a general regulator of ATR, Claspin operates downstream of TopBP1 to selectively regulate the Chk1-controlled branch of the genotoxic stress response...
  4. doi RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
    Carsten Doil
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell 136:435-46. 2009
    ..Thus, RNF168 defines a new pathway involving sequential ubiquitylations on damaged chromosomes and uncovers a functional cooperation between E3 ligases in genome maintenance...
  5. ncbi E2F activity is essential for survival of Myc-overexpressing human cancer cells
    Eric Santoni-Rugiu
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, 2100 Copenhagen E, Denmark
    Oncogene 21:6498-509. 2002
    ....
  6. ncbi Chk1 and Chk2 kinases in checkpoint control and cancer
    Jiri Bartek
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Cancer Cell 3:421-9. 2003
    ....
  7. ncbi CHK2 kinase--a busy messenger
    J Bartek
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Nat Rev Mol Cell Biol 2:877-86. 2001
    ..Defects in Chk2 contribute to the development of both hereditary and sporadic human cancers, and earmark this kinase as a candidate tumour suppressor and an attractive target for drug discovery...
  8. ncbi Mammalian G1- and S-phase checkpoints in response to DNA damage
    J Bartek
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Curr Opin Cell Biol 13:738-47. 2001
    ..Multiple links between defects in the G1/S checkpoints, genomic instability and oncogenesis are emerging, as are new challenges and hopes raised by this knowledge...
  9. ncbi Checking on DNA damage in S phase
    Jiri Bartek
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Rev Mol Cell Biol 5:792-804. 2004
    ....
  10. ncbi Pathways governing G1/S transition and their response to DNA damage
    J Bartek
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    FEBS Lett 490:117-22. 2001
    ....
  11. ncbi Perspective: defects in cell cycle control and cancer
    J Bartek
    Department of Cell Cycle and Cancer, Danish Cancer Society, Copenhagen, Denmark
    J Pathol 187:95-9. 1999
    ....
  12. ncbi The retinoblastoma protein pathway and the restriction point
    J Bartek
    Danish Cancer Society, Division of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Curr Opin Cell Biol 8:805-14. 1996
    ..Major advances have also been made in our understanding of a key role of the pathway involving cyclin D, Cdks, CKIs, pRb and E2F both in commitment to traversing the cell cycle and in restraining oncogenesis...
  13. doi HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
    Simon Bekker-Jensen
    Centre for Genotoxic Stress Research, Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Nat Cell Biol 12:80-6; sup pp 1-12. 2010
    ....
  14. ncbi Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
    Claus Storgaard Sørensen
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Cancer Cell 3:247-58. 2003
    ..Our results provide evidence that the mammalian S phase checkpoint functions via amplification of physiologically operating, Chk1-dependent mechanisms...
  15. ncbi Deregulation of the G1/S-phase control in human testicular germ cell tumours
    Jirina Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    APMIS 111:252-65; discussion 265-6. 2003
    ....
  16. ncbi RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
    Niels Mailand
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Cell 131:887-900. 2007
    ..These data suggest that MDC1-mediated and RNF8-executed histone ubiquitylation protects genome integrity by licensing the DSB-flanking chromatin to concentrate repair factors near the DNA lesions...
  17. ncbi DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nature 434:864-70. 2005
    ..Mutations compromising this checkpoint, including defects in the ATM-Chk2-p53 pathway, might allow cell proliferation, survival, increased genomic instability and tumour progression...
  18. ncbi Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
    Alwin Krämer
    Danish Cancer Society, Institute of Cancer Biology, Department of Cell Cycle and Cancer, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Nat Cell Biol 6:884-91. 2004
    ....
  19. ncbi Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway
    Jeppe Agner
    Danish Cancer Society, Institute of Cancer Biology, DK 2100 Copenhagen, Denmark
    Exp Cell Res 302:162-9. 2005
    ....
  20. pmc Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
    Randi G Syljuåsen
    Institute of Cancer Biology, Department of Cell Cycle and Cancer, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Mol Cell Biol 25:3553-62. 2005
    ..These results may help explain why Chk1 is an essential kinase and should be taken into account when drugs to inhibit this kinase are considered for use in cancer treatment...
  21. ncbi ATM activation in normal human tissues and testicular cancer
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 4:838-45. 2005
    ..The new tools characterized here should facilitate monitoring of ATM activation in clinical specimens, and help develop future treatment strategies...
  22. pmc Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
    Fredrik Melander
    Institute of Cancer Biology and 2Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 181:213-26. 2008
    ..Together, these data suggest that phosphorylation of the SDT repeats in the MDC1 N terminus functions to recruit NBS1 and, thereby, increases the local concentration of MRN at the sites of chromosomal breakage...
  23. pmc The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
    Dorthe Helena Larsen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 190:731-40. 2010
    ..Thus, CHD4 emerges as a novel genome caretaker and a factor that facilitates both checkpoint signaling and repair events after DNA damage...
  24. pmc Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
    Simon Bekker-Jensen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100, Copenhagen, Denmark
    J Cell Biol 170:201-11. 2005
    ....
  25. pmc Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
    Simon Bekker-Jensen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 173:195-206. 2006
    ..We propose that subclassification of DSB regulators according to their residence sites provides a useful framework for understanding their involvement in diverse processes of genome surveillance...
  26. pmc Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment
    Lenka Oplustilova
    Danish Cancer Society Research Center, Copenhagen, Denmark
    Cell Cycle 11:3837-50. 2012
    ..Overall, this study helps characterize genetic and functional determinants of cellular responses to PARP-1i and contributes to the search for biomarkers to exploit PARP inhibitors in cancer therapy...
  27. doi HCLK2 is required for activity of the DNA damage response kinase ATR
    Jannie M Rendtlew Danielsen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    J Biol Chem 284:4140-7. 2009
    ..Importantly, our results suggest that HCLK2 functions in the same pathway as TopBP1 but that the two proteins regulate different steps in ATR activation...
  28. pmc Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities
    Kasper Fugger
    Institute of Cancer Biology and Center for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 186:655-63. 2009
    ..Thus, by possessing both pro- and anti-recombinogenic potential, hFbh1 may cooperate with other DNA helicases in tightly controlling cellular HR activity...
  29. pmc Differentiation-induced radioresistance in muscle cells
    Lucia Latella
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Mol Cell Biol 24:6350-61. 2004
    ....
  30. ncbi Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation
    Zuzana Horejsi
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, Copenhagen DK 2100 Denmark
    Oncogene 23:3122-7. 2004
    ..Although not absolutely required for ATM activation, the MRN nuclease complex may help reach the threshold activity of ATM necessary for optimal genome maintenance and prevention of cancer...
  31. ncbi Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks
    Simon Bekker-Jensen
    Centre for Genotoxic Stress Research and Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen DK 2100, Denmark
    J Biol Chem 282:19638-43. 2007
    ..Collectively, these findings implicate Xip1 as a new regulator of genome maintenance pathways, which may function to organize DNA strand break repair complexes at sites of DNA damage...
  32. ncbi Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation
    Randi G Syljuåsen
    Department of Cell Cycle and Cancer and Apoptosis Laboratory, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Cancer Res 64:9035-40. 2004
    ..These results demonstrate that transient Chk1 inhibition by CEP-3891 allows premature mitotic entry of irradiated cells, thereby leading to accelerated onset of mitotic nuclear fragmentation and increased cell death...
  33. pmc Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
    Claudia Lukas
    Danish Cancer Society, Institute of Cancer Biology, Copenhagen, Denmark
    EMBO J 23:2674-83. 2004
    ....
  34. doi Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene
    Jirina Bartkova
    Institute Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Mol Oncol 2:296-316. 2008
    ....
  35. ncbi ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
    Claus Storgaard Sørensen
    Danish Cancer Society, Institute of Cancer Biology, Copenhagen, Denmark
    Cell Cycle 3:941-5. 2004
    ..DNA damage further activates and switches this pathway from its constitutively operating "surveillance mode" compatible with DNA replication into an "emergency" checkpoint response...
  36. doi 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
    Claudia Lukas
    Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 13:243-53. 2011
    ..Together, these data indicate that restoration of DNA or chromatin integrity at loci prone to replication problems requires mitotic transmission to the next cell generations...
  37. ncbi Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time
    Jiri Lukas
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    DNA Repair (Amst) 3:997-1007. 2004
    ....
  38. doi TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
    Thorkell Gudjonsson
    Chromosome Biology Unit, Danish Cancer Society Research Center and Center for Genotoxic Stress Research, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cell 150:697-709. 2012
    ..We provide evidence that this mechanism is vital for the homeostasis of ubiquitin-controlled events after DNA breakage and can be subverted during tumorigenesis...
  39. ncbi Deregulation of the RB pathway in human testicular germ cell tumours
    Jirina Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    J Pathol 200:149-56. 2003
    ..We hope that this study will inspire further immunohistochemical applications of phosphospecific antibodies in pathology, and examination of the RB pathway defects in relation to curability of TGCTs...
  40. ncbi Cell biology. The stress of finding NEMO
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Science 311:1110-1. 2006
  41. ncbi Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4
    Thomas Farkas
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, Copenhagen DK 2100, Denmark
    J Biol Chem 277:26741-52. 2002
    ..These results further elucidate the complex regulation of p130 and provide a molecular mechanism to explain the differential control of p107 and p130 by cyclin-dependent kinases...
  42. ncbi Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis
    Frederic Tort
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cancer Res 66:10258-63. 2006
    ....
  43. pmc USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin
    Helene Faustrup
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 184:13-9. 2009
    ..Thus, Claspin turnover is controlled by multiple ubiquitylation and deubiquitylation activities, which together provide a flexible means to regulate the ATR-Chk1 pathway...
  44. pmc Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint
    Anja Groth
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    EMBO J 22:1676-87. 2003
    ....
  45. doi LEDGF (p75) promotes DNA-end resection and homologous recombination
    Mads Daugaard
    Cell Death and Metabolism, Danish Cancer Society Research Center, Copenhagen, Denmark
    Nat Struct Mol Biol 19:803-10. 2012
    ..These data highlight the role of PWWP-domain proteins in DNA repair and provide a molecular explanation for the antiapoptotic and cancer cell survival-activities of LEDGF...
  46. ncbi The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
    Jacob Falck
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Genet 30:290-4. 2002
    ..We conclude that in response to ionizing radiation, phosphorylations of Nbs1 and Chk2 by ATM trigger two parallel branches of the DNA damage-dependent S-phase checkpoint that cooperate by inhibiting distinct steps of DNA replication...
  47. ncbi Cell biology. Balancing life-or-death decisions
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Science 314:261-2. 2006
  48. ncbi TOPping up ATR activity
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cell 124:888-90. 2006
    ..In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity...
  49. ncbi The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
    Claus Storgaard Sørensen
    Danish Cancer Society, Institute of Cancer Biology, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 7:195-201. 2005
    ..These results highlight a crucial role for the Chk1 signalling pathway in protecting cells against lethal DNA lesions through regulation of HRR...
  50. ncbi Imaging of protein movement induced by chromosomal breakage: tiny 'local' lesions pose great 'global' challenges
    Claudia Lukas
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, Copenhagen, Denmark
    Chromosoma 114:146-54. 2005
    ..We delineate benefits and limitations of these assays and highlight the key recent discoveries where live microscopy provided unprecedented insights into how cells defend themselves against genome-destabilizing effects of DNA damage...
  51. ncbi Inhibitory effects of 1alpha,25-dihydroxyvitamin D(3) on the G(1)-S phase-controlling machinery
    S S Jensen
    Institute of Cancer Biology, The Danish Cancer Society, DK-2100 Copenhagen, Denmark
    Mol Endocrinol 15:1370-80. 2001
    ....
  52. ncbi Human Asf1 regulates the flow of S phase histones during replicational stress
    Anja Groth
    Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell 17:301-11. 2005
    ....
  53. ncbi Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis
    Martin Mistrik
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 8:2592-9. 2009
    ....
  54. ncbi DNA damage checkpoints: from initiation to recovery or adaptation
    Jiri Bartek
    Department of Cell Cycle and Cancer, and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Curr Opin Cell Biol 19:238-45. 2007
    ..Such studies highlight the dynamic nature of these processes and help us to better understand the molecular basis, spatiotemporal orchestration and biological significance of the DNA damage response in normal and cancerous cells...
  55. ncbi Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases
    Randi G Syljuåsen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cancer Res 66:10253-7. 2006
    ..Such cell division in the presence of damaged DNA may be detrimental for genetic stability and could potentially contribute to cancer development...
  56. pmc Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis
    C S Sorensen
    Danish Cancer Society, Institute of Cancer Biology, DK 2100 Copenhagen O, Denmark
    Mol Cell Biol 20:7613-23. 2000
    ....
  57. ncbi Checking out the centrosome
    Alwin Krämer
    Danish Cancer Society, Institute of Cancer Biology, Department of Cell Cycle and Cancer, Copenhagen, Denmark
    Cell Cycle 3:1390-3. 2004
    ..This review will focus on recent advances in the understanding of the role of centrosomes as integrators of positive and negative pathways for mitotic entry...
  58. ncbi Watching the DNA repair ensemble dance
    Jiri Lukas
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100, Copenhagen
    Cell 118:666-8. 2004
    ..In this issue of Cell, Lisby et al. (2004) provide a visual glimpse into how the diverse signaling and repair machines are organized in space and time around the deadliest genetic lesions--the DNA double-strand breaks...
  59. ncbi Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Nature 444:633-7. 2006
    ..Thus, senescence in human preneoplastic lesions is a manifestation of oncogene-induced DNA replication stress and, together with apoptosis, provides a barrier to malignant progression...
  60. pmc Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block
    K Hansen
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    EMBO J 20:422-32. 2001
    ....
  61. ncbi Rapid destruction of human Cdc25A in response to DNA damage
    N Mailand
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Science 288:1425-9. 2000
    ..These results identify specific degradation of Cdc25A as part of the DNA damage checkpoint mechanism and suggest how Cdc25A overexpression in human cancers might contribute to tumorigenesis...
  62. ncbi DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
    C Lukas
    Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark
    Cancer Res 61:4990-3. 2001
    ..These data highlight striking differences between Chk2 and Chk1 and show unexpected correlation of Chk2 expression with tissue biology...
  63. ncbi DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 6:2344-7. 2007
    ....
  64. ncbi Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
    Claudia Lukas
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 5:255-60. 2003
    ..These results unravel a dynamic nature of Nbs1 interaction with DSB lesions and identify Chk2 as a candidate transmitter of the checkpoint signal, allowing for a coordinated pan-nuclear response to focal DNA damage...
  65. doi More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
    Jiri Lukas
    Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 13:1161-9. 2011
    ..Recent research has provided insights into these issues and suggests that chromatin responses induced by DNA damage are not simply the accumulation of 'nuclear foci' but are mechanisms required to guard genome integrity...
  66. ncbi Cyclin E-induced S phase without activation of the pRb/E2F pathway
    J Lukas
    Danish Cancer Society, Division of Cancer Biology, Copenhagen
    Genes Dev 11:1479-92. 1997
    ..They furthermore indicate that a lack of E2F-mediated transactivation can be compensated by hyperactivation of this cyclin E-controlled event...
  67. ncbi Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines
    Harald Loffler
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Oncogene 22:8063-71. 2003
    ..Given the frequency of this mechanism, we propose that the DNA integrity checkpoint controlling Cdc25A protein stability might be a common target for deregulation in breast cancer...
  68. doi SUMO boosts the DNA damage response barrier against cancer
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cancer Cell 17:9-11. 2010
    ..Two recent articles published in Nature show that such genome maintenance requires modifications of tumor suppressor proteins BRCA1 and 53BP1 by the small ubiquitin-like modifier SUMO...
  69. ncbi A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3
    Christina Aaen Hansen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 7:325-34. 2008
    ..Collectively, our findings suggest an intimate functional relationship between the Cdc14A phosphatase and the Erk3 kinase in signaling pathways that regulate key cell-fate decisions in human cells...
  70. pmc Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability
    Niels Mailand
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    EMBO J 21:5911-20. 2002
    ..Thus, phosphorylation-mediated switches among three differentially stable forms ensure distinct thresholds, and thereby distinct roles for Cdc25A in multiple cell cycle transitions and checkpoints...
  71. ncbi Microcephalin guards against small brains, genetic instability, and cancer
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cancer Cell 10:91-3. 2006
    ..These findings and aberrantly reduced expression in human carcinomas identify microcephalin as a candidate novel tumor suppressor...
  72. ncbi Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation
    Niels Mailand
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 4:317-22. 2002
    ..These results indicate that Cdc14A is a physiological regulator of the centrosome duplication cycle, which, when disrupted, can lead to genomic instability in mammalian cells...
  73. ncbi Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors
    M Thullberg
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    FEBS Lett 470:161-6. 2000
    ....
  74. pmc A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
    C S Sørensen
    Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen Ø, Denmark
    Mol Cell Biol 21:3692-703. 2001
    ..Collectively, these data provide a mechanistic explanation for the mutual functional interplay between cyclin A-Cdk2 and APC-Cdh1 and the first evidence that Cdh1 may activate the APC by binding specific substrates...
  75. ncbi Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
    C Lukas
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen
    Nature 401:815-8. 1999
    ..These results implicate an E2F-dependent, cyclin A/Cdk2-mediated phosphorylation of Cdh1 in the timely accumulation of cyclin B1 and the coordination of cell-cycle progression during the post-restriction point period...
  76. ncbi Cell-cycle regulatory proteins in human wound healing
    Jirina Bartkova
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Arch Oral Biol 48:125-32. 2003
    ..These data indicate that downmodulation of several G(1)/S-phase cyclins and a relative excess of CKIs may cooperate to ensure the quiescent state of migrating keratinocytes during wound healing...
  77. ncbi The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    J Falck
    Institute of Cancer Bioloyg, Danish Cancer Society, Copenhagen, Denmark
    Nature 410:842-7. 2001
    ..These results support Chk2 as a candidate tumour suppressor, and identify the ATM-Chk2-Cdc25A-Cdk2 pathway as a genomic integrity checkpoint that prevents radioresistant DNA synthesis...
  78. ncbi Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis
    J Bartkova
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen O, Denmark
    Oncogene 19:4146-50. 2000
    ..Oncogene (2000) 19, 4146 - 4150..
  79. ncbi Expression of a p16INK4a-specific ribozyme downmodulates p16INK4a abundance and accelerates cell proliferation
    J Nylandsted
    Danish Cancer Society, Institute of Cancer Biology, Copenhagen
    FEBS Lett 436:41-5. 1998
    ....
  80. ncbi Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation
    J Bartkova
    Division for Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 66:732-7. 1996
    ..Our data are consistent with the emerging role for CDK7/CAK in multiple biological processes, possibly providing a link between cell-cycle control, transcriptional regulation and genomic integrity control...
  81. ncbi Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
    J Falck
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, , Denmark
    Oncogene 20:5503-10. 2001
    ....
  82. ncbi The retinoblastoma protein pathway in cell cycle control and cancer
    J Bartek
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Exp Cell Res 237:1-6. 1997
    ..This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine...
  83. ncbi DNA damage signalling guards against activated oncogenes and tumour progression
    J Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Oncogene 26:7773-9. 2007
    ....
  84. ncbi Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon
    J Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Copenhagen, Denmark
    Gastroenterology 120:1680-8. 2001
    ..Here, the abundance and localization of key components of the retinoblastoma (RB) pathway were determined in exophytic and flat colorectal adenomas...
  85. ncbi D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy
    J Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Pathol 187:573-81. 1999
    ....
  86. ncbi The emerging phenotype of the testicular carcinoma in situ germ cell
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    APMIS 111:267-78; discussion 278-9. 2003
    ....
  87. ncbi DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
    J Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Oncogene 26:7414-22. 2007
    ....
  88. ncbi Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer
    Jirina Bartkova
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, Copenhagen DK 2100, Denmark
    Oncogene 23:8545-51. 2004
    ....
  89. doi Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas
    J Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Oncogene 29:5095-102. 2010
    ....
  90. ncbi DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy
    J Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Int J Androl 30:282-91; discussion 291. 2007
    ....
  91. pmc Human CtIP promotes DNA end resection
    Alessandro A Sartori
    The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 450:509-14. 2007
    ..These findings establish evolutionarily conserved roles for CtIP-like proteins in controlling DSB resection, checkpoint signalling and homologous recombination...
  92. ncbi Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events
    Harald Loffler
    Clinical Cooperation Unit for Molecular Hematology Oncology, German Cancer Research Center DKFZ
    Cell Cycle 5:2543-7. 2006
    ..Analogous to Chk1 inhibition, the 'paraspindle' phenotype was induced by overexpression of Cdc25B but not Cdc25A. Our results suggest that Chk1 functions to coordinate mitotic events through regulation of Cdc25B...
  93. ncbi Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
    Yael Ziv
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Cell Biol 8:870-6. 2006
    ..These results suggest that chromatin relaxation is a fundamental pathway in the DNA-damage response and identify its primary mediators...
  94. ncbi Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1)
    Takashi Shiromizu
    Division of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Aichi 464 8681, Japan
    Genes Cells 11:477-85. 2006
    ..These observations imply the regulation of mitotic Chk1 function through Chk1 phosphorylation at novel sites by Cdk1...
  95. ncbi ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    Ali Jazayeri
    The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, Cambridge University, Tennis Court Road, Cambridge, CB2 1QN, UK
    Nat Cell Biol 8:37-45. 2006
    ..Thus, in response to DSBs, ATR activation is regulated by ATM in a cell-cycle dependent manner...
  96. ncbi Evaluation of RAD50 in familial breast cancer predisposition
    Johanna Tommiska
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Cancer 118:2911-6. 2006
    ..Altogether, these results suggest RAD50 can only be making a very minor contribution to familial breast cancer predisposition in UK and Finland...
  97. ncbi MDC1 is required for the intra-S-phase DNA damage checkpoint
    Michal Goldberg
    The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology and Department of Zoology, University of Cambridge, Cambridge CB2 1QR, UK
    Nature 421:952-6. 2003
    ..These findings reveal that MDC1-mediated focus formation by the MRE11 complex at sites of DNA damage is crucial for the efficient activation of the intra-S-phase checkpoint...
  98. ncbi Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
    Magtouf Gatei
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    J Biol Chem 278:14806-11. 2003
    ..In addition, this study also demonstrates that Chk1 is essential for IR-induced inhibition of DNA synthesis and the G(2)/M checkpoint...
  99. ncbi DNA repair: Damage alert
    Jiri Bartek
    Nature 421:486-8. 2003
  100. ncbi 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
    Richard A DiTullio
    Wistar Institute, Philadelphia, PA 19104 4268, USA
    Nat Cell Biol 4:998-1002. 2002
    ..We conclude that the constitutive activation of the DNA damage checkpoint pathway may be linked to the high frequency of p53 mutations in human cancer, as p53 is a downstream target of Chk2 and ATM...
  101. ncbi CHEK2 variant I157T may be associated with increased breast cancer risk
    Outi Kilpivaara
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital HUCH, Helsinki, Finland
    Int J Cancer 111:543-7. 2004
    ..The I157T variant may be associated with breast cancer risk, but the risk is lower than for 1100delC...